kabasurakudineer乙醇提取物的Gc-ms、光学表征、生物学特性研究以及(e)-3-苯基-1-(2,2,4 -三甲基喹啉-1-基)prop-2-en-1-one的分子对接研究

IF 0.5 Q4 EDUCATION & EDUCATIONAL RESEARCH

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI:10.31788/rjc.2023.1628147a

K. Laavanya, B. Manju, D. A. Shirmila, M. Priya, J. Hemalatha, G. Usha

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引用次数: 0

摘要

最近的全球COVID-19大流行引起了人们对印度泰米尔纳德邦Kabasura Kudineer (KSK)及其医疗保健福利的认识。传统上，它被用于有效治疗呼吸道疾病，如流感和感冒。通过气相色谱-质谱(GCMS)研究，从乙醇提取的KSK提取物中鉴定出9种植物化学物质。傅里叶变换红外(FT-IR)， FTRAMAN和UV研究对同一KSK提取物进行了光谱研究。体外评价显示其对人癌(HT29)细胞具有抗菌、细胞毒性和抗癌活性。其中一种化合物被用于AutoDocking以检查KSK提取物的抗癌功效。

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GC-MS AND OPTICAL CHARACTERIZATION, BIOLOGICAL PROPERTY STUDIES OF ETHANOLIC EXTRACT OF KABASURAKUDINEER AND MOLECULAR DOCKING INVESTIGATION OF (E)-3-PHENYL-1-(2, 2, 4- TRIMETHYLQUINOLIN-1-YL) PROP-2-EN-1-ONE

The recent global COVID-19 pandemic has drawn awareness among the people towards Kabasura Kudineer (KSK) and its healthcare benefits in Tamil Nadu, India. It has been traditionally used for effective management of respiratory ailments such as flu and colds. Nine Phytochemicals were identified through the Gas ChromatographyMass Spectrometry (GCMS) study, from the KSK extract with ethanol. Fourier transforms infrared (FT-IR), FTRAMAN, and UV studies were carried out for spectral investigations on the same KSK extract. The in vitro evaluation reveals the antimicrobial, cytotoxicity, and anticancer activity against human carcinoma (HT29) cells. One of the compounds was utilized for AutoDocking to check the anticancer efficacy of the KSK extract.

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来源期刊

Rasayan Journal of Chemistry Energy-Energy (all)

CiteScore

1.90

自引率

0.00%

发文量

196

期刊介绍： RASĀYAN Journal of Chemistry [RJC] signifies a confluence of diverse streams of chemistry to stir up the cerebral powers of its contributors and readers. By introducing the journal by this name, we humbly intent to provide an open platform to all researchers, academicians and readers to showcase their ideas and research findings among the people of their own fraternity and to share their vast repository of knowledge and information. The journal seeks to embody the spirit of enquiry and innovation to augment the richness of existing chemistry literature and theories. We also aim towards making this journal an unparalleled reservoir of information and in process aspire to inculcate and expand the research aptitude.