SAGE Open Medicine最新文献

{"title":"Graduating prelicensure nursing students: Compassion satisfaction, burnout, or secondary traumatic stress?","authors":"Brittany Nicole Hudgins-Graham","doi":"10.1177/20503121261474086","DOIUrl":"10.1177/20503121261474086","url":null,"abstract":"<p><strong>Background: </strong>Professional quality of life is a factor that may influence the well-being of nursing students as they transition into professional practice. Nursing students, especially those nearing graduation, face significant academic and clinical demands that may contribute to burnout and/or secondary traumatic stress, while also fostering compassion satisfaction.</p><p><strong>Purpose: </strong>To examine professional quality of life among graduating prelicensure nursing students and to explore student-recommended interventions to support stress management.</p><p><strong>Methods: </strong>An exploratory descriptive study using a mixed-methods approach was conducted using a convenience sample of graduating students (N = 44) from a university located in the southeastern United States. Participants completed the Professional Quality of Life Scale (ProQOL-Version 5). Subscale scores were calculated at the individual level and categorized into low, moderate, and high levels. Descriptive statistics, including means, standard deviations, and confidence intervals were computed. Internal consistency reliability was assessed using Cronbach's alpha. An open-ended question inquiring about recommendations for managing compassion fatigue or stress was analyzed using thematic analysis.</p><p><strong>Results: </strong>Participants demonstrated high levels of compassion satisfaction (M = 36.52, SD = 10.91). Burnout scores were predominantly moderate (M = 26.91, SD = 5.65), with 81.8% in the moderate range. Secondary traumatic stress scores were also primarily moderate (M = 25.61, SD = 7.95), with 54.5% categorized as moderate. Reliability was strong for compassion satisfaction (α = 0.97) and secondary traumatic stress (α = 0.87), and acceptable for burnout (α = 0.79). Qualitative analysis identified three themes: need for education, coping and support, and consideration of non-academic responsibilities.</p><p><strong>Conclusion: </strong>Graduating nursing students experience high compassion satisfaction alongside moderate burnout and secondary traumatic stress, highlighting the need for proactive, evidence-based strategies to support student well-being and transition into practice.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261474086"},"PeriodicalIF":2.2,"publicationDate":"2026-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13420073/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disparities in the quality of care in patients with empty sella based on etiology: A cross-sectional study from Saudi Arabia.","authors":"Abrar Alfaifi, Amal Alturkistani, Fatimah Altaleb, Nouf Aboalsamh, Mussa H Almalki","doi":"10.1177/20503121261460554","DOIUrl":"10.1177/20503121261460554","url":null,"abstract":"<p><strong>Background: </strong>Empty sella (ES) is characterized by the replacement of pituitary tissue with cerebrospinal fluid (CSF) in the sella turcica. Despite its frequency in clinical settings, ES is often underrecognized and incompletely evaluated. The aim of this study was to examine patterns of care and potential disparities across different ES etiologies.</p><p><strong>Methods: </strong>This retrospective cross-sectional study aimed to evaluate differences in hormonal assessment and referral patterns among patients with various etiologies of empty sella. All patients aged ≥14 years diagnosed with ES between February 2021 and December 2022 at King Fahad Medical City (KFMC), Riyadh, Saudi Arabia, were included. Relevant data were extracted from electronic medical records, and comparisons of hormonal assessment were made based on etiology and reason for endocrine referral.</p><p><strong>Results: </strong>Among 287 patients (75.3% female, mean age 49.7 years), 84.6% had primary ES. Only 29.9% were referred to endocrinology (52.4% for ES-specific evaluation). Secondary ES patients received more comprehensive hormonal assessments than primary ES (<i>P</i><0.001). Primary ES referrals for ES-specific evaluation correlated with thorough testing (<i>P</i><0.001).</p><p><strong>Conclusions: </strong>Significant disparities exist in ES management, driven by etiology and referral intent. Standardized referral pathway and universal screening are essential to improve care.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261460554"},"PeriodicalIF":2.2,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13392326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographical variations of health facilities management teams' functionality in Ethiopia: Spatial analysis of Ethiopian Service Provision Assessment (SPA) 2021-2022.","authors":"Endalkachew Mesfin Gebeyehu, Aznamariam Ayres, Shimels Derso Kebede, Eyob Tilahun Abeje, Lakew Asmare, Fekade Demeke Bayou, Asnakew Molla Mekonen","doi":"10.1177/20503121261473100","DOIUrl":"10.1177/20503121261473100","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to assess the spatial distribution of Health Facility Management Teams (HFMTs) functionality and identify geographic hotspots of non-functionality among Ethiopian health facilities.