Planta medica最新文献_第4页

Immunomodulatory Activity and Inhibitory Effects of Viscum album on Cancer Cells, Its Safety Profiles and Recent Nanotechnology Development. 白花蛇舌草的免疫调节活性和对癌细胞的抑制作用、其安全性概况以及最新的纳米技术发展。

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-01 Epub Date: 2024-09-23 DOI: 10.1055/a-2412-8471

Nermeen Yosri, Nurkhalida Kamal, Ahmed Mediani, Sameh AbouZid, Ahmed Swillam, Mahmoud Swilam, Ahmed M Ayyat, Ibrahim Jantan

{"title":"Immunomodulatory Activity and Inhibitory Effects of Viscum album on Cancer Cells, Its Safety Profiles and Recent Nanotechnology Development.","authors":"Nermeen Yosri, Nurkhalida Kamal, Ahmed Mediani, Sameh AbouZid, Ahmed Swillam, Mahmoud Swilam, Ahmed M Ayyat, Ibrahim Jantan","doi":"10.1055/a-2412-8471","DOIUrl":"10.1055/a-2412-8471","url":null,"abstract":"Viscum album has been employed traditionally to treat various ailments including as add-on therapy for cancer treatment. V. album formulations have been employed as adjuvants in cancer treatment due to their immunomodulatory activities as well as to alleviate the side effects of conventional cancer therapies. The present review provides updated information from the past 10 years on the immunomodulatory activity and inhibitory effects of V. album on cancer cells, its safety profile, and recent nanotechnology development. V. album extracts and their bioactive phytochemicals, particularly lectins, viscotoxins, and polyphenols, have demonstrated immunomodulatory activity and inhibitory effects against various types of cancer, with low cytotoxicity and side effects, in experimental studies and demonstrated promising anticancer activity in clinical studies in cancer patients. V. album extracts have been shown to enhance immune function by promoting cytokine secretion and inducing both innate and adaptive immune responses, which can help improve immune surveillance against cancer cells. The development of V. album nanoparticles has boosted their biological activities, including inhibitory activity on cancer cells, and could possibly reduce undesired side effects of the plant. Further prospective studies on the plant as a source of new medicinal agents for use as an adjuvant in the treatment of cancer must be performed to provide sufficient efficacy and safety data.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1059-1079"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Consensus Statement on the Outcome of the European Herbal Health Products Summit - Which Way Forward? 关于欧洲草药保健品峰会成果的共识声明--何去何从？

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-01 Epub Date: 2024-10-10 DOI: 10.1055/a-2419-1602

Michael Heinrich, Babette Reiken, Bernd Roether, Angela Müller, Julia Rumsch, Nico Symma

{"title":"Consensus Statement on the Outcome of the European Herbal Health Products Summit - Which Way Forward?","authors":"Michael Heinrich, Babette Reiken, Bernd Roether, Angela Müller, Julia Rumsch, Nico Symma","doi":"10.1055/a-2419-1602","DOIUrl":"10.1055/a-2419-1602","url":null,"abstract":"Herbal medicinal products are a vital part of the healthcare system in Europe and beyond. Being predominantly sold as non-prescription medicines in pharmacies, they are very popular with patients, physicians, and pharmacists and are therefore an important part of self-medication. Interest in this sector has recently gained momentum, reflecting the ongoing revision of the general pharmaceutical legislation and the recent discussion on nutrition and health claims on foods based on the implementation report of Regulation (EC) No 1924/2006 by the European Parliament 1. Therefore, on 20th February 2024, the Society for Medicinal Plant and Natural Product Research (GA), in collaboration with the German Pharmaceutical Industry Association (BPI) and the German Medicines Manufacturers' Association (BAH, now Pharma Deutschland), hosted an in-person summit in Brussels entitled 'European Herbal Health Products Summit - Which way forward?'. The summit featured a wide range of speakers, including policymakers, regulatory authorities, industry representatives, and academic experts. It was divided into several sessions covering topics such as the future and relevance of herbal medicinal products in the EU, the revision of the EU pharmaceutical legislation, and the resulting impact on herbal medicinal products. Furthermore, the discussions delved into the \"Health Claims Regulation\" - the European Parliament's implementation report and the related regulatory challenges of herbal medicinal products at an EU level. This consensus paper summarises the current status and provided recommendations to pave the way for future strategies to ascertain the continued use of herbal medicinal products as an important therapeutic option for patients.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1052-1055"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11557087/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Antimicrobial Activity of Selected Plant Extracts against Staphylococcus Strains Isolated from Wound Infections. 评估精选植物提取物对伤口感染中分离出的葡萄球菌菌株的抗菌活性。

