埃塞俄比亚亚的斯亚贝巴选定政府医院1型糖尿病儿童糖尿病酮症酸中毒恢复时间及其预测因素一项为期五年的回顾性随访研究。

IF 2.3 Q2 MEDICINE, GENERAL & INTERNAL
SAGE Open Medicine Pub Date : 2025-05-26 eCollection Date: 2025-01-01 DOI:10.1177/20503121251343175
Shimeles Tefera Mamo, Tigistu Gebreyohannis Gebretensaye, Feven Mulugeta, Gemechu Gelan Bekele
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引用次数: 0

摘要

背景:糖尿病酮症酸中毒是1型糖尿病的一种严重并发症,仍然是儿童发病和死亡的主要原因,特别是在埃塞俄比亚等资源有限的国家。尽管糖尿病酮症酸中毒的负担很高,但有关该人群的恢复时间和预测因素的数据很少。因此,本研究旨在评估埃塞俄比亚亚的斯亚贝巴选定的政府医院中糖尿病酮症酸中毒儿童的恢复时间及其预测因素。方法:对2018年1月1日至2022年12月30日在亚的斯亚贝巴选定的政府医院住院的391例糖尿病酮症酸中毒患儿进行5年回顾性随访研究。采用简单的随机抽样方法选取参与者和医院。从类似的研究中改编并修改了结构化数据收集清单。检查数据的完整性,并输入Stata版本16进行分析。结果:最终分析共纳入423例糖尿病酮症酸中毒患儿,有效率391例(92.4%)。其中370人被回收并出院。其余21例被审查。从糖尿病酮症酸中毒中解脱的总中位时间为27小时,四分位数范围为16-38。糖尿病史(校正危险比(AHR) = 0.41, 95% CI: 0.30-0.56)、糖尿病酮症酸中毒的严重程度(AHR = 2.35, 95% CI: 1.34-6.1)、合并症的存在(AHR = 1.76, 95% CI: 1.37-2.26)和血糖水平(AHR = 0.61, 95% CI: 0.39-0.96)都是糖尿病酮症酸中毒恢复时间的独立预测因子。结论和建议:糖尿病酮症酸中毒的中位恢复时间为27 h。主要预测因素包括入院血糖、合并症、糖尿病酮症酸中毒严重程度和糖尿病史。早期诊断、全面评估和优化管理对于降低风险和改善结果至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Time to recovery from diabetic ketoacidosis and its predictors among children with type 1 diabetes at selected governmental hospitals in Addis Ababa, Ethiopia; A five-year retrospective follow-up study.

Background: Diabetic ketoacidosis, a severe complication of type 1 diabetes, remains a major cause of morbidity and mortality in children, particularly in resource-limited settings such as Ethiopia. Despite its high burden, data on recovery time and predictors of diabetic ketoacidosis in this population are scarce. Therefore, this study aimed to assess the time to recovery from diabetic ketoacidosis and its predictors among children with diabetic ketoacidosis at selected governmental hospitals in Addis Ababa, Ethiopia.

Methods: A 5-year retrospective follow-up study was conducted among 391 hospitalized children with diabetic ketoacidosis in selected governmental hospitals in Addis Ababa, from January 1, 2018 to December 30, 2022. Participants and hospitals were selected using a simple random sampling method. A structured data collection checklist was adapted from similar studies and modified. The data were checked for completeness and entered into Stata version 16 for analysis. Variables with p-value < 0.05 in the multivariate Cox proportional hazards model were considered significant predictors of the time to recovery from diabetic ketoacidosis.

Results: A total of 423 records of children with diabetic ketoacidosis with 391 (92.4%) response rates were included in the final analysis. Out of these, 370 were recovered and discharged. The remaining 21 cases were censored. The overall median time taken to resolution from diabetic ketoacidosis was 27 h, with an interquartile range of 16-38. Diabetic mellitus history (Adjusted Hazard Ratio (AHR) = 0.41, 95% CI: 0.30-0.56), severity of diabetic ketoacidosis (AHR = 2.35, 95% CI: 1.34-6.1), presence of comorbidity (AHR = 1.76, 95% CI: 1.37-2.26), and blood sugar level (AHR = 0.61, 95% CI: 0.39-0.96) were all independent predictors of time to recovery from diabetic ketoacidosis.

Conclusion and recommendation: The median diabetic ketoacidosis recovery time was 27 h. Key predictors included admission glucose, comorbidities, diabetic ketoacidosis severity, and diabetes history. Early diagnosis, thorough assessment, and optimized management are crucial to reducing risks and improving outcomes.

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SAGE Open Medicine
SAGE Open Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.50
自引率
4.30%
发文量
289
审稿时长
12 weeks
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