SAGE Open Medicine最新文献

{"title":"Retrospective observational study of safety, performance, and duration of use of battery-powered intraosseous access device in pediatric patients.","authors":"Thomas E Philbeck, John G McDonald, Melvin Carew, Christopher Ross","doi":"10.1177/20503121241306959","DOIUrl":"10.1177/20503121241306959","url":null,"abstract":"<p><strong>Background: </strong>To demonstrate the safety and performance of the Arrow EZ-IO Intraosseous Vascular Access System, particularly in the pediatric patient population, a retrospective observational study was conducted in 2021 and 2022.</p><p><strong>Methods: </strong>Following study design, IRB approval, and investigator selection, data were collected for all patients needing intraosseous access-adult and pediatric. The primary endpoint was the success rate for achieving intraosseous access; the secondary endpoint was the rate of adverse events. Following initial data collection, additional data were collected and a sub-set analysis was conducted to demonstrate the same in pediatric patients only, which is the focus of this report.</p><p><strong>Results: </strong>Data for 106 pediatric cases were collected. The success rate for achieving intraosseous access and infusion was 96.2%. There were three adverse events in two patients (1.9%); none serious or previously unreported. The mean duration of device use was 60 h (SD = 46). For 46 patients, the device was used for up to 48 h, and for another 45 patients, the device was used for a longer duration.</p><p><strong>Conclusions: </strong>This report is the first characterization of the safety and performance of the Arrow EZ-IO Intraosseous Vascular Access System when used in the pediatric population for longer dwell times (>24 h), with no serious complications reported. Performance and safety objectives were met. The results of this real-world evidence study are in alignment with findings from the clinical literature concluding that, for pediatric patients, the Arrow EZ-IO Intraosseous Vascular Access System is safe and effective for providing vascular access in urgent, emergent, and medically necessary situations, in which intravenous access is difficult or impossible to obtain. In addition, this study supports the use of intraosseous access for dwell times greater than 24 h.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241306959"},"PeriodicalIF":2.3,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11650499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The LncRNA PRNCR1 rs13252298 GG genotype is correlated with reducing susceptibility to recurrent spontaneous miscarriage in a southern Chinese population.","authors":"Hanran Mai, Junyi Ke, Xilian Luo, Zilin Zheng, Jieyi Luo, Chenlu Wang, Yueling Lin, Menghua He, Yanxia Qu, Yufen Xu, Lanyan Fu, Lei Pi, Huazhong Zhou, Xiaoqiong Gu, Di Che, Liandong Zuo","doi":"10.1177/20503121241303075","DOIUrl":"https://doi.org/10.1177/20503121241303075","url":null,"abstract":"<p><strong>Background: </strong>LncRNAs play diverse roles and participate in various biological processes within the human body. It has been frequently reported that they are involved in the occurrence and development of recurrent spontaneous miscarriage. <i>PRNCR1</i>, a crucial player in several types of cancers, may also have implications for recurrent spontaneous miscarriage risk. However, the correlation between <i>PRNCR1</i> rs13252298 A > G polymorphism and this risk remains unclear. In summary, we conducted the following experiments to investigate the association between the <i>PRNCR1</i> polymorphic site rs13252298 and susceptibility to recurrent spontaneous miscarriage.</p><p><strong>Method: </strong>Our research included 695 healthy controls and 413 patients with recurrent spontaneous miscarriage from southern China. Genotyping was performed using the TaqMan method.</p><p><strong>Result: </strong>Our findings revealed that there is a relationship between <i>PRNCR1</i> rs13252298 A > G polymorphism and lower susceptibility to recurrent spontaneous miscarriage (AG and AA: adjusted OR = 0.794, 95% CI = 0.527-1.196, <i>p</i> = 0.2696; GG and AA: adjusted OR = 0.705, 95% CI = 0.542-0.917, <i>p</i> = 0.0092; dominant model: adjusted OR = 0.722, 95% CI = 0.563-0.926, <i>p</i> = 0.0104; recessive model: adjusted OR = 0.949, 95% CI = 0.644-1.398, <i>p</i> = 0.7912).</p><p><strong>Conclusion: </strong>The results of our study demonstrate that the <i>PRNCR1</i> rs13252298 A > G allele may contribute to a decreased risk of recurrent spontaneous miscarriage. The rs13252298 polymorphism could potentially serve as a biomarker for detecting recurrent spontaneous miscarriage risk and aiding prevention efforts.