Przeglad lekarski最新文献

{"title":"Long-term follow-up after Holmium:YAG laser revascularization combined with autologous bone marrow derived stem cells implantation.","authors":"Janusz Konstanty-Kalandyk,&nbsp;Jacek Piątek,&nbsp;Anna Kędziora,&nbsp;Tomasz Miszalski-Jamka,&nbsp;Bogusław Kapelak,&nbsp;Krzysztof Bartuś,&nbsp;Tomasz Darocha,&nbsp;Rafał Drwiła,&nbsp;Jerzy Sadowski","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Coronary artery disease\u0000is a major cause of death worldwide.\u0000Despite different standard revascularization\u0000options, significant number\u0000of patients remains not suitable for any\u0000treatment. The aim of the study was to\u0000evaluate long-term outcome of patients\u0000with diffuse coronary artery disease,\u0000treated with autologous stem cells injections\u0000combined with transmyocardial\u0000laser revascularization.</p><p><strong>Material and methods: </strong>9 patients underwent\u0000Holmium:YAG laser revascularization\u0000and autologous bone marrow\u0000derived stem cells implantation between\u00002007 and 2009 in the Department of Cardiovascular\u0000Surgery and Transplantology,\u0000John Paul II Hospital, Kraków and\u0000were subsequently followed up in 2015.</p><p><strong>Results: </strong>The mean follow-up period\u0000was 73 months. The mean CCS\u0000class significantly improved (1.4±0.5\u0000vs 3.3±1.0; p<0.001) and cardiac related\u0000hospitalizations significantly decreased\u0000(1.1±0.8 vs 3.1±2.1; p<0.001). One death\u0000due to heart failure was observed. The\u0000mean LVEF increased from 38% to 42%\u0000(p>0.05).</p><p><strong>Conclusions: </strong>Clinical status improvement\u0000was observed with low mortality\u0000rate in the long-term follow-up. No\u0000new regional wall motion abnormalities\u0000were observed, and the increase of\u0000global ejection fraction was noted.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36045765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Klotho not only antiageing protein].","authors":"Bartosz Sosnowski,&nbsp;Hanna Bachórzewska-Gajewska,&nbsp;Slawomir Dobrzycki,&nbsp;Jolanta Malyszko","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Klotho, the gene encoding the\u0000antiaging protein, was discovered in\u00001997 and named after a Greek Goddes\u0000who spun the thread of life. Numerous\u0000experiments on mice confirmed that\u0000destruction of the klotho gene or loss\u0000of klotho function leads to an accelerated\u0000aging and premature death.\u0000In addition to shortened life span,\u0000klotho-deficient mice demonstrated\u0000changes in functioning of multiple\u0000organs, ectopic calcification, enhanced\u0000development of arteriosclerosis,\u0000osteoporosis and atrophy of skin. In\u0000contrast, overexpression of a gene in\u0000mice inhibited aging and prolonged\u0000survival. The multisystemic phenotype\u0000induced by Klotho deficiency indicates\u0000that Klotho works on a variety of\u0000organs. Klotho is highly expressed\u0000in the kidney, brain, and to a lesser\u0000extent in other organs. Protein Klotho\u0000exists in two forms: membrane and\u0000secreted which play different functions.\u0000Membrane Klotho function as\u0000an obligate co-receptor required for\u0000signaling for the phosphaturic factor\u0000FGF23, regulates calcium-phosphate\u0000homeostasis through renal ion transport\u0000in addition to modulation of PTH\u0000and 1,25(OH)2D3. Soluble klotho functions\u0000as a humoral factor and regulates\u0000the activity of several ion channels and\u0000transporters. The secreted Klotho can\u0000also inhibit oxydative stres and the\u0000insulin and insulin-like growth factor 1\u0000(IGF-1) pathways. The discovery of the\u0000protein klotho led to the identification\u0000of new axes connecting endocrine\u0000disturbances in the homeostasis of\u0000the calcium-phosphate to the aging of\u0000the organism. Klotho deficiency may\u0000not only be a trigger for accelerated\u0000aging but also in development of age-\u0000-associated diseases, including hypertension,\u0000osteoporosis, cardiovascular\u0000disease, and CKD. Conceivably, better\u0000understanding of Klotho protein might\u0000provide a novel treatment strategy for\u0000aging and age-associated diseases.