Planta medica最新文献

{"title":"Curcumin: Epigenetic Modulation and Tumor Immunity in Antitumor Therapy.","authors":"Xin Wan, Dong Wang","doi":"10.1055/a-2499-1140","DOIUrl":"10.1055/a-2499-1140","url":null,"abstract":"<p><p>Curcumin (turmeric) is the main ingredient of the Chinese herbal turmeric rhizome, used to treat tumors, diabetes, inflammation, neurodegenerative diseases, cardiovascular diseases, metabolic syndrome, and liver diseases. The antitumor effects of curcumin have received even more attention. One of the main mechanisms of the antitumor effects includes inhibition of tumor invasion and migration, induction of tumor cell apoptosis, and inhibition of various cell signaling pathways. It has been found that the antitumor biological activity of curcumin in the body is associated with epigenetic mechanisms. That also implies that curcumin may act as a potential epigenetic modulator to influence the development of tumor diseases. The immune system plays an essential role in the development of tumorigenesis. Tumor immunotherapy is currently one of the most promising research directions in the field of tumor therapy. Curcumin has been found to have significant regulatory effects on tumor immunity and is expected to be a novel adjuvant for tumor immunity. This paper summarizes the antitumor effects of curcumin from four aspects: molecular and epigenetic mechanisms of curcumin against a tumor, mechanisms of curcumin modulation of tumor immunotherapy, reversal of chemotherapy resistance, and a novel drug delivery system of curcumin, which provide new directions for the development of new antitumor drugs.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Compounds against Mpox: Mapping Evidence and Identifying Gaps.","authors":"Amin Sharifan","doi":"10.1055/a-2560-1844","DOIUrl":"https://doi.org/10.1055/a-2560-1844","url":null,"abstract":"<p><p>The global spread of Mpox necessitates exploration of novel treatment options. Considering the established history of herbal medicine in managing infectious diseases, this study reviewed the literature on phytotherapy for Mpox, addressing gaps in evidence-based herbal interventions. A thorough search was conducted across the Scopus, PubMed, and Cochrane databases, as well as grey literature, up to August 2024 to retrieve studies on natural compounds with potential efficacy against Mpox and its associated symptoms. Data were analysed for publication characteristics, the compounds or herbal plants investigated, and their effects on the virus. A total of 37 articles with 242 citations were identified, demonstrating a steady increase in research activity since the first study in 2011, peaking in 2023 with 21 publications and 114 citations. The majority of studies originated from South-East Asian countries. In terms of study design, most investigations were in silico (n=31, 84%), followed by in vitro studies (n=4, 11%), with no in vivo or clinical interventions reported. The primary focus was on the antiviral activities of natural products, with polyphenols identified as the most prevalent lead compounds. Whilst these findings highlight the growing interest in phytotherapy for Mpox, they also underscore the predominance of computational studies. To build upon this foundation of in silico evidence, further laboratory and animal studies are imperative for translating these insights into clinical applications. The comprehensive library of compounds gathered through this research provides a valuable resource to facilitate this crucial next step in the development of herbal interventions against Mpox.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Datura stramonium - A Dangerous Weed and Alternative Drug of Abuse: An Overview of Poisoning Cases in 21st Century.","authors":"Milica Aćimović","doi":"10.1055/a-2552-4434","DOIUrl":"https://doi.org/10.1055/a-2552-4434","url":null,"abstract":"<p><p><i>Datura stramonium</i> is a well-known cosmopolitan weed known by several common names: thorn apple (due to the appearance of its fruits), Angel's trumpet (linked to its flowers), loco seed (referring to the hallucinogenic properties of its seeds), jimson weed (originating from the first recorded poisoning involving this plant), and apple of Peru (indicating the plant's origin). All parts of the plant contain the tropane alkaloids hyoscyamine, scopolamine, and atropine together with several minor alkaloids, which cause poisoning such as typical anticholinergic syndrome with neuropsychiatric effects. A review of 114 papers from various databases (Scopus, Web of Science, PubMed, and Google Scholar) revealed that poisoning incidents involving this plant have been relatively common from 2001 to 2024. The analysis indicated that all cases of poisoning