SAGE Open Medicine最新文献

{"title":"Magnetic resonance venography study of venous structures of the transverse-sigmoid sinus region in the Han Chinese population: A cross-sectional study.","authors":"Zibo Zhou, Jinlu Yu","doi":"10.1177/20503121241274244","DOIUrl":"https://doi.org/10.1177/20503121241274244","url":null,"abstract":"<p><strong>Objective: </strong>Venous structures of the transverse-sigmoid sinus region have been insufficiently studied by magnetic resonance venography, especially in the healthy Han Chinese population.</p><p><strong>Methods: </strong>Magnetic resonance venography data were reconstructed. The relevant parameters were recorded. A paired <i>t</i>-test was used to compare the diameters of the inferior petrous sinus at the origin and termination. An unpaired <i>t</i>-test, a chi-squared test or Fisher's exact test was used to compare other data.</p><p><strong>Results: </strong>One hundred healthy participants were included. The average age was 36.6 ± 17.1 years, and the ratio of males to females was 1:1. The development of the transverse-sigmoid sinus had a right-sided predominance in 51% of patients. Statistical analysis revealed significant differences (<i>p</i> < 0.05) in the lengths of bilateral TSs, the lengths of bilateral partial TSs from the torcular to lateral tentorial sinus, the diameters between bilateral TSs at the origin and the lateral tentorial sinus, the diameters between bilateral TS-sigmoid sinus junctions and sigmoid sinus terminations, and the inferior petrous sinus diameters at the origin and termination. Statistical analysis revealed that the right lateral tentorial sinus was more likely to originate from the TS (<i>p</i> < 0.05). Statistical analysis revealed no significant differences (<i>p</i> < 0.05) between transverse-sigmoid sinus development and inferior petrous sinus continuity or between transverse-sigmoid sinus development and inferior petrous sinus continuity and bilateral inferior petrous sinus continuity.</p><p><strong>Conclusions: </strong>This study revealed that the right transverse-sigmoid sinus was predominantly larger in diameter, the torcular Herophili tended to deviate to the right, and the right lateral tentorial sinus tended to drain into the TS. The inferior petrous sinus at the origin was thicker than that at the termination, and the right inferior petrous sinus was thicker than the left inferior petrous sinus. transverse-sigmoid sinus development had no effect on inferior petrous sinus continuity, and there was no difference in inferior petrous sinus continuity between the left and right sides.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241274244"},"PeriodicalIF":2.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11520009/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nurses' knowledge toward hemodialysis vascular access devices: A cross-sectional study in Palestine.","authors":"Sae'd Abu El-Kass, Nisreen Ahmed, Tahreer Kannan, Narmean Abu Shediq, Esraa El Dirani","doi":"10.1177/20503121241264444","DOIUrl":"10.1177/20503121241264444","url":null,"abstract":"<p><strong>Objective: </strong>To assess the nurses' knowledge of vascular access devices for patients undergoing hemodialysis programs in the Gaza Strip, Palestine.</p><p><strong>Methods: </strong>A descriptive cross-sectional study was conducted to assess the nurses' knowledge of hemodialysis vascular access using the convenience sampling technique. The assessment tool comprised 60 items related to the nurses' knowledge and 7 items on demographic characteristics at hemodialysis units in 5 governmental hospitals in the Gaza Strip, between March and June 2023. Statistical analysis of the collected data was performed using SPSS version 22.</p><p><strong>Results: </strong>A total of 65 nurses in hemodialysis units were included. Of the majority of study nurses 71% were male, 21.5% of nurses had fair knowledge, and 78.5% had good knowledge about vascular access devices. The overall average score was more than 70% in all dimensions, which revealed good knowledge about vascular access devices. The study indicated that there was a statistically significant association between nurses' knowledge of vascular access devices and (years of experience in the hemodialysis unit, and received training of nurses).</p><p><strong>Conclusions: </strong>The knowledge of hemodialysis nurses toward vascular access devices for patients undergoing hemodialysis was good. The years in the hemodialysis unit and having training have shown significant association with knowledge among hemodialysis nurses on vascular access devices care. Thus, interventions should focus on providing training for nurses about vascular access devices care in hemodialysis units to improve the comprehensive knowledge of nurses and to maintain patient's health status.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241264444"},"PeriodicalIF":2.