Planta medica最新文献

Therapeutic Potential of Ugonins: Bioactive Flavonoids from Helminthostachys zeylanica with Multifaceted Biological Activities. 乌根素的治疗潜力：具有多方面生物活性的泽兰花黄酮。

IF 2 4区医学

Planta medica Pub Date : 2025-10-06 DOI: 10.1055/a-2717-2323

Abdul Bari Shah, Aizhamal Baiseitova, Young Jun Kim, Ki Yong Lee

引用次数: 0

The Medicinal Chemistry of Cyanidin and its Glycoside Derivatives: Focus on the Antiproliferative and Potential Anticancer Activity. 花青素及其苷类衍生物的药物化学研究：以其抗增殖和潜在的抗癌活性为重点。

IF 2 4区医学

Planta medica Pub Date : 2025-10-01 Epub Date: 2025-06-12 DOI: 10.1055/a-2634-4300

Abdur Rauf, Ahmed Olatunde, Rahaf Ajaj, Nabia Hafeez, Mohamed Y Zaky, Md Rezaul Islam, Md Mozahidul Islam, Giovanni Ribaudo

{"title":"The Medicinal Chemistry of Cyanidin and its Glycoside Derivatives: Focus on the Antiproliferative and Potential Anticancer Activity.","authors":"Abdur Rauf, Ahmed Olatunde, Rahaf Ajaj, Nabia Hafeez, Mohamed Y Zaky, Md Rezaul Islam, Md Mozahidul Islam, Giovanni Ribaudo","doi":"10.1055/a-2634-4300","DOIUrl":"10.1055/a-2634-4300","url":null,"abstract":"Cyanidin and its glucosides are anthocyanins belonging to the class of flavonoid phytochemicals. These pigments give fruits and vegetables their typical reddish-purple nuance, and their peculiar chemical features result in a remarkable ability to neutralize reactive oxygen species and other mutagens. Thus, both cyanidin and its glycosides were proposed as candidates for chemoprevention, as anticancer agents, and as adjuvant therapies. Indeed, the compounds were investigated through various in vitro and in vivo models of colon, breast, kidney, prostate and liver cancer, and glioma. Cyanidin and its derivatives have been found to inhibit key signaling pathways, such as PI3K/Akt, MAPK, and NF-κB, which can reduce cancer cell growth, induce apoptosis, and suppress metastasis. In the first part of the review, the chemical properties of cyanidin and its glycoside analogues will be discussed. Then, an overview of in vitro evidence on activity will be presented, followed by a report on preclinical and clinical data together with comments on the mechanisms involved. Eventually, the aspect of pharmacokinetic properties, bioavailability, and formulation will be dissected. Overall, the review indicates that cyanidin and its derivatives could be effective anticancer agents but also calls for a deeper understanding of the molecular mechanisms underlying their bioactivity. Despite promising results, resolving issues like stability, absorption, and targeted distribution is crucial to maximize their therapeutic potential. More research is needed to develop innovative cyanidin-based formulations for efficient cancer treatment.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"635-644"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144286116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroprotective Role of Eupalitin in Streptozotocin-Induced Diabetic Rats: In Silico and In Vivo Studies. 绿豆素对链脲佐菌素诱导的糖尿病大鼠的神经保护作用：计算机和体内研究。

IF 2 4区医学

Planta medica Pub Date : 2025-10-01 Epub Date: 2025-07-23 DOI: 10.1055/a-2654-7657

Sunil Shukla, Shipra Shukla, Sunil Sharma, Neeru Vasudeva, Ramchander Khatri, Amit Lather, Tanuj Hooda

