Katarzyna Szczeklik, Jolanta Pytko-Polończyk, Dorota Cibor, Danuta Owczarek, Tomasz Mach
{"title":"活动期克罗恩病患者口腔黏膜病变的前瞻性研究","authors":"Katarzyna Szczeklik, Jolanta Pytko-Polończyk, Dorota Cibor, Danuta Owczarek, Tomasz Mach","doi":"","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Crohn’s disease (CD)\nis a chronic inflammatory disease,\nwhich may involve any part of the gastrointestinal\ntract, including the oral\ncavity. Mucosal lesions in the oral cavity\nare described in various populations,\nbut observations in active disease\nwith severe clinical symptoms are\nquite rare.</p><p><strong>Objectives: </strong>To evaluate the prevalence\nand nature of oral mucosa lesions\nin adult patients with active CD\nand their correlation with clinical and\nlaboratory indicators of disease activity.</p><p><strong>Material and methods: </strong>Prospective\nstudy was performed in 62 patients\n(29 women, 33 men, age 18-49 years)\nadmitted between December 2010 and\nFebruary 2013 to the gastroenterology\ndepartment with a confirmed diagnosis\nof CD and exacerbations of symptoms,\nand 40 sex- and gender-matched\nhealthy volunteers. CD activity was\nclassified according to clinical and\nblood parameters, and the CD activity\nindex (CDAI). We examined: blood morphology,\nhemoglobin and CRP levels,\nBMI. Examination of the oral cavity included\na detailed interview and physical\nexamination, based on the WHO\nrecommendations.</p><p><strong>Results: </strong>In patients with active\nCD we found: increased CDAI\nscore (258.4±21.5), higher CRP levels\n(24.6±1.3 mg/l) and platelet count, anemia\nwith significantly reduced RBC and\nhemoglobin level, and reduced BMI, in\ncomparison to controls. The specific\nfor CD symptoms were found in the\nmouth: indurated tag polypoid lesions\non vestibular retromolar region in\n12.9% of patients, cobblestoning of the\nmucosa in 9.7%, diffuse asymptomatic\nbuccal swelling in 16.2%, mucogingivitis\nin 19.4% of patients. Oral nonspecific\nlesions were more frequent: angular\ncheilitis in 29.1%, atrophic glossitis in\n14.5% of patients. Oral lesions correlated\nwith hemoglobin and CRP concentrations\n(r=-0.431 and r=0.437; respectively;\np<0.001), platelet count (r=0.45;\np<0.003), CDAI (r=0.421; p<0.001) and\nBMI (r=0.307; p<0.006). No correlation\nhas been found between specific or\nnon-specific lesions and location of\ninflammatory changes in the gastrointestinal\ntract.</p><p><strong>Conclusions: </strong>Changes in the oral mucosa in adult patients\nwith active CD are frequent. They should be correlated\nwith other clinical symptoms of gastrointestinal tract and biochemical\nparameters in patients with CD. The nature of these\nchanges may have an impact on the further therapeutic approach.</p>","PeriodicalId":21148,"journal":{"name":"Przeglad lekarski","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Oral mucosa lesions in patients with active Crohn’s disease - a prospective study.\",\"authors\":\"Katarzyna Szczeklik, Jolanta Pytko-Polończyk, Dorota Cibor, Danuta Owczarek, Tomasz Mach\",\"doi\":\"\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Crohn’s disease (CD)\\nis a chronic inflammatory disease,\\nwhich may involve any part of the gastrointestinal\\ntract, including the oral\\ncavity. Mucosal lesions in the oral cavity\\nare described in various populations,\\nbut observations in active disease\\nwith severe clinical symptoms are\\nquite rare.</p><p><strong>Objectives: </strong>To evaluate the prevalence\\nand nature of oral mucosa lesions\\nin adult patients with active CD\\nand their correlation with clinical and\\nlaboratory indicators of disease activity.</p><p><strong>Material and methods: </strong>Prospective\\nstudy was performed in 62 patients\\n(29 women, 33 men, age 18-49 years)\\nadmitted between December 2010 and\\nFebruary 2013 to the gastroenterology\\ndepartment with a confirmed diagnosis\\nof CD and exacerbations of symptoms,\\nand 40 sex- and gender-matched\\nhealthy volunteers. CD activity was\\nclassified according to clinical and\\nblood parameters, and the CD activity\\nindex (CDAI). We examined: blood morphology,\\nhemoglobin and CRP levels,\\nBMI. Examination of the oral cavity included\\na detailed interview and physical\\nexamination, based on the WHO\\nrecommendations.