Planta medica最新文献

Preclinical evidence of mulberry leaf polysaccharides on diabetic kidney disease: a systematic review and meta-analysis. 桑叶多糖治疗糖尿病肾病的临床前证据：系统综述和荟萃分析。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-02 DOI: 10.1055/a-2432-2732

Yisu Wang, Baifan Chen, Jinghong Zhang, Dan Wang, Yuan Ruan

{"title":"Preclinical evidence of mulberry leaf polysaccharides on diabetic kidney disease: a systematic review and meta-analysis.","authors":"Yisu Wang, Baifan Chen, Jinghong Zhang, Dan Wang, Yuan Ruan","doi":"10.1055/a-2432-2732","DOIUrl":"https://doi.org/10.1055/a-2432-2732","url":null,"abstract":"Mulberry leaf polysaccharides (MLPs) have a variety of biological activities. Preliminary scattered evidence of preclinical studies have reported their potential effects on diabetic kidney disease (DKD). Here, we intended to assess the preclinical evidence of MLPs and explore their potential mechanisms on DKD, offering a scientific reference for the therapeutic use of MLPs. The study has been registered under the CRD42022309117 registration number at PROSPERO. A comprehensive search was conducted across eight databases from their establishment till January 2024 and eight studies with 270 animals were included in the meta-analysis. The primary outcome measurements in the MLP group, including serum creatinine (Scr) (P=0.0005), blood urea nitrogen (BUN) (P=0.02), 24-hour urinary protein (UP) (P=0.001), and urinary microalbumin (UAlb) (P<0.0001), were significantly reduced compared to the control group. Additionally, MLP treatment was significantly correlated with fasting blood glucose (FBG), total cholesterol (TC), protein expression of TGF-β1, CTGF mRNA, and the kidney index (all P values <0.05), and delayed the progression of local pathological changes in the kidney. Subgroup analysis revealed significant species differences in the efficacy of MLPs. Also, it showed that the dosage of streptozotocin potentially affected the Scr and UAlb results, while the duration of MLP treatment influenced UAlb results. MLPs may exert potential renal protection by delaying renal fibrosis, inhibiting inflammatory reactions, suppressing the growth hormone-insulin-like growth factor-insulin-like growth factor binding protein axis, and regulating the insulin receptor pathway. In summary, MLPs have multifaceted renal protective effects, suggesting their potential for treating DKD.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Withaphysalin Derivatives from Iochroma arborescens Induce Antiproliferative and Antimigratory Activities in vitro. Iochroma arborescens 中的 Withaphysalin 衍生物在体外诱导抗增殖和抗移植物活性。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI: 10.1055/a-2381-5060

Rodrigo Elísio de Sá, Gisele Santos de Araújo, Fabrício Dos Santos Machado, Jessica Maria Teles Souza, Ayslan Batista Barros, Francisco das Chagas Lima Pinto, Joana Deyse Lima Agostinho, Alejandro Pedro Ayala, José Delano Barreto Marinho Filho, Otília Deusdênia Loiola Pessoa, Ana Jérsia Araújo

{"title":"Withaphysalin Derivatives from Iochroma arborescens Induce Antiproliferative and Antimigratory Activities in vitro.","authors":"Rodrigo Elísio de Sá, Gisele Santos de Araújo, Fabrício Dos Santos Machado, Jessica Maria Teles Souza, Ayslan Batista Barros, Francisco das Chagas Lima Pinto, Joana Deyse Lima Agostinho, Alejandro Pedro Ayala, José Delano Barreto Marinho Filho, Otília Deusdênia Loiola Pessoa, Ana Jérsia Araújo","doi":"10.1055/a-2381-5060","DOIUrl":"10.1055/a-2381-5060","url":null,"abstract":"Withanolides are steroidal lactones commonly found in plants of the Solanaceae family that have significant medicinal value. In this study, three withanolides extracted from Iochroma arborescens leaves were isolated and characterized. These included withaphysalin F (3: ) and two newly identified epimeric compounds: 18R- and 18S-O-methyl-withaphysalin F (1: and 2: ). Their structures were elucidated by NMR, IR, MS, CD, and X-ray diffraction analysis, and their potential against cell proliferation and migration was investigated. The cytotoxic assay revealed activity against different tumor and non-tumor cell lines. (18S)-O-methyl-withaphysalin F (2: ) presented cell death effects after at least 6 hours of exposure. MDA-MB-231 cells were exposed to 0.06 and 0.6 µM of (18S)-O-methyl-withaphysalin F (2: ), and reductions in cell adhesion, migration, and clonogenicity were observed. Morphological analysis revealed negative regulation in filopodia, salience, and roughness, as well as alterations in cellular microarchitecture. These results provide clues as to the effects of (18S)-O-methyl-withaphysalin F (2: ), allowing new molecular modifications to improve potency and selectivity and increase our antineoplastic arsenal.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142004998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory Principles of the Plant Family Amaryllidaceae. 天南星科植物的抗炎原理。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-07-19 DOI: 10.1055/a-2369-8104