{"title":"Neuroprotective Role of Eupalitin in Streptozotocin-Induced Diabetic Rats: In Silico and In Vivo Studies.","authors":"Sunil Shukla, Shipra Shukla, Sunil Sharma, Neeru Vasudeva, Ramchander Khatri, Amit Lather, Tanuj Hooda","doi":"10.1055/a-2654-7657","DOIUrl":"10.1055/a-2654-7657","url":null,"abstract":"Alzheimer's disease (AD) is a neurodegenerative condition with marked cognitive loss and impaired thinking abilities as well as spatial memory, working memory, and communication skills. Numerous studies have found that both type 1 and type 2 diabetes lead to neuropathological and neurobehavioral problems, which lead to notable cognitive dysfunction and deterioration in memory. The aims of this study are to find out the neuroprotective potential of eupalitin on memory in streptozotocin-induced diabetic rats and to evaluate its in silico binding affinity on acetylcholinesterase by using molecular docking studies. Eupalitin (dose 1 mg/kg/day) was used to study the behavior model and other biochemical parameters measurement in acute as well as chronic streptozotocin (STZ)-induced diabetic rats. Eupalitin treatment increased the level of acetylcholinesterase (AChE) and lipid peroxidation and decreased glutathione in STZ-infused diabetic rat's brain tissue, suggesting that this substance may modulate cognitive function that is altered by oxidative stress. Results were comparable to standard drugs metformin and donepezil. Docking score and molecular mechanics generalized born surface area (MMGBSA) study results of eupalitin in comparison with donepezil possess superior predicted binding affinity toward AChE. The level of Aβ (1 - 42) was considerably lower in the eupalitin-treated group than in the STZ-treated group during both the acute and chronic phases of treatment, but results were more prominent in the case of chronic-level treatment. In silico studies showed the binding affinity toward AChE. This result concluded that eupalitin antioxidant potential may be utilized as a therapy for diabetes mellitus (DM)-related cognitive impairment.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"664-675"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nitidine Isolated from the Bark of Zanthoxylum myriacanthum and its Effects on NTERA-2 Cancer Stem Cells. 多棘花椒皮中尼替丁的分离及其对肿瘤干细胞的作用。

IF 2 4区医学

Planta medica Pub Date : 2025-10-01 Epub Date: 2025-07-23 DOI: 10.1055/a-2654-6627

Trieu Ha Phuong, Pham Minh Quan, Pham Cao Bach, Tran Thi Tuyen, Nguyen Phuong Nga, Nguyen Thi Cuc, Do Thi Thao, Nguyen Thi Hong Van

{"title":"Nitidine Isolated from the Bark of Zanthoxylum myriacanthum and its Effects on NTERA-2 Cancer Stem Cells.","authors":"Trieu Ha Phuong, Pham Minh Quan, Pham Cao Bach, Tran Thi Tuyen, Nguyen Phuong Nga, Nguyen Thi Cuc, Do Thi Thao, Nguyen Thi Hong Van","doi":"10.1055/a-2654-6627","DOIUrl":"10.1055/a-2654-6627","url":null,"abstract":"Nitidine (NIT) was isolated from the bark of Zanthoxylum myriacanthum and assessed for anti-proliferative effects on NTERA-2 cancer stem cells using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide assay, spheroid assay, DNA and lysosome staining, flow cytometry, caspase assay, immunoblotting, and molecular docking studies. Moreover, nitidine suppresses stemness properties like in vitro tumorsphere forming, c-myc, Oct4, Nanog proteins of NTERA-2 cancer stem cells after 48-hour treatment. Nitidine selectively induced anti-survival activities by triggering the intrinsic apoptotic process through p53 signaling and lysosome-dependent cell death (LDCD). The mechanism of action of nitidine on cancer stem cells was also investigated using molecular docking studies to provide physical insights. Molecular docking studies revealed that nitidine induces LDCD by effectively inhibiting the MHR1/2 domain of the TRPM2 protein on liposome membrane. These results suggested the potential capacity of nitidine in inhibiting cancer stem cells or tumor-initiating cells for therapeutic cancer application.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"676-689"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144699210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alkaloid Composition and Antiarrhythmic Activity of the Extracts from Rauvolfia serpentina Tissue Culture. 蛇尾草组织培养提取物的生物碱组成及抗心律失常活性研究。

IF 2 4区医学

Planta medica Pub Date : 2025-10-01 Epub Date: 2025-07-09 DOI: 10.1055/a-2629-0226

