Revue neurologique最新文献

Zilucoplan as a fast-acting treatment for severe myasthenic exacerbation: A case series. Zilucoplan作为严重肌无力加重的速效治疗：一个病例系列。

IF 2.8 4区医学

Revue neurologique Pub Date : 2025-07-19 DOI: 10.1016/j.neurol.2025.06.010

V Fabry, B Acket, P Girardie, L Espagno, O Cointault, P Cintas

引用次数: 0

Migraine management in France: Practices of general practitioners and neurologists. 偏头痛在法国的管理：全科医生和神经科医生的做法。

IF 2.8 4区医学

Revue neurologique Pub Date : 2025-07-17 DOI: 10.1016/j.neurol.2025.06.006

C Lucas, V Raclot, M Gugenheim, H Lefebvre, B Braithwaite, A Ducros

{"title":"Migraine management in France: Practices of general practitioners and neurologists.","authors":"C Lucas, V Raclot, M Gugenheim, H Lefebvre, B Braithwaite, A Ducros","doi":"10.1016/j.neurol.2025.06.006","DOIUrl":"https://doi.org/10.1016/j.neurol.2025.06.006","url":null,"abstract":"Background: In 2024, despite updated French guidelines, migraine remains underdiagnosed and undertreated. We conducted a comprehensive survey to evaluate the management of migraine patients by French general practitioners (GPs) and neurologists, and to identify factors linked to low prescription rates of recommended treatments.Methods: A total of 320 GPs and 215 neurologists practicing in France were analyzed after completing an online questionnaire (between June and October 2023) regarding their prescribing behaviors and influencing factors, whose potential associations were analyzed statistically.Results: GPs most commonly prescribe triptans (71.6%) and non-steroidal anti-inflammatory drugs (NSAIDs, 66.6%) for acute migraine treatment, and propranolol (71.6%) as prophylaxis. Lower prescribing rates were associated with shorter practice duration, negative perceptions of risk-benefit and lack of recent migraine training. Conversely, recent migraine training significantly reduced low prescription rates of prophylactic treatments. Neurologists frequently prescribe triptans (93.5%) and NSAIDs (89.3%) for acute treatment, as well as propranolol (76.3%) and amitriptyline (61.4%) as prophylaxis. The prescription of newer treatments like calcitonin gene-related peptide monoclonal antibodies is limited, with only 7.0% of respondents frequently using them.Conclusion: While GPs and neurologists often use recommended acute treatments, prophylactic and newer therapies are less commonly prescribed, despite recently updated French guidelines on migraine management.","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144668265","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Description of peripheral nervous system involvement in wild-type transthyretin amyloidosis: A clinical and electrophysiological study. 野生型转甲状腺蛋白淀粉样变累及周围神经系统的描述：一项临床和电生理研究。

IF 2.8 4区医学

Revue neurologique Pub Date : 2025-07-15 DOI: 10.1016/j.neurol.2025.06.007

R Barriol, B Lemarchant, F Cassim, J-B Davion, L Defebvre, J-B Gibier, N Lamblin, C Tard

{"title":"Description of peripheral nervous system involvement in wild-type transthyretin amyloidosis: A clinical and electrophysiological study.","authors":"R Barriol, B Lemarchant, F Cassim, J-B Davion, L Defebvre, J-B Gibier, N Lamblin, C Tard","doi":"10.1016/j.neurol.2025.06.007","DOIUrl":"https://doi.org/10.1016/j.neurol.2025.06.007","url":null,"abstract":"Introduction: Wild-type transthyretin amyloidosis (ATTRwt) is not clearly known to be associated with peripheral neurological complications. The aim of our study was to characterize neurological involvement in ATTRwt, as well as its evolution over time, using clinical and electrodiagnostic (EDX) data.Methods: We prospectively included patients diagnosed with ATTRwt who were addressed by cardiologists. All patients underwent neurological evaluation, including examination (neuropathy impairment score) and an EDX study including electrochemical skin conductance and/or sympathetic skin response testing. Motor, sensory, and small fiber composite sum scores were calculated based on the EDX data. Clinical and EDX scores were then reassessed during the follow-up period.Results: Fifty-two patients were included, 94% of whom were treated with tafamidis. At inclusion 98% of patients presented peripheral nerve involvement at EDX, the most common being carpal tunnel syndrome (88%), polyneuropathy (67%), and ulnar tunnel syndrome (21%). Twenty-nine patients were reevaluated and mean follow-up was 16.7months with no significant change of clinical or neurophysiological data.Discussion: In our cohort, a large majority of ATTRwt patients showed peripheral nerve involvement, generally expressed as the combination of different neurological syndromes (entrapment syndromes, large and/or small fiber polyneuropathy, radicular impairment). Polyneuropathy in ATTRwt seemed stable over our follow-up period. Clinical and EDX screening should be conducted in ATTRwt patients with symptoms suggestive of neurological involvement in order not to oversee these frequent complications which could affect therapeutic decision making.","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Criteria for the use of plasmapheresesis in optic neuritis: A practice review from French expert centers. 视神经炎血浆置换的使用标准：法国专家中心的实践回顾。

IF 2.8 4区医学

Revue neurologique Pub Date : 2025-07-15 DOI: 10.1016/j.neurol.2025.06.005

A Gaulier, V Touitou, M-B Rougier, M P Robert, H Merle, M Aubart, P Cabre, C Cochard, N Stolowy, J De Seze, A Gueguen, J Aboab, H Zephir, A Ungureanu, A Caignard, C Scherer, M Gobert, S Saheb, N Fage, J-B Ducloyer, A Rivet, S Beltran, A-M Guennoc, B Audoin, M-A Laville, P Branger, R Khanna, C Roth, C Bensa, J Bursztyn, D Biotti, D Laplaud, B Brochet, S Wiertlewski, C Froment, P Lebranchu

