SAGE Open Medicine最新文献

{"title":"The association of empirical treatment with oseltamivir with the outcome of critically ill patients admitted with severe acute respiratory illness (SARI).","authors":"Raymond M Khan, Linah Mosleh AlMarashi, Mohamad-Hani Temsah, Ghassan Ali Ahmed Al Ghamdi, Musharaf Sadat, Felwa Bin Humaid, Jesna Jose, Fahad Al-Hameed, Kasim Al Khatib, Mohammed AlObaidi, Mohammed Shaim Alanezi, Faisal Fouad Al-Basseet, Rasha Alanazi, Yaseen Arabi","doi":"10.1177/20503121261478401","DOIUrl":"https://doi.org/10.1177/20503121261478401","url":null,"abstract":"<p><strong>Objective: </strong>Neuraminidase inhibitors (NAIs) are widely used empirically in critically ill patients with suspected influenza; however, their effect on mortality remains uncertain. This multicenter study evaluates the association between empirical treatment with oseltamivir and the outcome of critically ill patients with Severe Acute Respiratory Infection (SARI) admitted to the Intensive Care Unit (ICU).</p><p><strong>Methods: </strong>This was a retrospective cohort study conducted in the ICUs of four hospitals in Saudi Arabia, involving adult patients with SARI from September 2012 to December 2018. Data collected were: demographics, comorbidities, clinical presentation, and outcomes among patients treated with oseltamivir and those who were not. The primary outcome was 90-day mortality. The association of oseltamivir and mortality was evaluated adjusting for propensity score.</p><p><strong>Results: </strong>During the study period, 456 patients with SARI were included in the study, 301 were treated with empirical oseltamivir within a median of 1 day from presentation (interquartile range, 0-1 day) and a median of 4 days after symptom onset, while 155 patients were not. No significant differences were observed in baseline characteristics between the two groups. Of the included patients, 334 (73%) were tested for influenza using PCR, and 87 (26%) had a confirmed diagnosis of influenza. Patients on oseltamivir were less likely to require rescue oxygen therapy (22.9% vs. 34.8%, p=0.007), and had shorter hospital stay (20 days vs. 27 days, p=0.01). Patients treated with oseltamivir had significantly reduced 90-day mortality on adjusted analyses (aOR: 0.87, 95% CI: 0.81-0.94, p=0.0002). Subgroup analysis revealed that the association with reduced mortality extends to patients >70 years old (aOR: 0.94, 95% CI: 0.89-0.99, p=0.02) and those with negative influenza tests (aOR: 0.81, 95% CI: 0.79, 0.84, p<0.0001).</p><p><strong>Conclusion: </strong>Among critically ill patients with SARI, empirical treatment with oseltamivir was associated with lower mortality. These results add to the body of evidence suggesting clinical benefits of oseltamivir in managing critically ill patients with influenza-like illnesses.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261478401"},"PeriodicalIF":2.2,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13473781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to \"Pathophysiological pathways of post-traumatic stress disorder in relation to traumatic brain injury: An observational cross-sectional study\".","authors":"","doi":"10.1177/20503121261467819","DOIUrl":"10.1177/20503121261467819","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1177/20503121251375865.].</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261467819"},"PeriodicalIF":2.2,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13462632/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148724996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An assessment of Correctional Officers' health beliefs in relationship to COVID-19 vaccine uptake and hesitancy.","authors":"Bethany Hedden-Clayton, Ariel L Roddy, Juliette K Roddy, Yvane Ngassa, Bridget Pickard, Rachel A Tam, Alysse G Wurcel","doi":"10.1177/20503121261476907","DOIUrl":"10.1177/20503121261476907","url":null,"abstract":"<p><strong>Objective: </strong>During the COVID-19 pandemic, incarcerated populations faced heightened risk of exposure due to healthcare barriers, restrictive environments, and pre-existing health conditions. Consequently, Correctional Officers (COs) faced increased risk of COVID-19 exposure. Given the health benefits of COVID-19 vaccination and the rise in vaccine hesitancy, this study aims to examine the relationship between COs health beliefs and COVID-19 vaccine uptake.</p><p><strong>Methods: </strong>A health beliefs survey was administered to Massachusetts-based COs (n=118). Chi-squared Automatic Interaction Detection (CHAID) modeling and logistic regression were utilized to analyze the survey data.