Revue neurologiquePub Date : 2024-06-01DOI: 10.1016/j.neurol.2024.05.002
F. Sellal
{"title":"Tribute to Maurice Collard (1931–2024)","authors":"F. Sellal","doi":"10.1016/j.neurol.2024.05.002","DOIUrl":"10.1016/j.neurol.2024.05.002","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 473-474"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0035378724005289/pdfft?md5=7cbcb58f725f7d0b19c7204cab2f9d8c&pid=1-s2.0-S0035378724005289-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Revue neurologiquePub Date : 2024-06-01DOI: 10.1016/j.neurol.2023.09.006
M. Dhoisne , A. Delval , D. Mathieu , A. Mazeraud , L. Bournisien , P. Derambure , R. Tortuyaux
{"title":"Seizure recurrences in generalized convulsive status epilepticus under sedation: What are its predictors and its impact on outcome?","authors":"M. Dhoisne , A. Delval , D. Mathieu , A. Mazeraud , L. Bournisien , P. Derambure , R. Tortuyaux","doi":"10.1016/j.neurol.2023.09.006","DOIUrl":"10.1016/j.neurol.2023.09.006","url":null,"abstract":"<div><h3>Background</h3><p>Management of status epilepticus (SE) is focused on the early seizure termination. Refractory SE is an indication for sedation in patients with SE, but up to 75% of patients may be ventilated due to a neurological or respiratory failure. In patients requiring sedation, the clinical assessment is not sufficient to assess seizure control. Identifying those at risk of recurrent seizures could be useful to adapt their management. On the other hand, patients with low risk could benefit from an early withdrawal of sedation to avoid the impact of inappropriate sedation on outcome.</p></div><div><h3>Objective</h3><p>To determine the prevalence and the predictors of uncontrolled SE and its impact on outcome in patients with generalized convulsive SE (GCSE) requiring mechanical ventilation (MV).</p></div><div><h3>Methods</h3><p>We retrospectively included patients admitted to the intensive care unit with GCSE requiring MV. Uncontrolled SE was defined as persistent or recurrent seizures during sedation or within 24<!--> <!-->hours following withdrawal. A multivariable logistic regression model was used to assess the associated factors.</p></div><div><h3>Results</h3><p>Uncontrolled SE occurred in 37 out of 220 patients (17%). Persistent seizures at admission, higher SAPS II and central nervous system infection were associated with a higher risk of uncontrolled SE. Acute toxic or metabolic etiologies were associated with a decreased risk of uncontrolled SE. In a supplementary analysis, decrease of albumin blood levels was associated with uncontrolled SE. Uncontrolled SE was associated with a poor functional outcome and mortality at 90 days.</p></div><div><h3>Conclusions</h3><p>Seventeen percent of patients with a GCSE requiring MV suffered from uncontrolled SE. Etiology and persistent seizures at admission were the main predictors of uncontrolled SE. Patients with uncontrolled SE had a longer duration of sedation and MV, a poor functional outcome and a higher mortality. Further studies are required to determine the impact of continuous electroencephalogram monitoring on the clinical course.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 507-516"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Revue neurologiquePub Date : 2024-06-01DOI: 10.1016/j.neurol.2023.05.003
A. Espanol , F. Lerebours , L. Calviere , F. Bonneville , A. Ducros , V. Larrue , C. Gollion
{"title":"Silent brain infarct in migraine: Systematic review and meta-analysis","authors":"A. Espanol , F. Lerebours , L. Calviere , F. Bonneville , A. Ducros , V. Larrue , C. Gollion","doi":"10.1016/j.neurol.2023.05.003","DOIUrl":"10.1016/j.neurol.2023.05.003","url":null,"abstract":"<div><h3>Background</h3><p><span>While migraine, particularly migraine with aura, is a recognized risk factor for </span>ischemic stroke<span>, the association of migraine with silent brain infarction is a matter of debate, as studies on this topic have yielded conflicting results.</span></p></div><div><h3>Methods</h3><p>A systematic review of the literature was conducted of studies reporting migraine and silent brain infarction, assessed by magnetic resonance imaging, between January 1980 and April 2022, by consulting Medline and Embase databases. Studies with a control group were included in a meta-analysis of population-based studies. An exploratory meta-analysis of both population-based and clinical-based studies was further performed to test the association between migraine with aura and silent brain infarction.</p></div><div><h3>Results</h3><p>A total of 2,408 articles were identified, among which 24 were included in the systematic review and 10 in the meta-analysis. The meta-analysis of population-based studies showed no association of migraine with silent brain infarction (odds ratio (OR)<!