</p><p><strong>Methods: </strong>This cross-sectional study utilized data from the Ethiopian Service Provision Assessment (ESPA) 2021-2022, conducted by the Ethiopian Public Health Institute (EPHI) in collaboration with the Ministry of Health (MoH) and ICF. A total of 1,407 health facilities were included, excluding facilities from the Tigray region. HFMT functionality was assessed using four indicators, and facilities meeting all indicators were classified as functional. Descriptive analyses were performed using STATA version 17. Spatial analyses, including Global Moran's I, Getis-Ord Gi* hotspot analysis, ordinary Kriging interpolation, and SaTScan cluster detection, were conducted using ArcGIS 10.7.1 and SaTScan software.</p><p><strong>Results: </strong>Most health facilities had functional HFMTs. However, significant spatial clustering of non-functional HFMTs was observed (Moran's I = 0.098, p = 0.000024), indicating a non-random geographic distribution. Hotspot analysis identified western, central, and southern Benishangul Gumuz as the primary hotspot areas, with additional hotspots in parts of Afar, Harari, Somali, and Oromia regions. Kriging interpolation predicted a high probability of HFMT non-functionality in central Benishangul Gumuz and surrounding areas. SaTScan analysis confirmed a significant primary cluster centered in Benishangul Gumuz (RR =17.63, LLR = 12.16, p = 0.0042).</p><p><strong>Conclusion: </strong>HFMT functionality in Ethiopia exhibits significant geographic variation. Benishangul Gumuz emerged as the principal hotspot of HFMT non-functionality, highlighting the need for targeted management strengthening interventions in high-risk areas.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261473100"},"PeriodicalIF":2.2,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13392331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Navigating reproductive health: Drivers of youth-friendly service utilization among secondary school students in Yeka Sub-City, Addis Ababa, Ethiopia.","authors":"Yitbarek Biru Huluka, Tamirat Tesfaye Dasa, Liyew Mekonen Ayehubizu","doi":"10.1177/20503121261470964","DOIUrl":"10.1177/20503121261470964","url":null,"abstract":"<p><strong>Introduction: </strong>Accurate global statistics on reproductive health challenges within schools are difficult to obtain due to variations in data collection and dissemination across countries. Nevertheless, these issues significantly impact the development and well-being of young people worldwide.</p><p><strong>Objective: </strong>This study assessed the utilization of youth-friendly reproductive health services (YFRHS) and associated factors by secondary school students in Yeka Sub-City, Addis Ababa, Ethiopia.</p><p><strong>Method: </strong>An institution-based cross-sectional survey was conducted from May 20-24, 2024, among 415 randomly selected students from 15 secondary schools in Yeka Sub-City, Addis Ababa, to examine YFRHS utilization. Data were collected using a standardized, self-administered questionnaire and analyzed using SPSS version 27. Binary logistic regression identified factors associated with YFRHS use. Variables with p < 0.25 in the bivariate analyses were included in multivariable logistic regression. Statistical significance was determined at p ≤ 0.05, with adjusted odds ratios (AOR) and 95% confidence intervals (CI) used to evaluate the strength of associations.</p><p><strong>Results: </strong>YFRHS utilization was 18.8% (95% CI: 0.154-0.227). Having a sexual partner (AOR = 3.8; 95% CI: 1.7-8.4), parental communication (AOR = 2.2; 95% CI: 1.20-4.02), proximity to YFRHS facilities (AOR = 5.1; 95% CI: 2.5-10.3), and believing that seeking such services improves youth health (AOR = 4.6; 95% CI: 1.50-14.04) were significantly associated with YFRHS utilization.</p><p><strong>Conclusion: </strong>Approximately one in five school-aged youth utilized YFRHS. Utilization was significantly associated with having a sexual partner, positive perceptions regarding the benefits of seeking services, parental communication, and proximity to YFRHS facilities.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261470964"},"PeriodicalIF":2.2,"publicationDate":"2026-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13385594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148550418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dexmedetomidine in Palestinian intensive care units: The first multicenter cross-sector survey of sedation practices, protocol gaps, and withdrawal challenges.","authors":"Isra'a Abu Eid, Malak Odeh, Mawada Doaar, Mohammad Jaber, Iyad Maqboul, Ramzi Shawahna","doi":"10.1177/20503121261470962","DOIUrl":"10.1177/20503121261470962","url":null,"abstract":"<p><strong>Objective: </strong>Dexmedetomidine has emerged as an important sedative due to its ability to provide cooperative sedation while preserving respiratory drive. However, its clinical use may vary across healthcare systems, particularly in resource-limited settings. This study aimed to assess patterns of dexmedetomidine use, associated protocols, withdrawal experiences, and perceived barriers across different intensive care units in the Palestinian healthcare system.