SAGE Open Medicine最新文献

{"title":"Clinical indications and outcomes of pediatric gastrointestinal endoscopy in a resource-limited healthcare system: Findings from the first multicenter study.","authors":"Shahd Abu Halima, Khadija Salhab, Bayan Al-Thuluth, Ayah Nassar, Iyad Maqboul, Mohammad Jaber, Ramzi Shawahna","doi":"10.1177/20503121261469061","DOIUrl":"10.1177/20503121261469061","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study was to provide the first multicenter evaluation of pediatric gastrointestinal endoscopy in Palestine, specifically characterizing clinical indications, sedation practices, diagnostic and histopathologic yield, and outcomes.</p><p><strong>Methods: </strong>This study was conducted across multiple hospitals in the West Bank, Palestine, including patients ≤18 years who underwent gastrointestinal endoscopy between January 2019 and December 2023.</p><p><strong>Results: </strong>A total of 245 pediatric endoscopic procedures were performed across participating centers (mean age 15.2 ± 2.9 years; 51.0% female). Of these, 149 were upper endoscopies and 96 were lower endoscopies. Abnormal findings were documented in 113 upper endoscopies (75.8%), most commonly gastritis, esophagitis, and duodenitis, and in 72 lower endoscopies (75.0%), including colitis, polyps, and terminal ileitis. Biopsies were submitted in 186 procedures (75.9%), with histopathological abnormalities confirmed in 127 cases (68.3% of biopsied specimens). The most frequent final diagnosis was gastritis (n = 68; 27.8%), including <i>Helicobacter pylori</i>-associated and nodular gastropathy, followed by esophagitis (n = 17; 6.9%), Crohn's disease (n = 10; 4.1%), and ulcerative colitis (n = 10; 4.1%). Patients who underwent lower endoscopy were significantly older (mean age 16.3 ± 1.8 years) compared with those undergoing upper endoscopy (14.6 ± 3.2 years) or combined procedures (15.6 ± 3.0 years; p < 0.001). The chief presenting complaint was diarrhea (n = 24; 9.8%) and inflammatory bowel disease symptoms (n = 10; 4.1%) when patients underwent lower endoscopy, whereas the chief presenting complaint was abdominal pain (n = 54; 22.0%) and nausea/vomiting (n = 16; 6.5%) when patients underwent upper endoscopy.</p><p><strong>Conclusion: </strong>This multicenter study demonstrates that pediatric gastrointestinal endoscopy in Palestine yields a high diagnostic rate, with abnormal findings documented in approximately three-quarters of both upper and lower procedures. The findings primarily emphasize the importance of strengthening biopsy protocols and diagnostic pathways in resource-limited healthcare systems.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261469061"},"PeriodicalIF":2.2,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and associated factors of depression among persons with Tuberculosis in Ghana: A cross-sectional study.","authors":"Jacob Solomon Idan, Enock Ko-Mati-Oo Yentariba, Benjamin Spears Ngmekpele Cheabu, Jerry Amoah-Larbi, Francis Adjei Osei, Georgina Benyah, Aliyu Mohammed","doi":"10.1177/20503121261467893","DOIUrl":"10.1177/20503121261467893","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis remains a significant global public health challenge, with the African region accounting for one-quarter of global incident cases. In Ghana, TB prevalence reaches 356 cases per 100,000 population. Depression is prevalent among persons with tuberculosis, potentially worsening treatment outcomes and patient prognosis. This study aimed to investigate the prevalence and predictors of depression among persons with TB in Ghana.</p><p><strong>Methods: </strong>A cross-sectional study was conducted across 20 randomly selected healthcare facilities providing TB care in eight administrative regions of Ghana. The study included 1,103 participants aged 18 years and older. Depression was assessed using the Patient Health Questionnaire (PHQ-9), with depression defined as a score ≥5. Data collection utilized systematic random sampling and a structured questionnaire implemented through the Research Electronic Data Capture (REDCap) platform. Modified Poisson regression with robust standard error was used for statistical analysis with STATA version 17.</p><p><strong>Results: </strong>The study revealed a depression prevalence of 40.98% among PWTB. Among the predictors of depression, Females had a 28% higher likelihood of depression (Adjusted Relative Risk = 1.28 [1.06-1.56]). Participants with poor health had 2.19 times higher depression risk (Adjusted Relative Risk = 2.19[1.64-2.92]). Additionally, stigmatized participants showed 52% higher depression risk (Adjusted Relative Risk = 1.52 [1.22-1.89]).</p><p><strong>Conclusions: </strong>The high prevalence of depression among TB patients in Ghana underscores the need for integrated mental health services in TB care. The study highlights the importance of addressing factors such as gender, health status, and stigma to improve mental health outcomes for persons with tuberculosis.