--> <!-->=<!--> <!-->1.32 [95% CI 0.92;1.90], <em>P</em> <!-->=<!--> <!-->0.13) and migraine with aura with silent brain infarction (OR<!--> <!-->=<!--> <!-->1.56 [0.74;3.30], <em>P</em> <!-->=<!--> <!-->0.24). However, in the exploratory meta-analysis of population-based and clinical-based studies, migraine with aura was significantly associated with silent brain infarction (OR<!--> <!-->=<!--> <!-->1.91 [1.02;3.59], <em>P</em> <!-->=<!--> <!-->0.04) and to silent cerebellar infarcts (OR<!--> <!-->=<!--> <!-->2.57 [1.01;6.56], <em>P</em> <!-->=<!--> <!-->0.05).</p></div><div><h3>Conclusion</h3><p>In this updated systematic review and meta-analysis of population-based studies, migraine and migraine with aura were not associated with silent brain infarction.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 486-493"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41164890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Revue neurologiquePub Date : 2024-06-01DOI: 10.1016/j.neurol.2023.11.006
M. Kandemir Yilmaz
{"title":"The effect of gabapentin and pregabalin on agitation in dementia: Case series of ten patients","authors":"M. Kandemir Yilmaz","doi":"10.1016/j.neurol.2023.11.006","DOIUrl":"10.1016/j.neurol.2023.11.006","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 559-563"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139677862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Revue neurologiquePub Date : 2024-06-01DOI: 10.1016/j.neurol.2023.07.013
K.G. Langer , J. Bogousslavsky
{"title":"Between neurology and psychiatry: The lively history of right hemisphere syndromes","authors":"K.G. Langer , J. Bogousslavsky","doi":"10.1016/j.neurol.2023.07.013","DOIUrl":"10.1016/j.neurol.2023.07.013","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 568-579"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61564942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Revue neurologiquePub Date : 2024-06-01DOI: 10.1016/j.neurol.2023.08.020
W. Abou Loukoul , S. Richard , G. Mione , S. Finitsis , A.-L. Derelle , F. Zhu , L. Liao , R. Anxionnat , M. Douarinou , L. Humbertjean , B. Gory
{"title":"Outcome of stroke patients eligible to mechanical thrombectomy managed by spoke center, primary stroke center or comprehensive stroke center in the East of France","authors":"W. Abou Loukoul , S. Richard , G. Mione , S. Finitsis , A.-L. Derelle , F. Zhu , L. Liao , R. Anxionnat , M. Douarinou , L. Humbertjean , B. Gory","doi":"10.1016/j.neurol.2023.08.020","DOIUrl":"10.1016/j.neurol.2023.08.020","url":null,"abstract":"<div><h3>Background and purpose</h3><p><span>Patients with suspected stroke are referred to the nearest hospital and are managed either in a spoke center (SC), a primary stroke center (PSC), or a comprehensive stroke center (CSC) in order to benefit from early intravenous thrombolysis<span> (IVT). In case of large vessel occlusion (LVO), </span></span>mechanical thrombectomy (MT) is only performed in the CSC, whereas the effectiveness of MT is highly time-dependent. There is a debate about the best management model of patients with suspected LVO. Therefore, we aimed to compare functional and safety outcomes of LVO patients eligible for MT managed through our regional telestroke system.</p></div><div><h3>Method</h3><p><span>We performed a retrospective analysis of our observational prospective clinical registry in all consecutive subjects with LVO within six hours of onset who were admitted to the SC, PSC, or CSC in the east of France between October 2017 and November 2022. The primary endpoint was the functional independence defined as modified Rankin scale (mRS) score 0 to 2 at 90 days. Secondary endpoints were functional outcome, early neurological improvement, symptomatic </span>intracranial hemorrhage and 90-day mortality.</p></div><div><h3>Results</h3><p><span>Among the 794 included patients with LVO who underwent MT, 122 (15.4%) were managed by a SC, 403 (50.8%) were first admitted to a PSC, and 269 (33.9%) were first admitted to the CSC. The overall median NIHSS<span> and ASPECTS score were 16 and 8, respectively. Multivariate analysis did not find any significant difference for the primary endpoint between patients managed by PSC versus CSC (OR 1.06 [95% CI 0.64;1.76], </span></span><em>P</em> <!-->=<!--> <!-->0.82) and between patient managed by SC versus CSC (OR 0.69 [0.34;1.40], <em>P</em> <!-->=<!--> <span>0.30). No difference between the three groups was found except for the parenchymal hematoma rate between PSC and CSC (15.7 versus 7.4%, OR 2.25 [1.07;4.74], </span><em>P</em> <!-->=<!--> <!-->0.032).</p></div><div><h3>Conclusions</h3><p>Compared with a first admission to a CSC, the clinical outcomes of stroke patients with LVO eligible for MT first admitted to a SC or a PSC are similar.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 517-523"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138462366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Revue neurologiquePub Date : 2024-06-01DOI: 10.1016/j.neurol.2023.11.009