Aleksandr Khromov, Natalia Dobrelia, Iryna Konvalyuk, Oleksandr Bieda, Igor Andreev, Ludmyla Mozhylevska, Sergiy Yarmoluk, Anatoliy Soloviev, Viktor Kunakh

{"title":"Alkaloid Composition and Antiarrhythmic Activity of the Extracts from Rauvolfia serpentina Tissue Culture.","authors":"Aleksandr Khromov, Natalia Dobrelia, Iryna Konvalyuk, Oleksandr Bieda, Igor Andreev, Ludmyla Mozhylevska, Sergiy Yarmoluk, Anatoliy Soloviev, Viktor Kunakh","doi":"10.1055/a-2629-0226","DOIUrl":"10.1055/a-2629-0226","url":null,"abstract":"Rauvolfia serpentina produces a number of indole alkaloids and has long been used in the traditional treatment of arrhythmia. Given the shortage of natural resources, the K-27M strain of R. serpentina tissue culture was established. The aim was to evaluate the antiarrhythmic activity of extracts with different compositions and ratios of indole alkaloids derived from the cell biomass of the K-27M strain. Chemical analysis was conducted using HPLC-MS. Adrenaline-induced (rats) and ischemia-reperfusion arrhythmia (isolated guinea pig hearts) models were used to study the antiarrhythmic activity of the extracts. Extracts were obtained from dry (extracts 1, 2, and 3) and fresh biomass (fractions 1 and 2 of extract 4). Extract 1 contained ajmaline and acetylajmaline (the total indole alkaloid content (TIAC) was 2.2% of the dry biomass); extract 2-ajmaline, acetylajmaline, and raucaffricine (TIAC 6.4%); extract 3-ajmaline and raucaffricine (TIAC 29.0%). Fraction 1 of extract 4 was dominated by vomilenine, methylajmalicine, ajmalicine, and raufloridine (TIAC 65.0%), and fraction 2 of extract 4 contained acetylajmaline (TIAC 47.4%). Extracts 1 and 2 containing negligible amounts of indole alkaloids showed a weak proarrhythmic effect. Fractions 1 and 2 of extract 4 had a pronounced antiarrhythmic effect in the adrenaline-induced arrhythmia model. In addition, fraction 2 of extract 4 had an antiarrhythmic effect in the ischemia-reperfusion arrhythmia model. The level of this activity depended on the composition and ratio of alkaloids in the extract. Thus, the K-27M strain of R. serpentina tissue culture is a promising source of indole alkaloids with antiarrhythmic activity.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"645-655"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Antifungal Activity and Potential Mechanism of Kalopanax septemlobus against Trichophyton mentagrophytes and T. rubrum. 九色Kalopanax对红毛癣菌和红毛癣菌的抑菌活性及其潜在机制。

IF 2 4区医学

Planta medica Pub Date : 2025-10-01 Epub Date: 2025-08-05 DOI: 10.1055/a-2654-9361

Wei Liu, Zhaoyi Yang, Xueyan Li, Ye Wang, Yuling Ding, Yong Li

{"title":"The Antifungal Activity and Potential Mechanism of Kalopanax septemlobus against Trichophyton mentagrophytes and T. rubrum.","authors":"Wei Liu, Zhaoyi Yang, Xueyan Li, Ye Wang, Yuling Ding, Yong Li","doi":"10.1055/a-2654-9361","DOIUrl":"10.1055/a-2654-9361","url":null,"abstract":"Kalopanax septemlobus (K. septemlobus) has been documented for therapeutic efficacy against scabies, but with fewer modern studies. In this paper, the inhibitory effects of K. semtemlobus extract and monomeric compounds on Trichophyton mentagrophytes and Trichophyton rubrum were studied, and the mechanism of action was preliminarily discussed. The chemical constituents of the ethyl acetate layer of K. semtemlobus were isolated and purified under the trace of antifungal activity (microdilution method). The structure was characterized by nuclear magnetic resonance spectroscopy (NMR) and mass spectrometry (MS); in vitro antifungal activity was investigated by microdilution (MIC, MFC), spore germination suppression, serum induced culture, extracellular protein determination, intracellular nucleic acid release, and PI fluorescence staining. Two compounds were isolated and elucidated, hederagenin (1: ) and kalopanaxsaponin A (2: ), respectively. The antifungal study showed that kalopanaxsaponin A had strong activity and could inhibit fungal growth from growth appreciation, transformation, and cell membrane (protein, nucleic acid leakage). The above data show that kalopanaxsaponin A has a strong antifungal effect (MIC50=7.8 µg/mL), but in vivo and clinical experiments are needed to verify whether it has a curative effect. This study provides a potential compound for the development of natural antifungal drugs.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"690-700"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144789694","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory and Antioxidant Properties of Almond-Skin Acetonic Extract in Zebrafish (Danio rerio) Copper-Sulphate-induced Inflammation. 杏仁皮丙酮提取物对斑马鱼（Danio rerio）硫酸铜诱导炎症的抗炎和抗氧化作用。