</p><p><strong>Methods: </strong>A multicenter cross-sectional survey was conducted between October 2025 and January 2026 in governmental, teaching, and private hospitals. Anesthesiologists, intensive care physicians, and nurses with ≥ 6 months of experience were invited to complete a structured questionnaire addressing sedation practices, dosing, monitoring, withdrawal, perceptions, and institutional protocols.</p><p><strong>Results: </strong>A total of 158 healthcare professionals participated (response rate 71.8%). Propofol (86.7%) and midazolam (70.9%) were the most commonly used sedatives, while dexmedetomidine was reported in 56.3% of intensive care units, predominantly as an adjunct (73.4%). Formal protocols were present in only 29.7% of units, and validated monitoring tools were used by 43.7%. Withdrawal symptoms were reported by 38.0% of respondents, most often after 48-72 hours of infusion. Significant sectoral differences were observed, with dexmedetomidine use reported in 55.1% of teaching hospitals and 43.8% of private hospitals, but only 1.1% of governmental hospitals (p < 0.001). Professional role also influenced practice. Fentanyl use was reported by 86.2% of ICU physicians, 66.7% of anesthesiologists, and 47.3% of nurses (p = 0.001). Cost was identified as a barrier by 46.2% of respondents, and inconsistent availability was reported by 43.7%, with both factors limiting routine use.</p><p><strong>Conclusion: </strong>Limited protocols, inconsistent monitoring, and cost barriers hindered routine use of dexmedetomidine, while withdrawal was reported after prolonged infusions. These findings provide context-specific evidence to guide national guidelines, hospital protocols, and workforce training, with procurement and monitoring reforms as immediate priorities.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261470962"},"PeriodicalIF":2.2,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13380696/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148520832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, associated factors, and quality of life impact of urinary incontinence in heart failure patients: A multicenter cross-sectional study from a low- and middle-income country.","authors":"Faris Abushamma, Abdallah Abdallah, Thabit Sweileh, Osama Faqih, Yunis Daralammouri, Rola Abu Alwafa, Amir Aghbar","doi":"10.1177/20503121261469944","DOIUrl":"10.1177/20503121261469944","url":null,"abstract":"<p><strong>Background: </strong>Urinary incontinence (UI) is a frequent yet often neglected issue in patients with chronic heart failure (HF), significantly impacting their quality of life (QoL) and possibly hindering adherence to treatment. However, there is limited research on its prevalence, risk factors, and effects in low- and middle-income countries. This study seeks to assess the prevalence of UI among individuals with HF, identify related demographic, clinical, and treatment factors, and evaluate its influence on the patients' QoL.</p><p><strong>Methods: </strong>This cross-sectional study included 148 HF patients from two major hospitals and used convenience sampling. Data on demographics, medical characteristics, and UI were obtained via the Urogenital Distress Inventory-6 (UDI-6) and the Incontinence Impact Questionnaire-7 (IIQ-7). Statistical methods were applied to determine associations between patient factors and UI severity.</p><p><strong>Results: </strong>The prevalence of UI among HF patients was 46.6% (69 out of 148 participants). Compared with male participants, female participants had significantly higher median UDI-6 scores (27.7 [16.6-38.8] vs. males, <i>p</i> = 0.007) and higher IIQ-7 scores (mean rank 84.36, <i>p</i> = 0.002). Diuretic use was significantly associated with greater UI severity, reflected by higher median UDI-6 scores (27.7 [11.1-33.3], p = 0.025) and higher IIQ-7 scores (p = 0.04). Nonsmoking status was significantly associated with higher UI burden, with a median UDI-6 score of 27.7 (16.6-38.8) and a higher IIQ-7 mean rank (83.77; both p < 0.05). Similarly, participants who did not consume caffeine demonstrated significantly higher UI scores, with a median UDI-6 score of 33.3 (19.4-54.1) and a higher IIQ-7 mean rank (98.53; both p < 0.05). In contrast, age, body mass index, duration of heart failure, hypertension, and diabetes mellitus were not significantly associated with UI severity.