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36042810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[CyberKnife for prostate cancer patients. Update of 200 patients treatment results].","authors":"Leszek Miszczyk,&nbsp;Aleksandra Napieralska,&nbsp;Agnieszka Namysł-Kaletka,&nbsp;Grzegorz Woźniak,&nbsp;Małgorzata Stapór-Fudzińska,&nbsp;Grzegorz Głowacki,&nbsp;Andrzej Tukiendorf","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>This is an update regarding\u0000the treatment results of 200\u0000prostate cancer patients’ (PCP) CyberKnife\u0000based radioablation (the first\u0000group in Poland).\u0000The purpose of this study is reevaluation\u0000(after 2 years) of this treatment\u0000modality results of low (LR) and\u0000intermediate risk (IR) (including T2c)\u0000PCP and failure analysis.</p><p><strong>Material and methods: </strong>200 PCP (95\u0000LR, 86 IR, 19 T2c) 53 – 83 y.o. (mean 69)\u0000treated between 2011 and 2014. 48%\u0000used neoadjuvant ADT. The patients\u0000were irradiated every other day with\u0000a fraction dose of 7.25 Gy to the total\u0000dose 36.25 Gy (5 fractions in 9 days).\u0000Fiducials based tracking was performed.\u0000The patients were controlled\u0000on the treatment completion day, 1, 4,\u00008 months later and subsequently every\u00006 months. The PSA concentration,\u0000ADT usage, acute and late adverse effects\u0000(EORTC/RTOG) and other symptoms\u0000were evaluated. FU ranged from\u00001 to 63.6 months (mean 32.2, median\u000032.9).</p><p><strong>Results: </strong>The adverse effects percentage\u0000was very low; only 1 month\u0000after treatment the percentage of\u0000acute urinary reaction exceeded 40%.\u0000Only single G3 adverse effects were\u0000noted. Over 4 months the median\u0000PSA concentration declined from 3.75\u0000to 0.27 ng/ml. 9 failures (4.5%) were\u0000noted – more among IR and patients\u0000without neoadjuvant ADT. No failure\u0000in the T2c group was found. Median\u0000time to failure was 32.4 months. Cox\u0000analysis revealed that the failure risk\u0000increases with the value of maximal\u0000PSA before treatment.</p><p><strong>Conclusions: </strong>CK based radioablation of LR and\u0000IR PCP is a safe and highly effective\u0000treatment modality.\u0000The main prognostic factor of failure\u0000after this treatment is probably\u0000the maximal PSA concentration before\u0000treatment.\u0000The neoadjuvant ADT in IR group\u0000should be considered.\u0000The lack of failures in the T2c group enables us to suggest\u0000that even more locally advanced patients (T3) with\u0000low PSA and maximal Gleason 3+4 could be treated with\u0000this modality.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36044334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of gender on the frequency of syncope provoking factors and prodromal signs in patients with vasovagal syncope.","authors":"Katarzyna Cubera,&nbsp;Piotr J Stryjewski,&nbsp;Agnieszka Kuczaj,&nbsp;Jadwiga Nessler,&nbsp;Ewa Nowalany-Kozielska,&nbsp;Jolanta Pytko-Polończyk","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>According to the\u0000ESC guidelines, syncope is a transient\u0000loss of consciousness caused\u0000by transient, general cerebral hypoperfusion,\u0000characterized by rapid onset,\u0000short duration and spontaneous\u0000recovery.</p><p><strong>Objectives: </strong>The aim of the study\u0000was a comparative analysis of syncope\u0000provoking factors and prodromal\u0000signs in patients with vasovagal\u0000syncope with consideration given to\u0000gender.</p><p><strong>Materials and methods: </strong>We investigated 80 patients, aged 18-74\u0000years with previously diagnosed\u0000vasovagal cause of syncope. Special\u0000attention was paid to the frequency\u0000of triggering factors and prodromal signs.</p><p><strong>Results: </strong>In the studied group the\u0000mean age at first syncope was significantly\u0000lower in women (23.2±10.7)\u0000as compared to men (30.7±17.4).\u0000The mean total number of syncopal\u0000and presyncopal episodes was significantly\u0000higher in women (13.3±11.0\u0000vs. 7.8±6.6; 26.6±12.9 vs. 13.8±6.9). In\u0000the group of men syncopal episodes\u0000were more frequent after urination\u0000and defecation. The remaining\u0000circumstances related to syncope\u0000were more prevalent in women, but\u0000only the occurrence of a syncopal\u0000episode during walking achieved\u0000statistical significance. All the prodromal\u0000signs that were analysed occurred\u0000more frequently in the group\u0000of women compared to men. Statistical\u0000significance was achieved for the\u0000analysed signs such as generalized\u0000weakness, dyspnea, heart palpitations,\u0000cold sweats, feeling of cold or\u0000heat, visual disturbances, tinnitus,\u0000headache.