from <i>D. stramonium</i> can be categorized into two main groups: accidental and misuse. Accidental poisonings are primarily linked to the contamination of other crops in the field, leading to mass poisoning of humans and animals. They can also result from misidentifying the plant as another edible species, children's curiosity, and self-medication. On the other hand, misuse is typically associated with recreational drug use, suicide attempts, criminal activities, and magico-religious practices. To prevent poisoning from this plant, it is essential to eliminate the weed from fields, yards, gardens, and other disturbed areas. Additionally, it is important to educate the general public about the plant's appearance and the dangers associated with its consumption, particularly in the context of self-medication and recreational drug use.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudopeptides of Marine Vibrio spp. from Taiwan and Their Combined Treatment Effects with Commercial Antibiotics.","authors":"Mao-Xuan Hong, Bo-Wei Wang, Li-Hua Lo, Gamaralalage Eranga Dilshan Jayalath, Wei-Tsen Lin, Yu-Liang Yang, Sung-Pin Tseng, Yen-Hsu Chen, Wan-Chi Tsai, Wei-Chieh Cheng, Chih-Chuang Liaw","doi":"10.1055/a-2536-8292","DOIUrl":"10.1055/a-2536-8292","url":null,"abstract":"<p><p><i>Vibrio</i> strains, identified by 16S rDNA, were isolated from the marine environment surrounding Taiwan, revealing diverse bioactive effects, such as iron-chelating and antimicrobial activities. Notably, the hierarchical clustering dendrogram of mass spectrum profiles of the <i>Vibrio</i> strains using matrix-assisted laser desorption ionization time-of-flight, in contrast to the phylogenetic tree based on 16S rDNA sequencing analysis, exhibited a strong correlation with their observed bioactivities. Within this set, global natural products social molecular network analysis by LC-HRMS/MS highlighted that three strains, <i>Vibrio tubiashii</i> DJW05 - 1, <i>Vibrio japonicus</i> DJW05 - 8, and <i>Vibrio fortis</i> DJW21 - 4, shared similar bioactive pseudopeptides in the same cluster. Subsequent chromatographical isolation and purification yielded an unprecedented unsaturated diketopiperazine, (<i>Z</i>)-3-(2-methylpropylidene)-2,3-dihydropyrrolo[1,2-<i>a</i>]pyrazine-1,4-dione (1: ), along with a series of diketopiperazines, and a potential new annotated pseudopeptide (2: ), as well as three pseudopeptides, including andrimid (10: ), moiramide B (11: ), and moiramide C (12: ), and several alkaloids from <i>V. tubiashii</i> DJW05 - 1. Further investigation into the combined applications of the major antimicrobial compound and commercial antibiotics revealed that andrimid (10: ) displayed significant inhibitory effects against gram-positive <i>Staphylococcus aureus</i>, and gram-negative <i>Escherichia coli, Salmonella typhimurium</i>, and <i>Acinetobacter baumannii</i>, but not <i>Pseudomonas aeruginosa</i>. Nevertheless, the potential for synergistic and additive effects of andrimid (10: ) with certain antibiotics remains, presenting valuable prospects for medicinal applications.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Natural Products Targeting Tau Protein Phosphorylation: A Promising Therapeutic Avenue for Alzheimer's Disease.","authors":"Ziying Chen, Yan Lu, Yiyun Wang, Qi Wang, Liangwen Yu, Jinman Liu","doi":"10.1055/a-2536-8919","DOIUrl":"https://doi.org/10.1055/a-2536-8919","url":null,"abstract":"<p><p>Alzheimer's disease is a progressive neurodegenerative disorder characterized by tau protein hyperphosphorylation and neurofibrillary tangle formation, which are central to its pathogenesis. This review focuses on the therapeutic potential of natural products in targeting tau phosphorylation, a key factor in Alzheimer's disease progression. It comprehensively summarizes current research on various natural compounds, including flavonoids, alkaloids, saponins, polysaccharides, phenols, phenylpropanoids, and terpenoids, highlighting their multitarget mechanisms, such as modulating kinases and phosphatases. The ability of these compounds to mitigate oxidative stress, inflammation, and tau pathology while enhancing cognitive function underscores their value as potential anti-Alzheimer's disease therapeutics. By integrating recent advances in extraction methods, pharmacological studies, and artificial intelligence-driven screening technologies, this review provides a valuable reference for future research and development of natural product-based interventions for Alzheimer's disease.