</p><p><strong>Conclusions: </strong>UI is prevalent among HF patients and adversely affects their QoL. Recognizing associated factors such as sex and diuretic use can help clinicians design targeted management strategies.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261469944"},"PeriodicalIF":2.2,"publicationDate":"2026-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13373392/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148472543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Determinants of viral load non-suppression among adult HIV positive patients on antiretroviral therapy in public health facilities in Ambo town, Ethiopia: A case-control study.","authors":"Bedilu Hirpa Negeri, Gemechu Tulu Gemeda, Habtamu Oljira Desta, Belay Tafa Regassa","doi":"10.1177/20503121261469343","DOIUrl":"10.1177/20503121261469343","url":null,"abstract":"<p><strong>Background: </strong>Viral non-suppression is still a major obstacle to putting an end to the epidemic, although Antiretroviral Therapy (ART) has made HIV a chronic illness that can be managed. Ethiopia has made strides, but there are still regional differences and particular structural obstacles that rural populations must overcome. The purpose of this study was to determine the factors that contribute to adult HIV-positive patients in public health facilities in Ambo town, Ethiopia, not having their viral loads suppressed.</p><p><strong>Methods: </strong>A facility-based unmatched case-control study was carried out from March to May 2023. There were 376 participants in all (131 cases and 245 controls). Trained data collectors conducted secondary reviews of patient charts and electronic records in addition to structured interviews. Data were entered into EpiData version 3.1, then exported to SPSS version 26 for additional statistical analysis. Both bivariate and multivariable logistic regression analyses were performed. In the multiple logistic regression analysis, a p-value of less than 0.05 paired with a 95% confidence interval was utilized to determine statistical significance.</p><p><strong>Results: </strong>According to the multivariable logistic regression analysis, marital status (AOR = 0.232, 95% CI: 0.065-0.830), complexity of the treatment regimen (AOR = 7.333, 95% CI: 3.357-16.017), treatment interruption (AOR = 2.298, 95% CI: 1.146-4.609), follow-up schedule (AOR = 3.721, 95% CI: 2.033-6.812), and adherence (AOR = 16.568, 95% CI: 5.587-49.129) were found to be significantly associated with the viral non-suppression.</p><p><strong>Conclusion: </strong>Viral non-suppression in Ambo is primarily associated with behavioral and treatment-related factors, including poor adherence, high pill burden, and irregular follow-ups. One protective factor observed to have an inverse association is social support, particularly through marriage. A single-tablet regimen and improved adherence support systems, especially for a single group category patients, to meet the 95-95-95 targets.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261469343"},"PeriodicalIF":2.2,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13369395/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Construction and evaluation of a prediction model for postoperative low muscle mass in older adult patients with gastric cancer.","authors":"Linfang Li, Rong Zhang, Yuexuan Liu, Bai Li, Zhihui Zhang, Han Sun, Shuhua Wu","doi":"10.1177/20503121261469844","DOIUrl":"10.1177/20503121261469844","url":null,"abstract":"<p><strong>Background: </strong>With global population aging, the prevalence of gastric cancer among patients aged 60 years and older continues to rise. Radical gastrectomy frequently induces postoperative skeletal muscle loss, which correlates with poor clinical prognosis. Currently, few prediction models are available to screen for new-onset postoperative low muscle mass in older gastric cancer patients. This study aimed to construct and internally validate a preoperative prediction model for low muscle mass at six months after radical gastrectomy in this elderly population.</p><p><strong>Methods: </strong>A total of 69 eligible older adult patients with pTNM stage I-III gastric adenocarcinoma were retrospectively enrolled. Those with preoperative low muscle mass, neoadjuvant therapy, or incomplete clinical and imaging data were excluded. Postoperative low muscle mass was diagnosed using L3-level skeletal muscle index based on Asian cutoff criteria. Univariate and multivariate logistic regression analyses were applied to screen independent predictors. Model performance was assessed via ROC curves, calibration curves, and leave-one-out cross-validation (LOOCV).</p><p><strong>Results: </strong>Among all participants, 17 patients (24.6%) developed postoperative low muscle mass. Preoperative BMI, skeletal muscle area, lymphocyte-monocyte ratio, and surgical method were confirmed as independent influencing factors. The established model yielded an AUC of 0.857, with a sensitivity of 94.1% and specificity of 67.3%, and the LOOCV AUC reached 0.832. Total gastrectomy was linked to a higher risk of low muscle mass compared with partial gastrectomy.