Planta medica最新文献

Evaluation of the Estrogenic Activity of Green and Fermented Aspalathus linearis (Rooibos) Extracts. 绿色和发酵芦笋提取物的雌激素活性评价。

IF 2.1 4区医学

Planta medica Pub Date : 2026-10-12 DOI: 10.1055/a-2963-2494

Sasha M J Marais, Glenn Averia, Lee-Maine L Spies, Dalene De Beer, Ann Louw, Nicolette Verhoog

{"title":"Evaluation of the Estrogenic Activity of Green and Fermented Aspalathus linearis (Rooibos) Extracts.","authors":"Sasha M J Marais, Glenn Averia, Lee-Maine L Spies, Dalene De Beer, Ann Louw, Nicolette Verhoog","doi":"10.1055/a-2963-2494","DOIUrl":"https://doi.org/10.1055/a-2963-2494","url":null,"abstract":"Abstract: The presence of plant polyphenols with pharmacophoric features similar to estrogens in an Aspalathus linearis (rooibos) extract warranted the in vitro evaluation of the estrogenic activity of green and fermented rooibos extracts (n = 18). Whole-cell receptor binding assays demonstrated that compounds found within the rooibos extracts interact with both estrogen receptor (ER) subtypes, as they displaced radiolabeled E2. Although the extracts were much less potent than E2 in inducing agonism in promoter-reporter luciferase assays, most extracts displayed ERβ selectivity with higher efficacy via ERβ than via ERα. In contrast, extract potencies were generally comparable to ICI-182,780, an ER antagonist, in antagonizing E2, while their efficacies showed no ER-subtype selectivity. The preference of selected water extracts (WEs) to signal via ERβ was apparent in their inability to induce progesterone receptor (PGR) mRNA expression, an ERα-activated gene. Furthermore, the lack of PGR stimulation was consistent with Western blot assay results, where most WEs downregulated PR-B protein expression after shorter treatment times (2 or 4 h) and inhibited E2-induced PR-B protein expression after 24 or 48 h. To our knowledge, this study is the first to report that rooibos possesses antiestrogenic activity. This warrants further research for identifying the active compound(s) underlying the antiestrogenic effect, and for supporting the potential of rooibos as a therapeutic agent in diseases regulated by E2, such as ER-positive breast cancer.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149168972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Integrated LC-DAD-QToF-MS Characterization and Quantitative Profiling of Polyphenolic Metabolites in Idesia polycarpa. 多酚代谢产物的LC-DAD-QToF-MS综合表征及定量分析

IF 2.1 4区医学

Planta medica Pub Date : 2026-10-08 DOI: 10.1055/a-2974-8646

Ji-Yeong Bae, Bharathi Avula, Kiran Kumar Tatapudi, Kumar Katragunta, Minseo Jeon, Hyunwoo Kim, Sang Ho Lee, Ikhlas A Khan

{"title":"Integrated LC-DAD-QToF-MS Characterization and Quantitative Profiling of Polyphenolic Metabolites in Idesia polycarpa.","authors":"Ji-Yeong Bae, Bharathi Avula, Kiran Kumar Tatapudi, Kumar Katragunta, Minseo Jeon, Hyunwoo Kim, Sang Ho Lee, Ikhlas A Khan","doi":"10.1055/a-2974-8646","DOIUrl":"https://doi.org/10.1055/a-2974-8646","url":null,"abstract":"Idesia polycarpa, a dioecious tree distributed in East Asia, is known for its pharmacologically relevant secondary metabolites. In this study, a comprehensive phytochemical investigation was conducted to characterize and quantify the major polyphenolic metabolites across different plant tissues. Leaves and stems from both female and male plants, together with unripe and ripe fruits from female trees, were analyzed using liquid chromatography coupled with diode-array detection and quadrupole time-of-flight mass spectrometry (LC-DAD-QToF-MS). Four major polyphenolic compounds (idesin, chlorogenic acid, idescarpin, and apigenin-7-O-glucuronide) were identified and quantified. Idescarpin was the predominant compound in all tissues, with the highest concentration in ripe fruits (122.9 mg/g), followed by unripe fruits (105.0 mg/g) and female leaves (99.1 mg/g). Idesin was also enriched in fruits, reaching 16.3 mg/g in ripe fruits. In contrast, chlorogenic acid and apigenin-7-O-glucuronide were mainly detected at 4.6 and 5.8 mg/g, respectively, in female leaves. Comparisons between male and female plants indicated moderate differences, although organ type and developmental stage had a greater influence on metabolite accumulation. This study provides a detailed quantitative profile of major polyphenolic metabolites in I. polycarpa and highlights significant tissue-and developmental-stage-dependent variation, contributing to a better understanding of the chemical diversity of this species.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149137624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and Validation of an Optimized HPLC-DAD Method for Simultaneous Quantification of 14 Bioactive Compounds in Lonicerae. HPLC-DAD同时测定金银花中14种活性成分方法的建立与验证