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241303075"},"PeriodicalIF":2.3,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608446/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142772139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of oral zinc and steroids on long COVID hyposmia and hypogeusia.","authors":"Yi-Fang Chiang, Rong-San Jiang","doi":"10.1177/20503121241301894","DOIUrl":"10.1177/20503121241301894","url":null,"abstract":"<p><strong>Objective: </strong>We studied the prognosis of olfactory and gustatory dysfunctions in patients with long COVID (Coronavirus Disease 2019) after treatment with oral zinc and steroids.</p><p><strong>Methods: </strong>We measured olfactory and gustatory functions of long COVID patients at their first visits, and after 2-4 months of treatment with oral zinc and steroids using the traditional Chinese version of the University of Pennsylvania Smell Identification Test and the Waterless Empirical Taste Test. We also assessed by phone the recovery of olfactory and gustatory functions at a mean of about 10 months of follow-up.</p><p><strong>Results: </strong>Among our 71 long COVID patients, 34 complained of loss of smell and taste. Their objective test results showed 88.2% hyposmic, 23.5% hypogeusic at the first visit. After treatment, 77.8% of the patients were hyposmic, and 16.7% were hypogeusic. After a mean follow-up of 10.35 months, 91.2% of the patients reported improvement in their olfactory function. Among the 36 patients who had complained only of smell loss, the objective test results showed 75% hyposmic at their first visit. After treatment, 71.4% of the patients were hyposmic. After a mean of 10.42 months of follow-up, 77.8% of the patients reported improvement in their olfactory function. Only one patient complained of taste loss.</p><p><strong>Conclusions: </strong>We found that olfactory dysfunction in most long COVID patients persisted for more than 10 months.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241301894"},"PeriodicalIF":2.3,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11603462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142751498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal function outcomes in living kidney donors in a transplant center in Colombia.","authors":"Rodolfo Torres, Maricely Reina, Camilo Montero, Andres Tunjano, David Andrade, Valeria Mancera, Maria Amaya, Lizeth Arias, Laura Castellanos, Valentina Vanegas","doi":"10.1177/20503121241298139","DOIUrl":"10.1177/20503121241298139","url":null,"abstract":"<p><strong>Introduction: </strong>Living kidney donation is currently low in Colombia, and this is associated with the lack of knowledge of the risks and renal function outcomes of potential donors; there are no studies that evaluate these outcomes. The objective of this study is to evaluate the outcomes of renal function, the incidence of metabolic diseases, arterial hypertension, as well as the finding of albuminuria and/or proteinuria in living kidney donors with a 2-year follow-up post donation.</p><p><strong>Methods: </strong>Observational study in living kidney donor patients, in which renal function outcomes were evaluated between the predonation period and up to 24 months postdonation.</p><p><strong>Results: </strong>Ninety-one patients were included, with a median predonation glomerular filtration rate of 98 ml/min/1.73 m², interquartile range (90.5-109), and 24-month postdonation of 66.3 ml/min/1.73 m² interquartile range (57.9-75). A total of 60.26% of the population was in stage 2 at the end of follow-up and no patient had a glomerular filtration rate less than 30 ml/min/1.73 m² or required renal support therapy.</p><p><strong>Conclusion: </strong>A living donor evaluation process based on risk factor stratification and adequate assessment of renal function was found to generate safe renal function outcomes both in the perioperative period and in medium- and long-term follow-up.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241298139"},"PeriodicalIF":2.3,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580066/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper limb disabilities and associated factors among breast cancer survivors: A quantitative cross-sectional study.","authors":"Davidson Okwudili John, Augustine Amaeze, Onyinyechi Peace Ransome, Jeneviv Nene John, Obinna Chinedu Okezue, Oluwatoyin Iyare, Ngozi Immaculata Ugwu","doi":"10.1177/20503121241283341","DOIUrl":"10.1177/20503121241283341","url":null,"abstract":"<p><strong>Objectives: </strong>Complications following breast cancer treatment result in chronic upper limb disabilities. To plan an informed and effective rehabilitation for timely intervention to prevent, mitigate, or manage the functional impairments for breast cancer survivors, especially in settings with limited resources, the burden of upper limb disabilities needs to be ascertained. This study examined upper limb disabilities and associated factors among breast cancer survivors.