</p><p><strong>Conclusions: </strong>Preoperative BMI, SMA, and LMR can independently predict postoperative low muscle mass in older adult gastric cancer patients. The model shows moderate-to-good predictive performance in this single-center cohort and may help identify high-risk patients preoperatively. Prioritizing partial gastrectomy when oncologically safe and providing preoperative nutritional and exercise support may help reduce muscle loss.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261469844"},"PeriodicalIF":2.2,"publicationDate":"2026-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13369412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148456088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of electrocardiographic abnormalities and predictors of QTc prolongation in patients with diabetic ketoacidosis: A retrospective cohort study.","authors":"Winpob Kovichsakul, Varinsawat Prakongwong, Kitti Thammakosol, Chutintorn Sriphrapradang","doi":"10.1177/20503121261469076","DOIUrl":"10.1177/20503121261469076","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the prevalence of electrocardiographic (ECG) abnormalities in diabetic ketoacidosis (DKA) patients, evaluate their associations with metabolic parameters, and identify independent predictors of clinical outcomes.</p><p><strong>Methods: </strong>This retrospective study included 374 DKA patients (2012-2023). Baseline clinical characteristics, laboratory data, and initial ECG findings were analyzed. Multivariable logistic regression was performed to assess associations between metabolic parameters and corrected QT (QTc) prolongation, as well as clinical outcomes.</p><p><strong>Results: </strong>Sinus tachycardia occurred in 54.8%, while QTc prolongation was found in 64.7% of patients using Bazett's formula versus 27.5% using Fridericia's correction. In multivariable analysis, lower serum bicarbonate levels were independently associated with QTc prolongation using both formulas (Bazett's: adjusted OR 0.92, 95%CI 0.87-0.98, p=0.007; Fridericia's: adjusted OR 0.91, 95%CI 0.85-0.97, p=0.002). These associations remained consistent across different QTc thresholds, including high-risk and very high-risk QTc prolongation. However, QTc prolongation was not independently associated with length of stay or in-hospital mortality.</p><p><strong>Conclusions: </strong>QTc prolongation was frequently observed in patients with DKA and showed an association with the severity of metabolic acidosis, particularly reduced serum bicarbonate levels. Given its potential implication for arrhythmogenic risk, careful ECG assessment and monitoring should be considered during the initial evaluation and management of DKA.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261469076"},"PeriodicalIF":2.2,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148448979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mst1 participates in the progression of severe acute pancreatitis-induced intestinal barrier dysfunction via inhibiting autophagy and enhancing apoptosis.","authors":"Rong Zhang, Ziwen Liu, Tao Lin, Rui Shen, Chuqi Xiang, Pengtao Zhao, Wang Lu","doi":"10.1177/20503121261468931","DOIUrl":"10.1177/20503121261468931","url":null,"abstract":"<p><strong>Objective: </strong>Severe acute pancreatitis (SAP) is a common emergency condition associated with high mortality. Intestinal barrier dysfunction plays a critical role in the pathogenesis of SAP. Mammalian sterile 20-like kinase 1 (Mst1) has been shown to coordinately regulate autophagy and apoptosis in cardiac and aging-related diseases. However, the precise role of Mst1 in SAP-induced intestinal barrier dysfunction remains largely unknown. This study aimed to investigate the pathophysiological impact of Mst1 on SAP-induced intestinal barrier dysfunction.</p><p><strong>Methods: </strong>Mst1-knockout and wild-type mice were challenged intraperitoneally with caerulein combined with lipopolysaccharide (LPS) to establish an experimental SAP model. TNF-α-stimulated MODE-K cells were used to analyze the impact on autophagy and apoptosis and to elucidate the underlying mechanisms.</p><p><strong>Results: </strong>Mst1 knockout up-regulated tight junction proteins, alleviated apoptosis and enhanced autophagy in the ileocolic mucosa tissue of SAP mice, which consequently improved cumulative survival and alleviated intestinal barrier dysfunction. Conversely, Mst1 overexpression inhibited autophagy and promoted apoptosis in TNF-α-stimulated MODE-K cells.</p><p><strong>Conclusion: </strong>Mst1 plays an important role in SAP-related intestinal barrier dysfunction by inhibiting autophagy and enhancing apoptosis.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261468931"},"PeriodicalIF":2.2,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13365704/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148449014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}