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility, acceptability, and preliminary effectiveness of implementing a 12-week home-based aerobic and resistance exercise program for breast cancer patients receiving endocrine treatment in Indonesia: A mixed methods study.","authors":"Yufi Kartika Astari, Susanna Hilda Hutajulu, Yayi Suryo Prabandari, Bagas Suryo Bintoro, Rakhmat Ari Wibowo, Mardiah Suci Hardianti, Anggoro Budi Hartopo, Katie M Di Sebastiano, Matthew John Allsop, Shaunna Burke","doi":"10.1177/20503121241272706","DOIUrl":"10.1177/20503121241272706","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the feasibility, acceptability, and preliminary effectiveness of implementing a home-based aerobic and resistance exercise for patients with breast cancer receiving endocrine treatment in Indonesia.</p><p><strong>Methods: </strong>This is a mixed methods study with concurrent design consisting of quantitative single-arm pre-post intervention and qualitative study. We recruited patients with breast cancer (<i>N</i> = 36) receiving endocrine treatment and assigned 12 weeks of home-based pedometer-driven walking and resistance exercises using therapeutic bands. Descriptive statistics were used to assess the feasibility (recruitment, retention, and adherence) and safety. The modified Bruce treadmill test was used to measure predicted aerobic capacity (V̇O₂ peak). Quality of life and fatigue were assessed using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire and fatigue severity scale. Measurements were performed at baseline and post-intervention and analyzed with the paired <i>t</i>-test or Wilcoxon test. Semi-structured interviews and thematic analysis were conducted post-intervention to explore patients' acceptability.</p><p><strong>Results: </strong>The results showed a recruitment rate of 75%, retention rate of 89%, and adherence rates were 53% for aerobic and 78% for resistance exercise. No severe adverse events were reported. Post-intervention interviews identified positive attitudes toward the intervention, with low burden and high perceived benefit. Exercise duration and predicted V̇O₂ peak increased significantly (+1.1 min, <i>p</i> = 0.001 and +2.3 ml/kg/min, <i>p</i> = 0.043), but no significant change was detected for Quality of Life (<i>p</i> > 0.050) or fatigue severity (<i>p</i> = 0.299).</p><p><strong>Conclusions: </strong>A home-based aerobic and resistance exercise was feasible when implemented in the context of routine care in our study population, improving predicted aerobic capacity. Further research is required to understand limited changes to Quality of Life and fatigue and adaptations to support implementation in additional sites in Indonesia.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241272706"},"PeriodicalIF":2.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142547089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of resilience training in improving the ability to cope with stress and hope of mothers with cancer children.","authors":"Arash Khalili, Mahnaz Khatiban, Sajjad Ebrahimi, Khodayar Oshvandi","doi":"10.1177/20503121241284851","DOIUrl":"10.1177/20503121241284851","url":null,"abstract":"<p><strong>Background: </strong>The present study investigates the effect of resilience training in improving the ability to cope with stress and hope of mothers with cancer children.</p><p><strong>Methods: </strong>In this interventional study, 70 mothers parenting children with cancer were selected as available and randomly classified into the control and experimental groups. The mothers of the two groups completed the parenting stress and hope questionnaire. In the test group, nine sessions of resilience training were held by the researcher for 60 min. One month after the intervention, they were again asked to complete the parenting stress and hope questionnaires. Moreover, in the control group, the mothers completed the parenting stress and hope questionnaires again 2 months later without any intervention.</p><p><strong>Result: </strong>The difference between the average scores of hope and parental stress showed that the mean score of hope in the intervention and control groups increased by about 5.45 and 2.74 units, and the hope variable was improved in both groups. The mean score of parental stress in the intervention group decreased by 39.62 units. However, in the control group, it increased by 2.45 units, and parental stress in this group declined.</p><p><strong>Conclusion: </strong>Resilience training significantly reduced the level of parental stress and increased the level of hope in the mothers of the test group. Therefore, it is recommended to use resilience in reducing the level of parental stress and increasing the hope level of mothers with children with cancer.