</p><p><strong>Conclusions: </strong>Syncope provoking\u0000factors and prodromal signs occur\u0000more frequently in women.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36044571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral mucosa lesions in patients with active Crohn’s disease - a prospective study.","authors":"Katarzyna Szczeklik,&nbsp;Jolanta Pytko-Polończyk,&nbsp;Dorota Cibor,&nbsp;Danuta Owczarek,&nbsp;Tomasz Mach","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Crohn’s disease (CD)\u0000is a chronic inflammatory disease,\u0000which may involve any part of the gastrointestinal\u0000tract, including the oral\u0000cavity. Mucosal lesions in the oral cavity\u0000are described in various populations,\u0000but observations in active disease\u0000with severe clinical symptoms are\u0000quite rare.</p><p><strong>Objectives: </strong>To evaluate the prevalence\u0000and nature of oral mucosa lesions\u0000in adult patients with active CD\u0000and their correlation with clinical and\u0000laboratory indicators of disease activity.</p><p><strong>Material and methods: </strong>Prospective\u0000study was performed in 62 patients\u0000(29 women, 33 men, age 18-49 years)\u0000admitted between December 2010 and\u0000February 2013 to the gastroenterology\u0000department with a confirmed diagnosis\u0000of CD and exacerbations of symptoms,\u0000and 40 sex- and gender-matched\u0000healthy volunteers. CD activity was\u0000classified according to clinical and\u0000blood parameters, and the CD activity\u0000index (CDAI). We examined: blood morphology,\u0000hemoglobin and CRP levels,\u0000BMI. Examination of the oral cavity included\u0000a detailed interview and physical\u0000examination, based on the WHO\u0000recommendations.</p><p><strong>Results: </strong>In patients with active\u0000CD we found: increased CDAI\u0000score (258.4±21.5), higher CRP levels\u0000(24.6±1.3 mg/l) and platelet count, anemia\u0000with significantly reduced RBC and\u0000hemoglobin level, and reduced BMI, in\u0000comparison to controls. The specific\u0000for CD symptoms were found in the\u0000mouth: indurated tag polypoid lesions\u0000on vestibular retromolar region in\u000012.9% of patients, cobblestoning of the\u0000mucosa in 9.7%, diffuse asymptomatic\u0000buccal swelling in 16.2%, mucogingivitis\u0000in 19.4% of patients. Oral nonspecific\u0000lesions were more frequent: angular\u0000cheilitis in 29.1%, atrophic glossitis in\u000014.5% of patients. Oral lesions correlated\u0000with hemoglobin and CRP concentrations\u0000(r=-0.431 and r=0.437; respectively;\u0000p<0.001), platelet count (r=0.45;\u0000p<0.003), CDAI (r=0.421; p<0.001) and\u0000BMI (r=0.307; p<0.006). No correlation\u0000has been found between specific or\u0000non-specific lesions and location of\u0000inflammatory changes in the gastrointestinal\u0000tract.</p><p><strong>Conclusions: </strong>Changes in the oral mucosa in adult patients\u0000with active CD are frequent. They should be correlated\u0000with other clinical symptoms of gastrointestinal tract and biochemical\u0000parameters in patients with CD. The nature of these\u0000changes may have an impact on the further therapeutic approach.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36041727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The influence of living conditions and lifestyle on the anxiety level in women in the postpartum period-questionnaire study].","authors":"Barbara Piech,&nbsp;Marta Kiałka,&nbsp;Anna Baran,&nbsp;Sandra Mrozińska,&nbsp;Marek Janeczko,&nbsp;Ewa Humeniuk,&nbsp;Tomasz Milewicz","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Due to the high incidence of postpartum anxiety disorders and their serious health and social consequences, it is essential to analyze the possible risk factors to identify groups of women particularly vulnerable to cover their proper care and control. The aim of our study was to investigate the relationship between the anxiety in women in the postpartum period, and their living conditions and lifestyle.