A. Kreisler , K. Watel , L. Defebvre , L. Mortain , A. Duhamel
{"title":"Does the guidance method affect the doses of botulinum toxin in writer's cramp?","authors":"A. Kreisler , K. Watel , L. Defebvre , L. Mortain , A. Duhamel","doi":"10.1016/j.neurol.2023.11.009","DOIUrl":"10.1016/j.neurol.2023.11.009","url":null,"abstract":"<div><h3>Purpose</h3><p><span>Botulinum neurotoxin (BoNT) injections are the main medical treatment of </span>writer's cramp. When the outcome is favourable, patients usually receive injections several times per year in the long-term. However, we know little about the course of BoNT doses and nothing about the impact of the guidance method on the clinical outcome or injection strategy.</p></div><div><h3>Methods</h3><p>We studied, in the long-term, the doses of BoNT and the target muscles in a group of patients with writer's cramp, according to the guidance method (electrical stimulation or ultrasound). Patients received at least three injection cycles guided by electrical stimulation, followed by at least three injection cycles guided by ultrasound.</p></div><div><h3>Results</h3><p>Twenty-four patients were included. More target muscles were injected after switching to ultrasound guidance, especially the flexor carpi ulnaris and the flexor carpi radialis. The mean dose by muscle was lower when ultrasound guidance was used. When using electrical stimulation guidance, the dose in the flexors of the fingers decreased in the long-term, but increased in the flexors of the wrist. The course of the BoNT doses and of the number of target muscles per cycle were not the same during the first period (electrical stimulation) and the second period (ultrasound).</p></div><div><h3>Conclusions</h3><p>Switching to ultrasound guidance, the BoNT dose decreased, mainly in the flexors of the wrist. Based on the results of our study, we suggest a starting dose in several muscles (flexor carpi ulnaris, flexor carpi radialis, flexor digitorum profundus and flexor pollicis longus).</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 548-558"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139712951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Revue neurologiquePub Date : 2024-06-01DOI: 10.1016/j.neurol.2023.09.007
P. Capitaine , B. Thomas , A. Gradel , T. Ferté , O. Branchard , E. Frison , V. Renaudeau , J. Aupy
{"title":"Evaluation of quality of life's prognostic factors in people with functional seizures","authors":"P. Capitaine , B. Thomas , A. Gradel , T. Ferté , O. Branchard , E. Frison , V. Renaudeau , J. Aupy","doi":"10.1016/j.neurol.2023.09.007","DOIUrl":"10.1016/j.neurol.2023.09.007","url":null,"abstract":"<div><h3>Aims</h3><p>Functional non-epileptic seizures significantly impact the quality of life of patients. We aimed to identify prognostic factors associated with the quality of life in individuals with functional non-epileptic seizures.</p></div><div><h3>Subjects and methods</h3><p>Adult patients diagnosed with definite or documented functional seizures based on LaFrance's criteria (<em>n</em> <!-->=<!--> <!-->72) were enrolled at the time of diagnosis. Quality of life was assessed using the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) at diagnosis and at a six-month follow-up. Demographic and medical information was collected, and psychiatric comorbidities were evaluated using validated scales.</p></div><div><h3>Results</h3><p>Comparisons between diagnosis and follow-up did not reveal any factors associated with improvement in quality of life at six months after diagnosis. However, multivariable analysis, adjusted for age, sex, diagnosis delay, and frequency of functional seizures showed a significant cross-sectional relationship with a QOLIE-31 score decrease of 0.66 [95% CI −0.93;−0.39], −0.32 [−0.61; −0.03], and −0.22 [−0.42; −0.02] for an increase of 1 point of BDI-2 score, BAI score, and CTQ score respectively.</p></div><div><h3>Conclusion</h3><p>Psychiatric comorbidities, particularly depression and anxiety, are associated with worse quality of life in patients with functional seizures. This underscores the crucial importance of multidisciplinary care involving both neurological and psychiatric expertise when managing individuals with functional seizures.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":"180 6","pages":"Pages 524-531"},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138470762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}