{"title":"Criteria for the use of plasmapheresesis in optic neuritis: A practice review from French expert centers.","authors":"A Gaulier, V Touitou, M-B Rougier, M P Robert, H Merle, M Aubart, P Cabre, C Cochard, N Stolowy, J De Seze, A Gueguen, J Aboab, H Zephir, A Ungureanu, A Caignard, C Scherer, M Gobert, S Saheb, N Fage, J-B Ducloyer, A Rivet, S Beltran, A-M Guennoc, B Audoin, M-A Laville, P Branger, R Khanna, C Roth, C Bensa, J Bursztyn, D Biotti, D Laplaud, B Brochet, S Wiertlewski, C Froment, P Lebranchu","doi":"10.1016/j.neurol.2025.06.005","DOIUrl":"https://doi.org/10.1016/j.neurol.2025.06.005","url":null,"abstract":"Introduction: Some patients remain severely disabled after an episode of optic neuritis. Several studies have shown that plasmapheresis (PE) can improve visual prognosis in the absence of satisfactory recovery after corticosteroids. However, there is no clear ophthalmological criterion for doing PE, and practices vary widely. The objective of the present study was to better define the rationales for use of PE.Material and methods: We investigated the real-life indications for PE in French expert centers. Based on the responses to a questionnaire and the current literature, we further provided guidelines aiming to standardize the use of PE for the management of optic neuritis.Results: Twenty expert centers completed the questionnaire. Together, they accounted for 90% of patients treated by PE in France during the study period. The main criteria for using PE were as follows: severely impaired visual acuity despite corticosteroids (mean visual acuity<0.6 logMAR or 20/80), high suspicion for neuromyelitis optica spectrum disorder, bilateral optic neuritis, or a profound visual field alteration.Conclusion: This study provides insightful information about the real-life indications for PE in French centers for the treatment of optic neuritis. Based on our findings and the available data in the literature, we provide a decision-making algorithm for the management of optic neuritis.","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and management of psychosis in an outpatient population with Parkinson's disease: A real-life descriptive study. 帕金森病患者门诊人群精神病的患病率和管理：一项真实的描述性研究。

IF 2.8 4区医学

Revue neurologique Pub Date : 2025-07-15 DOI: 10.1016/j.neurol.2025.06.008

G Costentin, M Diguet, D Wallon, L Grangeon, D Maltête

{"title":"Prevalence and management of psychosis in an outpatient population with Parkinson's disease: A real-life descriptive study.","authors":"G Costentin, M Diguet, D Wallon, L Grangeon, D Maltête","doi":"10.1016/j.neurol.2025.06.008","DOIUrl":"https://doi.org/10.1016/j.neurol.2025.06.008","url":null,"abstract":"Background: Previous studies reporting prevalence of psychosis were predominantly cross-sectional, with a limited focus on the full spectrum of features seen in psychosis associated with Parkinson's disease (PDPsy).Objectives: To assess the prevalence of PDPsy, explore the association of PDPsy with demographic, drug-related, and disease-related characteristics and describe the management of PDPsy in an outpatient population with PD.Methods: We analysed the psychosis prevalence and clinical correlates in PD patients seen for an outpatient visit at the Parkinson Expert Centre of Rouen. PD patients were evaluated with detailed clinical history taken by an investigator trained in PD (DM). Psychosis was diagnosed according to NINDS diagnostic criteria. PDPsy characteristics were collected using a standardized questionnaire composed of ten qualitative items on hallucinations, minor phenomena, and delusions. All PD patients considered to have a previous or ongoing PDPsy underwent an interview to assess the age at onset, exacerbating and relieving factors, the management and outcomes.Results: From June to December 2021, 315 outpatients with PD were included in the study, 42% had previous or ongoing psychosis, mostly visual hallucinations. PD patients with PDPsy were older, with a more advanced form of the disease and were treated with a higher dose of anti-Parkinson drugs. Psychotic symptoms can be adequately managed with nonpharmacoligical approaches, while in other patients, reduction or withdrawal of drugs, or introduction of clozapine was necessary.Conclusions: Untreated PDPsy is associated with impaired quality of life, and significant distress to caregivers and patients. Early detection of psychotic symptoms may yield prognostic and therapeutic benefits.","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":" ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144650288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rethinking Parkinson's disease therapy: The overlooked role of GPR143 in L-DOPA effects. 重新思考帕金森病治疗：GPR143在左旋多巴作用中被忽视的作用。

IF 2.8 4区医学

Revue neurologique Pub Date : 2025-07-09 DOI: 10.1016/j.neurol.2025.07.001

M Aubignat

引用次数: 0

Comment on "Postural balance and visual dependence in patients with demyelinating neuropathies differ between acquired and hereditary etiologies". 评论“脱髓鞘神经病变患者的姿势平衡和视觉依赖在获得性和遗传性病因之间存在差异”。

IF 2.8 4区医学

Revue neurologique Pub Date : 2025-07-04 DOI: 10.1016/j.neurol.2025.06.003

S M Sheriff, M Hasan, M H Chola

引用次数: 0

When sound replaces pain: A case of exploding head syndrome mistaken for headache. 当声音代替疼痛：爆头综合征误诊为头痛一例。