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261467893"},"PeriodicalIF":2.2,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13356323/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148430966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uptake of human papillomavirus vaccine among school girls and its associated factors in Addis Ababa, Ethiopia.","authors":"Aklilu Feleke Haile, Yemane Berhane","doi":"10.1177/20503121261465825","DOIUrl":"10.1177/20503121261465825","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the HPV vaccine uptake among adolescent public high school girls aged 15-19 years and the factors associated with it in Addis Ababa, Ethiopia.</p><p><strong>Methods: </strong>A school-based cross-sectional study was conducted among 754 adolescent public high school girls aged 15-19 years in Addis Ababa. A multistage cluster sampling technique was used, and data were collected using a structured self-administered questionnaire. Data were analyzed using Stata version 14. We calculated the proportion (95% CI) to measure uptake. A multivariable logistic regression analysis was used to identify the factors associated with HPV vaccine uptake.</p><p><strong>Results: </strong>HPV vaccine uptake was reported by 55.3% (95% CI: 51.7%, 58.8%) of school girls aged 15-19 years. Knowing the HPV vaccine [AOR=3.0, (95% CI:2.2, 4.2), p-value 0.001] and a positive attitude toward the HPV vaccine [AOR=3.3, (95% CI:1.6, 6.9), p-value 0.001] were significantly associated with HPV vaccine uptake.</p><p><strong>Conclusions: </strong>Half of the school girls in the study area received the HPV vaccine. Interventions that enhance knowledge about the HPV vaccine and a positive attitude towards it can increase HPV vaccine uptake among schoolgirls.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261465825"},"PeriodicalIF":2.2,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13338536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148405847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective feasibility study of a telehealth platform for community-based NCD risk assessment by community health leaders in rural northern Thailand.","authors":"Sujittra Kaewkart, Pitaya Suebtam, Sawittree Thatong, Nisachon Kaewkart, Aphirak Pinasu, Premmarin Inmonthian, Napatsakorn Kohklang, Kittichai Wantanajittikul, Sakorn Pornprasert, Faiz Shah, Tanawan Samleerat Carraway, Woottichai Khamduang","doi":"10.1177/20503121261465826","DOIUrl":"10.1177/20503121261465826","url":null,"abstract":"<p><strong>Introduction: </strong>Limited access to preventive healthcare in rural and remote areas poses a persistent challenge for early identification of non-communicable disease (NCD) risk. We evaluated the feasibility and acceptability of <i>HealthD</i>, a telehealth-supported platform that enables Community Health Leaders (CHLs) to conduct community-based NCD risk assessment and facilitate follow-up in rural northern Thailand.</p><p><strong>Methods: </strong>We conducted a prospective, single-arm feasibility and acceptability study from June to November 2023 in Chiang Mai Province, Thailand. A total of 120 adults aged 30-70 years without a prior recorded diagnosis of the target NCDs were enrolled. Trained CHLs used <i>HealthD</i> to perform community-based assessment for diabetes mellitus (DM), cardiovascular disease (CVD), and respiratory symptom/functional limitation screening using guideline-informed algorithms and field-based measures, followed by risk-tailored counseling or teleconsultation at two- and four-month follow-up. Feasibility was assessed through recruitment, retention, CHL competency, workflow delivery, and acceptability among CHLs and participants.</p><p><strong>Results: </strong>Of 126 individuals approached, 120 were enrolled (recruitment rate 95.2%), and 119 completed follow-up (retention rate 99.2%). CHL competency improved after training, with mean assessment scores increasing from 8.4 to 9.3 (<i>p</i>= 0.010). Acceptability was high among CHLs (92%) and participants (97%). The <i>HealthD</i> workflow, including in-person assessment, point-of-care testing, digital data entry, algorithm-based risk-output generation, and teleconsultation follow-up, was implemented in the study setting. NCD-related risk outputs are presented as descriptive, exploratory findings. At baseline, 73% of participants were classified for DM-related risk, 3% for CVD-related risk, and 9% for respiratory symptom/functional limitation category. Across follow-up visits, DM-related risk categories changed, whereas CVD- and respiratory symptom/functional limitation categories remained relatively stable.</p><p><strong>Conclusion: </strong>This prospective study suggests that <i>HealthD</i> is feasible and acceptable for CHL-led, telehealth-supported community-based NCD risk assessment and follow-up in a rural Thai setting. These findings are preliminary and are intended to inform workflow refinement and the design of larger studies evaluating effectiveness, implementation outcomes, and sustainability.