Rasayan Journal of Chemistry最新文献_第3页

A NOVEL STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF PIBRENTASVIR AND GLECAPREVIR IN BULK AND PHARMACEUTICAL DOSAGE FORMS 一种稳定性指示反相高效液相色谱法同时测定原料药和制剂中吡布他韦和格卡韦的含量

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI: 10.31788/rjc.2023.1638458

Vyshali Veerareddy, umaraswamy Gandla

{"title":"A NOVEL STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF PIBRENTASVIR AND GLECAPREVIR IN BULK AND PHARMACEUTICAL DOSAGE FORMS","authors":"Vyshali Veerareddy, umaraswamy Gandla","doi":"10.31788/rjc.2023.1638458","DOIUrl":"https://doi.org/10.31788/rjc.2023.1638458","url":null,"abstract":"Development and validation of RP-HPLC method for the simultaneous determination of Glecaprevir & Pibrentasvir in pure form and their combined tablet dosage forms. The current separation was achieved on a Chromasil ODS Column (4.6 x 250mm, 5.0 μ) using the composition of the mobile phase of (0.1 M KH 2 PO 4 buffer: methanol) in the ratio of (60:40) at pH 4.5. The pump flow rate was adjusted after several one milliliter per minute and both the samples were separated at 230nm. The retention times are 1.7 min and 2.3 min, for Glecaprevir and Pibrentasvir respectively with linear ranges 20 µg/ml-60 µg/ml and 50 µg/ml-150 µg/ml. The method was statistically validated for linearity, accuracy, precision and selectivity as per ICH guidelines. The drugs were subjected to stress conditions of hydrolysis, oxidation, photolysis of the RP-HPLC method. Both medications were tested under various stress forced conditions, including alkali, acid, oxidative, photodegradation, & hydrolysis degradation. The accuracy limit is the percentage recovery should be in the range of 98.0% - 101.0%. The total recovery was found to be 99.69% and 99.39% for Glecaprevir and Pibrentasvir. The validation of developed method shows that the accuracy is well within the limit, which shows that the method is capable of showing good accuracy and reproducibility. The robustness limit for mobile phase variation and flow rate variation are well within the limit, which shows that the method is having good system suitability and precision under given set of conditions.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136259734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BIOACTIVITY OF CHEMICAL COMPOUNDS FROM MORINGA SEEDS (Moringa oleifera) AND ANTIBACTERIAL ACTIVITY TEST AGAINST Streptococcus pyogenes BACTERIA 辣木种子化学成分的生物活性及对化脓性链球菌的抑菌活性试验

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI: 10.31788/rjc.2023.1638264

None H. Hidayat, M.M. Musawwa, F.I. Fajarwati

引用次数: 0

GREEN SYNTHESIS AND CHARACTERIZATION OF CODOPED ZnO NANOPARTICLES VIA THE ACCUMULATION OF COBALT ION ONTO PISTIA (Pistia stratiotes L.,) PLANT TISSUE AND ITS PHOTOCATALYTIC ACTIVITY TOWARD ORGANOSULFUR POLLUTANTS 绿色合成、钴离子富集共掺杂氧化锌纳米粒子及其对有机硫污染物的光催化活性研究

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI: 10.31788/rjc.2021.1618165

N. Rani, P. Pavani, Chebolu Naga Sesha Sai Pavan Kumar, Satwinder Singh Marok, S. Tulasi

{"title":"GREEN SYNTHESIS AND CHARACTERIZATION OF CODOPED ZnO NANOPARTICLES VIA THE ACCUMULATION OF COBALT ION ONTO PISTIA (Pistia stratiotes L.,) PLANT TISSUE AND ITS PHOTOCATALYTIC ACTIVITY TOWARD ORGANOSULFUR POLLUTANTS","authors":"N. Rani, P. Pavani, Chebolu Naga Sesha Sai Pavan Kumar, Satwinder Singh Marok, S. Tulasi","doi":"10.31788/rjc.2021.1618165","DOIUrl":"https://doi.org/10.31788/rjc.2021.1618165","url":null,"abstract":"Water pollution has recently become a serious global problem and hence researchers were focusing to develop innovative methods for the purification of water and then getting access to purified water by reducing pollution. As a result, the current study concentrated on synthesizing cobalt-doped zinc oxide nanoparticles by accumulating cobalt ions on Pistia (Pistiastratiotes L.) plant tissue and combining them with zinc acetate precursor. Further, the synthesized particles were analyzed for their efficiency in photo-desulphurization of organo sulphur compounds such as Dibenzothiophene and 2,5-dimethyl thiophene. Various characterization studies proved that the nanoparticles were oval in shape and had particle sizes of 8-34 nm and the particles were distributed with less aggregation. The particles have 47 % of zinc element and 21% cobalt with hexagonal (wurtzite) crystalline structure. The synthesized Co-doped ZnO nanoparticles were utilized for the desulfurization of Sulphur containing pollutants such as dibenzothiophene and 2,5-dimethyl thiophene. The results proved that rapid desulfurization was observed during the initial time of the study. The % desulfurization of 14.36±0.136 and 19.63±0.201% was observed within 5 min of the study for dibenzothiophene and 2,5-dimethyl thiophene. Whereas the high % desulfurization was noticed within less time of 25 min wherein the % desulfurization was observed to be 95.61±0.279 and 93.66±0.137 for dibenzothiophene and 2,5-dimethyl thiophene respectively. The removal of harmful heavy metals utilizing the Pistia plant and recycling in the wastewater treatment process may therefore be inferred as being highly valued. Additionally, the Co-doped ZnO photocatalysts might improve photocatalytic activity owing to the catalysts' porosity and the hole recombination and electron suppression.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69405206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SIMULTANEOUS REVERSE PHASE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (RP-HPLC) ESTIMATION OF AZELASTINE HYDROCHLORIDE, FLUTICASONE PROPIONATE, AND PHENYL ETHYL ALCOHOL IN DYMISTA (MEDA) NASAL SPRAY 反相高效液相色谱(rp-hplc)同时测定盐酸氮唑elastine、丙酸氟替卡松和苯乙醇在dymista (meda)鼻喷雾剂中的含量