IF 2.1 4区医学

Planta medica Pub Date : 2026-10-07 DOI: 10.1055/a-2966-9951

Jinghua Li, Xizhe Sun, Xiaoyuan Peng, Hongjing Zhang, Ye Li

{"title":"Development and Validation of an Optimized HPLC-DAD Method for Simultaneous Quantification of 14 Bioactive Compounds in Lonicerae.","authors":"Jinghua Li, Xizhe Sun, Xiaoyuan Peng, Hongjing Zhang, Ye Li","doi":"10.1055/a-2966-9951","DOIUrl":"10.1055/a-2966-9951","url":null,"abstract":"Abstract: Lonicerae Flos, an important traditional Chinese medicine, possesses a complex chemical composition and variable bioactive compound profiles, thereby necessitating reliable analytical methods for its quality control. In this study, a novel high-performance liquid chromatography-diode array detection method was developed for the simultaneous quantification of 14 bioactive compounds in Lonicerae Flos. A two-stage optimization strategy was employed, combining gradient elution refinement with response surface methodology based on a Box-Behnken design to systematically optimize injection volume, column temperature, and flow rate. Under the optimal conditions, baseline separation of all analytes was achieved within 25 min. The validated method exhibited excellent linearity (R² > 0.9990), sensitivity (LOQ ≤ 0.40 μg/mL, LOD ≤ 0.12 μg/mL), precision (intra- and inter-day RSD ≤ 3.59%), and recovery (97.03-102.62%), with satisfactory stability over 24 h. When applied to Lonicerae Flos samples from three geographical regions, the method revealed significant variations in chlorogenic acid, neochlorogenic acid, and 3,4-dicaffeoylquinic acid, highlighting its utility for geographical origin tracing and regional quality assessment. Specifically, chlorogenic acid showed a gradual increasing trend from Xiushan and Suiyang to Longhui, whereas neochlorogenic acid and 3,4-dicaffeoylquinic acid reached their highest levels in Longhui samples. Compared with existing methods, the proposed approach demonstrates superior performance with wider analyte coverage, improved separation efficiency, and simplified sample pretreatment. Accordingly, this work provides a practical tool to address the key challenges in the quality control of this medicinal plant, particularly the complex and variable profiles of bioactive constituents, thus supporting the standardization and quality evaluation of Lonicerae Flos.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149031129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

METABOLOMIC PROFILING-BASED CHEMOTAXONOMIC EVALUATION OF THE GENUS IBERIS L. (BRASSICACEAE) IN TÜRKİYE. tÜrkİye油菜科iberis属的代谢组学分析。