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monotherapy or Combination Therapy of Oleanolic Acid? From Therapeutic Significance and Drug Delivery to Clinical Studies: A Comprehensive Review.","authors":"Md Adil Shaharyar, Tanmoy Banerjee, Monalisha Sengupta, Rudranil Bhowmik, Arnab Sarkar, Pallab Mandal, Sami I Alzarea, Nilanjan Ghosh, Jamal Akhtar, Imran Kazmi, Sanmoy Karmakar","doi":"10.1055/a-2510-9958","DOIUrl":"10.1055/a-2510-9958","url":null,"abstract":"<p><p>Oleanolic acid is a pentacyclic triterpenoid molecule widely distributed throughout medicinal plants. This naturally occurring oleanolic acid has attracted considerable interest due to its wide range of pharmacological characteristics, notably its cytotoxic effects on various human cancer cell lines, making it a potential candidate for extensive therapeutic uses. <i>In vivo</i> studies have shown that oleanolic acid possesses hepatoprotective, cardioprotective, anti-inflammatory, and antimicrobial properties. The inherent obstacles of oleanolic acid, such as low permeability, limited bioavailability, and poor water solubility, have restricted its therapeutic applicability. However, recent developments in drug delivery techniques have given oleanolic acid an additional advantage by overcoming issues with its solubility, stability, and bioavailability. This review briefly summarises the signalling pathways involved in the pharmacological activities of oleanolic acid as a monotherapy and in combination with other drugs. The review devotes a substantial portion to explaining the formulation developments, emphasising nanotechnology as a key factor in the improvement of the therapeutic potential of oleanolic acid. Several investigated novel formulations have been discussed, including liposomes, nanoemulsions, phospholipids, and polymeric nanoparticles, emerging synergistically as an efficient delivery of oleanolic acid and several other drugs. Based on our literature evaluation, it can be inferred that combination therapy had a more favourable outcome than using oleanolic acid alone in <i>in vivo</i> trials, primarily due to its synergistic effects. However, it is essential to note that this finding was inconsistent across all investigations. The combination of oleanolic acid with other drugs has not yet been considered for clinical trials. However, it is interesting that neither therapy has obtained approval from the U. S. Food and Drug Administration.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory Potential of Plants of Genus Rhus: Decrease in Inflammatory Mediators In Vitro and In Vivo - a Systematic Review.","authors":"Alejandra Jazmín Rodríguez-Castillo, César Pacheco-Tena, Rubén Cuevas-Martínez, Blanca Estela Sánchez-Ramírez, Susana Aideé González-Chávez","doi":"10.1055/a-2535-1655","DOIUrl":"https://doi.org/10.1055/a-2535-1655","url":null,"abstract":"<p><p>Plants from the <i>Rhus</i> genus are renowned for their medicinal properties, including anti-inflammatory effects; however, the mechanisms underlying these effects remain poorly understood. This systematic review, conducted following PRISMA guidelines, evaluated the anti-inflammatory effects of <i>Rhus</i> plants and explored their potential pharmacological mechanisms. A total of 35 articles were included, with the majority demonstrating a low-risk bias, as assessed using the SYRCLE tool. <i>Rhus verniciflua, Rhus chinensis, Rhus coriaria, Rhus succedanea, Rhus tripartite, Rhus crenata</i>, and <i>Rhus trilobata</i> were analyzed in the reviewed articles. <i>In vitro</i> studies consistently demonstrated the ability of <i>Rhus</i> plants to reduce key inflammatory mediators such as TNF-<i>α</i>, IL-1<i>β</i>, and IL-6. <i>In vivo</i> studies confirmed these effects in murine models of inflammation, with doses mostly of 400 and 800 mg/kg body weight, with no reports of toxicity. Fifty-four distinct inflammatory mediators were assessed <i>in vivo</i>; no pattern of mediators was identified that could elucidate the anti-inflammatory mechanisms of the action of <i>Rhus</i> in acute or chronic inflammation. The clinical trial reported anti-inflammatory effects in humans at 1000 mg/kg for 6 weeks. The review data on the <i>Rhus</i>-mediated reduction in inflammatory mediators were integrated and visualized using the Reactome bioinformatics database, which suggested that the mechanism of action of <i>Rhus</i> involves the inhibition of inflammasome signaling. These findings support the potential of <i>Rhus</i> plants as a basis for developing anti-inflammatory therapies. Further research is needed to optimize dosage regimens and fully explore their pharmacological applications.