Jerald J Nair, Johannes van Staden

{"title":"Anti-inflammatory Principles of the Plant Family Amaryllidaceae.","authors":"Jerald J Nair, Johannes van Staden","doi":"10.1055/a-2369-8104","DOIUrl":"10.1055/a-2369-8104","url":null,"abstract":"There is considerable interest in the utilisation of plants against inflammation. Over 50 species of the plant family Amaryllidaceae are known for such usage in traditional medicine. This review was undertaken to identify the chemical principles responsible for these anti-inflammatory effects. It describes the findings from in vitro, in vivo and in silico studies, as well as the probes made on the mechanisms of action. The literature search returned over 600 hits, of which around 130 were chosen for their relevance to the text. Over 140 compounds have thus far been screened for anti-inflammatory effects. These were mostly isoquinoline alkaloids but also included other classes of secondary metabolites such as chromones, flavonoids and triterpenoids. In vitro studies were carried out in mononuclear cells such as lymphocytes, monocytes, neutrophils and macrophages, against which no serious side effects were observed. The constituents were also effective against inflammation induced by physical and chemical stimuli in a variety of murine test subjects. Chief among the compounds were the isoquinoline alkaloids lycorine and narciclasine, which displayed potent effects against pain, swelling, asthma and arthritis, amongst others. From a mechanistic perspective, several of the compounds were shown to mediate in inflammatory pathways, notably via the modulation of both pro-inflammatory (such as NF-κB, TNF-α and IL-1) and anti-inflammatory (such as IL-10 and TGF-β) factors. Useful insights also emerged from active-site docking studies of some of the compounds. The Amaryllidaceae affords a rich and diverse platform for the discovery of potential anti-inflammatory drugs.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ajuga taiwanensis Extract Promotes Wound-healing via Activation of PDGFR/MAPK Pathway. 台湾刺五加提取物通过激活 PDGFR/MAPK 通路促进伤口愈合

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI: 10.1055/a-2378-9274

Wei-Hsiang Hsu, Jing-Jy Cheng, Ching-Fen Wu, Yun-Lian Lin

引用次数: 0

Design and Development of a Self-nanoemulsifying Drug Delivery System for Co-delivery of Curcumin and Naringin for Improved Wound Healing Activity in an Animal Model. 设计和开发用于姜黄素和柚皮苷联合给药的 SNEDDS，提高动物模型的伤口愈合活性。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-07-30 DOI: 10.1055/a-2376-6380

Ajmal Hayat, Ismail Shah, Abdul Jabbar, Shafi Ullah, Muhammad Raza Shah, Muhammad Shafique, Aziz Balouch, Farah Gul

{"title":"Design and Development of a Self-nanoemulsifying Drug Delivery System for Co-delivery of Curcumin and Naringin for Improved Wound Healing Activity in an Animal Model.","authors":"Ajmal Hayat, Ismail Shah, Abdul Jabbar, Shafi Ullah, Muhammad Raza Shah, Muhammad Shafique, Aziz Balouch, Farah Gul","doi":"10.1055/a-2376-6380","DOIUrl":"10.1055/a-2376-6380","url":null,"abstract":"The present study endeavored to design and develop a self-nanoemulsifying drug delivery system to improve the solubility and dermatological absorption of curcumin and naringin. Curcumin and naringin-loaded self-nanoemulsifying drug delivery system formulations were developed using aqueous phase titration. Phase diagrams were used to pinpoint the self-nanoemulsifying drug delivery system zones. Tween 80 and Labrasol (surfactants), Transcutol (cosurfactant), and cinnamon oil were chosen from a large pool of surfactants, cosurfactants, and oils based on their solubility and greatest nano-emulsion region. Fourier transform infrared spectroscopy, zeta sizer, and atomic force microscopy were used to characterize the optimized formulations and test for dilution and thermodynamic stability. The optimized curcumin-naringin-self-nanoemulsifying drug delivery system demonstrated the following characteristics: polydispersity index (0.412 ± 0.03), % transmittance (97%), particle size (212.5 ± 05 nm), zeta potential (- 25.7 ± 1.80 mV) and having a smooth and spherical droplet shape, as shown by atomic force microscopy. The ability of their combined formulation to cure wounds was tested in comparison to pure curcumin suspension, empty self-nanoemulsifying drug delivery system, and standard fusidic acid. Upon topical administration, the optimized curcumin-naringin-self-nanoemulsifying drug delivery system demonstrated significant wound healing activity in comparison with a pure curcumin suspension, empty self-nanoemulsifying drug delivery system, and standard fusidic acid. Based upon this result, we assume that skin penetration was increased by using the optimized curcumin-naringin-self-nanoemulsifying drug delivery system with enhanced solubility.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Basic Requirements and Framework Conditions of Real-World Data (RWD) on Herbal Medicinal Products. 草药产品真实世界数据 (RWD) 的基本要求和框架条件。