IF 2.1 4区医学

Planta medica Pub Date : 2026-10-04 DOI: 10.1055/a-2973-6912

Golshan Zare, N Y Diker, Ozan Kaplan, Emre Çilden, İffet İrem Çankaya

{"title":"METABOLOMIC PROFILING-BASED CHEMOTAXONOMIC EVALUATION OF THE GENUS IBERIS L. (BRASSICACEAE) IN TÜRKİYE.","authors":"Golshan Zare, N Y Diker, Ozan Kaplan, Emre Çilden, İffet İrem Çankaya","doi":"10.1055/a-2973-6912","DOIUrl":"https://doi.org/10.1055/a-2973-6912","url":null,"abstract":"The genus Iberis L. is mainly distributed in the Mediterranean basin, with Europe representing the primary center of diversity, while a limited number of species occur in Northwest Africa and Southwest to Central Asia. The genus is represented by ten taxa in Türkiye, including four endemic taxa: Iberis carica (Bornm.) Prain, Iberis halophila Vural & H. Duman, Iberis gypsicola Yıld. and Iberis saxatilis subsp. Magnesiana Oskay. Previous studies emphasized morphology and phylogeny, whereas comprehensive metabolomic and phytochemical analyses of the genus remain limited. In this study, plant materials from prior morphological and molecular analyses underwent LC-MS-based untargeted metabolomic profiling to provide complementary chemotaxonomic evidence and evaluate how closely metabolomic patterns align with other taxonomic datasets. A total of 149 LC-MS features were putatively annotated. Primary metabolites showed high conservation across taxa, whereas secondary metabolites displayed significant interspecific variation. Multivariate analyses revealed clear clustering patterns largely consistent with molecular phylogenies and morphological data. I. sempervirens, I. saxatilis, and I. odorata formed distinct groups, and the I. simplex complex structure was reflected in metabolite-based clustering. Furthermore, the enrichment of pathways like riboflavin and tryptophan metabolism highlights the interplay between core primary metabolism and specialized secondary metabolite diversification across the investigated taxa. Metabolite profiling of Turkish Iberis taxa, combined with morphological, anatomical, and phylogenetic data, provides a valuable complementary approach for exploring chemotaxonomic relationships and chemical evolution. The findings highlight the genus as a promising bioactive source and support integrating metabolomics with other taxonomic datasets to improve chemotaxonomic interpretations within Iberis.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ruscus aculeatus Extract Inhibits Amyloid Beta Production and Upregulates the Active form of ADAM10 in Human Neural Progenitor Cells. 芦花提取物抑制β淀粉样蛋白的产生并上调人神经祖细胞中ADAM10的活性形式。

IF 2.1 4区医学

Planta medica Pub Date : 2026-10-02 DOI: 10.1055/a-2943-8874

Kenta Murata, Yoshiyuki Mizushina, Daisuke Izawa, Yasunori Matsui, Tomoko Wakabayashi, Tadafumi Hashimoto, Takeshi Iwatsubo, Yuji Matsushima

{"title":"Ruscus aculeatus Extract Inhibits Amyloid Beta Production and Upregulates the Active form of ADAM10 in Human Neural Progenitor Cells.","authors":"Kenta Murata, Yoshiyuki Mizushina, Daisuke Izawa, Yasunori Matsui, Tomoko Wakabayashi, Tadafumi Hashimoto, Takeshi Iwatsubo, Yuji Matsushima","doi":"10.1055/a-2943-8874","DOIUrl":"https://doi.org/10.1055/a-2943-8874","url":null,"abstract":"Abstract: Alzheimer's disease is characterized by the accumulation of cerebral amyloid beta (Aβ) peptides, making the inhibition of Aβ production a key therapeutic strategy. We screened a plant extract library for Aβ42 inhibitors using human neural progenitor cells and identified a Ruscus aculeatus extract as a potential candidate. Although rhizome extracts of R. aculeatus exhibit vasotonic, and anti-inflammatory properties, their effects on amyloid-β precursor protein (APP) processing have not been investigated. We aimed to elucidate how R. aculeatus extract influences Aβ production and its underlying mechanisms. R. aculeatus extract significantly reduced Aβ40 and Aβ42 production and the pathogenic Aβ42/Aβ40 ratio in both human neural progenitor (ReNcell VM) and mouse neuroblastoma (Neuro2a) cells in concentration-dependent manner. The extract enhanced non-amyloidogenic APP pathway processing, evidenced by increased levels of ADAM10 active form, soluble APPα and C-terminal fragment α levels. Despite increasing BACE1 protein levels, the extract reduced soluble APPβ production, suggesting inhibition of BACE1-mediated APP cleavage. RNA-seq analysis revealed Notch signaling pathway downregulation, implying γ-secretase activity modulation. In conclusion, the R. aculeatus extract suppresses Aβ production by modulating multiple APP processing pathways, primarily through enhancing non-amyloidogenic pathway via ADAM10 activation. By reducing amyloidogenic peptides levels, R. aculeatus extract may contribute to decreased amyloid plaques formation. These findings identify R. aculeatus extract as a modulator of APP metabolism.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149113629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glechoma hederacea: A Comprehensive Insight into the Botanical Specification, Traditional Uses, Phytochemistry, Nutritional Value, Pharmacology, and Non-medicinal Applications. hederacea：植物学规范，传统用途，植物化学，营养价值，药理学和非药物应用的综合见解。

