鱿鱼笼介导的纳米银合成、表征及其生物活性

IF 0.5 Q4 EDUCATION & EDUCATIONAL RESEARCH

Rasayan Journal of Chemistry Pub Date : 2023-01-01 DOI:10.31788/rjc.2023.1618129

V. Ragunathan, Meenambiga Setti Sudharsan, Roshini S.R., Gomathy Sundar, Chithra K.

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引用次数: 0

摘要

本研究以鱿鱼圈壳聚糖(C-AgNps)为还原剂和稳定剂合成纳米银，并评价其抗氧化、抗菌和抗癌潜力。纳米颗粒粒径为240 ~ 290 nm，稳定性为+98.2 mV。C-AgNps具有良好的2,2-二苯基-1-苦味酰肼(DPPH)清除活性，IC50为6.65µg/mL。通过良好的扩散试验，C-AgNps对金黄色葡萄球菌、枯草芽孢杆菌、铜绿假单胞菌和大肠杆菌表现出优异的抗菌性能。C-AgNps对A375人皮肤恶性黑色素瘤也表现出显著的抗癌特性。因此，经过先导优化和体内临床试验，C-AgNps可作为新型治疗药物的抗菌和抗癌药物。

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SQUID PENS MEDIATED SILVER NANOPARTICLES SYNTHESIS, ITS CHARACTERISATION, AND BIOLOGICAL ACTIVITIES

This research scintillates the synthesis of silver nanoparticles from chitosan (C-AgNps) from squid pens as a reducing and stabilizing agent and assesses its antioxidant, antibacterial, and anticancer potentials. The nanoparticles were 240 to 290 nm with excellent stability of +98.2 mV. The C-AgNps possessed an excellent 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity with an IC50 of 6.65 µg/mL. The C-AgNps showed exceptional antibacterial properties against S. aureus, B. subtilis, P. aeruginosa, and E. coli using a good diffusion assay. The C-AgNps also showed outstanding anticancer properties against A375 human skin malignant melanoma. Thus, the C-AgNps could be used as antimicrobial and anticancer agents for novel therapeutics after lead optimization and in-vivo clinical trials.

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来源期刊

Rasayan Journal of Chemistry Energy-Energy (all)

CiteScore

1.90

自引率

0.00%

发文量

196

期刊介绍： RASĀYAN Journal of Chemistry [RJC] signifies a confluence of diverse streams of chemistry to stir up the cerebral powers of its contributors and readers. By introducing the journal by this name, we humbly intent to provide an open platform to all researchers, academicians and readers to showcase their ideas and research findings among the people of their own fraternity and to share their vast repository of knowledge and information. The journal seeks to embody the spirit of enquiry and innovation to augment the richness of existing chemistry literature and theories. We also aim towards making this journal an unparalleled reservoir of information and in process aspire to inculcate and expand the research aptitude.