IF 2.1 4区医学

Planta medica Pub Date : 2024-09-25 DOI: 10.1055/a-2409-3125

Salome Sophie Hölzle, Thorsten Reineke, Stefan Hoch, Bernd Roether, Matthew Francis, Christelle Anquez-Traxler, Nico Symma

引用次数: 0

Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function. 从转化的角度看牛膝草精油萜烯对平滑肌功能的治疗潜力。

IF 2.1 4区医学

Planta medica Pub Date : 2024-09-23 DOI: 10.1055/a-2409-3735

André Nogueira Cardeal Dos Santos, José Ednésio da Cruz Freire, Bruna Ferreira Rodrigues, Francisco Walber Ferreira-da-Silva, José Eduardo Ribeiro Honório Júnior, José Henrique Leal Cardoso, Andrelina Noronha Coelho de Souza

{"title":"Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function.","authors":"André Nogueira Cardeal Dos Santos, José Ednésio da Cruz Freire, Bruna Ferreira Rodrigues, Francisco Walber Ferreira-da-Silva, José Eduardo Ribeiro Honório Júnior, José Henrique Leal Cardoso, Andrelina Noronha Coelho de Souza","doi":"10.1055/a-2409-3735","DOIUrl":"10.1055/a-2409-3735","url":null,"abstract":"Monoterpenes and sesquiterpenes are classes of organic compounds found in various natural products, such as the essential oil of Hyptis crenata (EOHc). The therapeutic potential of these terpenes present in EOHc is evidenced by their effect on smooth muscle and potential clinical applications. Among the highlighted monoterpenes, such as sabinene, α-pinene, and β-pinene, a relaxing effect on rat intestinal smooth muscles is observed, attributed to interaction with calcium channels. Furthermore, monoterpenoids like borneol, cineole, and linalool also demonstrate vasorelaxant properties, suggesting potential in the treatment of cardiovascular conditions. Sesquiterpenes, such as caryophyllene and aromadendrenes, exhibit relaxing effects in various smooth muscle tissues, such as rat uterus and guinea pig ileum, indicating pharmacological potential in these areas. The translational exploration of targets, such as calcium channels and G protein-coupled receptors, highlights the importance of these compounds in discovering new therapies based on natural products for treating various medical conditions.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulatory Activity and Inhibitory Effects of Viscum album on Cancer Cells, Its Safety Profiles and Recent Nanotechnology Development. 白花蛇舌草的免疫调节活性和对癌细胞的抑制作用、其安全性概况以及最新的纳米技术发展。

IF 2.1 4区医学

Planta medica Pub Date : 2024-09-23 DOI: 10.1055/a-2412-8471

Nermeen Yosri, Nurkhalida Kamal, Ahmed Mediani, Sameh AbouZid, Ahmed Swillam, Mahmoud Swilam, Ahmed M Ayyat, Ibrahim Jantan

{"title":"Immunomodulatory Activity and Inhibitory Effects of Viscum album on Cancer Cells, Its Safety Profiles and Recent Nanotechnology Development.","authors":"Nermeen Yosri, Nurkhalida Kamal, Ahmed Mediani, Sameh AbouZid, Ahmed Swillam, Mahmoud Swilam, Ahmed M Ayyat, Ibrahim Jantan","doi":"10.1055/a-2412-8471","DOIUrl":"https://doi.org/10.1055/a-2412-8471","url":null,"abstract":"Viscum album has been employed traditionally to treat various ailments including as add-on therapy for cancer treatment. V. album formulations have been employed as adjuvants in cancer treatment due to their immunomodulatory activities as well as to alleviate the side effects of conventional cancer therapies. The present review provides updated information from the past 10 years on the immunomodulatory activity and inhibitory effects of V. album on cancer cells, its safety profile, and recent nanotechnology development. V. album extracts and their bioactive phytochemicals, particularly lectins, viscotoxins, and polyphenols, have demonstrated immunomodulatory activity and inhibitory effects against various types of cancer, with low cytotoxicity and side effects, in experimental studies and demonstrated promising anticancer activity in clinical studies in cancer patients. V. album extracts have been shown to enhance immune function by promoting cytokine secretion and inducing both innate and adaptive immune responses, which can help improve immune surveillance against cancer cells. The development of V. album nanoparticles has boosted their biological activities, including inhibitory activity on cancer cells, and could possibly reduce undesired side effects of the plant. Further prospective studies on the plant as a source of new medicinal agents for use as an adjuvant in the treatment of cancer must be performed to provide sufficient efficacy and safety data.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erigeron breviscapus: A Promising Medication for Protecting the Optic Nerve in Glaucoma. Erigeron breviscapus：保护青光眼视神经的有效药物