</p><p><strong>Materials and methods: </strong>The study was conducted from April to July 2016. We included 102 women in the postpartum period, living in the city of Cracow and the Cracow district. The study was based on a survey of our own authorship, State Anxiety Inventory (STAI) and the Jurczyński’s Inventory of Health Behavior (IZZ).</p><p><strong>Results: </strong>The anxiety level in women in the postpartum period depends on the conditions of life and health behaviors. The level of health behavior of women in the postpartum period is an average and independent of age, number of children, and the material situation. Residents of cities, women with higher education, who planned pregnancy, have a higher level of health behavior. Good housing conditions have a positive influence on health behavior. Low levels of health behavior significantly affect the severity of maternal anxiety. Residents of the village, women with lower education and who not planning pregnancy have higher levels of anxiety during the postpartum period. Anxiety level of women in the postpartum period is inversely proportional to their housing conditions. Women with a job have lower levels of anxiety than non-working. The anxiety level in women in childbirth does not depend on age or financial situation.</p><p><strong>Conclusions: </strong>The anxiety level in women in the postpartum period, significantly depends on the living conditions and health behaviors. Verification of distinguished factors should be applied appropriately in health promotional activities and prevention programs.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36045762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Postpartum thyroiditis as the first clinical manifestation of autoimmune polyendocrine syndrome type 2 – case report].","authors":"Robert Krysiak,&nbsp;Karolina Kowalcze,&nbsp;Bogusław Okopień","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Postpartum thyroiditis is a form\u0000of autoimmune thyroiditis developing\u0000during the first 12 months postpartum\u0000in 5-10% of women as a consequence\u0000of the immunologic flare\u0000following the immune suppression\u0000of pregnancy. Autoimmune polyendocrine\u0000syndromes are rarely diagnosed\u0000conditions characterized by\u0000the association of at least two organspecific\u0000autoimmune disorders, and\u0000on the basis of their clinical picture,\u0000they may be divided into four different\u0000types. The underestimation of\u0000their real frequency probable results\u0000from physicians’ inadequate knowledge\u0000of these clinical entities and\u0000sometimes their atypical clinical picture.\u0000Although autoimmune thyroid\u0000disease may be a component of both\u0000type 2 and 3 autoimmune polyendocrine\u0000syndromes, but the association\u0000between postpartum thyroiditis\u0000and autoimmune conditions of other\u0000endocrine organs has very rarely\u0000been described in literature. We report\u0000a case of a young woman, who\u0000after two subsequent pregnancies\u0000developed postpartum thyroiditis\u0000of different clinical pictures. After\u0000her second pregnancy, postpartum\u0000thyroiditis was followed by the development\u0000of autoimmune adrenal\u0000failure and premature ovarian failure,\u0000which allowed to diagnose type 2 autoimmune\u0000polyendocrine syndrome.\u0000Our case study suggests that every\u0000person with postpartum thyroiditis,\u0000particularly if this disorder is accompanied\u0000by atypical clinical manifestation,\u0000should be assessed for the\u0000possible presence of autoimmune\u0000polyendocrine syndrome.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36047838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ocular outcomes in 4-year old prematurely born children.","authors":"Anna Leśniak,&nbsp;Małgorzata Klimek,&nbsp;Anna Kubatko-Zielińska,&nbsp;Joanna Kobylarz,&nbsp;Magdalena Nitecka,&nbsp;Grażyna Dutkowska,&nbsp;Bożena Romanowska-Dixon,&nbsp;Przemko Kwinta","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study was\u0000to assess functional and structural\u0000ophthalmologic outcomes in 4-year old\u0000very low birth weight children (VLBW).