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI: 10.31788/rjc.2023.1616916

A. Gupta, P. Singour, S. K. Jain

{"title":"SIMULTANEOUS REVERSE PHASE-HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (RP-HPLC) ESTIMATION OF AZELASTINE HYDROCHLORIDE, FLUTICASONE PROPIONATE, AND PHENYL ETHYL ALCOHOL IN DYMISTA (MEDA) NASAL SPRAY","authors":"A. Gupta, P. Singour, S. K. Jain","doi":"10.31788/rjc.2023.1616916","DOIUrl":"https://doi.org/10.31788/rjc.2023.1616916","url":null,"abstract":"This work reported a reverse phase-high performance liquid chromatography method for quantitative estimation of Azelastine Hydrochloride, Fluticasone Propionate, and Phenylethyl Alcohol in Nasal Spray formulation. The assay involved an isocratic elution of these components by using Intersil Octadecylsilane (C18) column (25 cm x 4.6 mm x 5 μm) using mobile phase composition of Buffer: Solvent Mixture (40:60 %v/v) and pH adjusted to 6.5 with dilute orthophosphoric acid. The flow rate was 1.4 mLmin-1 and the analytes are monitored at 254 nm. Separation was completed within 20 minutes. Calibration curves were linear with correlation coefficient more than 0.99 over a concentration range of 50%, 75%, 100%, 125%, and 150% for Azelastine Hydrochloride, Fluticasone Propionate and Phenylethyl Alcohol. The method was proven to be accurate between 50 to 150% with 98 to 102 % recovery of the actives from a spiked placebo. The method was shown to be precise yielding acceptable results for the system reproducibility and method repeatability. All the validation parameters were within the acceptance range according to International Conference on Harmonization norms. The developed method is simple and rapid which could be applied for routine estimation of the formulation.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69409717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

APPLICATION OF HETEROGENEOUS CATALYST OF Meti SHELLS (Batissa violecea L. von Lamark 1818) IN THE PRODUCTION OF BIODIESEL BASED ON MORINGA SEED OIL 木壳(Batissa violecea L. von Lamark 1818)非均相催化剂在辣木籽油生产生物柴油中的应用

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI: 10.31788/rjc.2023.1616951

Ruslan, J. Hardi, M. Mirzan, Muliana, M. Ganti

引用次数: 0

PHYTOCHEMICALS ANALYSIS AND CYTOTOXIC ACTIVITY OF Lansium domesticum Corr EXTRACT-CISPLATIN COMBINATION AGAINST PANC-1 CELL LINE 国产兰提取物-顺铂联合对PANC-1细胞株的植物化学分析及细胞毒活性

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI: 10.31788/rjc.2023.1617074