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-01 Epub Date: 2024-10-10 DOI: 10.1055/a-2416-8584

Anna Pietruczuk-Padzik, Milena Śliwińska, Marta Mainka, Monika E Czerwińska, Weronika Skowrońska, Agnieszka Bazylko

{"title":"Evaluation of Antimicrobial Activity of Selected Plant Extracts against Staphylococcus Strains Isolated from Wound Infections.","authors":"Anna Pietruczuk-Padzik, Milena Śliwińska, Marta Mainka, Monika E Czerwińska, Weronika Skowrońska, Agnieszka Bazylko","doi":"10.1055/a-2416-8584","DOIUrl":"10.1055/a-2416-8584","url":null,"abstract":"Wound infections are a significant medical problem, with Staphylococcus species being one of the most common etiological factors. Treatment is complex due to bacterial antibiotic resistance and the ability to form a biofilm. The aim of this study was to determine the drug susceptibility of the clinical isolates of Staphylococcus species obtained from wound infections, assess their ability to form a biofilm in vitro, evaluate the level of extracellular slime synthesis, and test the antistaphylococcal properties of selected plant extracts against plate-cultured bacteria and activity against mature biofilms. A total of 20 Staphylococcus strains were evaluated. The antibiotic susceptibility and sensitivity of the strains to the tested extracts were determined using the disc diffusion method. The production of extracellular bacterial slime was assessed using Congo Red agar plates. The biofilm formation and the effect of plant extracts on the biofilm layer were examined using the MTT method on polystyrene microtiter plates. Diverse drug susceptibility profiles, slime production ability, and in vitro biofilm formation were observed among the tested strains. It was found that aqueous extracts from the Serpylli herba, Arctii lappae folium, Taraxaci folium, and Galii aparini herba showed antibacterial activity against some of the tested strains. In contrast, their antibiofilm activity was not confirmed. Among all tested preparations, the most promising antimicrobial extracts in both planktonic cultures and biofilm were Thymus serpyllum herb and Taraxacum officinale leaf extracts. These results allowed us to conclude their potential application in medicine to support the treatment of challenging wound conditions.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1080-1096"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: Translational perspectives on the therapeutic potential of Hyptis crenata essential oil terpenes in smooth muscle function. 更正：从转化的角度看克雷纳塔（Hyptis crenata）精油萜烯对平滑肌功能的治疗潜力。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-08 DOI: 10.1055/a-2426-9835

André Nogueira Cardeal Dos Santos, José Ednésio da Cruz Freire, Bruna Ferreira Rodrigues, Francisco Walber Ferreira-da-Silva, José Eduardo Ribeiro Honório Júnior, José Henrique Leal-Cardoso, Andrelina Coelho de Souza

引用次数: 0

Withaphysalin Derivatives from Iochroma arborescens Induce Antiproliferative and Antimigratory Activities in vitro. Iochroma arborescens 中的 Withaphysalin 衍生物在体外诱导抗增殖和抗移植物活性。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI: 10.1055/a-2381-5060

Rodrigo Elísio de Sá, Gisele Santos de Araújo, Fabrício Dos Santos Machado, Jessica Maria Teles Souza, Ayslan Batista Barros, Francisco das Chagas Lima Pinto, Joana Deyse Lima Agostinho, Alejandro Pedro Ayala, José Delano Barreto Marinho Filho, Otília Deusdênia Loiola Pessoa, Ana Jérsia Araújo

