In-vitro ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF NOVEL 1-SUBSTITUTED-3-SUBSTITUTED PROPANE-1,3-DIONES (β-DIKETONES) DERIVED FROM VANILLIN

Abstract

In synthetic chemistry,propane-1,3-diones or β-diketones act as significant intermediates for the synthesis of core heterocycles due to their specific chemoselectivity properties as well as provide convenient building blocks to biologically active substituents. In the present work, a new series of β-diketones namely 1-(5’-Formyl-2’-hydroxy3’-methoxyphenyl)-3-(substitutedphenyl) propane-1,3-diones 4(a-e) have been synthesized from versatile 4- hydroxy-3-methoxybenzaldehyde viz. vanillin and studied their invitro anti-inflammatory and antioxidant potential by performing inhibition of protein denaturation assay and reducing power assay method respectively. All the newly synthesized compounds exhibit notable and satisfactory anti-inflammatory potential as well as potent antioxidant activity due to the presence of vanillin moiety in their molecular structure