IF 2.1 4区医学

Planta medica Pub Date : 2026-10-01 Epub Date: 2026-05-22 DOI: 10.1055/a-2866-3799

Weronika Krasocka, Monika Anna Olszewska, Anna Magiera

{"title":"Glechoma hederacea: A Comprehensive Insight into the Botanical Specification, Traditional Uses, Phytochemistry, Nutritional Value, Pharmacology, and Non-medicinal Applications.","authors":"Weronika Krasocka, Monika Anna Olszewska, Anna Magiera","doi":"10.1055/a-2866-3799","DOIUrl":"10.1055/a-2866-3799","url":null,"abstract":"Abstract: Glechoma hederacea (ground ivy) is an aromatic perennial plant extensively utilized in traditional medicine. Its therapeutic properties have been recorded in Europe since antiquity. Traditionally, it is still used to treat gastrointestinal disorders, liver/bile diseases, respiratory ailments, and skin disorders. This review presents, for the first time, an in-depth examination of ethnopharmacology, phytochemistry, botany, safety of use, biological activity, and non-medical aspects associated with ground ivy. The data were extracted through detailed probing of key databases, including PubMed, Web of Science, Scopus, and SciFinder. In addition, books, papers from conference proceedings, and websites were used. This study reveals that compounds belonging to various classes, including phenolic acids, flavonoids, lignans, alkaloids, and terpenoids, have been identified. Crude extracts, fractions, and some individual compounds have shown various pharmacological activities, including hepatoprotective, anti-inflammatory, antioxidant, anticancer, and melanogenesis-modulating effects. Apart from its value in phytotherapy, G. hederacea also shows potential as a natural pesticide and stabilizing agent in the food industry. The traditional medicinal uses of the ground ivy, combined with modern scientific research, underscore its pharmacological potential. However, future studies should incorporate relevant animal experiments and clinical studies to provide a more comprehensive assessment of the efficacy and bioavailability. Although there is a rich literature on secondary metabolites detected in G. hederacea, it seems right to fill in which compounds are determinants of a given activity. Finally, research on using G. hederacea as a natural pesticide, which could lead to its implementation, warrants further investigation.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1072-1135"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148005808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Deep Eutectic Solvent Extraction Optimization of Alkaloids from Mitragyna speciosa: A Methodological Evaluation. 天然深共熔溶剂萃取密天牛中生物碱的优化：方法学评价。

IF 2.1 4区医学

Planta medica Pub Date : 2026-10-01 Epub Date: 2026-05-20 DOI: 10.1055/a-2880-8498

Christina Koufali, Alexandros Polyzois, Marina Kritsanida, Nektarios Aligiannis, Ioanna Chinou, Nikolas Fokialakis