M. F. Lubis, P. Hasibuan, V. E. Kaban, R. Astyka

{"title":"PHYTOCHEMICALS ANALYSIS AND CYTOTOXIC ACTIVITY OF Lansium domesticum Corr EXTRACT-CISPLATIN COMBINATION AGAINST PANC-1 CELL LINE","authors":"M. F. Lubis, P. Hasibuan, V. E. Kaban, R. Astyka","doi":"10.31788/rjc.2023.1617074","DOIUrl":"https://doi.org/10.31788/rjc.2023.1617074","url":null,"abstract":"The use of chemotherapy such as cisplatin in treating cancer alone can cause many problems, including side effects and resistance. Therefore, currently, efforts are being made to combine cisplatin with natural ingredients such as ethanol extract from duku leaves. Then extracted using ethanol as a solvent. The secondary metabolites of the extract were identified using LC-MS/MS with mobile phase A (0.1 percent formic acid in water) and phase B (0.1 percent formic acid in acetonitrile). The extract and cisplatin were determined by their IC50 values as the basis for carrying out the combination test using the MTT method. All data obtained were processed with Microsoft Excel and analyzed with SPSS 23. The ethanol extract of duku leaves contains about 15 compounds that cannot be clearly identified because they are not listed in the LC-MS/MS library used. Interestingly, there were 5 compounds that gave a sufficiently large absorption each at a retention time of 1.08; 5.18; 9.45; 9.57; 10.70; and 10.82. Cisplatin has stronger cytotoxic properties than the extract with IC50 values of 3.02±0.05 µg/mL and 28.61±0.13 µg/mL, respectively. The combination of these two substances is synergistic with a combination index <1. the combination of extract and cisplatin at doses of 1.75:0.75 and 1.75:0.375 had very strong synergy with a combination index of 0.01 (p>0.05). However, the mechanism of action of this combination is not yet known clearly, so further research is needed on it.","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69409795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

SQUID PENS MEDIATED SILVER NANOPARTICLES SYNTHESIS, ITS CHARACTERISATION, AND BIOLOGICAL ACTIVITIES 鱿鱼笼介导的纳米银合成、表征及其生物活性

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI: 10.31788/rjc.2023.1618129

V. Ragunathan, Meenambiga Setti Sudharsan, Roshini S.R., Gomathy Sundar, Chithra K.

引用次数: 0

QUALITY TEST OF CMC (CARBOXYMETHYL CELLULOSE) USING SEMI-BATCH REAKTOR 半间歇反应器法测定羧甲基纤维素的质量

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI: 10.31788/rjc.2023.1626922

R. Futeri, S. Samah, G. R. Putri

{"title":"QUALITY TEST OF CMC (CARBOXYMETHYL CELLULOSE) USING SEMI-BATCH REAKTOR","authors":"R. Futeri, S. Samah, G. R. Putri","doi":"10.31788/rjc.2023.1626922","DOIUrl":"https://doi.org/10.31788/rjc.2023.1626922","url":null,"abstract":"Carboxymethyl Cellulose, one of the additives commonly used in the industrial sector, is carboxymethyl cellulose. The state of the art of this research is because no research makes a reactor to manufacture carboxymethyl cellulose. This study tested the quality of making carboxymethyl cellulose using a semi-batch reactor using samples of potential organic cellulose waste materials: durian seeds, taro rods, and bagasse. This sample has been used to make carboxymethyl cellulose in previous studies using a laboratory scale. Then compared, the manufacture of carboxymethyl cellulose using a reactor laboratory scale. From the result obtained, carboxymethyl cellulose from durian seeds, taro rod, and bagasse made on a laboratory scale and using a reactor has become carboxymethyl cellulose in quality number 1 and 2, which are commonly called carboxymethyl cellulose industrial grade and food chemical codex quality which met the minimum quality requirements by SNI 8762; 2019. Carboxymethyl cellulose from durian seeds, taro rod, and bagasse obtained from research that has been tested with FTIR, the spectra of the best results of carboxymethyl cellulose from durian seeds, taro rod, and bagasse can be seen in the picture there are similar peaks that appear indicates carboxymethyl cellulose durian seeds, carboxymethyl cellulose taro rod, and carboxymethyl cellulose bagasse produced in this study have the same chemical molecule as industrial grade and food chemical codex.1.2","PeriodicalId":21063,"journal":{"name":"Rasayan Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69410795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GC-MS AND OPTICAL CHARACTERIZATION, BIOLOGICAL PROPERTY STUDIES OF ETHANOLIC EXTRACT OF KABASURAKUDINEER AND MOLECULAR DOCKING INVESTIGATION OF (E)-3-PHENYL-1-(2, 2, 4- TRIMETHYLQUINOLIN-1-YL) PROP-2-EN-1-ONE kabasurakudineer乙醇提取物的Gc-ms、光学表征、生物学特性研究以及(e)-3-苯基-1-(2,2,4 -三甲基喹啉-1-基)prop-2-en-1-one的分子对接研究

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI: 10.31788/rjc.2023.1628147a

K. Laavanya, B. Manju, D. A. Shirmila, M. Priya, J. Hemalatha, G. Usha

引用次数: 0

SYNTHESIS OF LiFe1-xNixPO4/C USING THE REFLUX WITH MICROWAVE IRRADIATION METHOD 微波辐照回流法制备LiFe1-xNixPO4/C

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI: 10.31788/rjc.2023.1628164

D. Purwaningsih, H. Sutrisno, K. Sugiyarto, C. Kusumawardani, N. A. Kusumaningrum

引用次数: 0