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Andrographolide and its Derivatives in Cardiovascular Disease: A Comprehensive Review.","authors":"Shenjie Zhang, Xiaokai Xie, Juan Zhao, Yilong Jiang, Chao Huang, Qi Li, Boyu Xia, Le Yin, Xiaomei Yuan, Qingsheng You","doi":"10.1055/a-2542-0756","DOIUrl":"https://doi.org/10.1055/a-2542-0756","url":null,"abstract":"<p><p>Cardiovascular disease is one of the main causes of mortality worldwide. Andrographolide represents an important category of natural phytochemicals that has significant therapeutic potential in various conditions such as acute lung injury, heart disease, and viral infections due to its anti-oxidative, anti-inflammatory, and anti-apoptotic properties. This compound plays a protective role in human pathophysiology. This review provides a comprehensive overview of the effects of andrographolide on cardiovascular disease and examines its essential roles and mechanisms in cardiovascular disease and other vascular dysfunctions. The data collected in this review serve as a comprehensive reference for the role of andrographolide in cardiovascular disease and provide valuable insights for further research and the development of andrographolide as a novel therapeutic approach for cardiovascular disease.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Galactomannan and Vicilin from Fenugreek Seeds (Trigonella foenum-graecum) Impair Early Pathogen-Host Interaction of Campylobacter jejuni with Intestinal Cells via JlpA.","authors":"Leon Kemper, Fabian Herrmann, Simone König, Franco H Falcone, Andreas Hensel","doi":"10.1055/a-2536-8392","DOIUrl":"10.1055/a-2536-8392","url":null,"abstract":"<p><p><i>Campylobacter jejuni</i> is the leading cause of severe enteritis worldwide. Identification of natural products against <i>C. jejuni</i> that inhibit early-stage host-pathogen interactions is a promising strategy, particularly by blocking bacterial adhesion to and invasion into the host cells. This should help to reduce the bacterial load in vector animals. From the seeds of <i>Trigonella foenum-graecum</i>, an aqueous extract (fenugreek high molecular fraction) of high-molecular compounds (polysaccharides, proteins) was obtained. The polysaccharide was characterized as galactomannan (1,4-mannose backbone, substituted at <i>O</i>-6 with single galactose residues and galactose oligosaccharide chains). The protein part consisted of 50 kDa vicilin as the main compound. The fenugreek high molecular fraction did not influence proliferation of <i>C. jejuni</i> and viability of Caco-2 cells (1 - 1000 µg/mL). The fenugreek high molecular fraction reduced bacterial adhesion to Caco-2 significantly (500 - 1000 µg/mL), which was due to an interaction with the bacterial adhesin JlpA, preventing the interaction of this outer membrane protein to its ligand HSP90<i>α</i> (IC₅₀ = 23.4 µg/mL). Bacterial invasion was reduced significantly. Both polysaccharides as well as vicilin contribute to the observed antiadhesive effect. As vicilin-like proteins are widely found in plants from the Fabaceae family, a vicilin-enriched protein preparation from <i>Pisum sativum</i> was investigated for antiadhesive activity. These findings suggest that fenugreek seeds or vicilin-rich plant extracts could be used to develop novel strategies to control <i>C. jejuni</i> infections in food-producing animals, ultimately helping to decrease the prevalence of campylobacteriosis in humans.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review on phytochemistry and recent pharmacology of Dragon's Blood (Croton lechleri Muell. Arg.), a multifunctional ethnomedicinal resource from AmazonForest.","authors":"Ricardo Diego Albuquerque, Frank León-Vargas, Daniel Carrasco-Montañez, Jorge Carranza-Gonzales, Yessenia Ramos-Rivas","doi":"10.1055/a-2551-5681","DOIUrl":"https://doi.org/10.1055/a-2551-5681","url":null,"abstract":"<p><p><i>C. lechleri</i>, known as \"Sangre de Drago\", is an ethnomedicinal resource widely used in the Amazon region, presenting several properties, such as wound healing activity, anti-inflammatory and antitumor effects, among others. However, the scope of its scientific studies carried out in the last 20 years lacks a comprehensive review, in order to inform readers and researchers about the current state of the art on the chemical and pharmacological theme of the species. Using databases such as Scopus and Google Scholar, 33 articles on the themes of phytochemistry and recent pharmacological studies were found, which, in turn, report proanthocyanidins as the main phytochemical group in relative quantity, in addition to the presence of alkaloids, diterpenoids, phytosteroids, saponins, phenolics and polyphenolics as other groups of phytochemical importance. The studies also describe the healing, antitumor, anti-inflammatory, gastrointestinal, and other potential effects of <i>C. lechleri</i>, which demonstrate the notable medicinal importance of the species today.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}