</p><p><strong>Methods: </strong>This cross-sectional quantitative study recruited 60 breast cancer survivors using purposive sampling method. Text messages and face-to-face interactions were used to inform participants about the study. Disability of the Arm, Shoulder and Hand questionnaire was used to ascertain the upper limb disabilities. To determine lymphedema, tape measurements of upper limb circumference were translated into a limb volume with the geometric formula for a truncated cone. Visual analogue scale, hand dynamometer, and goniometer were used to measure pain, grip strength, and shoulder range of movement, respectively. Descriptive statistics were used to summarize data. Linear regression was used to determine the correlation between upper limb disabilities and selected variable. Alpha level was set at <i>p</i> < 0.05.</p><p><strong>Result: </strong>The prevalence of upper limb disabilities was 73%. Pain, lymphedema, shoulder range of movement, and grip strength showed strong correlation with upper limb disabilities. Pain and lymphedema increased by around 0.095 and 0.061 units, respectively, for every unit increase in disability. Conversely, there was a decrease of 1.394, 0.770, 0.285, and 0.045 in shoulder flexion, shoulder abduction, grip strength, and body mass index, respectively, for every unit increase in disability.</p><p><strong>Conclusion: </strong>Upper limb disabilities had high prevalence and significantly correlated with every variable that was examined. The high prevalence of upper limb disabilities and their interaction with related variables calls to action for routine screening and prompt intervention to identify, prevent, or manage upper limb functional impairments in breast cancer survivors.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241283341"},"PeriodicalIF":2.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580077/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refining patient care: Evaluating prescription practices of medical residents and interns in a teaching hospital through an audit.","authors":"Afrah, Lahal Mohammed Abdulla, Nishfa Saleem, Aishwarya Baktharatchagan, Usha Vishwanath","doi":"10.1177/20503121241300902","DOIUrl":"10.1177/20503121241300902","url":null,"abstract":"<p><strong>Objective: </strong>Hospitals in India use the National Accreditation Board for Hospitals and Healthcare Providers guidelines as criteria to ensure safe prescribing practices. This audit was conducted to provide insight into in-patient prescription of drugs to (1) evaluate the quality of prescriptions (2) reduce prescription and medication errors (3) improve the quality of care in terms of prescriptions that the hospital provides to the patient.</p><p><strong>Methods: </strong>The cross-sectional study was conducted in an in-patient department of a tertiary care teaching hospital in Chennai where 153 paper-based prescriptions were continuously collected from the internal medicine department over 1 month. The prescriptions were evaluated on 13 parameters that is, patient details (including name, age, sex and Hospital unique ID), height and weight, allergies, capital letters, legibility, date and time of prescription, medicine prescribed by generic name, brand name or both, dosage, route of administration, frequency, relation with food, stop order and signature of the doctor. The data obtained was summarised and analysed using Google Sheets.</p><p><strong>Results: </strong>A total of 153 prescriptions from the in-patient department of a tertiary care teaching hospital were audited. Out of the 153 prescriptions and 13 parameters assessed, patient details (including name, age, sex and Hospital unique ID), legibility, route of administration and frequency were found in all of the prescriptions. On further analysis, we found that only 12.26% of the prescriptions were compliant with the components of the stop order. The majority of the prescriptions (69.28%) contained both generic and trade names.</p><p><strong>Conclusion: </strong>Prescriptions are the most common areas of errors. This study shows the form of errors that can arise while prescribing medications. Doctors must be adequately trained to write prescriptions and follow the standards set by the National Accreditation Board for Hospitals and Healthcare Providers. Audits need to be conducted regularly to ensure and improve the quality of prescriptions.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241300902"},"PeriodicalIF":2.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580091/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of pathogenic <i>BRCA1/2</i> tumor mutation status on high grade serous epithelial ovarian cancer survival outcome: A multicenter study from Indonesia.","authors":"Sutrisno Sutrisno, Dina Marlina, Kevin Dominique Tjandraprawira, Putri Nadhira Adinda Adriansyah","doi":"10.1177/20503121241299849","DOIUrl":"10.1177/20503121241299849","url":null,"abstract":"<p><strong>Introduction: </strong>Ovarian cancer is still a major health problem in Indonesia. development of breast cancer gene-related personalized medicine to increase the survival outcome of epithelial ovarian cancer patients in Indonesia is expected to be achieved. This research aims to evaluate the impact of pathogenic breast cancer gene 1 and breast cancer gene 2 tumor mutation on high-grade serous epithelial ovarian cancer survival outcome.