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261465826"},"PeriodicalIF":2.2,"publicationDate":"2026-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13333062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Obstetric Care Providers' Practices and Associated Factors Towards Birth Companionship in Public Hospitals of South Gondar zone, Northwest Ethiopia, 2025.","authors":"Rahel Birhanu Arage, Begizew Yimenu Mekuriaw, Habtam Desse Alemayhu, Mahider Shimelis Feyisa, Wassie Yazie Ferede, Besfat Berihun Erega","doi":"10.1177/20503121261465497","DOIUrl":"10.1177/20503121261465497","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to assess obstetric care providers' practices and associated factors towards birth companionship in public hospitals of South Gondar zone, North West Ethiopia, 2025.</p><p><strong>Methods: </strong>An institution-based cross-sectional study was conducted from January 01 to February 28, 2025 among obstetric care providers working in 10 public hospitals of South Gondar zone, North West, Ethiopia. A census of 218 participants was conducted. Data were collected using a structured, self-administered questionnaire. The data were entered into EpiData version 4.6 and analyzed using Statistical Package for Social Science version 27. Descriptive statistics were computed, and both bivariate and multivariate logistic regression analysis were performed, and statistical significance was declared at P< 0.05. Ethical clearance was obtained and informed consent was secured from all the participants.</p><p><strong>Results: </strong>A total of 211 respondents participated in the study, making the response rate 96.7%, of these the prevalence of birth companionship practice among obstetric care providers was 16.59% (95% CI, 11.6-21.6). Obstetric care providers who had received training on Compassionate and Respectful care, Respectful Maternity Care, Basic Emergency Obstetric and Newborn Care were 1.55 times (AOR: 1.55; 95%CI: 1.09- 2.21) more likely to practice companion presence during childbirth. Additionally, health professionals working in facilities equipped with privacy measures between delivery couches were 1.48 more likely to permit companion presence during childbirth (AOR1.95; 95%CI: 1.08-2.02).</p><p><strong>Conclusion: </strong>Birth companionship remains poorly practiced among obstetric care providers in South Gondar zone public hospitals, pointing deep rooted gap between the existing policies and the implementation. Training on respectful maternity care and presence of privacy measures emerged as key factors shaping provider practice. Strengthening policy enforcement, embedding companionship with provider training programs and ensuring adequate privacy infrastructures in labor wards are essential steps forward to encourage of practice.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261465497"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13323644/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148376770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between clinical features of isolated coronary artery ectasia and circulating levels of inflammatory markers.","authors":"Junping Ou, Zhijia Zhuo, Zhongwen Liu, Yuping Wang, Jie Zeng, Xiaolin Li, Lingjuan Liu","doi":"10.1177/20503121261463207","DOIUrl":"10.1177/20503121261463207","url":null,"abstract":"<p><strong>Background and aims: </strong>Coronary artery ectasia (CAE) can lead to adverse clinical outcomes, including coronary spasm, thrombosis, dissection and myocardial ischaemia. In patients with isolated CAE- in the absence of coronary artery stenosis, clinical symptoms such as angina pectoris may still occur. This study aimed to investigate the relationship between clinical features and circulating inflammatory marker levels in patients with isolated CAE.</p><p><strong>Methods: </strong>Patients undergoing coronary angiography (CAG) who consented to participate underwent cardiovascular disease and risk assessment. The study enrolled 52 patients with isolated CAE and 25 control individuals with normal coronary angiograms. Coronary blood flow in the three groups was assessed using the Thrombolysis in Myocardial Infarction (TIMI) frame count. Levels of inflammatory markers-including C-reactive protein (CRP), interleukin-1β (IL-1β), interleukin-8 (IL-8), IL-10 and tumor necrosis factor-alpha (TNF-α) - were measured in the circulating blood of symptomatic and asymptomatic patients with isolated CAE and compared between the two groups.</p><p><strong>Results: </strong>Symptomatic patients with isolated CAE showed significantly higher circulating levels of IL-1β and TNF-α than asymptomatic patients (<i>p<</i>0.05). In addition, coronary TIMI frame counts were lower (indicating slower blood flow) in symptomatic patients compared with asymptomatic individuals (<i>p<</i>0.05).</p><p><strong>Conclusions: </strong>In patients with isolated CAE, the presence of symptoms is associated with elevated circulating levels of pro-inflammatory markers such as IL-1β and TNF-α, as well as reduced coronary blood flow.