Planta medica最新文献

Phytochemical characterization and comparative analysis of cycloartane-type triterpenes in Astragalus adsurgens and Astragalus membranaceus.

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-25 DOI: 10.1055/a-2486-8873

Guanglian Zhou, Yin Chen, Bingyan Xu, Guoqing Peng, Li Wang, Jian-Ping Huang, Zhiyin Yu, S Huang

{"title":"Phytochemical characterization and comparative analysis of cycloartane-type triterpenes in Astragalus adsurgens and Astragalus membranaceus.","authors":"Guanglian Zhou, Yin Chen, Bingyan Xu, Guoqing Peng, Li Wang, Jian-Ping Huang, Zhiyin Yu, S Huang","doi":"10.1055/a-2486-8873","DOIUrl":"https://doi.org/10.1055/a-2486-8873","url":null,"abstract":"Astragalus adsurgens, a significant forage plant cultivated in arid regions of northwest China, remains underexplored for its triterpenoid saponins and medicinal properties compared to the extensively studied Astragalus membranaceus. To explore the phytochemical profile of A. adsurgens for its potential application in the medical field, we employed ultra-pressure liquid chromatography coupled with tandem mass spectrometry-based method to identify cycloartane-type triterpenes. Eventually, five new cycloartane-type triterpenoids, adsurgosides A‒D (1‒4) and 3-methyl-3,4-seco-cyclostellanol (5), together with two known analogues cycloastragenol (6) and cyclopycanthogenin (7), were isolated from the roots of A. adsurgens. Their structures were elucidated using 1D and 2D NMR analyses in combination with HRESIMS data. Additionally, a comparative study on the distribution patterns of these compounds revealed qualitative and quantitative variations between A. adsurgens and A. membranaceus. Our findings not only identified an alternative plant for isolating cycloartane-type triterpenoids but also offer new insights into the chemical properties of A. adsurgens.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New constituents from Zanthoxylum rhoifolium Lam.

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-25 DOI: 10.1055/a-2486-9139

Mauro Di Stasi, Valentina Parisi, Vanessa Hernandez, Erica Gazzillo, Maria Giovanna Chini, Giuseppe Bifulco, Alessandra Braca, Giuliana Donadio, Nunziatina De Tommasi

引用次数: 0

Aloe vera and the Proliferative Phase of Cutaneous Wound Healing: Status Quo Report on Active Principles, Mechanisms, and Applications. 芦荟与皮肤伤口愈合的增殖阶段：活性原理、机制和应用现状报告》。

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-20 DOI: 10.1055/a-2446-2146

Zhuang Min Lee, Bey Hing Goh, Kooi Yeong Khaw

{"title":"Aloe vera and the Proliferative Phase of Cutaneous Wound Healing: Status Quo Report on Active Principles, Mechanisms, and Applications.","authors":"Zhuang Min Lee, Bey Hing Goh, Kooi Yeong Khaw","doi":"10.1055/a-2446-2146","DOIUrl":"https://doi.org/10.1055/a-2446-2146","url":null,"abstract":"Aloe vera is commonly used as traditional medicine for cutaneous wound healing. Nonetheless, the wound healing mechanisms of Aloe vera remain unclear. This review aims to provide insight into the molecular mechanisms of Aloe vera in promoting cutaneous wound healing, with particular emphasis on the mechanisms that stimulate cell proliferation and migration. Aloe vera has been shown to upregulate growth factors such as keratinocyte growth factor-1 (KGF-1), transforming growth factor-β (TGF-β), cyclin D1, insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), basic fibroblastic growth factor (bFGF), and microfibril-associated glycoprotein 4 (MFAP4), as well as collagen, fibrillin, elastin, α-smooth muscle actin (α-SMA), integrins, and platelet endothelial cell adhesion molecule 1 (PECAM-1, also known as CD31), while downregulating the expression of matrix metalloproteinases (MMPs). In addition, Aloe vera was also found to upregulate PI3K/Akt and MAPK pathways, as well as the TGF-β signalling pathway via Smad proteins. