Revue neurologique最新文献

{"title":"Emerging autophagic endo-lysosomal targets in the management of Parkinson's disease","authors":"T. Siddiqui,&nbsp;L.K. Bhatt","doi":"10.1016/j.neurol.2023.07.007","DOIUrl":"10.1016/j.neurol.2023.07.007","url":null,"abstract":"<div><p>Synucleopathies, specifically Parkinson's disease, are still incurable and available therapeutic options are scarce and symptomatic. The autophagy-lysosomal-endosomal system is an indigenous mechanism to manage the proteome. Excess/misfolded protein accumulation activates this system, which degrades the undesired proteins via lysosomes. Cells also eliminate these proteins by releasing them into the extracellular space via exosomes. However, the sutophagy-lysosomal-endosomal system becomes unfunctional in Parkinson's disease and there is accumulation and spread of pathogenic alpha-synuclein. Neuronal degeneration results Owing to pathogenic alpha-synuclein. Thus, the autophagy-lysosomal-endosomal system could be a promising target for neuroprotection. In the present review, we discuss the autophagy-lysosomal-endosomal system as an emerging target for the management of Parkinson's disease. Modulation of these targets associated with the autophagy-lysosomal-endosomal system can aid in clearing pathogenic alpha-synuclein and prevent the degeneration of neurons.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 477-485"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10367816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In young patients with stroke of undetermined etiology, large vessel occlusions are less frequent in the group with high-risk patent foramen ovale","authors":"A. Ter Schiphorst ,&nbsp;A. Lippi ,&nbsp;L. Corti ,&nbsp;I. Mourand ,&nbsp;P. Prin ,&nbsp;A. Agullo ,&nbsp;F. Cagnazzo ,&nbsp;J.-C. Macia ,&nbsp;C. Arquizan","doi":"10.1016/j.neurol.2023.11.002","DOIUrl":"10.1016/j.neurol.2023.11.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Patent foramen ovale (PFO) is present in a significant proportion of young patients with stroke of undetermined etiology, but is not always causal. Therefore, classifications (RoPE, PASCAL) have been developed to determine the probability that PFO is the stroke cause. However, the presence of an initial arterial occlusion as a prediction factor was not studied when these classifications were built. Our aim was to evaluate the presence of arterial occlusion in young patients with stroke of undetermined etiology with/without high-risk PFO.</p></div><div><h3>Methods</h3><p>From a prospectively-built monocentric database, we identified patients aged<!--> <!-->≥<!--> <!-->18 to<!--> <!-->&lt;<!--> <!-->60-years with strokes of undetermined etiology and complete etiological work-up, including transesophageal echocardiography. We divided patients in two groups: (i) with high-risk PFO [i.e. PFO with large interatrial shunt (&gt;<!--> <!-->30 microbubbles) or associated with atrial septal aneurysm] and (ii) with low-risk/without PFO. We recorded the presence of arterial occlusion and large vessel occlusion (LVO) in the acute phase.</p></div><div><h3>Results</h3><p>We included 96 patients; 55 (57%) had high-risk PFO. Their median age was 48 (40–52) years, and 28 (29%) were women. The percentages of patients with arterial occlusion and with LVO were lower in the high-risk PFO group than in the low-risk/without PFO group: 11 (20%) versus 19 (46%) (<em>P</em> <!-->=<!--> <!-->0.008), and 5 (9%) versus 15 (37%) (<em>P</em> <!-->=<!--> <!-->0.002), respectively. There was no difference in the median RoPE score between groups (<em>P</em> <!-->=<!--> <!-->0.30).</p></div><div><h3>Conclusion</h3><p>The presence of LVO could represent a “red flag” of PFO causality in stroke of undetermined etiology, and could be implemented in future PFO-related stroke classifications.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 539-547"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138714642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tribute to Maurice Collard (1931–2024)","authors":"F. Sellal","doi":"10.1016/j.neurol.2024.05.002","DOIUrl":"10.1016/j.neurol.2024.05.002","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 473-474"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0035378724005289/pdfft?md5=7cbcb58f725f7d0b19c7204cab2f9d8c&pid=1-s2.0-S0035378724005289-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurodystrophic hand dermatitis – Sannino-Barduagni syndrome","authors":"A. Demas ,&nbsp;T. Apard ,&nbsp;A.-L. Bedat-Millet ,&nbsp;T. Maisonobe","doi":"10.1016/j.neurol.2023.11.007","DOIUrl":"10.1016/j.neurol.2023.11.007","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 564-565"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139677857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seizure recurrences in generalized convulsive status epilepticus under sedation: What are its predictors and its impact on outcome?","authors":"M. Dhoisne ,&nbsp;A. Delval ,&nbsp;D. Mathieu ,&nbsp;A. Mazeraud ,&nbsp;L. Bournisien ,&nbsp;P. Derambure ,&nbsp;R. Tortuyaux","doi":"10.1016/j.neurol.2023.09.006","DOIUrl":"10.1016/j.neurol.2023.09.006","url":null,"abstract":"<div><h3>Background</h3><p>Management of status epilepticus (SE) is focused on the early seizure termination. Refractory SE is an indication for sedation in patients with SE, but up to 75% of patients may be ventilated due to a neurological or respiratory failure. In patients requiring sedation, the clinical assessment is not sufficient to assess seizure control. Identifying those at risk of recurrent seizures could be useful to adapt their management. On the other hand, patients with low risk could benefit from an early withdrawal of sedation to avoid the impact of inappropriate sedation on outcome.</p></div><div><h3>Objective</h3><p>To determine the prevalence and the predictors of uncontrolled SE and its impact on outcome in patients with generalized convulsive SE (GCSE) requiring mechanical ventilation (MV).</p></div><div><h3>Methods</h3><p>We retrospectively included patients admitted to the intensive care unit with GCSE requiring MV. Uncontrolled SE was defined as persistent or recurrent seizures during sedation or within 24<!--> <!-->hours following withdrawal. A multivariable logistic regression model was used to assess the associated factors.</p></div><div><h3>Results</h3><p>Uncontrolled SE occurred in 37 out of 220 patients (17%). Persistent seizures at admission, higher SAPS II and central nervous system infection were associated with a higher risk of uncontrolled SE. Acute toxic or metabolic etiologies were associated with a decreased risk of uncontrolled SE. In a supplementary analysis, decrease of albumin blood levels was associated with uncontrolled SE. Uncontrolled SE was associated with a poor functional outcome and mortality at 90 days.</p></div><div><h3>Conclusions</h3><p>Seventeen percent of patients with a GCSE requiring MV suffered from uncontrolled SE. Etiology and persistent seizures at admission were the main predictors of uncontrolled SE. Patients with uncontrolled SE had a longer duration of sedation and MV, a poor functional outcome and a higher mortality. Further studies are required to determine the impact of continuous electroencephalogram monitoring on the clinical course.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 507-516"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Silent brain infarct in migraine: Systematic review and meta-analysis","authors":"A. Espanol ,&nbsp;F. Lerebours ,&nbsp;L. Calviere ,&nbsp;F. Bonneville ,&nbsp;A. Ducros ,&nbsp;V. Larrue ,&nbsp;C. Gollion","doi":"10.1016/j.neurol.2023.05.003","DOIUrl":"10.1016/j.neurol.2023.05.003","url":null,"abstract":"<div><h3>Background</h3><p><span>While migraine, particularly migraine with aura, is a recognized risk factor for </span>ischemic stroke<span>, the association of migraine with silent brain infarction is a matter of debate, as studies on this topic have yielded conflicting results.</span></p></div><div><h3>Methods</h3><p>A systematic review of the literature was conducted of studies reporting migraine and silent brain infarction, assessed by magnetic resonance imaging, between January 1980 and April 2022, by consulting Medline and Embase databases. Studies with a control group were included in a meta-analysis of population-based studies. An exploratory meta-analysis of both population-based and clinical-based studies was further performed to test the association between migraine with aura and silent brain infarction.</p></div><div><h3>Results</h3><p>A total of 2,408 articles were identified, among which 24 were included in the systematic review and 10 in the meta-analysis. The meta-analysis of population-based studies showed no association of migraine with silent brain infarction (odds ratio (OR)<!--> <!-->=<!--> <!-->1.32 [95% CI 0.92;1.90], <em>P</em> <!-->=<!--> <!-->0.13) and migraine with aura with silent brain infarction (OR<!--> <!-->=<!--> <!-->1.56 [0.74;3.30], <em>P</em> <!-->=<!--> <!-->0.24). However, in the exploratory meta-analysis of population-based and clinical-based studies, migraine with aura was significantly associated with silent brain infarction (OR<!--> <!-->=<!