作为潜在候选药物的戊内酯:生产和治疗应用综述。

IF 2 4区 医学 Q3 CHEMISTRY, MEDICINAL
Planta medica Pub Date : 2025-08-12 DOI:10.1055/a-2659-7263
Anu Gupta, M Vasundhara
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引用次数: 0

摘要

Withanolides是一组甾体内酯,主要存在于Withania属中。这些化合物具有细胞毒性、神经、免疫调节和抗炎活性。结构的多样性导致了不同种类的金皂荚内酯具有不同的生物学功能。由于它们具有巨大的治疗潜力,可以开发新的药物实体,因此市场对它们的需求不断增加。Withanolides主要是从那些更容易患病和濒临灭绝的植物中生产出来的。从植物源上看,金戊内酯的产率很低(0.5-2%),不能满足市场需求,而且生产成本很高。这导致探索替代可持续来源的威纳醇内酯生产。内生真菌可以产生寄主植物的代谢物,可以作为一种替代来源进行研究。内生真菌可以从产生吲哚内酯的寄主植物中分离出来,并进一步培养用于生产。研究其生物合成途径的基因(上调或下调)、培养基优化、共培养和多种激发子可提高其产量。分子对接和定量构效关系研究等计算机方法也可能有助于理解糖醇内酯对特定靶点的作用机制,从而治疗疾病。纳米技术有助于设计金皂荚内酯的配方,使它们能够穿过血脑屏障,提高治疗效果。本文重点介绍了植物内酯的生物化学、生物合成途径、作用方式、治疗潜力,并探讨了内生真菌作为一种经济有效地生产植物内酯的替代来源。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Withanolides as Prospective Drug Candidates: Production and Therapeutic Applications-A Review.

Withanolides are a group of steroidal lactones predominantly present in the genus 'Withania'. These compounds exhibit cytotoxic, neurological, immunomodulatory, and anti-inflammatory activities. Structural diversity leads to various kinds of withanolides with different biological functionality. There is an increasing market demand for withanolides as they exhibit great therapeutic potential and can be explored for developing novel drug entities. Withanolides are primarily produced from plants that are more prone to diseases and are on the verge of endangerment. From the plant sources, the yield of withanolides is meagre (0.5 - 2%), which cannot meet the market demand, and the production cost is very high. This leads to the exploration of an alternative sustainable source for withanolide production. Endophytic fungi can produce host plant metabolites and can be investigated as an alternative source for withanolides production. Endophytic fungi can be isolated from the host plant species producing withanolides and cultured further for production. Studying the genes of the withanolides' biosynthetic pathway (their upregulation or downregulation), media optimisation, co-culture, and various elicitors may enhance withanolides production. In silico approaches like molecular docking and quantitative structure-activity relationship studies may also aid in understanding the mechanism of action of withanolides on a specific target to cure a disease. Nanotechnology techniques help in designing the formulation of withanolides so that they can cross the blood-brain barrier and improve therapeutic effectiveness. This article highlights the biochemistry, biosynthetic pathway, mode of action, therapeutic potential of withanolides, and exploration of endophytic fungi as an alternative source to produce withanolides cost-effectively.

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来源期刊
Planta medica
Planta medica 医学-药学
CiteScore
5.10
自引率
3.70%
发文量
101
审稿时长
1.8 months
期刊介绍: Planta Medica is one of the leading international journals in the field of natural products – including marine organisms, fungi as well as micro-organisms – and medicinal plants. Planta Medica accepts original research papers, reviews, minireviews and perspectives from researchers worldwide. The journal publishes 18 issues per year. The following areas of medicinal plants and natural product research are covered: -Biological and Pharmacological Activities -Natural Product Chemistry & Analytical Studies -Pharmacokinetic Investigations -Formulation and Delivery Systems of Natural Products. The journal explicitly encourages the submission of chemically characterized extracts.
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