{"title":"[Postpartum depression].","authors":"D. Dudek, M. Siwek, A. Zięba, G. Nowak","doi":"10.32388/65rw98","DOIUrl":"https://doi.org/10.32388/65rw98","url":null,"abstract":"This paper is a literature review of current knowledge about postpartum depression. It presents the course and clinical picture of this disorder with regard of possible complications. The stress was laid on early and efficient diagnosis and differentiation. The general rules of prophylaxis and treatment were also described. The authors also presented new hypothesis concerning biological basis of postpartum depression. The article should be useful not only for psychiatrists, but also for physicians of other specializations with special regard of obstetricians, paediatrists and general practitioners.","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75039179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Kiałka, Anna Gałuszka-Bednarczyk, A. Wajda, Patrycja Czekańska, Barbara Zdzierak, S. Mrozinska, Marek Janeczko, T. Milewicz
{"title":"Metformin and changes in serum lipid profile in lean patients with polycystic ovary syndrome.","authors":"M. Kiałka, Anna Gałuszka-Bednarczyk, A. Wajda, Patrycja Czekańska, Barbara Zdzierak, S. Mrozinska, Marek Janeczko, T. Milewicz","doi":"10.1530/ENDOABS.49.EP371","DOIUrl":"https://doi.org/10.1530/ENDOABS.49.EP371","url":null,"abstract":"Introduction\u0000The aim of our study\u0000was to assess the values of total cholesterol,\u0000high-density lipoprotein cholesterol\u0000(HDL-C), low-density lipoprotein\u0000cholesterol (LDL-C) and triglycerides\u0000before and after treatment with metformin\u0000in lean patients with polycystic\u0000ovary syndrome (PCOS).\u0000\u0000\u0000Material and Methods\u000032 patients received metformin 1500 mg per day in\u0000three divided doses. Lipids measurements\u0000were performed twice: before\u0000and after 6 months of treatment with metformin.\u0000\u0000\u0000Results\u0000In lean patients with\u0000PCOS after treatment with metformin\u0000we observed: statistically significant\u0000lower LDL-C levels (4.16±0.79 mmol/l\u0000vs 3.4±0.86 mmol/l, p<0.05) and triglycerides\u0000levels (1.8±0.53 mmol/l vs\u00001.12±0.64 mmol/l, p<0.05). We observed\u0000an increase in HDL values and a decrease\u0000in total cholesterol values, but\u0000these changes were not statistically significant\u0000(1.5±0.71 mmol/l vs 1.71±0.69\u0000mmol/l, p=0.09; 5.87±0.92 mmol/l vs\u00005.69±0.97 mmol/l, p=0.11).\u0000\u0000\u0000Conclusion\u0000Our study showed that\u0000treatment of 1500 mg metformin for\u0000about six months among PCOS women\u0000results in an improvement in serum\u0000lipid profiles. We observed a significant\u0000decrease in LDL-C and triglycerides values\u0000after metformin therapy.","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79830654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rita Tomczyk, Agnieszka Ociepka, M. Kiałka, T. Milewicz, K. Migacz, A. Kowalczuk, M. Klocek
{"title":"[Metformin and changes in blood pressure and heart rate in lean patients with polycystic ovary syndrome (PCOS)--preliminary study].","authors":"Rita Tomczyk, Agnieszka Ociepka, M. Kiałka, T. Milewicz, K. Migacz, A. Kowalczuk, M. Klocek","doi":"10.1530/endoabs.49.EP357","DOIUrl":"https://doi.org/10.1530/endoabs.49.EP357","url":null,"abstract":"INTRODUCTION\u0000The aim of our study was to assess the value of blood pressure and heart rate using the 24-hour blood pressure monitoring (ABPM) before and after treatment with metformin to patients with polycystic ovary syndrome (PCOS) and normal lean.\u0000\u0000\u0000MATERIAL AND METHODS\u00005 patients received metformin 1500 mg per day in three divided doses. ABPM was performed to each patient with PCOS twice: before and after 6 months of treatment with metformin.\u0000\u0000\u0000RESULTS\u0000In patients with PCOS and normal lean after treatment with metformin we observed: statistically significant lower systolic blood pressure (120.2 ± 22.33 mmHg vs 113.22 ± 21.43 mm Hg, p = 0.0248); lower systolic blood pressure of daily measurements (127.1 ± 32.13 mmHg vs 116.1 ± 22.08 mmHg, p = 0.0062); reduction in average arterial pressure MAP in the measurement of the day (95.52 ± 22.76 mmHg vs 88.36 ± 16.41 mmHg, p = 0.048); oscillometric pressure reduction (96.27 ± 27.93 mmHg vs 87.82 ± 21.61, p = 0.0004 mmHg); oscillometric pressure reduction of daily measurements (102.1 ± 27.93 mmHg vs 91.85 ± 21.61 mmHg, p = 0.0032); oscillometric pressure reduction in the measure- ment of the night (88.81 ± 24.85 mmHg vs 82.22 ± 20.54 mmHg, p = 0.0089). In women after treatment with metformin has also been observed higher average heart rate (65.82 ± 13.48 / min vs. 70.71 ± 16.04 min; p < 0.01). The calculations included 500 measurements.\u0000\u0000\u0000CONCLUSION\u0000Treatment with metformin in patients with PCOS and normal lean leads to lower blood pressure and increases the frequency of heart rate.","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76415872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Mrozinska, M. Kiałka, K. Doroszewska, T. Milewicz, R. Jach