{"title":"Natural Deep Eutectic Solvent Extraction Optimization of Alkaloids from Mitragyna speciosa: A Methodological Evaluation.","authors":"Christina Koufali, Alexandros Polyzois, Marina Kritsanida, Nektarios Aligiannis, Ioanna Chinou, Nikolas Fokialakis","doi":"10.1055/a-2880-8498","DOIUrl":"10.1055/a-2880-8498","url":null,"abstract":"Abstract: Mitragyna speciosa (kratom) is a psychoactive plant native to Southeastern Asia, belonging to the Rubiaceae family. Traditionally, its fresh leaves have been consumed in the region for centuries due to their therapeutic properties, including pain relief. The leaves contain a variety of phytochemicals with the alkaloids being the most biologically significant constituents. In the present study-the first investigation exploring sustainable extraction methods for kratom-47 natural deep eutectic solvent (NaDES) systems were screened. The most effective system demonstrated significantly higher extraction efficiency compared to commonly used organic solvents. The food-grade system, lactic acid : glucose was subsequently selected for optimization using a one-factor-at-a-time approach, and the optimal conditions were a molar ratio of 4 : 1 and a water content of 20%. Further optimization using a Box-Behnken design and response surface methodology identified the optimal extraction conditions as a solid-to-liquid ratio of 30 mg/mL, a temperature of 70 °C and an ultrasound treatment time of 12 min. Finally, three recovery methods were evaluated: solid phase extraction (including strong cation exchange and reversed-phase types), macroporous resins (six types), and acid-base extraction. The highest recovery yields were obtained with strong cation exchange solid phase extraction (95%) followed by the macroporous resins XAD 18 and XAD 1600 N (85%).","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1136-1146"},"PeriodicalIF":2.1,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13630439/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147982719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Untargeted Metabolomics and anti-Helicobacter pylori Activity of Amphipterygium adstringens Bark: Influence of Tree Sex and Seasonal Variation. 雌雄翼状胬肉树皮的非靶向代谢组学和抗幽门螺杆菌活性：树种性别和季节变化的影响。

IF 2.1 4区医学

Planta medica Pub Date : 2026-09-22 DOI: 10.1055/a-2955-3855

Cynthia Castillo-Mendoza, Israel Castillo-Juárez, L Gerardo Zepeda-Vallejo, Erick Alejandro Herrera-Jurado, Jorge Gutiérrez, Mireya Sotelo-Barrera, Esmeralda Rangel-Vargas, Javier Castro-Rosas, Antonio García-Esteva, Lucero Del Mar Ruiz-Posadas

{"title":"Untargeted Metabolomics and anti-Helicobacter pylori Activity of Amphipterygium adstringens Bark: Influence of Tree Sex and Seasonal Variation.","authors":"Cynthia Castillo-Mendoza, Israel Castillo-Juárez, L Gerardo Zepeda-Vallejo, Erick Alejandro Herrera-Jurado, Jorge Gutiérrez, Mireya Sotelo-Barrera, Esmeralda Rangel-Vargas, Javier Castro-Rosas, Antonio García-Esteva, Lucero Del Mar Ruiz-Posadas","doi":"10.1055/a-2955-3855","DOIUrl":"https://doi.org/10.1055/a-2955-3855","url":null,"abstract":"Abstract: Cuachalalate bark (Amphipterygium spp.), relevant in Mexican herbal medicine for its gastroprotective, and anti-Helicobacter pylori effects, as well as its reported antiproliferative/cytotoxic and antitumor effects, lacks systematic studies on bioactive metabolites influenced by biotic and abiotic factors. This study used untargeted 1H NMR metabolomics to characterize chemical profiles, quantify anacardic acids and 3α-hydroxymasticadienoic acid (3α-HMDA) according to climatic season, tree sex, and bark type (stem or branch), and evaluate anti-H. pylori activity. Three hundred sixty samples from 40 juvenile-adult A. adstringens trees were collected in Chiautla de Tapia, Puebla, Mexico. Principal component analysis (PCA) and partial least squares-discriminant analysis (PLS-DA) of chemical profiles discriminated variations by collection month, tree sex, and bark type. Only minor variations in biomarker concentrations were recorded in specific cases (e.g., July > September/December [3α-HMDA: 28.9 vs. ∼19 mM; anacardic acids: 18.7 vs. ∼12 mM]; males > females in July [19.6 vs. 17.8 mM; 30.3 vs. 23.6 mM]; stem > branch in December [15.7 vs. 9.6 mM; 20.8 vs. 15.1 mM] and September [14.3 vs. 10.4 mM; 20.6 vs. 17.1 mM]), with no significant overall differences by seasonality, sex, or bark type. Despite some differences in biomarker concentrations in specific cases, anti-H. pylori activity remained stable (59.4 ± 14.6% at 0.125 mg/mL; 82.7 ± 11.8% at 0.25 mg/mL; and 99.5 ± 6.5% at 0.5 mg/mL). In conclusion, PCA/PLS-DA discriminated chemical variations by month, sex, and bark type, but biomarkers showed overall stability and consistent anti-H. pylori activity, supporting phytotherapeutic standardization.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calquiquelignan D from Attalea butyracea Exhibits Selective Cytotoxicity Against Prostate and Skin Cancer Cells with Dual ERK2/PI3Kα Inhibitory Activity. 丁酸荷叶提取物Calquiquelignan D具有ERK2/PI3Kα双抑制活性，对前列腺癌和皮肤癌具有选择性细胞毒性。