{"title":"Withaphysalin Derivatives from Iochroma arborescens Induce Antiproliferative and Antimigratory Activities in vitro.","authors":"Rodrigo Elísio de Sá, Gisele Santos de Araújo, Fabrício Dos Santos Machado, Jessica Maria Teles Souza, Ayslan Batista Barros, Francisco das Chagas Lima Pinto, Joana Deyse Lima Agostinho, Alejandro Pedro Ayala, José Delano Barreto Marinho Filho, Otília Deusdênia Loiola Pessoa, Ana Jérsia Araújo","doi":"10.1055/a-2381-5060","DOIUrl":"10.1055/a-2381-5060","url":null,"abstract":"Withanolides are steroidal lactones commonly found in plants of the Solanaceae family that have significant medicinal value. In this study, three withanolides extracted from Iochroma arborescens leaves were isolated and characterized. These included withaphysalin F (3: ) and two newly identified epimeric compounds: 18R- and 18S-O-methyl-withaphysalin F (1: and 2: ). Their structures were elucidated by NMR, IR, MS, CD, and X-ray diffraction analysis, and their potential against cell proliferation and migration was investigated. The cytotoxic assay revealed activity against different tumor and non-tumor cell lines. (18S)-O-methyl-withaphysalin F (2: ) presented cell death effects after at least 6 hours of exposure. MDA-MB-231 cells were exposed to 0.06 and 0.6 µM of (18S)-O-methyl-withaphysalin F (2: ), and reductions in cell adhesion, migration, and clonogenicity were observed. Morphological analysis revealed negative regulation in filopodia, salience, and roughness, as well as alterations in cellular microarchitecture. These results provide clues as to the effects of (18S)-O-methyl-withaphysalin F (2: ), allowing new molecular modifications to improve potency and selectivity and increase our antineoplastic arsenal.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"938-948"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hematoxylin, an Alternative Substrate of Tyrosinase. 血色素，酪氨酸酶的另一种底物。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI: 10.1055/a-2381-5201

Chantalle Crous, Ivanke A Swart, Judey Pretorius, Frank van der Kooy, Jacobus P Petzer, Anél Petzer

引用次数: 0

Psidium Exotic and Native Species from Brazil Abolish Depression-like Behavior and Oxidative Stress induced by Corticosterone in Mice. 巴西鹅掌楸外来种和本地种可消除皮质酮诱导的小鼠抑郁样行为和氧化应激。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-08-27 DOI: 10.1055/a-2404-3294

Ana Lúcia Bertarello Zeni, Ana Paula Dalmagro, Lucas Henrique Junges, Natália Cavichioli, Otto Rodolfo Sasse

{"title":"Psidium Exotic and Native Species from Brazil Abolish Depression-like Behavior and Oxidative Stress induced by Corticosterone in Mice.","authors":"Ana Lúcia Bertarello Zeni, Ana Paula Dalmagro, Lucas Henrique Junges, Natália Cavichioli, Otto Rodolfo Sasse","doi":"10.1055/a-2404-3294","DOIUrl":"10.1055/a-2404-3294","url":null,"abstract":"Depression is a highly prevalent neuropsychiatric disorder worldwide. One currently accepted hypothesis of this pathogenesis is the hypothalamic-pituitary-adrenal axis dysfunction, which involves oxidative stress and brain damage. Therefore, antioxidants, such as phenolic compounds, could be used in depression. In this study, we investigated the antidepressant-like and antioxidant effects of an aqueous extract of the leaves of three species of the genus Psidium, Myrtaceae family, in mice. The exotic Psidium guajava L. and the natives Psidium guineense Sw. and Psidium cattleianum Sabine (10, 1, and 0.1 mg/kg, respectively) and fluoxetine (10 mg/kg) were administered orally (p. o.) once daily for 21 days, with or without corticosterone (20 mg/kg). After behavioral assessments (tail suspension, splash, and open-field tests), the hippocampus, prefrontal cortex, liver, kidneys, and plasma were examined to determine the oxidative stress status. The three extracts and fluoxetine treatment decreased the immobility time and counteracted the oxidative stress induced by corticosterone administration. The phenolic compounds identified as major components of the extracts, quercetin in P. guajava and P. guineense and o-coumaric acid in P. cattleianum, may be involved in the biological activities. Therefore, the aqueous leaf extracts of P. guajava, P. cattleianum, and P. guineense could be potential antidepressants helpful in treating depression and other diseases with elevated nitro-oxidative stress.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1030-1039"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function. 从转化的角度看牛膝草精油萜烯对平滑肌功能的治疗潜力。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-09-03 DOI: 10.1055/a-2409-3735

