Marginal B-cell lymphoma: A 10-year retrospective study at national institute of hematology and blood transfusion, Vietnam.

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL
SAGE Open Medicine Pub Date : 2025-04-27 eCollection Date: 2025-01-01 DOI:10.1177/20503121251334508
Binh Duc Vu, Hung Quang Nguyen, Chiem Quang Le, Cuong Ba Nguyen, Tuong Quang Le, Anh Vu-Bao Nguyen, Thanh Hoang Nguyen, Tai Phu Le, Hieu Van Nguyen
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Abstract

Objective: The prognostic factors of patients diagnosed with marginal zone B-cell lymphoma at the National Institute of Hematology and Blood Transfusion between January 2014 and January 2024 were analyzed.

Subjects and methods: This cross-sectional descriptive study included 86 newly diagnosed and treated marginal zone B-cell lymphoma patients. Myelogram, histopathology, and immunohistochemical staining were performed for all patients. Diagnosis and classification were conducted according to the WHO 2008 criteria, while disease staging was determined using the Ann Arbor staging system.

Results: All three subtypes of marginal zone B-cell lymphoma were identified: mucosa-associated lymphoid tissue lymphoma (73.3%), nodal marginal zone lymphoma (20.9%), and splenic marginal zone lymphoma (5.8%). The most frequently affected extranodal sites were the stomach (25.6%) and eyes (24.4%). The likelihood of stages III-IV disease was found to be 14 times higher in patients with B symptoms, 17 times higher in those with elevated lactate dehydrogenase, 34 times higher in those with increased B2-M levels, and 5.7 times higher in those with a Ki67 index > 30%. Bone marrow invasion was observed to be 14.8 times more likely in patients with elevated lactate dehydrogenase, 40 times more likely in those with increased B2-M levels, and 4.4 times more likely in those with a Ki67 index > 30%. A significant correlation was identified among hemoglobin concentration, lactate dehydrogenase, B2-M, and Ki67, indicating their potential as prognostic markers.

Conclusion: Lactate dehydrogenase, B2-M, and Ki67 were found to be significantly associated with the prognosis of patients with marginal zone B-cell lymphoma.

边缘b细胞淋巴瘤:越南国家血液学和输血研究所10年回顾性研究。
目的:分析2014年1月至2024年1月在美国国家血液输血研究所诊断为边缘带b细胞淋巴瘤患者的预后因素。对象和方法:本横断面描述性研究包括86例新诊断和治疗的边缘区b细胞淋巴瘤患者。所有患者均行骨髓造影、组织病理学和免疫组织化学染色。根据WHO 2008标准进行诊断和分类,采用Ann Arbor分期系统确定疾病分期。结果:边缘带b细胞淋巴瘤有3种亚型:粘膜相关淋巴组织淋巴瘤(73.3%)、淋巴结边缘带淋巴瘤(20.9%)和脾边缘带淋巴瘤(5.8%)。结外最常见的部位是胃(25.6%)和眼睛(24.4%)。发现III-IV期疾病的可能性在B症状患者中高14倍,在乳酸脱氢酶升高的患者中高17倍,在B2-M水平升高的患者中高34倍,在Ki67指数bb0 30%的患者中高5.7倍。骨髓侵袭在乳酸脱氢酶升高的患者中是14.8倍,在B2-M水平升高的患者中是40倍,在Ki67指数为30%的患者中是4.4倍。血红蛋白浓度、乳酸脱氢酶、B2-M和Ki67之间存在显著相关性,表明它们有可能作为预后指标。结论:乳酸脱氢酶、B2-M、Ki67与边缘区b细胞淋巴瘤患者的预后有显著相关性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
SAGE Open Medicine
SAGE Open Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
4.30%
发文量
289
审稿时长
12 weeks
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