</p><p><strong>Methods: </strong>This study is an observational analytic study, using a historical cohort study design. A total of 68 from 144 patients diagnosed with International Federation of Gynecology and Obstetrics 2014 stage IIB-IV high-grade serous epithelial ovarian cancer between January 1st, 2015 until March 31st, 2021, at three centers in Jakarta. Next-generation sequencing tumor breast cancer gene 1 and breast cancer gene 2 testing and were included in this cohort historical study. We compared patient's overall survival outcomes, according to pathogenic breast cancer gene 1 and breast cancer gene 2 tumor mutational status. Clinicopathological characteristic factors that might affect patient's survival outcomes were also investigated.</p><p><strong>Results: </strong>In the group of individuals with pathogenic breast cancer gene 1 and breast cancer gene 2 tumour mutations, the risk of death was significantly lower by 86% (adjusted RR 0.149; 95% CI: 0.046-0.475; <i>p</i>-value = 0.001), and the median survival time was significantly better (median 46 months; 95% CI: 34.009-57.991; <i>p</i>-value = 0.001) compared to the group without pathogenic breast cancer gene 1 and breast cancer gene 2 tumor mutations (median 23 months; 95% CI: 15.657-30.343; <i>p</i>-value = 0.001). The multivariate analysis revealed that the presence of a pathogenic breast cancer gene 1 and breast cancer gene 2 tumor mutation is an independent and positive prognostic factor for survival outcome. The adjusted relative risk was 0.149, with a 95% CI of 0.046-0.475, <i>p</i>-value = 0.001.</p><p><strong>Conclusions: </strong>In high-grade serous ovarian cancer patients, the pathogenic breast cancer gene 1 and breast cancer gene 2 tumor mutations group have a better prognosis with longer survival outcomes than those without pathogenic breast cancer gene 1 and breast cancer gene 2 tumor mutations.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241299849"},"PeriodicalIF":2.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring ideal nasal aesthetics in Thailand: Trends and participants' awareness of rhinoplasty.","authors":"Chunanuch Kaewsomnuk, Surapol Suetrong, Wisoot Reechaipichitkul, Seksun Chainansamit, Pornthep Kasemsiri, Kan Komany, Patorn Piromchai","doi":"10.1177/20503121241299066","DOIUrl":"10.1177/20503121241299066","url":null,"abstract":"<p><strong>Backgrounds: </strong>Beauty standards vary across cultures and regions. To date, no research has identified ideal nasal profiles for Thai individuals. This study aims to determine the preferred nasal aesthetics among the Thai population.</p><p><strong>Methods: </strong>This cross-sectional study employed an online self-assessment questionnaire to investigate the ideal nasal profiles among Thai adults aged 18-60. Data were collected from participants across all regions of Thailand and included demographic information, rhinoplasty intentions, and perceptions of ideal nasal features.</p><p><strong>Results: </strong>Of the 1452 respondents, 35.74% (519 individuals) have either undergone or plan to undergo rhinoplasty, while the remaining 64.26% (933 individuals) expressed either no interest or uncertainty about the procedure. The ideal nasolabial angle was found to be between 97 and 108 degrees for males and 88 to 98 degrees for females, respectively. Male participants in the rhinoplasty and control groups exhibited statistically significant differences in nasolabial angle (<i>p</i> = 0.017), nasofrontal angle (<i>p</i> < 0.001), and alar-intercanthal distance ratio (<i>p</i> < 0.001). Female participants demonstrated statistically significant differences between groups in nasofacial angle (<i>p</i> < 0.001) and nasolabial angle (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>Our study identified distinct ideal nasal profiles among the Thai general population and those considering rhinoplasty. Our findings differed from the neoclassical orbitonasal proportion (canon V). These findings offer insights into contemporary Thai beauty standards for the nose, which can inform clinical decision-making in nasal treatment.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241299066"},"PeriodicalIF":2.3,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11580085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142688601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior cardiac drain for atrial fibrillation after aortic valve replacement.","authors":"Yuichi Koga, Manabu Sato, Eiji Sadashima, Jun Ushigusa, Hiromitsu Kawasaki, Keiji Kamohara","doi":"10.1177/20503121241296566","DOIUrl":"10.1177/20503121241296566","url":null,"abstract":"<p><strong>Background: </strong>Postoperative atrial fibrillation occurs in 27% to 40% of patients after cardiac surgery. One cause of postoperative atrial fibrillation is pericardial effusion, which can be a significant source of inflammation. In this study, we investigated the effect of a drain placed in a posterior site to the heart to reduce pericardial effusion in the early postoperative period to prevent postoperative atrial fibrillation.