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241284851"},"PeriodicalIF":2.3,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526236/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacists perspectives on challenges and facilitators in initiating medications take-back program in Indonesia: A qualitative study.","authors":"Sofa D Alfian, Annisa M Azzahra, Qisty A Khoiry, Meliana Griselda, Irma M Puspitasari, Rizky Abdulah","doi":"10.1177/20503121241290968","DOIUrl":"10.1177/20503121241290968","url":null,"abstract":"<p><strong>Objective: </strong>The establishment of a medication take-back program is an important intervention to prevent the improper disposal of expired or unused household medications. However, such a program has not been established in Indonesia. A significant step in establishing the program is to gain a better understanding of pharmacists' perspectives on the associated challenges and facilitators. Therefore, this study aimed to explore pharmacists' perspectives on the associated challenges and facilitators in initiating medications take-back program in Indonesia.</p><p><strong>Methods: </strong>This qualitative study was conducted through Key Informant Interviews with a purposive sample of nine pharmacists working in community health centers (CHC) in Bandung City, Indonesia. The discussions were transcribed, coded, and analyzed using Atlas.ti9 software.</p><p><strong>Results: </strong>Pharmacists' perspectives on initiating medications take-back program were categorized into two main themes, including challenges and facilitators. The identified challenges comprised a lack of personnel, financial constraints, geographical constraints, lack of facilities, and inadequate knowledge. Meanwhile, the facilitators included the good responsibility of pharmacists, incentives, and convenient locations.</p><p><strong>Conclusion: </strong>The identified challenges and facilitators should be considered when initiating medication take-back programs in Indonesia.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241290968"},"PeriodicalIF":2.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11492182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered trace elements, antioxidant vitamin C, and malondialdehyde levels are associated with the pathophysiology and development of pre-hepatic jaundice: A case-control study.","authors":"Syed Masudur Rahman Dewan, Abhijit Das, Zahra Labiba Ahmed, Sakif Ahamed Khan, Rehnuma Nasim, Md Shahid Sarwar, Mohammad Safiqul Islam, Md Rabiul Islam","doi":"10.1177/20503121241291977","DOIUrl":"10.1177/20503121241291977","url":null,"abstract":"<p><strong>Objectives: </strong>Pre-hepatic jaundice results from an imbalance between bilirubin production and clearance, often linked to hemoglobinopathies. Antioxidant vitamin C, malondialdehyde, and trace elements play roles in jaundice, yet their specific associations remain unclear. The objective is to assess and compare these biomarkers in pre-hepatic jaundice patients and healthy controls, aiming to identify potential diagnostic markers and understand distinctive characteristics related to the disease's pathogenesis.</p><p><strong>Methods: </strong>This case-control study enrolled 50 pre-hepatic jaundice patients and 50 healthy controls, utilizing advanced techniques for biomarker quantification. We completed blood sample collection from study participants between 1 September 2023 and 31 December 2023. This study investigates the correlation between various biomarkers and pre-hepatic jaundice using serum samples with a focus on antioxidant vitamin C, malondialdehyde, and trace elements.</p><p><strong>Results: </strong>This study demonstrates elevated concentrations of malondialdehyde in patients with pre-hepatic jaundice, suggesting alterations in bilirubin metabolism and increased oxidative stress. We found that the serum levels of malondialdehyde were significantly higher in pre-hepatic jaundice patients compared to healthy controls. Our observations revealed a notable decrease in the average serum vitamin C levels in patients with pre-hepatic jaundice compared to healthy controls. The patients had lower serum Zn levels and higher serum Cu and Mn levels compared to the healthy controls. The correlation study demonstrates robust positive correlations among these biomarkers in pre-hepatic jaundice. As the levels of vitamin C rise, the levels of the other criteria often fall, and vice versa. There is an inverse relationship between higher levels of vitamin C and lower levels of malondialdehyde. The current investigation identifies possible changes in antioxidant vitamins, malondialdehyde levels, and trace elements, which provide significant insights for targeted interventions.</p><p><strong>Conclusions: </strong>The present research highlights the integrated significance of vitamin C, malondialdehyde, and trace elements in the progression of the disease.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241291977"},"PeriodicalIF":2.