André Nogueira Cardeal Dos Santos, José Ednésio da Cruz Freire, Bruna Ferreira Rodrigues, Francisco Walber Ferreira-da-Silva, José Eduardo Ribeiro Honório Júnior, José Henrique Leal Cardoso, Andrelina Noronha Coelho de Souza

{"title":"Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function.","authors":"André Nogueira Cardeal Dos Santos, José Ednésio da Cruz Freire, Bruna Ferreira Rodrigues, Francisco Walber Ferreira-da-Silva, José Eduardo Ribeiro Honório Júnior, José Henrique Leal Cardoso, Andrelina Noronha Coelho de Souza","doi":"10.1055/a-2409-3735","DOIUrl":"10.1055/a-2409-3735","url":null,"abstract":"Monoterpenes and sesquiterpenes are classes of organic compounds found in various natural products, such as the essential oil of Hyptis crenata (EOHc). The therapeutic potential of these terpenes present in EOHc is evidenced by their effect on smooth muscle and potential clinical applications. Among the highlighted monoterpenes, such as sabinene, α-pinene, and β-pinene, a relaxing effect on rat intestinal smooth muscles is observed, attributed to interaction with calcium channels. Furthermore, monoterpenoids like borneol, cineole, and linalool also demonstrate vasorelaxant properties, suggesting potential in the treatment of cardiovascular conditions. Sesquiterpenes, such as caryophyllene and aromadendrenes, exhibit relaxing effects in various smooth muscle tissues, such as rat uterus and guinea pig ileum, indicating pharmacological potential in these areas. The translational exploration of targets, such as calcium channels and G protein-coupled receptors, highlights the importance of these compounds in discovering new therapies based on natural products for treating various medical conditions.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1005-1014"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory Principles of the Plant Family Amaryllidaceae. 天南星科植物的抗炎原理。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-07-19 DOI: 10.1055/a-2369-8104

Jerald J Nair, Johannes van Staden

{"title":"Anti-inflammatory Principles of the Plant Family Amaryllidaceae.","authors":"Jerald J Nair, Johannes van Staden","doi":"10.1055/a-2369-8104","DOIUrl":"10.1055/a-2369-8104","url":null,"abstract":"There is considerable interest in the utilisation of plants against inflammation. Over 50 species of the plant family Amaryllidaceae are known for such usage in traditional medicine. This review was undertaken to identify the chemical principles responsible for these anti-inflammatory effects. It describes the findings from in vitro, in vivo and in silico studies, as well as the probes made on the mechanisms of action. The literature search returned over 600 hits, of which around 130 were chosen for their relevance to the text. Over 140 compounds have thus far been screened for anti-inflammatory effects. These were mostly isoquinoline alkaloids but also included other classes of secondary metabolites such as chromones, flavonoids and triterpenoids. In vitro studies were carried out in mononuclear cells such as lymphocytes, monocytes, neutrophils and macrophages, against which no serious side effects were observed. The constituents were also effective against inflammation induced by physical and chemical stimuli in a variety of murine test subjects. Chief among the compounds were the isoquinoline alkaloids lycorine and narciclasine, which displayed potent effects against pain, swelling, asthma and arthritis, amongst others. From a mechanistic perspective, several of the compounds were shown to mediate in inflammatory pathways, notably via the modulation of both pro-inflammatory (such as NF-κB, TNF-α and IL-1) and anti-inflammatory (such as IL-10 and TGF-β) factors. Useful insights also emerged from active-site docking studies of some of the compounds. The Amaryllidaceae affords a rich and diverse platform for the discovery of potential anti-inflammatory drugs.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"900-937"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ajuga taiwanensis Extract Promotes Wound-healing via Activation of PDGFR/MAPK Pathway. 台湾刺五加提取物通过激活 PDGFR/MAPK 通路促进伤口愈合

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI: 10.1055/a-2378-9274

Wei-Hsiang Hsu, Jing-Jy Cheng, Ching-Fen Wu, Yun-Lian Lin

引用次数: 0