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261463207"},"PeriodicalIF":2.2,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13329008/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148391564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Compliance with WHO-recommended ≥8 antenatal contacts and associated factors among women at primary health facilities in Mbarara district, Uganda.","authors":"Racheal Agaba, Henry Ochola, Abraham Muhwezi, Tom Murungi, Sylvester Namanya, Daniel Lule, Brian Turigye, Jerome Kabakyenga","doi":"10.1177/20503121261464652","DOIUrl":"10.1177/20503121261464652","url":null,"abstract":"<p><strong>Background: </strong>The World Health Organisation (WHO) recommends ≥8 antenatal care (ANC) contacts to improve detection of pregnancy risks and maternal newborn outcomes. However, uptake of the 8-contact model remains low in many low-resource settings.</p><p><strong>Objectives: </strong>To assess compliance with the WHO-recommended ≥8 ANC contacts and associated factors among women attending primary health facilities in Mbarara District, south-western Uganda.</p><p><strong>Design: </strong>Facility-based cross-sectional study.</p><p><strong>Methods: </strong>Postnatal women attending postnatal and immunisation clinics at five randomly selected primary health facilities in Mbarara district were recruited between April and May 2025. Data were collected using interviewer-administered questionnaires and verified with antenatal cards. Data were analysed using Stata version 18 software. Descriptive statistics summarised participant characteristics. Bivariate and multivariable logistic regression analyses identified factors associated with compliance with the WHO-recommended ≥8 ANC contacts.</p><p><strong>Results: </strong>Of 433 participants enrolled (median age 27 years; interquartile range 23-31 years), the majority (67%; 290/433) were aged 21-34 years. Overall compliance with WHO-recommended ≥8 ANC Contacts was 15.0% (65/433; 95% CI: 11.8%-18.7%). The factors significantly associated with compliance with the WHO-recommended ≥8 Antenatal Contacts were initiating ANC in the first trimester of the index pregnancy (aOR = 43.08; 95% CI:14.84-124.97; <i>p</i><0.001), staying within a distance of less than 5 km (aOR = 2.00; 95% CI:1.05-3.77; <i>p</i>=0.034), and monthly income of ≥100,000 Uganda shillings (aOR = 1.13; 95% CI:1.03-4.33; <i>p</i>=0.041).</p><p><strong>Conclusion: </strong>Compliance with the WHO-recommended ≥8 ANC contacts was low. Higher compliance was observed among women who initiated ANC early, lived closer to health facilities, and had higher incomes. Future strategies focus on factors associated with compliance, including early ANC initiation, geographic accessibility, and socioeconomic barriers.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261464652"},"PeriodicalIF":2.2,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Link between physical activity, nutrition, and antimicrobial pharmacokinetics and therapeutic efficacy: Implications for resistance management.","authors":"Vicente Javier Clemente-Suárez, Ana Isabel Beltrán-Velasco, Domingo Jesús Ramos-Campo, Alejandro Rubio-Zarapuz, José Francisco Tornero-Aguilera, Alexandra Martín-Rodríguez, Rodrigo Yáñez-Sepúlveda, José Francisco López-Gil","doi":"10.1177/20503121261462838","DOIUrl":"10.1177/20503121261462838","url":null,"abstract":"<p><p>Antimicrobial resistance (AMR) is a critical global health challenge, as it reduces the effectiveness of current therapies and demands novel integrative approaches. This narrative, integrative review analyzes how physical activity and nutrition interact with the pharmacological design of antimicrobial agents, influencing their absorption, metabolism, distribution, efficacy, and resistance development, drawing on studies published between 2015 and 2025 across microbiology, pharmacology, nutrition, and exercise physiology. Available evidence indicates that physical activity enhances immune competence, modifies pharmacokinetics, and promotes microbiome diversity, whereas nutrition influences bioavailability, micronutrient support, and nutrient-drug interactions. Conditions such as obesity, malnutrition, and metabolic disorders can critically alter drug disposition and therapeutic outcomes. Nutraceuticals and functional foods may act synergistically with antimicrobials, although antagonistic effects can impair their absorption or potency, and lifestyle-driven modulation of the microbiota and host metabolism appears to play an important role in resistance pathways. Emerging strategies, including prodrugs, nanocarriers, and personalized dosing algorithms, have the potential to optimize therapy according to lifestyle and metabolic profiles. Overall, incorporating lifestyle determinants into antimicrobial research and stewardship may improve therapeutic efficacy, reduce resistance, support precision medicine, and position diet and physical activity as key modulators of infection management.