Long-term follow-up after Holmium:YAG laser revascularization combined with autologous bone marrow derived stem cells implantation.

Przeglad lekarski Pub Date : 2017-01-01
Janusz Konstanty-Kalandyk, Jacek Piątek, Anna Kędziora, Tomasz Miszalski-Jamka, Bogusław Kapelak, Krzysztof Bartuś, Tomasz Darocha, Rafał Drwiła, Jerzy Sadowski
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Abstract

Background: Coronary artery disease is a major cause of death worldwide. Despite different standard revascularization options, significant number of patients remains not suitable for any treatment. The aim of the study was to evaluate long-term outcome of patients with diffuse coronary artery disease, treated with autologous stem cells injections combined with transmyocardial laser revascularization.

Material and methods: 9 patients underwent Holmium:YAG laser revascularization and autologous bone marrow derived stem cells implantation between 2007 and 2009 in the Department of Cardiovascular Surgery and Transplantology, John Paul II Hospital, Kraków and were subsequently followed up in 2015.

Results: The mean follow-up period was 73 months. The mean CCS class significantly improved (1.4±0.5 vs 3.3±1.0; p<0.001) and cardiac related hospitalizations significantly decreased (1.1±0.8 vs 3.1±2.1; p<0.001). One death due to heart failure was observed. The mean LVEF increased from 38% to 42% (p>0.05).

Conclusions: Clinical status improvement was observed with low mortality rate in the long-term follow-up. No new regional wall motion abnormalities were observed, and the increase of global ejection fraction was noted.

钬:YAG激光血管重建术联合自体骨髓源性干细胞移植术后的长期随访。
背景:冠状动脉疾病是世界范围内死亡的主要原因之一。尽管有不同的标准血运重建选择,但仍有相当数量的患者不适合任何治疗。该研究的目的是评估弥漫性冠状动脉疾病患者接受自体干细胞注射联合经心肌激光血管重建术治疗的长期疗效。材料和方法:2007年至2009年在约翰保罗二世医院(Kraków)心血管外科和移植科接受钬激光血管重建术和自体骨髓源性干细胞植入的9例患者,并于2015年随访。结果:平均随访73个月。ccs平均分级显著提高(1.4±0.5vs 3.3±1.0;p0.05)。结论:经长期随访,患者临床状况改善,病死率低。未观察到新的区域壁面运动异常,整体射血分数增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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