</p><p><strong>Results: </strong>In patients with active\\nCD we found: increased CDAI\\nscore (258.4±21.5), higher CRP levels\\n(24.6±1.3 mg/l) and platelet count, anemia\\nwith significantly reduced RBC and\\nhemoglobin level, and reduced BMI, in\\ncomparison to controls. The specific\\nfor CD symptoms were found in the\\nmouth: indurated tag polypoid lesions\\non vestibular retromolar region in\\n12.9% of patients, cobblestoning of the\\nmucosa in 9.7%, diffuse asymptomatic\\nbuccal swelling in 16.2%, mucogingivitis\\nin 19.4% of patients. Oral nonspecific\\nlesions were more frequent: angular\\ncheilitis in 29.1%, atrophic glossitis in\\n14.5% of patients. Oral lesions correlated\\nwith hemoglobin and CRP concentrations\\n(r=-0.431 and r=0.437; respectively;\\np<0.001), platelet count (r=0.45;\\np<0.003), CDAI (r=0.421; p<0.001) and\\nBMI (r=0.307; p<0.006). No correlation\\nhas been found between specific or\\nnon-specific lesions and location of\\ninflammatory changes in the gastrointestinal\\ntract.</p><p><strong>Conclusions: </strong>Changes in the oral mucosa in adult patients\\nwith active CD are frequent. They should be correlated\\nwith other clinical symptoms of gastrointestinal tract and biochemical\\nparameters in patients with CD. The nature of these\\nchanges may have an impact on the further therapeutic approach.</p>\",\"PeriodicalId\":21148,\"journal\":{\"name\":\"Przeglad lekarski\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Przeglad lekarski\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Przeglad lekarski","FirstCategoryId":"1085","ListUrlMain":"","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Oral mucosa lesions in patients with active Crohn’s disease - a prospective study.
Introduction: Crohn’s disease (CD)
is a chronic inflammatory disease,
which may involve any part of the gastrointestinal
tract, including the oral
cavity. Mucosal lesions in the oral cavity
are described in various populations,
but observations in active disease
with severe clinical symptoms are
quite rare.
Objectives: To evaluate the prevalence
and nature of oral mucosa lesions
in adult patients with active CD
and their correlation with clinical and
laboratory indicators of disease activity.
Material and methods: Prospective
study was performed in 62 patients
(29 women, 33 men, age 18-49 years)
admitted between December 2010 and
February 2013 to the gastroenterology
department with a confirmed diagnosis
of CD and exacerbations of symptoms,
and 40 sex- and gender-matched
healthy volunteers. CD activity was
classified according to clinical and
blood parameters, and the CD activity
index (CDAI). We examined: blood morphology,
hemoglobin and CRP levels,
BMI. Examination of the oral cavity included
a detailed interview and physical
examination, based on the WHO
recommendations.
Results: In patients with active
CD we found: increased CDAI
score (258.4±21.5), higher CRP levels
(24.6±1.3 mg/l) and platelet count, anemia
with significantly reduced RBC and
hemoglobin level, and reduced BMI, in
comparison to controls. The specific
for CD symptoms were found in the
mouth: indurated tag polypoid lesions
on vestibular retromolar region in
12.9% of patients, cobblestoning of the
mucosa in 9.7%, diffuse asymptomatic
buccal swelling in 16.2%, mucogingivitis
in 19.4% of patients. Oral nonspecific
lesions were more frequent: angular
cheilitis in 29.1%, atrophic glossitis in
14.5% of patients. Oral lesions correlated
with hemoglobin and CRP concentrations
(r=-0.431 and r=0.437; respectively;
p<0.001), platelet count (r=0.45;
p<0.003), CDAI (r=0.421; p<0.001) and
BMI (r=0.307; p<0.006). No correlation
has been found between specific or
non-specific lesions and location of
inflammatory changes in the gastrointestinal
tract.
Conclusions: Changes in the oral mucosa in adult patients
with active CD are frequent. They should be correlated
with other clinical symptoms of gastrointestinal tract and biochemical
parameters in patients with CD. The nature of these
changes may have an impact on the further therapeutic approach.