IF 2 4区医学

Planta medica Pub Date : 2025-10-01 DOI: 10.1055/a-2654-9426

Rúben Barbosa, Ana Martins, Ivo Vaz Oliveira, Maria Inês Dias, Sandra M Monteiro, Carlos Venâncio, Luís Félix

{"title":"Anti-inflammatory and Antioxidant Properties of Almond-Skin Acetonic Extract in Zebrafish (Danio rerio) Copper-Sulphate-induced Inflammation.","authors":"Rúben Barbosa, Ana Martins, Ivo Vaz Oliveira, Maria Inês Dias, Sandra M Monteiro, Carlos Venâncio, Luís Félix","doi":"10.1055/a-2654-9426","DOIUrl":"https://doi.org/10.1055/a-2654-9426","url":null,"abstract":"This study aimed to assess the properties of an acetone-based almond-skin (Prunus dulcis) extract and examine its effects on chemically induced inflammation by evaluating associated oxidative changes in an in vivo model. The phytochemical composition was analysed by LC-MS/MS while the antioxidant capacity was evaluated using DPPH, ABTS, and FRAP assays. The neutrophil migration was assessed using a CuSO4-induced inflammation model in a transgenic zebrafish line (Tg(mpx : GFP)i114). Three days post-fertilisation zebrafish larvae were treated with 5 and 25 µg/mL extract for 1 h and then exposed to 10 µM CuSO4 for 40 min. Following exposure, various biochemical markers were assessed, along with neurobehavioral effects. The polyphenolic profile revealed a high flavonoid content and good antioxidant properties confirmed by the DPPH, ABTS, and FRAP assays. The extract reduced neutrophil migration in a concentration-dependent manner, indicating anti-inflammatory activity. Additionally, it decreased reactive oxygen species (ROS) production and cell death without affecting mitochondrial membrane potential. The extract also mitigated oxidative damage, as shown by reduced malondialdehyde and protein carbonylation levels, alongside decreased antioxidant response markers. Neurobehavioral effects induced by CuSO4 were alleviated, as evidenced by improved touch-evoked responses. These findings suggest that almond-skin extract holds significant antioxidant and anti-inflammatory properties, possibly through modulation of ROS and calcium signalling pathways.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145207418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Establishment of a Carrot Cell Plant Growth Regulators-free System to Produce a Low-Cost Vaccine Candidate. 建立不含植物生长调节剂的胡萝卜细胞体系，生产低成本的候选疫苗。

IF 2 4区医学

Planta medica Pub Date : 2025-10-01 Epub Date: 2025-06-03 DOI: 10.1055/a-2626-4703

Christian Carreño-Campos, Sahara Dubraiicka Elguea Zarate, Andrea Romero-Maldonado, María Luisa Villarreal, Sergio Rosales-Mendoza, Anabel Ortiz-Caltempa