</p><p><strong>Results: </strong>COs with higher trust in vaccines and a prior positive COVID-19 test were most likely to get vaccinated voluntarily. Those with low trust in vaccines and no previous positive COVID-19 test were least likely to receive the vaccine.</p><p><strong>Conclusion: </strong>Despite the severe impact of COVID-19 in correctional settings, and the evidence of vaccine efficacy against hospitalization and death, vaccine uptake among COs remains low.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261476907"},"PeriodicalIF":2.2,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aligning emergency admission and stroke center catchment areas: Association with intravenous thrombolysis rates.","authors":"Martin Faurholdt Gude, Thomas Basse, Arne Sylvester Rønde Jensen, Ulla Væggemose, Mohammad Ahmad Al-Jazi, Paul von Weitzel-Mudersbach, Rolf Ankerlund Blauenfeldt","doi":"10.1177/20503121261477313","DOIUrl":"10.1177/20503121261477313","url":null,"abstract":"<p><strong>Objectives: </strong>To assess whether co-location of a Primary Stroke Center (PSC) and an Emergency Department (ED) was associated with higher intravenous thrombolysis (IVT) rates after alignment of emergency admission pathways in the Central Denmark Region.</p><p><strong>Methods: </strong>This retrospective before-and-after cohort study compared two 6-month periods before (July 1 to December 31, 2021) and after (July 1 to December 31, 2022) co-location following a hospital merger in February 2022. Patients were identified through the Danish Stroke Center Database and linked with prehospital records. The primary outcome was the proportion of patients with acute ischemic stroke (AIS) treated with IVT. Secondary analyses included stroke mimic admissions and transport subgroups. Absolute risk differences were estimated using linear regression with robust variance estimation, and adjusted analyses used inverse probability weighting.</p><p><strong>Results: </strong>The study included 1,950 patients with suspected stroke: 1,059 before and 891 after co-location. Among 914 patients with AIS, the IVT rate increased by 4.6 percentage points (95% confidence interval [CI] 0.1-9.1), from 12.2% (95% CI 9.2-15.2) before co-location. This increase was driven by EMS-transported patients following emergency calls, in whom the IVT rate increased by 10.2 percentage points (95% CI 0.5-19.9). In this subgroup, median door-to-needle time increased from 26.5 to 40.0 minutes (p=0.003). Stroke mimic admissions decreased from 26.3% to 17.9%.</p><p><strong>Conclusion: </strong>Co-location of the PSC and ED was associated with higher IVT rates, particularly among EMS-transported emergency-call patients, suggesting that alignment of emergency admission pathways and stroke center catchment areas may improve access to time-critical reperfusion therapy.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261477313"},"PeriodicalIF":2.2,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13458115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time to diabetic nephropathy and its predictors among adult diabetic patients at public general and referral hospitals in South Wollo Zone, Northeast Ethiopia: A retrospective follow up study.","authors":"Tilaye Worku, Anissa Mohammed, Endalew Minwuye Andargie","doi":"10.1177/20503121261476914","DOIUrl":"10.1177/20503121261476914","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of diabetes mellitus and its micro vascular and macro vascular complications have been increasing among diabetic patients in Ethiopia. Diabetic nephropathy (DN) is one of the most serious complication of diabetes which leads to end-stage renal disease and other complication of diabetes mellitus. A small number of investigations were carried out in Ethiopia, and the incidence of DN was the main source of data for these studies. Therefore, this study was aimed to estimate time to diabetic nephropathy and its predictors among adult diabetes mellitus patients at public general and referral hospital of South Wollo Zone, Amhara National Regional State, Northeast Ethiopia.</p><p><strong>Methods: </strong>Retrospective follow up study was conducted among 408 adult diabetes mellitus patients who were on follow up at public general and referral hospital of South Wollo zone from December 10, 2012 to December 9, 2022. Data were entered into Epidata version 4.6, and then exported to Stata version 14 for further statistical analysis. Kaplan Meier survival curve was used to estimate the cumulative survival time and Log rank test was used to compare the survival time between different categories of the predictor variables. Multivariable Cox proportional hazards model was fitted to identify predictors of time to diabetic nephropathy.</p><p><strong>Result: </strong>Overall, 71 (17.4%) of the study participants developed diabetic nephropathy with incidence density of 2.35/1000 person-months (95% CI; 1.86, 2.97) and Median survival time of this study was 98 [95% CI: 95 -105] months. Sex [AHR: 0.293, 95%CI: 0.154, 0.555], hypertension [AHR: 1.81, 95% CI: 1.01, 3.24], HbA1C [AHR: 1.93, 95% CI: 1.069, 3.49] and HDL [AHR: 0.399, 95% CI: 0.225, 0.708] were predictors of time to diabetic nephropathy.</p><p><strong>Conclusion and recommendation: </strong>The median survival time of this study was 98 [95% CI: 95 -105] months which was relatively long time compared with previous study. Sex, hypertension, HbA1c and HDL were predictors of time to diabetic nephropathy.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261476914"},"PeriodicalIF":2.2,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451769/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148697535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geospatial variation of bottle feeding practice among children aged 0-23 months in East Africa: Geographically weighted regression analysis.","authors":"Andualem Addisu Birlie, Angwach Abrham Asnake, Bizunesh Fantahun Kase, Etsay Woldu Anbesu, Abdulkerim Hassen Moloro, Tesfaye Deribe Bedada, Alemayehu Kasu Gebrehana, Hiwot Altaye Asebe","doi":"10.1177/20503121261476905","DOIUrl":"10.1177/20503121261476905","url":null,"abstract":"<p><strong>Introduction: </strong>Bottle-feeding a baby aged 0-23 months is the act of giving any liquid or semi-solid food from a bottle with a nipple. Bottle feeding can increase their risk of excessive weight gain, malnutrition, iron deficiency, and reduced birth spacing. However, no study has been conducted on geographically weighted regression (GWR) analysis and the factors associated with bottle-feeding practice.</p><p><strong>Objective: </strong>To assess the geospatial variation and determinants of bottle-feeding practice among children aged 0-23 months in East Africa using GWR.</p><p><strong>Methods: </strong>A total sample of 28,562 children aged 0-23 months were included in the study. Excel 2019, STATA version 17, ArcGIS version 10.7.1, and SaTScan version 10.1 were used to analyze children's bottle-feeding practice. Spatial autocorrelation, hotspot analysis, interpolation, and spatial scan analysis were performed. Ordinary least squares analysis and geographically weighted regression analysis were employed to assess the association between bottle feeding practice and explanatory variables.</p><p><strong>Results: </strong>The magnitude of bottle feeding practice among children aged 0-23 months in East Africa was 13%. Rwanda, Central and Eastern Tanzania, Central and some coastal regions of Madagascar, Southern Kenya, and both Southern and Eastern Mozambique were found to have high hotspots of bottle-feeding practice among children aged 0-23 months The primary clusters were 244, and statistically significant clusters were observed in Madagascar and centered at -20.6258N, 46.6889E, 214.8715 km with an LLR of 155.9459, RR: 2.138.</p><p><strong>Conclusion: </strong>This study led to the conclusion that the spatial distribution of child bottle-feeding practice was clustered, and hotspot areas were identified in East Africa. Thus, this study aims to reduce the burden of child bottle-feeding practice in hotspot areas in East African countries. The local authorities and policymakers should focus on providing parental counseling, especially in the regions that are identified as high risk for child bottle-feeding practices.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261476905"},"PeriodicalIF":2.2,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13443257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and validation of a psychometric tool for assessing the readiness and feasibility of CRE screening in LMICs: A cross-sectional instrument validation study.","authors":"Ngo Anh The, Nguyen Thi Thu Huyen, Nguyen Duc Thanh, Tran Chi Thanh, Tran Thi Lien","doi":"10.1177/20503121261476931","DOIUrl":"10.1177/20503121261476931","url":null,"abstract":"<p><strong>Background & objectives: </strong>Carbapenem-resistant Enterobacterales (CRE) pose a critical threat in Intensive Care Units (ICUs) within low- and middle-income countries (LMICs), with prevalence exceeding 20% and mortality reaching 50%. Despite high clinical demand, routine screening remains unstandardized in Vietnam due to resource constraints and a lack of validated tools. This study aimed to develop and validate a psychometric instrument to evaluate healthcare workers' (HCWs) perspectives across three domains: barriers, feasibility and readiness.</p><p><strong>Methods: </strong>A cross-sectional validation study was conducted using total population census sampling (n=97, total front-line staff) across three hospitals in Vietnam (Viet Tiep, Kien Thuy, and Thuy Nguyen). Following expert panel review (S-CVI/Avg = 0.89) and a 10.3% pilot test (n=10), construct validity and reliability were evaluated via Exploratory and Confirmatory Factor Analysis (EFA/CFA). Group differences were analyzed using Fisher's Exact and Chi-square tests.</p><p><strong>Results: </strong>The barriers subscale was excluded due to low internal consistency (alpha < 0.60), yielding a refined 16-item, two-factor instrument (6.1:1 observation-to-item ratio). The final tool demonstrated excellent reliability (alpha: 0.84-0.89). CFA confirmed a robust model fit for the Feasibility and Readiness structure [GFI/CFI = 0.95; RMSEA = 0.062]. HCWs reported high Readiness but moderate Feasibility. Significant occupational divergences emerged: 88.9% of nurses viewed sampling as simple (Item R4) compared to only 45.8% of laboratory technicians (p = 0.003). Furthermore, an experience-perception paradox was identified (p < 0.05); mid-career staff (5-10 years) reported the lowest feasibility scores (50.0% high score) compared to junior and senior cohorts.</p><p><strong>Conclusion: </strong>The psychometric validation resulted in a methodologically sound 16-item tool tailored for LMICs. The divergence between clinical readiness and laboratory feasibility highlights critical implementation bottlenecks. Sustainable transition to routine CRE surveillance requires resource-optimized targeted workflows to reduce frontline workloads, alongside peer-led governance that leverages senior expertise to mitigate mid-career burnout.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261476931"},"PeriodicalIF":2.2,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13451695/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148698025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HMGA1 is associated with unfavorable outcome and accelerates the aggressiveness of cholangiocarcinoma.","authors":"Ratthaphong Phumphu, Saowaluk Saisomboon, Piya Prajumwong, Orawan Waenphimai, Kulthida Vaeteewoottacharn, Sopit Wongkham, Ubon Cha'on, Charupong Saengboonmee, Anucha Puapairoj, Chawalit Pairojkul, Ryusho Kariya, Seiji Okada, Kanlayanee Sawanyawisuth","doi":"10.1177/20503121261475804","DOIUrl":"10.1177/20503121261475804","url":null,"abstract":"<p><strong>Introduction: </strong>Cholangiocarcinoma (CCA) is a highly metastatic bile duct cancer with the highest global incidence in Northeastern Thailand. Most patients are diagnosed at advanced stages, necessitating the identification of novel prognostic markers and therapeutic targets. High mobility group A1 (HMGA1) is a non-histone chromosomal protein that orchestrates the transcription of genes involved in tumor progression, and its overexpression has been implicated in multiple malignancies. <b>Aims:</b> This study aimed to investigate the clinical significance and oncogenic roles of HMGA1 in CCA progression.</p><p><strong>Methods: </strong>HMGA1 expression was evaluated in a hamster CCA model and human CCA tissues using immunohistochemistry. The functional effects of HMGA1 on cell growth, migration, and invasion, along with the underlying molecular mechanisms were investigated <i>in vitro</i> using human CCA cell lines.</p><p><strong>Results: </strong>HMGA1 upregulation was detected as an early event in the cholangiocarcinogenesis of a hamster model. In the human cohort (n = 81), high HMGA1 expression significantly correlated with histological type (<i>p</i>=0.014), metastatic stage (<i>p</i>=0.004) and shorter overall survival (<i>p</i>=0.024). <i>In vitro</i>, siRNA-mediated suppression of HMGA1 remarkably inhibited cell proliferation. While HMGA1 silencing increased cleaved caspase-3, it resulted in only a modest increase in the apoptotic cells. Instead, this caspase activation was primarily associated with a marked reduction in cell migration and invasion through the modulation of epithelial-mesenchymal transition (EMT) markers, and cytoskeletal remodeling in a cell line-specific manner. <b>Conclusions:</b> These retrospective and preclinical findings suggest that HMGA1 is a critical driver of CCA progression and a valuable prognostic indicator. HMGA1 promotes neoplastic transformation and aggressiveness of CCA. Targeting HMGA1 may serve as a potential therapeutic strategy to attenuate CCA progression, warranting further clinical validation.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261475804"},"PeriodicalIF":2.2,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13438342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148679844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and age-related trends of overweight and obesity among Saudi children aged 2-14 years during the COVID-19 pandemic: A retrospective cross-sectional study.","authors":"Hanan Al Shaikh, Hayat Mushcab, Zainab Ghanim, Amena Al Yousif, Halima Al Talaq, Maha Abussaud, Anwar Alotaibi","doi":"10.1177/20503121261474088","DOIUrl":"10.1177/20503121261474088","url":null,"abstract":"<p><strong>Background: </strong>Childhood obesity is a growing public health crisis in Saudi Arabia, which was intensified by the COVID-19 pandemic. This study mapped the prevalence and trends among clinic-attending children to inform prevention strategies.</p><p><strong>Methods: </strong>A retrospective cross-sectional analysis of electronic records for 28,275 Saudi children (aged 2-14 years) attending primary care clinics in Saudi Arabia's Eastern Province (2018-2024). Body mass index (BMI) was classified according to the Centers for Disease Control criteria (overweight: 85th-95th percentile; obesity: ≥95th percentile), excluding secondary causes. Crude and age-standardized prevalence rates were calculated by age, sex, and year using R software.</p><p><strong>Results: </strong>Mean age was 5.46 years (51% female). Overall, obesity prevalence was 12.3% (higher in males: 13.1% vs. 11.5% females), rising from 6.2% (ages 2-3 years) to 23.8% (ages 12-14 years). Overweight prevalence was 10.5% (7.3%-17.2% by age). Both reached their highest observed values in 2020 (obesity: 19.1%; overweight: 14.5%), with year-to-year variation thereafter.</p><p><strong>Conclusion: </strong>Age-related increases underscore the obesogenic environments among Saudi youth, with COVID-19 amplifying these risks. Findings highlight the need for resilient, Vision 2030-aligned prevention strategies focusing on early intervention and equity.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261474088"},"PeriodicalIF":2.2,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13428829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148664397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of the Arabic version of the 23-item quality-of-life Kansas City Cardiomyopathy Questionnaire (KCCQ).","authors":"Oriana Awwad, Suha AlMuhaissen, Rama S Odeh, Wejdan Shroukh, Basima A Almomani, Abdulrahman Alsawafta, Mariam Abdeljalil","doi":"10.1177/20503121261472565","DOIUrl":"10.1177/20503121261472565","url":null,"abstract":"<p><strong>Background and aim: </strong>The 23-item Kansas City Cardiomyopathy Questionnaire (KCCQ) is widely used to assess health-related quality of life (HRQoL) in HF patients covering key HF-related health status domains. This study validated the Arabic KCCQ version and looked into potential correlation between patients' HRQoL and their demographics/clinical characteristics, health literacy, medication adherence/knowledge.</p><p><strong>Methods: </strong>This was a multicenter validation study from Jordan including HF adult patients. Cronbach's alpha coefficient was employed to assess the scale internal consistency. Test-retest reliability evaluated stability of participants' responses overtime. Construct validity was examined through exploratory factor analysis (EFA), supported by Kaiser-Meyer-Olkin measure and Bartlett's sphericity test. Model fit was evaluated by confirmatory factor analysis (CFA). Associations between KCCQ scores and patient demographic/clinical characteristics, health literacy, medication adherence/knowledge were analyzed using linear regressions.</p><p><strong>Results: </strong>A total of 331 participants were recruited from two centers. KCCQ domains' scores ranged from mean±SD of 42.90±25.43 for symptom stability to 76.80±30.63 for social limitation. The total symptom, clinical summary and overall summary scores were 70.96±29.13, 74.67±25.67 and 70.67±25.70, respectively. The scale demonstrated excellent internal consistency (Cronbach's alpha=0.937). Test-retest analysis showed strong significant intraclass correlation coefficients and Pearson's correlation indicating good reliability. EFA and CFA supported data suitability for factor analysis and good model fit. The multivariate regression showed being married, performing exercise, being adherent to medication and taking fewer medications to significantly correlate to better HRQoL.</p><p><strong>Conclusion: </strong>The Arabic KCCQ version is a reliable, valid tool for HRQoL assessment among Arabic-speaking communities. Implementing interventions targeting sedentary HF patients not adherent to treatment regimen can improve HRQoL.</p>","PeriodicalId":21398,"journal":{"name":"SAGE Open Medicine","volume":"14 ","pages":"20503121261472565"},"PeriodicalIF":2.2,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13428120/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148653766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}