</p><p><strong>Methods: </strong>Participants were patients who underwent initial standby aortic valve replacement at Saga-Ken Medical Centre Koseikan from January 2010 to December 2021. Patients with a history of atrial fibrillation, complex surgery, or emergency surgery were excluded. The patients were divided into two groups: those with a posterior cardiac drain in addition to the usual intrapericardial and subpleural drains from September 2017 (group P) and those without posterior cardiac drain from January 2010 to August 2017 (group N). Multiple logistic regression analysis was performed to evaluate the usefulness of posterior cardiac drain.</p><p><strong>Results: </strong>Of the 79 patients included the study, 40 were male and groups P and N comprised 27 and 52 patients, respectively. Of the 79 patients, 32 developed postoperative atrial fibrillation; among whom, 7/27 (25.9%) had posterior cardiac drain and 25/52 (48.1%) had no posterior cardiac drain (<i>p</i> = 0.09). When adjusted for body surface area, left ventricular end-diastolic and left atrial diameter, the incidence of postoperative atrial fibrillation was significantly lower in group P than in group N (adjusted odds ratio 0.270, 95% confidence interval 0.077-0.953, <i>p</i> = 0.042). Furthermore, no patient in the group P underwent postoperative thoracentesis in the subanalysis.</p><p><strong>Conclusions: </strong>The results suggest that early postoperative reduction of pericardial effusion by posterior cardiac drain placement may reduce the incidence of postoperative atrial fibrillation.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241296566"},"PeriodicalIF":2.3,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The pattern of antibiotic resistance and distribution of the biofilm-producing <i>Pseudomonas aeruginosa</i> (<i>PelD, PslB</i>) isolated from infectious hospital departments.","authors":"Negin Masoumi, Fatemeh Keshavarzi","doi":"10.1177/20503121241298826","DOIUrl":"10.1177/20503121241298826","url":null,"abstract":"<p><strong>Background: </strong>The ability of <i>Pseudomonas aeruginosa</i> to produce biofilm has established it as one of the most significant pathogens. The purpose of this study was to evaluate antimicrobial resistance and conduct a molecular investigation of the virulence genes <i>PslB</i> and <i>PelD</i> in <i>Pseudomonas aeruginosa</i> species isolated from patients.</p><p><strong>Methodology: </strong>One hundred clinical isolates were collected from patients of different age groups who were hospitalized in Kermanshah and Sonqor hospitals. The isolates were obtained through culture on specific media, biochemical confirmatory tests, and gram staining for confirmation. Biofilm production was assessed using an indirect quantification method with crystal violet. Additionally, antibiotic resistance was determined through the disc various method following Clinical and Laboratory Standards Institute guidelines. Finally, the presence of genes related to <i>PlsB</i> and <i>PelD</i> in resistant strains was examined using The polymerase chain reaction (PCR).</p><p><strong>Results: </strong>The results indicate that the highest resistance and lowest sensitivity were related to nitrofurantoin 100 μg, while the lowest resistance and highest sensitivity were related to cefepime 30 mg. Biofilm phenotypes were categorized as weak in 7% (<i>n</i> = 7) of isolates, medium in 13% (<i>n</i> = 13), and high in 80% (<i>n</i> = 80). The <i>PslB</i> and <i>PelD</i> genes were identified in 86% (<i>n</i> = 86) and 38% (<i>n</i> = 38) of isolates, respectively, while 4% (<i>n</i> = 4) did not possess either of these two genes. Additionally, a majority of the isolates exhibited multidrug-resistance (87%) due to their moderate-to-high biofilm formation.</p><p><strong>Conclusion: </strong>All isolates were capable of producing biofilm. A significant association were between strains with the high biofilm and multidrug-resistance species (<i>p</i> < 0.05). Multidrug-resistance (78%) isolates included 28% (<i>n</i> = 28) of isolates that were <i>PslB+ PelD+</i>, 45% (<i>n</i> = 45) of isolates that were only <i>PslB+</i>, and 5 (<i>n</i> = 5) isolates that were only <i>PelD+</i>. A significant relationship was found between the presence of the <i>PslB</i> gene multidrug-resistance and high producer (<i>p</i> < 0.05).</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"12 ","pages":"20503121241298826"},"PeriodicalIF":2.3,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11569483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142648577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}