IF 2.1 4区医学

Planta medica Pub Date : 2026-09-22 DOI: 10.1055/a-2955-9684

Rofida Wahman, Anber F Mohammed, Claire Simons, Islam El-Awaad, Shaymaa M M Mohamed

{"title":"Calquiquelignan D from Attalea butyracea Exhibits Selective Cytotoxicity Against Prostate and Skin Cancer Cells with Dual ERK2/PI3Kα Inhibitory Activity.","authors":"Rofida Wahman, Anber F Mohammed, Claire Simons, Islam El-Awaad, Shaymaa M M Mohamed","doi":"10.1055/a-2955-9684","DOIUrl":"https://doi.org/10.1055/a-2955-9684","url":null,"abstract":"Skin and prostate cancers pose therapeutic challenges due to drug resistance. Attalea butyracea, a Neotropical palm with profound ethnobotanical significance, remains largely unexplored for anticancer constituents. This study aimed to isolate bioactive metabolites from A. butyracea, assess their selective cytotoxicity against A-431 and PC-3 cancer cells relative to normal cells, and explore their potential molecular targets. High-Resolution Electrospray Ionization Mass Spectrometry (HR-ESI/MS) and one- and two-dimensional nuclear magnetic resonance (1D/2D NMR) spectroscopy provided structural confirmation. Cytotoxic activity was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Computational inverse docking and molecular dynamics simulations identified probable kinase targets, which were subsequently confirmed through enzyme inhibition assays. Phytochemical investigation yielded 17 compounds, including two previously undescribed glycosides, one megastigmane, and one flavonolignan. This marks the first report of flavonolignans within Attalea. Among isolated metabolites, calquiquelignan D showed notable activity, with CC50 values of 14.9 μM (A431) and 22.5 μM (PC3), comparable to those of cisplatin. Within the ATP pockets of oncogenic kinases, this compound demonstrated stable binding patterns as determined by computational analysis. Enzyme inhibition assays confirmed dual inhibition of ERK2 and PI3Kα at nanomolar concentrations. These findings suggest potential dual-pathway modulation of survival signaling. As chemotaxonomic markers with structurally distinct scaffolds, these metabolites merit further kinase-targeted drug development.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149025768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction: The Potential of Berberine to Target Telocytes in Rabbit Heart. 更正：黄连素靶向兔心脏Telocytes的潜力。

IF 2.1 4区医学

Planta medica Pub Date : 2026-09-01 Epub Date: 2023-11-06 DOI: 10.1055/a-2198-5523

Min Yang, Tong Yang, Lu Mei, Yingxing Zhang, Chunhua Liang, Xuebing Bai, Zhenwei Zhang, Yonghong Shi, Qiusheng Chen

引用次数: 0