</p><p><strong>Material and methods: </strong>A group of 82 VLBW children including: (1)\u0000children without retinopathy of prematurity\u0000– group O (n = 30), (2) children\u0000with retinopathy of prematurity with no\u0000indications for laser coagulation- group\u00001 (n = 20 ), (3) children with retinopathy\u0000of prematurity treated with laser\u0000coagulation – group 2 (n = 32) were\u0000enrolled. Functional (visual acuity,\u0000visual evoked potentials, stereopsis,\u0000color vision test) and structural (anterior\u0000eye segment examination and\u0000fundoscopy) outcome, cycloplegic\u0000refraction, intraocular pressure and\u0000angle of squint were examined in all\u0000children. Developmental Test of Visual\u0000Perception was also assessed.</p><p><strong>Results: </strong>Very good visual acuity\u0000was presented in 56 (68.3%) patients,\u0000good visual acuity in 11 (13.4%) children,\u0000visual acuity between 0.4 and 0.2\u0000in 13 (15.9%) and unfavorable function\u0000(equal or less than 0.1) was observed\u0000in 2 (2.4%) children. Twenty-three patients\u0000(28.1%) were myopic, 57 patients\u0000(69.5%) were hyperopic. Astigmatism\u0000> 1D occurred in 49 (59.8%) patients.\u0000Anisometropia larger than 2 D occurred\u0000in 7 patients (8.7%). There was no\u0000statistical difference between frequency\u0000of mentioned above complications\u0000between the groups. Abnormal VEP\u0000results were more common (14 children\u0000-54%) in group 2 as compared\u0000to other groups (group 0 - 7 children\u0000-25%, group 1 – 4 children -24%; p =\u00000.044). Moreover, the lower percentage\u0000of group 2 children presented stereopsis\u0000vision (46.9%, group 0 – 93.3%,\u0000group 1 – 90%; p<0.05). Children with\u0000retinopathy of prematurity treated with\u0000laser coagulation had significantly\u0000lower Developmental Test of Visual\u0000Perceptions scores. In group 1, in 1\u0000child naevus pigmentosus of the eyelid\u0000was observed, in group 2 in one child\u0000eyeball atrophy in the right eye and\u0000aphakia in the left eye were diagnosed.\u0000In 1 child in group 0 optic disc drusen\u0000were observed, in 2 children optic discs\u0000were pale. In 2 children in group 2\u0000retinal detachment stage 5 was diagnosed.</p><p><strong>Conclusion: </strong>An important factor affecting final ophthalomolgical\u0000assessment in prematurely born children is\u0000retinopathy of prematurity treated with laser coagulaion.\u0000Children with retinopathy of prematurity without laser\u0000coagulation had examinations results comparable wih\u0000children without retinopathy of prematurity. Diode laser\u0000photocoagulation is an effective method of treatment fot\u0000active stages of retinopathy of prematurity.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36042806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[The first three docents of urology in Poland].","authors":"Piotr Kuzaka,&nbsp;Bolesław Kuzaka","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36044187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Metformin–new potential medicine in pain treatment?]","authors":"Marta Kiałka,&nbsp;Katarzyna Doroszewska,&nbsp;Marek Janeczko,&nbsp;Tomasz Milewicz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Metformin, a drug of biguanide class, is now one of the most widely used drugs in the treatment of type 2 diabetes. It activates adenosine monophosphate-activated protein kinase (AMPK) and through AMPK activation, inhibits the mammalian target of rapamycin (mTOR) pathway. Recent literature has explored metformin as an option in pain management, given its role in the AMP-activated protein kinase (AMPK) pathway and its ability to modulate pain in animal models. Based on a variety of preclinical pain models, it is now clear that mTOR signaling plays a major role in the sensitization of the nervous system in chronic pain conditions. The activation of AMPK with metformin has led to decreased pain in neuropathic and postsurgical pain models, suggesting that these drugs and this mechanism of actin might be effective in humans. Despite the strong preclinical rationale, there are only very few data considered the utility of metformin as a potential pan therapeutic in humans. Further, randomized studies were needed to identify the role of metformin in pain perception and chronic pain conditions in humans.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36045763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}