香兰素衍生的新型1-取代-3-取代丙烷-1,3-二酮(β-二酮)的体外抗炎和抗氧化活性

IF 0.5 Q4 EDUCATION & EDUCATIONAL RESEARCH

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI:10.31788/rjc.2023.1618193

Pravin S. Bodkhe, Sushil K. Pagariya, Prafulla P.Chaudhari

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引用次数: 0

摘要

在合成化学中，丙烷-1,3-二酮或β-二酮由于其特定的化学选择性而成为核心杂环合成的重要中间体，并为生物活性取代基的合成提供了方便的基础。本文以多用途的4-羟基-3-甲氧基苯甲醛即香兰素为原料合成了1-(5 ' -甲酰基-2 ' -羟基3 ' -甲氧基苯基)-3-(取代苯基)丙烷-1,3-二酮4(a-e)系列β-二酮，并分别通过抑制蛋白变性实验和还原力实验研究了它们的体外抗炎和抗氧化能力。所有新合成的化合物由于其分子结构中存在香兰素片段而表现出令人满意的抗炎潜力和强大的抗氧化活性

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In-vitro ANTI-INFLAMMATORY AND ANTIOXIDANT ACTIVITY OF NOVEL 1-SUBSTITUTED-3-SUBSTITUTED PROPANE-1,3-DIONES (β-DIKETONES) DERIVED FROM VANILLIN

In synthetic chemistry,propane-1,3-diones or β-diketones act as significant intermediates for the synthesis of core heterocycles due to their specific chemoselectivity properties as well as provide convenient building blocks to biologically active substituents. In the present work, a new series of β-diketones namely 1-(5’-Formyl-2’-hydroxy3’-methoxyphenyl)-3-(substitutedphenyl) propane-1,3-diones 4(a-e) have been synthesized from versatile 4- hydroxy-3-methoxybenzaldehyde viz. vanillin and studied their invitro anti-inflammatory and antioxidant potential by performing inhibition of protein denaturation assay and reducing power assay method respectively. All the newly synthesized compounds exhibit notable and satisfactory anti-inflammatory potential as well as potent antioxidant activity due to the presence of vanillin moiety in their molecular structure

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来源期刊

Rasayan Journal of Chemistry Energy-Energy (all)

CiteScore

1.90

自引率

0.00%

发文量

196

期刊介绍： RASĀYAN Journal of Chemistry [RJC] signifies a confluence of diverse streams of chemistry to stir up the cerebral powers of its contributors and readers. By introducing the journal by this name, we humbly intent to provide an open platform to all researchers, academicians and readers to showcase their ideas and research findings among the people of their own fraternity and to share their vast repository of knowledge and information. The journal seeks to embody the spirit of enquiry and innovation to augment the richness of existing chemistry literature and theories. We also aim towards making this journal an unparalleled reservoir of information and in process aspire to inculcate and expand the research aptitude.