Planta medicaPub Date : 2025-08-01Epub Date: 2025-04-23DOI: 10.1055/a-2593-6351
Fernanda Dias Nader, Luis Phillipe Nagem Lopes, Alice Ramos-Silva, Maria Eline Matheus
{"title":"Evidence of Potential Drug Interactions Between Cannabidiol and Other Drugs: A Scoping Review to Guide Pharmaceutical Care.","authors":"Fernanda Dias Nader, Luis Phillipe Nagem Lopes, Alice Ramos-Silva, Maria Eline Matheus","doi":"10.1055/a-2593-6351","DOIUrl":"10.1055/a-2593-6351","url":null,"abstract":"<p><p>Cannabidiol (CBD), a non-psychoactive cannabinoid with therapeutic potential, is increasingly used in combination with other drugs, raising concerns about potential interactions and their impact on safety and efficacy. This scoping review aimed to map the current evidence on CBD interactions across different drug classes and assess their clinical significance. The study followed the Joanna Briggs Institute guidelines, utilizing a structured protocol based on the population, concept, and context (PCC) framework. Five databases were searched, and preclinical and clinical studies on CBD pharmacokinetic and pharmacodynamic interactions were included, with publications in English, Portuguese, or Spanish. Out of 136 studies analyzed, 91.91% were published after 2011, reflecting a sharp rise in interest in this area. A total of 271 interactions were identified, with 203 related to pharmacokinetics, primarily involving metabolism mediated by cytochrome P450 (CYP) enzymes, and 68 linked to pharmacodynamics, including additive effects such as sedation. Among the most relevant findings, CBD was shown to inhibit CYP enzymes like CYP3A4 and CYP2C19, potentially increasing plasma levels of co-administered drugs. However, only 5.15% of studies evaluated the clinical relevance of these interactions, indicating a substantial gap in knowledge regarding their safety implications. This review highlights the urgent need for rigorous clinical research to determine the clinical significance of CBD-drug interactions, particularly in patients undergoing polypharmacy. Understanding these interactions is crucial for optimizing therapeutic outcomes, minimizing adverse effects, and enabling safer clinical use of CBD in diverse treatment regimens.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"488-495"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Planta medicaPub Date : 2025-08-01Epub Date: 2025-05-14DOI: 10.1055/a-2595-7650
Muhammed Fayaz, Gollapalle Lakshminarayanashastry Viswanatha, Hanumanthappa Shylaja, Krishnadas Nandakumar
{"title":"Exploring the Hepatoprotective Effects of Naringin: A Systematic Review and Meta-Analysis of Preclinical Evidence.","authors":"Muhammed Fayaz, Gollapalle Lakshminarayanashastry Viswanatha, Hanumanthappa Shylaja, Krishnadas Nandakumar","doi":"10.1055/a-2595-7650","DOIUrl":"10.1055/a-2595-7650","url":null,"abstract":"<p><p>This study aimed to perform a systematic review and meta-analysis on the hepatoprotective effects of naringin based on the pre-clinical evidence.A detailed literature search was performed using online databases such as Google Scholar, PubMed, Scopus, and EMBASE. Based on the predefined inclusion and exclusion criteria, 20 studies were considered for meta-analysis.The outcomes of the meta-analysis revealed that naringin improved liver function by reducing the elevated levels of ALT, AST, GGT, LDH, ALP, and bilirubin. It improved the enzymatic and non-enzymatic antioxidants, such as SOD, catalase, GSH, GST, GR, and GPx (p < 0.05 for all the parameters), while reducing the LPO/MDA levels (p < 0.05). NAR treatment also alleviated the levels of inflammatory mediators (IL-1<i>β</i>, IL-6, and TNF-<i>α</i>, p < 0.001 for all the parameters; NF-<i>κ</i>B, p = 0.29) in various animal models of liver injury. In addition, NAR significantly reduced the caspase-3 and Bax/Bcl-2 ratio (p < 0.05) compared to the control group. Furthermore, naringin treatment has normalised the liver and body weights compared to the disease control group.This systematic review and meta-analysis demonstrate that naringin significantly improved the liver function in various animal models of liver injury, via potent antioxidant and anti-inflammatory mechanisms.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"466-487"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144079441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Planta medicaPub Date : 2025-08-01Epub Date: 2025-04-17DOI: 10.1055/a-2591-3765
Alexa Brouns, Matthias Lechtenberg, Andreas Hensel