{"title":"Establishment of a Carrot Cell Plant Growth Regulators-free System to Produce a Low-Cost Vaccine Candidate.","authors":"Christian Carreño-Campos, Sahara Dubraiicka Elguea Zarate, Andrea Romero-Maldonado, María Luisa Villarreal, Sergio Rosales-Mendoza, Anabel Ortiz-Caltempa","doi":"10.1055/a-2626-4703","DOIUrl":"10.1055/a-2626-4703","url":null,"abstract":"Parkinson's disease is characterized by an abnormal accumulation of alpha synuclein (α-syn) in different regions of the central nervous system. At present, only palliative pharmacological treatments are available for Parkinson´s disease. Immunotherapy is considered an alternative to treat Parkinson's disease, and plants are a convenient alternative platform for biopharmaceutical production. When compared to other systems, plants are particularly attractive because they offer cost-effectiveness, large-scale production, and enhanced safety. Therefore, this study aimed to establish a carrot cell suspension culture for the production of cLTB-Syn, a vaccine candidate against Parkinson's disease. The convenience of MS medium optimization was demonstrated. Transgenic callus cultures were maintained and adapted on solid MSU9 medium without phytohormones, followed by growth kinetics in suspension cultures. The maximum biomass yield was 15.8 ± 0.35 g/L DW at 14 days of culture, with a growth rate of µ = 0.1034/d and td = 6.7 days. The cLTB-Syn protein production reached a maximum value of 2.62 ± 0.03 µg/g DW, representing a 1.6-fold increase over the initial culture time. Finally, the presence of the transgene was confirmed by PCR, and the integrity of cLTB-Syn protein was determined by dot blot assays. This study presents evidence of a promising system for a toxin-free biopharmaceutical production, which has the potential to be scaled up for large manufacturing, at a low cost.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"656-663"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144216581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Allium ursinum as a Centuries-old Medicinal Plant. Short Review of Anti-inflammatory and Antimicrobial Properties of the Rare Garlic Species. 熊葱是一种具有百年历史的药用植物。稀有大蒜抗炎抗菌特性综述。

IF 2 4区医学

Planta medica Pub Date : 2025-10-01 Epub Date: 2025-07-09 DOI: 10.1055/a-2633-5581

Oskar Szczepaniak, Susanne Neugart, Monika Przeor, Tuba Esatbeyoglu

{"title":"Allium ursinum as a Centuries-old Medicinal Plant. Short Review of Anti-inflammatory and Antimicrobial Properties of the Rare Garlic Species.","authors":"Oskar Szczepaniak, Susanne Neugart, Monika Przeor, Tuba Esatbeyoglu","doi":"10.1055/a-2633-5581","DOIUrl":"10.1055/a-2633-5581","url":null,"abstract":"Wild garlic (Allium ursinum) is a wild plant growing in Middle and Eastern Europe that has been traditionally applied in local cuisine and herbal medicine practices. The leaves of the plant contain numerous bioactive compounds, i.e., flavonols, flavanols, phenolic acids, and thiopolysulfides. The aim of the study is to present the antioxidant, anti-inflammatory, and antimicrobial properties of this plant. The leaves of Allium ursinum possess strong antioxidant activity, which varies depending on extractant use and plant origin. The plant has limited capacity for ferric ion reduction in a FRAP test, as well. The previous studies showed that the high content of phenolic compounds was prevalently responsible for the high antiradical capacity. On the other hand, the thiopolysulfides present in the plant are responsible for its anti-inflammatory effect, observed as inhibition of TNF-α and interleukins, and as a bactericidal effect against skin pathogenic microflora. Wild garlic has a negative effect on cancer cell line viability, while it enhances the viability of non-cancerogenic tissue cells. All these effects clearly show that wild garlic is an interesting and potent raw material that should be more often applied in today's functional foods, as well as a novel additive for dietary supplements, herbal remedies, or materials with topical anti-bacterial action.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"626-634"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144601246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ovatodiolide: Recent Advances in Pharmacological Activities and Mechanisms. 卵黄内酯：药理活性和机制的最新进展。

IF 2 4区医学

Planta medica Pub Date : 2025-09-24 DOI: 10.1055/a-2696-1032

Yingying Zhou, Jianguo Zhang, Qingqing Xia, Lingmin Zhang, Miaomiao Zhang, Lijun Lu, Zaixing Yang, Jie Li

引用次数: 0