IF 2.1 4区医学

Planta medica Pub Date : 2024-09-20 DOI: 10.1055/a-2409-2999

Yuxin Cheng, Xuanyi Chen, Guangyu Zhu, Na Li, Yue Sun, Shichun Luo, Yujie Liu, Xuejing Lu

{"title":"Erigeron breviscapus: A Promising Medication for Protecting the Optic Nerve in Glaucoma.","authors":"Yuxin Cheng, Xuanyi Chen, Guangyu Zhu, Na Li, Yue Sun, Shichun Luo, Yujie Liu, Xuejing Lu","doi":"10.1055/a-2409-2999","DOIUrl":"https://doi.org/10.1055/a-2409-2999","url":null,"abstract":"Glaucoma is a common eye condition characterized by the loss of retinal ganglion cells and their axons, optic nerve damage, and visual field defects, which seriously affect a patient's quality of life. The pathogenesis of glaucoma is still unclear at present. It presents as damage to retinal ganglion cells, and the main treatment is primarily to reduce intraocular pressure by surgery or taking medication. However, even with well-controlled intraocular pressure, retinal ganglion cells still undergo degeneration, progressive apoptosis, and axonal loss. Therefore, protecting the optic nerve and inhibiting the apoptosis of retinal ganglion cells are the current hot topic for prevention and treatment of glaucoma. Recently, Erigeron breviscapus, originating from Yunnan province in China, has been shown to be a promising herb with neuroprotective effects to treat glaucoma. Therefore, the traditional usage, botanical characteristics, and phytochemical composition of E. breviscapus were explored through a literature review. Furthermore, we have summarized the pharmacological mechanisms of E. breviscapus and its active components in inhibiting the apoptosis of retinal ganglion cells. These research findings can not only provide guidance and recommendations for the protection of retinal ganglion cells but also further explore the potential of E. breviscapus in the treatment of glaucoma.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142293214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psidium Exotic and Native Species from Brazil Abolish Depression-like Behavior and Oxidative Stress induced by Corticosterone in Mice. 巴西鹅掌楸外来种和本地种可消除皮质酮诱导的小鼠抑郁样行为和氧化应激。

IF 2.1 4区医学

Planta medica Pub Date : 2024-09-18 DOI: 10.1055/a-2404-3294

Ana Lúcia Bertarello Zeni, Ana Paula Dalmagro, Lucas Henrique Junges, Natália Cavichioli, Otto Rodolfo Sasse

{"title":"Psidium Exotic and Native Species from Brazil Abolish Depression-like Behavior and Oxidative Stress induced by Corticosterone in Mice.","authors":"Ana Lúcia Bertarello Zeni, Ana Paula Dalmagro, Lucas Henrique Junges, Natália Cavichioli, Otto Rodolfo Sasse","doi":"10.1055/a-2404-3294","DOIUrl":"10.1055/a-2404-3294","url":null,"abstract":"Depression is a highly prevalent neuropsychiatric disorder worldwide. One currently accepted hypothesis of this pathogenesis is the hypothalamic-pituitary-adrenal axis dysfunction, which involves oxidative stress and brain damage. Therefore, antioxidants, such as phenolic compounds, could be used in depression. In this study, we investigated the antidepressant-like and antioxidant effects of an aqueous extract of the leaves of three species of the genus Psidium, Myrtaceae family, in mice. The exotic Psidium guajava L. and the natives Psidium guineense Sw. and Psidium cattleianum Sabine (10, 1, and 0.1 mg/kg, respectively) and fluoxetine (10 mg/kg) were administered orally (p. o.) once daily for 21 days, with or without corticosterone (20 mg/kg). After behavioral assessments (tail suspension, splash, and open-field tests), the hippocampus, prefrontal cortex, liver, kidneys, and plasma were examined to determine the oxidative stress status. The three extracts and fluoxetine treatment decreased the immobility time and counteracted the oxidative stress induced by corticosterone administration. The phenolic compounds identified as major components of the extracts, quercetin in P. guajava and P. guineense and o-coumaric acid in P. cattleianum, may be involved in the biological activities. Therefore, the aqueous leaf extracts of P. guajava, P. cattleianum, and P. guineense could be potential antidepressants helpful in treating depression and other diseases with elevated nitro-oxidative stress.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0