{"title":"Passionflower (Passiflora incarnata): Quality of Food Supplements Versus Registered Herbal Medicinal Products.","authors":"Alexa Brouns, Matthias Lechtenberg, Andreas Hensel","doi":"10.1055/a-2591-3765","DOIUrl":"10.1055/a-2591-3765","url":null,"abstract":"<p><p>The above-ground plant material from <i>Passiflora incarnata</i> is used for relief of symptoms of mental stress and to aid sleep. In Europe, passionflower products are marketed either as registered herbal medicinal products or as food supplements. Passionflower products for sleep disorders are increasingly recommended to patients by physicians or by social advertisement, but the potential consumers are in most cases not able to differentiate between food supplements or licensed herbal medicinal products. Analytical investigations by validated protocols on passionflower food supplements and registered medicinal products from different sources were performed to obtain an insight into the actual quality situation. TLC fingerprinting revealed the non-identity of five food supplements, while six products met the specification (five registered herbal medicinal products and one food supplement). A validated UHPLC method confirmed this result. LC-MS identified one food supplement containing only hyperoside and lacking other passionflower-related compounds. Quantitative determination of flavones by photometric protocol, as well as by a calibrated UHPLC, indicated that five out of six food supplements did not meet the specified content and identity, suggesting instances of food fraud. All registered herbal medicinal products conformed to the specification. As this analytical investigation is in line with other reports on the low quality of food supplements, transparent and intensified quality control is recommended. In addition, routine analyses of every batch using validated procedures by manufacturers on a batch-by-batch basis should provide a secure basis for improved product quality and for the safety of the consumer.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"532-540"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Planta medicaPub Date : 2025-08-01Epub Date: 2025-04-03DOI: 10.1055/a-2573-7718
Yifang Cui, Haitao Fan, Meng Sun, Xinyang He, Jie Li, Guangzhong Tu, Yanyan Jiang, Bin Liu
{"title":"Chemical Structural Elucidation and Immunomodulatory Activity of a New Polysaccharide from Saposhnikoviae Radix.","authors":"Yifang Cui, Haitao Fan, Meng Sun, Xinyang He, Jie Li, Guangzhong Tu, Yanyan Jiang, Bin Liu","doi":"10.1055/a-2573-7718","DOIUrl":"10.1055/a-2573-7718","url":null,"abstract":"<p><p>The chemical structure and immunomodulatory activity of a new homogeneous polysaccharide, SP4002501, isolated from Saposhnikoviae Radix (SR), were investigated. Purification of SP4002501 was performed by DEAE-Cellulose and Sepharose CL-6B column chromatography. The monosaccharidic constituents were identified as rhamnose (Rha), galacturonic acid (GalA), galactose (Gal), and arabinose (Ara) with a molar ratio of 3.7: 86.6: 2.7: 7.1. According to the methylation analysis, partial hydrolysis, FT-IR, and NMR analysis, SP4002501 had a backbone of polygalacturonic acid units with a small amount of galactose (Gal). Side chains are connected to C-3 of galactose (Gal) and consist of rhamnose (Rha), galacturonic acid (GalA), galactose (Gal), and arabinose (Ara), with arabinose (Ara) as terminal sugar. Biological activity assessment suggests that SP4002501 exhibits immunomodulatory activity through promoting macrophage proliferation and phagocytosis.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"513-523"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143780115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Fused Tricyclic Naphthalene Lactones and a Xanthone from Ventilago maingayi and their Anti-HIV-1 Activity.","authors":"Ponsiri Liangsakul, Chutima Kuhakarn, Siriporn Jungsuttiwong, Ratchadaree Intayot, Sariyarach Thanasansurapong, Radeekorn Akkarawongsapat, Arthit Chairoungdua, Narong Nuntasaen, Sakchai Hongthong, Vichai Reutrakul","doi":"10.1055/a-2589-5900","DOIUrl":"10.1055/a-2589-5900","url":null,"abstract":"<p><p>Three previously undescribed compounds, including two fused tricyclic naphthalene lactones (ventilaganones A and B, 1: and 2: ) and a xanthone (ventilagoxanthone, 3: ), along with eight known compounds (4: -11: ), were isolated from the bark of <i>Ventilago maingayi</i>. Their structures were elucidated by extensive analysis of their spectroscopic data and by comparison with those of related compounds reported in the literature. The absolute configuration of ventilaganone A (1: ) was established by single-crystal X-ray analysis. Anti-HIV-1 activity of the isolated compounds was evaluated with a reverse transcriptase (RT) assay and a syncytium reduction assay using the <sup>ΔTat/Rev</sup>MC99 virus in the 1A2 cell line. Compounds 1, 2, 4, 5: , and 8-11: showed inhibitory activity against syncytium formation, while most compounds were found to be inactive in the reverse transcriptase assay.