{"title":"[The ovarian origin of hiperandrogenism in the postmenopausal woman the adrenal adenoma--a case report].","authors":"S. Mrozinska, M. Kiałka, K. Doroszewska, T. Milewicz, R. Jach","doi":"10.1530/ENDOABS.49.EP141","DOIUrl":"https://doi.org/10.1530/ENDOABS.49.EP141","url":null,"abstract":"Hyperandrogenism is a clinical condition characterized by excessive secretion of male sex hormones. An excess amount of androgens in women is manifested by symptoms of defeminization and masculinization. Hormonally active adrenal and ovarian tumors and non-tumor causes must be considered in the differential diagnosis. The authors describe the case of a 77-year-old patient who had hirsutism and reduction of the timbre of the voice. At the beginning she was suspected to have adrenal hyperandrogenism because of the tumor in the adrenal gland. Then adrenalectomy was conducted but it did not lead to alleviate symptoms. A MRI of the pelvis revealed a change of appendages projection and the patient underwent the total hysterectomy. The normalization of testosterone levels as well as reduction of the symptoms was observed after the operation. Finally, the ovary etiology of hyperandrogenism was confirmed. This case report is an example of difficulties in recognition the etiology of hyperandrogenism.","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90660448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maciej Orzechowski, Anna Knafel, Tomasz Banas, Robert Jach, Kazimierz Pitynski, Marcin Wiechec
{"title":"Ultrasound evaluation of inferior facial angle (IFA) in a population of normal fetuses at 11-13 weeks (+6 days) gestation.","authors":"Maciej Orzechowski, Anna Knafel, Tomasz Banas, Robert Jach, Kazimierz Pitynski, Marcin Wiechec","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Retrognathia is a common feature\u0000of many fetal anomalies that may be\u0000diagnosed during ultrasound examination.\u0000The most common method\u0000used for the diagnosis of this condition\u0000is the inferior facial angle (IFA). The\u0000existing reference ranges for IFA have\u0000been established for the fetuses at 18-\u000028 weeks gestation and may be not applicable\u0000in the first trimester. The aim\u0000of the study was to document changes\u0000of IFA from 11+0 to 13+6 weeks gestation,\u0000to verify the reproducibility of IFA\u0000calculations obtained by the same examiner\u0000and to investigate the possible\u0000association between IFA values at the\u0000first and second trimester scans.</p><p><strong>Material and methods: </strong>A prospective\u0000study was performed in 512 singleton\u0000pregnancies during the first\u0000trimester ultrasound exam. IFA was\u0000calculated by measuring the angle\u0000made by the cross-section of a line\u0000orthogonal to the forehead at the level\u0000of nasofrontal suture and the line from\u0000the tip of the mentum to the anterior\u0000border of the more protrusive lip. In\u0000100 cases, stored images were used\u0000to calculate IFA twice by the same\u0000examiner. In a second trimester scan,\u0000IFA was measured again in 215 fetuses.</p><p><strong>Results: </strong>The median IFA value at\u0000the time of the first trimester (IFA-1)\u0000was 880 (IQR: 8.0) and decreased with\u0000crown-rump length (CRL) and biparietal\u0000diameter (BPD). A moderate negative\u0000correlation was shown between\u0000IFA-1 and CRL (r= 0.3; p<0.001) as well\u0000as between IFA-1 and BPD-1 (r= 0.176;\u0000p=0.010). An intraclass correlation\u0000coefficient (ICC) of 0.87 (95% CI: 0.81\u0000– 0.91) confirmed strong intraobserver\u0000agreement between two IFA measurements.\u0000In 215 fetuses that underwent\u0000a second trimester screening, the\u0000median IFA-2 was significantly lower\u0000compared to IFA-1(215) (750; IQR: 10.0\u0000vs.870; IQR: 8.0; p<0.001), and there\u0000was no correlation between IFA1215 and\u0000IFA-2 (r= -0.024; p=0.731).</p><p><strong>Conclusions: </strong>In the first trimester,\u0000IFA decreases with CRL and BPD.