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261462838"},"PeriodicalIF":2.2,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148345618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnitude and associated factors of poor surgical treatment outcomes of bowel obstruction in Ethiopia: A systematic review and meta-analysis.","authors":"Addisu Simachew Asgai, Jenberu Mekurianew Kelkay, Tsegaamlak Kumelachew Derse, Demeke Shumu Negesse, Tilahun Bitew, Alemnew Wale Tegegne, Tadios Lidetu, Desalegn Mitiku Kidie","doi":"10.1177/20503121261464761","DOIUrl":"10.1177/20503121261464761","url":null,"abstract":"<p><strong>Introduction: </strong>Bowel obstruction is a major surgical emergency associated with considerable postoperative morbidity and mortality, particularly in low-resource settings. Evidence on surgical outcomes in Ethiopia remains inconsistent. This systematic review and meta-analysis aimed to estimate the pooled magnitude of poor surgical treatment outcomes of bowel obstruction and identify associated factors.</p><p><strong>Methods: </strong>A comprehensive search of PubMed, Cochrane Library, HINARI, AJOL, and google scholar was conducted. Observational studies reporting surgical outcomes among Ethiopian patients with bowel obstruction were included. Poor surgical outcomes were identified as postoperative complications and/or death in the hospital. A random effect meta-analysis model was used to calculate pooled prevalence and pooled odds ratios with 95% confidence intervals. Heterogeneity and publication bias were assessed using standard statistical methods.</p><p><strong>Result: </strong>Twenty-one studies comprising 5,429 patients were included. The pooled prevalence of poor surgical treatment outcomes in Ethiopia was 24% (95% CI: 19%-28%), with substantial heterogeneity (I²=93.6%). Delayed hospital presentation (>=24hours) (OR=2.2; 95% CI: 1.52-3.24), hospital stay >7 days (OR=2.37; 95%CI 1.72-3.25), and undergoing resection and anastomosis (OR=3.35; 95% CI: 2.07-5.4) were significantly associated with poor outcomes.</p><p><strong>Conclusion and recommendations: </strong>The prevalence of poor surgical treatment outcomes of bowel obstruction in Ethiopia was relatively high. Early presentation, timely intervention, and strengthening perioperative care are critical to improving surgical outcomes.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261464761"},"PeriodicalIF":2.2,"publicationDate":"2026-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305402/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of acute kidney injury in geriatric patients: Equal contribution of arthroplasty and osteosynthesis of the proximal femur.","authors":"Besart Tara, Dominik Kylies, Matthias Priemel, Karl-Heinz Frosch, Tobias M Ballhause","doi":"10.1177/20503121261464331","DOIUrl":"10.1177/20503121261464331","url":null,"abstract":"<p><strong>Background: </strong>Proximal femoral fractures (PFFs) are among the most common fragility fractures among the elderly, and their incidence is increasing due to demographic changes. Elderly patients are at risk for developing acute kidney injury (AKI), which is linked to adverse clinical outcomes, morbidity, and mortality. The aim of this study was to investigate the prevalence of AKI following surgery for PFFs among geriatric patients. Patients with femoral neck fractures (FNFs) received a prosthesis, while patients with intertrochanteric fractures (ITFs) were treated with osteosynthesis.</p><p><strong>Methods: </strong>This retrospective single-center study was performed in a level-I trauma center and included 1554 patients with almost even distributions of FNF and ITF. Laboratory parameters, comorbidities, incidence of AKI, and need for dialysis were retrieved from electronic medical charts and statistically analyzed.</p><p><strong>Results: </strong>During hospital stay, AKI occurred in 22.6% of patients with PFF. The most common AKI stage was stage I. AKI stage III (requiring acute dialysis) was uncommon with a rate of 1.48%. The occurrence of AKI was highly associated with longer stay in the intensive care unit (ICU) and led to a higher rate of inpatient death. On average, the serum creatinine (SCr) level at hospital admission was higher for patients with FNF than those with ITF. Patients with FNF had significantly more comorbidities. A low estimated glomerular filtration rate (eGFR) at admission was a risk factor for the development of AKI.</p><p><strong>Conclusion: </strong>AKI is one of the most frequent and severe adverse events among geriatric patients with PFFs. Patients with low eGFR at admission had a higher risk for developing AKI than those with normal eGFR. No significant differences were observed in the prevalence of AKI between patients with FNF and ITF, although patients with FNF had more comorbidities and had longer hospital stays by one day on average.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261464331"},"PeriodicalIF":2.2,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13305638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148346081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}