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"524-531"},"PeriodicalIF":2.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Angelicone Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota.","authors":"Chengwei Ruan, Weiwei Gao, Guoguo Wang, Wenting Fan, Weifeng Zhang, Shuang Tao, Zheng Wu","doi":"10.1055/a-2565-6197","DOIUrl":"10.1055/a-2565-6197","url":null,"abstract":"<p><p>Ulcerative colitis (UC) is a persistent, periodically reoccurring inflammatory condition that impacts the gastrointestinal tract. Angelicone, a principal compound extracted from <i>Angelica sinensis</i>, may offer a potential alternative therapeutic approach for UC through the downregulation of inflammatory mediators. Nonetheless, the pharmacological impacts and molecular pathways of angelicone in UC management, particularly in relation to gut microbiota, remain unexplored. The current study scrutinized the modifications in gut microbiota in mice afflicted with UC, induced by 3% dextran sodium sulfate (DSS), utilizing 16S rRNA sequencing. The study demonstrated that angelicone substantially enhanced clinical indices, mitigated colonic damage, decreased cytokine levels, and reestablished the integrity of the intestinal epithelial barrier in UC mice. Furthermore, we discerned distinct bacterial genera that were responsive to angelicone treatment. Importantly, angelicone augmented the abundance of gut microbiota and partially reinstated the disrupted intestinal microbial composition, inclusive of the phyla <i>Proteobacteria, Firmicutes</i>, and <i>Bacteroidetes</i>. To summarize, our research offers novel perspectives into the intervention mechanisms of angelicone in the treatment of UC.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"430-439"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Assessment of Tanshinone IIA Derivatives for Cardioprotection in Myocardial Ischemic Injury.","authors":"Zhiwu Wu, Ying Xu, Ximing Guo, Zhilan Zhang, Jinxin Wang, Yiqun Tang","doi":"10.1055/a-2565-8285","DOIUrl":"10.1055/a-2565-8285","url":null,"abstract":"<p><p>Tanshinone ⅡA (TSA), a component of traditional Chinese medicine, effectively protects against myocardial injury. However, its clinical application is limited by poor water solubility and a short half-life. In this study, we report on four TSA derivatives designed and synthesized by our research group. The protective activity against hypoxia-reoxygenation injury in cells was evaluated, and derivative Ⅰ-3 was selected for <i>in vivo</i> experiments to verify its myocardial protective activity in rats with myocardial infarction. The results demonstrated that these four compounds could protect neonatal rat cardiomyocytes from hypoxia-reoxygenation injury. Among the derivatives, Ⅰ-3 showing superior protective effects, we found that Ⅰ-3 has enhanced metabolic stability and an extended half-life. Ⅰ-3 exhibited superior biological activity, effectively reducing the heart infarction area, alleviating myocardial hypertrophy, and enhancing cardiac pumping function. Ⅰ-3 reported in the present work represents a novel and effective derivative of TSA, showing great potential for the treatment of myocardial ischemia (MI).</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"451-460"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Recovery techniques for Hydroxynaphthoquinone Enantiomers of Alkanna tinctoria (L.) from Natural Deep Eutectic Solvents: A Comparative Analysis.","authors":"Elodie Bossard, Nikolaos Tsafantakis, Nektarios Aligiannis, Ioanna Chinou, Nikolas Fokialakis","doi":"10.1055/a-2563-7599","DOIUrl":"10.1055/a-2563-7599","url":null,"abstract":"<p><p>A natural deep eutectic solvent (NaDES) composed of levulinic acid and glucose using a molar ratio of 5 : 1 (mol<sub>HBA</sub>:mol<sub>HBD</sub>) and 20% of water (w/w) (LeG_5_20) was found as a great alternative to the commonly used organic solvents for the extraction of hydroxynaphthoquinone enantiomers (HNQs) from <i>Alkanna tinctoria</i> (L.) Tausch roots. In the present work, a comparative investigation of recovery methods for HNQs, such as solid-phase extraction, macroporous resin, and water as an anti-solvent, was performed to face the main disadvantage of NaDES: the inability to be evaporated. The highest recovery of HNQs was recorded using the solid-phase extraction on a reversed-phase C8 cartridge with a total hydroxynaphthoquinone content (TNC) of 46.79 ± 0.952 mg/g of dry weight (DW). In addition, a great recovery of HNQs was also reported for the macroporous resin Amberlite XAD 4 with a TNC value of 37.21 ± 1.789 mg/g DW, while the precipitation of HNQs by using water as an anti-solvent (1 : 5, v/v) offered a TNC value of 28.68 ± 0.023 mg/g DW. The macroporous resin Amberlite XAD also showed a great potential for larger-scale applications. In fact, the developed scale-up process, involving Amberlite XAD 4, showed a great recovery efficiency for HNQs (34.126 ± 1.093 mg/g DW), an acceptable robustness (RSD < 15%), and the possibility of recycling LeG_5_20 with a recovery greater than 50%; therefore, it is an excellent green alternative extraction procedure for HNQs.