\u0000When performed by the same operator,\u0000measurement of IFA is reproducible. There is no correlation\u0000between the IFA values in the first and second trimesters.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36042807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"[Microangiopathy CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) - a chalange for general practitioner].","authors":"Ewelina Nycz","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Small cerebral vessel disease is a\u0000relatively new group of angiopathies\u0000diagnosed more frequently thanks to\u0000common availability of neuroimaging.\u0000The most frequent and the most\u0000known disease which belongs to this\u0000group is CADASIL (cerebral autosomal\u0000dominant arteriopathy with subcortical\u0000infarcts and leukoencephalopathy).\u0000Despite the name, it is a generalized\u0000small vessel disease, in which\u0000symptoms of brain damage dominate.\u0000The disease manifests as recurrent\u0000ischemic strokes, progressing dementia,\u0000migraine and mental disorders –\u0000symptoms which usually appear in 4-5\u0000decade of life in patients without typical\u0000risk factors for vascular disease. In\u0000neuroimaging hyperintense changes\u0000and small ischemic foci disseminated\u0000in the cerebral white matter are seen.\u0000CADASIL is caused by mutations in\u0000the NOTCH 3 gene, which lead to the\u0000degeneration and loss of smooth muscle\u0000cells in small arteries. The disease\u0000is diagnosed on the basis of the result\u0000of the genetic test and microscopic\u0000examination of blood vessels in the\u0000material derived from a skin or skinmuscle\u0000biopsy. Since more and more\u0000frequently new techniques of neuroimaging\u0000reveal changes in the cerebral\u0000white matter - often asymptomatic or/\u0000and mistakenly diagnosed as demyelinating\u0000lesions - only knowledge about\u0000CADASIL and other microangiopathies\u0000allows to avoid diagnostic errors.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36042813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jarosław Stoliński, Dariusz Plicner, Michał Mędrzycki, Bogusław Kapelak
{"title":"[Pulmonary complications after minimally invasive aortic valve replacement surgery - a propensity score matching analysis].","authors":"Jarosław Stoliński, Dariusz Plicner, Michał Mędrzycki, Bogusław Kapelak","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Instruction: </strong>To answer the question\u0000if minimally invasive aortic valve\u0000replacement surgery through a right\u0000anterior minithoracotomy (RT-AVR)\u0000may result in increased incidence of\u0000postoperative pulmonary complications\u0000compared to conventional aortic\u0000valve replacement through a median\u0000sternotomy (AVR).</p><p><strong>Material and methods: </strong>It was retrospective\u0000analysis of 212 patients\u0000scheduled for RT-AVR and 212 for\u0000AVR between January 2011 and December\u00002014 selected with propensity\u0000score matching. Respiratory system\u0000complications are analysed.</p><p><strong>Results: </strong>Postoperative blood\u0000drainage was 353±249 and 524±325\u0000ml in RT-AVR and AVR groups respectively\u0000(p<0.001). Hospital stay was\u00005.7±1.6 and 8.5±4.3 days (p<0.001),\u0000ICU stay was 1.3±1.2 and 2.6±2.8 days\u0000(p<0.001) in RT-AVR and AVR patients\u0000respectively. Respiratory system\u0000complications occurred in 13.7% of\u0000RT-AVR patients and 17.0% of AVR\u0000patients (p=0.364). Pneumonia was diagnosed\u0000in 2.4% and 0.5% of patients\u0000(p=0.129), pneumothorax in 2.0% and\u00001.3% of patients (p=0.515), pleural effusion\u0000in 8.5% and 7.5% of patients\u0000(p =0.732) and thoracentesis was\u0000performed in 7.1% and 7.5% of patients\u0000from RT-AVR and AVR groups\u0000respectively. Mediastinitis was diagnosed\u0000in 0.0% of RT-AVR and 2.8% of\u0000AVR patients (p=0.020). Phrenic nerve\u0000dysfunction was present in 3.8% of\u0000RT-AVR and in 0.0% of AVR patients\u0000(p=0.006). COPD (OR=5.5; p<0.001)\u0000and increased postoperative blood\u0000loss (OR=3.5; p<0.001) were risk factors\u0000of postoperative pulmonary complications.</p><p><strong>Conclusion: </strong>Minimally invasive\u0000RT-AVR surgery did not result in increased\u0000rate of postoperative pulmonary\u0000complications compared to\u0000conventional AVR surgery through\u0000a median sternotomy.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36044337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}