Event-related potential biomarkers in temporal lobe epilepsy: N170, vertex positive potential, late positive potential, and P3 signatures of depression comorbidity.

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL
SAGE Open Medicine Pub Date : 2025-04-27 eCollection Date: 2025-01-01 DOI:10.1177/20503121251335468
Weifeng Peng, Zihan Hu, Jia Liang, Jing Ding, Xin Wang
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Abstract

Objective: This study aimed to identify which components of the event-related potentials N170, vertex positive potential, late positive potential, and P3 were most significantly associated with depression in temporal lobe epilepsy.

Methods: Patients with temporal lobe epilepsy were divided into two groups based on the presence or absence of comorbid depression as diagnosed by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition: those with depression (epilepsy patients with depression group) and those without depression (epilepsy patients without depression group). Both groups were matched for age, education, and seizure-related parameters. A control group of volunteers without epilepsy and depression was also included. Participants underwent electroencephalographic recordings while performing the Oddball task, and the emotional conflict Stroop face-word task. The electroencephalographic data were analyzed using the EEGLAB software.

Results: The study included 20 patients in the epilepsy patients with depression group and 16 in the epilepsy without depression group, matched for age, gender, and seizure-related parameters. In the epilepsy patients with depression group, the N170 peak amplitude and latency, the vertex positive potential peak latency, and the area under the late positive potential waveform were significantly greater, while the P3 peak latency was shorter compared to the epilepsy without depression group. The areas under the curve for N170, vertex positive potential, late positive potential, and P3 were 0.755, 0.692, 0.645, and 0.731, respectively. Notably, when these four event-related potential components were combined, the areas under the curve increased to 0.922, with a sensitivity of 0.950 and specificity of 0.812 for assessing depression based on the 17-item Hamilton Depression Rating Scale score.

Conclusion: Specific features of N170, vertex positive potential, late positive potential, and P3 components were significantly associated with depression in patients with temporal lobe epilepsy. These findings suggest that event-related potential components may provide an objective and quantitative approach to enhance the assessment and treatment of depression in epilepsy.

颞叶癫痫的事件相关电位生物标志物:抑郁症合并症的N170、顶点阳性电位、晚期阳性电位和P3特征
目的:探讨事件相关电位N170、顶点正电位、晚期正电位和P3与颞叶癫痫抑郁的关系。方法:将颞叶癫痫患者根据《精神障碍诊断与统计手册(第五版)》诊断是否存在共病抑郁分为有抑郁组(癫痫伴抑郁组)和无抑郁组(癫痫伴抑郁组)。两组在年龄、教育程度和癫痫相关参数上都是匹配的。另一组没有癫痫和抑郁症的志愿者也被纳入研究。参与者在执行古怪任务和情绪冲突斯特鲁普脸字任务时进行了脑电图记录。采用EEGLAB软件分析脑电图数据。结果:本研究纳入癫痫伴抑郁组20例,无抑郁组16例,年龄、性别、癫痫发作相关参数匹配。抑郁组癫痫患者N170峰幅和潜伏期、顶点正电位峰潜伏期、晚期正电位波形下面积均显著大于无抑郁组,P3峰潜伏期短于无抑郁组。N170、顶点正电位、晚期正电位和P3的曲线下面积分别为0.755、0.692、0.645和0.731。值得注意的是,当这四个事件相关电位分量合并时,曲线下面积增加到0.922,以17项汉密尔顿抑郁评定量表评分评估抑郁的灵敏度为0.950,特异性为0.812。结论:颞叶癫痫患者N170、顶点正电位、晚期正电位、P3组分特异性特征与抑郁有显著相关性。这些发现表明,事件相关电位成分可能为加强癫痫抑郁的评估和治疗提供一种客观和定量的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
SAGE Open Medicine
SAGE Open Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
4.30%
发文量
289
审稿时长
12 weeks
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