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11489948/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude of postpartum morbidity and associated factors in southeast Ethiopia, 2022: A facility-based cross-sectional study.","authors":"Feisal Hussein Hasen, Solomon Seyife Alemu, Derese Eshetu, Bedria Mohammed, Eden Nebi, Hana Israel, Yomilan Geneti, Lema Fikadu Wedajo, Woiynshet Gebretsadik","doi":"10.1177/20503121241272580","DOIUrl":"10.1177/20503121241272580","url":null,"abstract":"<p><strong>Objective: </strong>Maternal mortality in Ethiopia is estimated to be 205 per 100,000 live births, with postpartum morbidities expected to surpass maternal mortality substantially. Beside this, there is a lack of information on postpartum morbidities in the study area. Thus, the purpose of this study was to assess the magnitude of postpartum morbidities and associated factors in Bale Robe Town, southeast Ethiopia.</p><p><strong>Method: </strong>An institution-based cross-sectional study was employed among 371 from 1 April to 30 May 2022 among postpartum women attending postnatal care service in the Bale-Robe Town public health facilities. A face-to-face interviewer administered a structured questionnaire, and the participants were selected through a systematic random sampling technique. A bivariate analysis was performed to see the association between each independent variable and dependent variable, and variables with <i>p</i>-values less than 0.25 in the bivariate analysis were retrieved for multivariable analyses. A <i>p</i>-value of less than 0.05 indicated a 95% confidence interval as the level of statistical significance.</p><p><strong>Result: </strong>A total of 366 participants were involved in the study, giving us a response rate of 98.6%. The magnitude of postpartum morbidities among mothers was found to be 102 (27.9%), with a confidence interval of 95% CI: 23.3, 32.8. Women who hadn't had antenatal care follow-up (AOR = 2.47, 95% CI: 1.36, 4.50), instrumental delivery (AOR = 2.69, 95% CI: 1.16, 6.26), unskilled birth attendant (AOR = 3.35, 95% CI: 1.06, 10.63), rural residence (AOR = 2.21, 95% CI: 1.26, 3.89), and current pregnancy-related morbidity or abnormality (AOR = 3.81, 95% CI: 2.00, 7.25) were significantly associated factors.</p><p><strong>Conclusion: </strong>This study revealed that the occurrence of postpartum morbidity in Bale Robe is a great health concern. Therefore, we recommend health professionals and health extension workers strengthen early detection and management of intrapartum abnormalities, give attention during instrumental deliveries, and strengthen skilled birth attendants.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241272580"},"PeriodicalIF":2.3,"publicationDate":"2024-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11490979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Venopulmonary extracorporeal membrane oxygenation for right ventricular support as a bridge to lung transplantation: A narrative review.","authors":"Phan Quang Thuan, Nguyen Hoai Nam, Nguyen Hoang Dinh","doi":"10.1177/20503121241275410","DOIUrl":"10.1177/20503121241275410","url":null,"abstract":"<p><p>This review evaluates the effectiveness of veno-pulmonary support with an oxygenator using extracorporeal membrane oxygenation as a bridge to lung transplantation strategy in patients undergoing veno-venous extracorporeal membrane oxygenation while awaiting lung transplantation. Examining indications, contraindications, and clinical outcomes, the study highlights potential benefits, drawing insights from successful cases in South Korea and the United States. Despite limited sample sizes, veno-pulmonary support with an oxygenator using extracorporeal membrane oxygenation emerges as a promising approach for further investigation in lung transplantation support. The review emphasizes its role in improving hemodynamic status, preventing complications during extended waiting periods, and presenting a cost-effective alternative to traditional methods, especially in developing countries. While in-hospital mortality rates range from 0% to 10%, comparable to other approaches, cautious optimism surrounds veno-pulmonary support with an oxygenator using extracorporeal membrane oxygenation, urging expanded research to solidify its standing in enhancing patient outcomes, reducing costs, and promoting transplant success.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241275410"},"PeriodicalIF":2.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico prediction of some pharmacokinetic, safety, biological activity and molecular docking studies of 1-piperazine indole hybrid with nicotinic amide and nicotinic acid and their analogues.","authors":"Melese Legesse Mitku, Abera Dessie Dagnaw, Derso Teju Geremew, Yeniewa Kerie Anagaw, Minichil Chanie Worku, Liknaw Workie Limenh, Yabibal Berie Tadesse, Asrat Elias Ergena","doi":"10.1177/20503121241274212","DOIUrl":"10.1177/20503121241274212","url":null,"abstract":"<p><strong>Background: </strong>In silico predictions are now being utilized in drug discovery and design to assess the physicochemical, pharmacokinetics, and safety properties of compounds at the beginning of the drug discovery process. This early evaluation of the physicochemical, pharmacokinetics, and safety properties of compounds helps the researchers to invest their time and resources only in the best prospective lead compounds by eliminating compounds with a low chance of success.