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"440-450"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Planta medicaPub Date : 2025-07-01Epub Date: 2025-03-14DOI: 10.1055/a-2536-8919
Ziying Chen, Yan Lu, Yiyun Wang, Qi Wang, Liangwen Yu, Jinman Liu
{"title":"Natural Products Targeting Tau Protein Phosphorylation: A Promising Therapeutic Avenue for Alzheimer's Disease.","authors":"Ziying Chen, Yan Lu, Yiyun Wang, Qi Wang, Liangwen Yu, Jinman Liu","doi":"10.1055/a-2536-8919","DOIUrl":"10.1055/a-2536-8919","url":null,"abstract":"<p><p>Alzheimer's disease is a progressive neurodegenerative disorder characterized by tau protein hyperphosphorylation and neurofibrillary tangle formation, which are central to its pathogenesis. This review focuses on the therapeutic potential of natural products in targeting tau phosphorylation, a key factor in Alzheimer's disease progression. It comprehensively summarizes current research on various natural compounds, including flavonoids, alkaloids, saponins, polysaccharides, phenols, phenylpropanoids, and terpenoids, highlighting their multitarget mechanisms, such as modulating kinases and phosphatases. The ability of these compounds to mitigate oxidative stress, inflammation, and tau pathology while enhancing cognitive function underscores their value as potential anti-Alzheimer's disease therapeutics. By integrating recent advances in extraction methods, pharmacological studies, and artificial intelligence-driven screening technologies, this review provides a valuable reference for future research and development of natural product-based interventions for Alzheimer's disease.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"386-408"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Planta medicaPub Date : 2025-07-01Epub Date: 2025-03-05DOI: 10.1055/a-2551-5681
Ricardo D D G de Albuquerque, Frank R León-Vargas, Daniel D Carrasco-Montañez, Jorge L Carranza-Gonzales, Yessenia V S Ramos-Rivas
{"title":"A Review on Phytochemistry and Recent Pharmacology of Dragon's Blood (Croton lechleri), a Multifunctional Ethnomedicinal Resource from the Amazon Forest.","authors":"Ricardo D D G de Albuquerque, Frank R León-Vargas, Daniel D Carrasco-Montañez, Jorge L Carranza-Gonzales, Yessenia V S Ramos-Rivas","doi":"10.1055/a-2551-5681","DOIUrl":"10.1055/a-2551-5681","url":null,"abstract":"<p><p><i>Croton lechleri</i>, commonly known as \"Sangre de Drago\", is a widely utilized ethnomedicinal resource in the Amazon region, known for its diverse bioactive properties. These include wound-healing activity, anti-inflammatory effects, antitumor activity, and other therapeutic benefits. Despite its extensive traditional use, a comprehensive review of the scientific studies conducted over the past two decades is lacking, which hinders a thorough understanding of the chemical and pharmacological characteristics of this species. Hence, this review is essential to inform researchers and readers about the current state of knowledge in this field. A systematic search was conducted using databases such as Scopus and Google Scholar, yielding 33 relevant articles focusing on the phytochemistry and recent pharmacological investigations of <i>C. lechleri</i>. These studies identify proanthocyanidins as the predominant phytochemical group in terms of relative quantity. Additionally, other significant phytochemical groups include alkaloids, diterpenoids, phytosteroids, saponins, phenolics, and polyphenolics. The pharmacological studies reviewed highlight several potential therapeutic effects of <i>C. lechleri</i>, particularly those associated with its resin. These effects include wound-healing, antitumor, anti-inflammatory, and gastrointestinal benefits, among others. The findings underscore the remarkable medicinal importance of this species, supporting its continued investigation and potential therapeutic applications.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"409-418"},"PeriodicalIF":2.1,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}