--> <!-->1.91 [1.02;3.59], <em>P</em> <!-->=<!--> <!-->0.04) and to silent cerebellar infarcts (OR<!--> <!-->=<!--> <!-->2.57 [1.01;6.56], <em>P</em> <!-->=<!--> <!-->0.05).</p></div><div><h3>Conclusion</h3><p>In this updated systematic review and meta-analysis of population-based studies, migraine and migraine with aura were not associated with silent brain infarction.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 486-493"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41164890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of gabapentin and pregabalin on agitation in dementia: Case series of ten patients","authors":"M. Kandemir Yilmaz","doi":"10.1016/j.neurol.2023.11.006","DOIUrl":"10.1016/j.neurol.2023.11.006","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 559-563"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139677862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fatal natalizumab-associated progressive multifocal leukoencephalopathy with initial low JCV antibody index in a multiple sclerosis patient","authors":"M. Hay ,&nbsp;S. Leguy ,&nbsp;V. Cahagne ,&nbsp;N. Lassalle ,&nbsp;E. Le Page ,&nbsp;L. Michel","doi":"10.1016/j.neurol.2023.11.011","DOIUrl":"10.1016/j.neurol.2023.11.011","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 565-567"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between neurology and psychiatry: The lively history of right hemisphere syndromes","authors":"K.G. Langer ,&nbsp;J. Bogousslavsky","doi":"10.1016/j.neurol.2023.07.013","DOIUrl":"10.1016/j.neurol.2023.07.013","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 568-579"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61564942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcome of stroke patients eligible to mechanical thrombectomy managed by spoke center, primary stroke center or comprehensive stroke center in the East of France","authors":"W. Abou Loukoul ,&nbsp;S. Richard ,&nbsp;G. Mione ,&nbsp;S. Finitsis ,&nbsp;A.-L. Derelle ,&nbsp;F. Zhu ,&nbsp;L. Liao ,&nbsp;R. Anxionnat ,&nbsp;M. Douarinou ,&nbsp;L. Humbertjean ,&nbsp;B. Gory","doi":"10.1016/j.neurol.2023.08.020","DOIUrl":"10.1016/j.neurol.2023.08.020","url":null,"abstract":"<div><h3>Background and purpose</h3><p><span>Patients with suspected stroke are referred to the nearest hospital and are managed either in a spoke center (SC), a primary stroke center (PSC), or a comprehensive stroke center (CSC) in order to benefit from early intravenous thrombolysis<span> (IVT). In case of large vessel occlusion (LVO), </span></span>mechanical thrombectomy (MT) is only performed in the CSC, whereas the effectiveness of MT is highly time-dependent. There is a debate about the best management model of patients with suspected LVO. Therefore, we aimed to compare functional and safety outcomes of LVO patients eligible for MT managed through our regional telestroke system.</p></div><div><h3>Method</h3><p><span>We performed a retrospective analysis of our observational prospective clinical registry in all consecutive subjects with LVO within six hours of onset who were admitted to the SC, PSC, or CSC in the east of France between October 2017 and November 2022. The primary endpoint was the functional independence defined as modified Rankin scale (mRS) score 0 to 2 at 90 days. Secondary endpoints were functional outcome, early neurological improvement, symptomatic </span>intracranial hemorrhage and 90-day mortality.</p></div><div><h3>Results</h3><p><span>Among the 794 included patients with LVO who underwent MT, 122 (15.4%) were managed by a SC, 403 (50.8%) were first admitted to a PSC, and 269 (33.9%) were first admitted to the CSC. The overall median NIHSS<span> and ASPECTS score were 16 and 8, respectively. Multivariate analysis did not find any significant difference for the primary endpoint between patients managed by PSC versus CSC (OR 1.06 [95% CI 0.64;1.76], </span></span><em>P</em> <!-->=<!--> <!-->0.82) and between patient managed by SC versus CSC (OR 0.69 [0.34;1.40], <em>P</em> <!-->=<!--> <span>0.30). No difference between the three groups was found except for the parenchymal hematoma rate between PSC and CSC (15.7 versus 7.4%, OR 2.25 [1.07;4.74], </span><em>P</em> <!-->=<!--> <!-->0.032).</p></div><div><h3>Conclusions</h3><p>Compared with a first admission to a CSC, the clinical outcomes of stroke patients with LVO eligible for MT first admitted to a SC or a PSC are similar.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 517-523"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138462366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}