</p><p><strong>Objective: </strong>The purpose of this study was to explore a promising lead compound designed from 1-piperazine indole hybrid with nicotinic amide and nicotinic acid analogs targeted on <i>Trypanosoma brucei</i> phosphofructokinase for Trypanosomiasis activity by using in silico predictions strategy.</p><p><strong>Results: </strong>The physicochemical, safety, pharmacokinetic, and biological activity properties of those molecules were predicted by using ADMETlab 2.0, ACD labs Chem Sketch software version 14.0, Molinspiration software, and MolPredictX online tool. Our results indicate that several promising candidates exhibit favorable characteristics. Based on Molinspiration software both nicotinic acid and nicotinic amide derivatives showed higher kinase inhibitor activity and all nicotinic acid derivatives revealed enzyme inhibitors and GPCR ligand activity. According to the MolPredictX online tool, the most biologically active derivatives were NA-4, NA-11, and NAD-11.</p><p><strong>Conclusion: </strong>Overall, our findings offer valuable insights into the potential efficacy and safety of these compounds. It appears that almost all of the compounds have successfully passed the pharmacokinetic evaluations and integration of nicotinic acid into indole appears to be more beneficial than nicotinic amide regarding certain biological activities.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241274212"},"PeriodicalIF":2.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11526151/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142558667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between oral health conditions and the risk of major noncommunicable diseases: A protocol for systematic review and meta-analysis.","authors":"Natchanon Promruck, Chidchanok Ruengorn, Kednapa Thavorn, Panwadee Bandhaya, Surapon Nochaiwong","doi":"10.1177/20503121241290385","DOIUrl":"https://doi.org/10.1177/20503121241290385","url":null,"abstract":"<p><strong>Objective: </strong>Although epidemiological studies suggest that oral health conditions may be associated with an increased risk of noncommunicable diseases, the findings have yet to be comprehensively synthesized, particularly for a major noncommunicable diseases-related health and economic burden. Therefore, we will perform a systematic review and meta-analysis of all available observational studies investigating the association between oral health conditions and subsequent risk of major noncommunicable diseases.</p><p><strong>Methods: </strong>With limited English publications, we will search electronic databases, including MEDLINE, Embase, PubMed, Cochrane Library, Scopus, and CINAHL. Based on the temporal properties and natural course of disease progression, we will seek cohort or case-control studies that investigate the association between oral disease conditions and the risk of noncommunicable diseases. Regarding the World Health Organization agenda, oral health conditions will include dental caries, periodontal disease, oral cancer, edentulism, other oral conditions (i.e., oro-dental trauma, cleft lip and palate, and noma), and endodontic lesions. Based on the global disease burden, primary outcomes of interest will include the four major systemic noncommunicable diseases: cardiovascular diseases, cancers, chronic respiratory diseases, and type 2 diabetes mellitus. Random-effects meta-analysis will be used to estimate pooled effects estimate and 95% confidence intervals. Statistical heterogeneity will be investigated using the <i>I</i> ² index and <i>τ</i> ² statistics. Preplanned subgroup and sensitivity analyses and random-effects meta-regression analyses will be performed to address possible heterogeneity and establish the robustness of the meta-analytic estimates. The prediction intervals, expected (<i>E</i>)-value, and evidence certainty will be appraised to synthesize the findings and draw evidence-based conclusions.</p><p><strong>Conclusion: </strong>This systematic review will summarize all available evidence regarding the association between oral health conditions and the risk of major noncommunicable diseases. The findings will encourage collaboration between oral health and primary care professionals for early detection and management of noncommunicable diseases and promote oral health well-being.</p><p><strong>Systematic review registration: </strong>PROSPERO: CRD42021274184.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241290385"},"PeriodicalIF":2.3,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11483790/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142473706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}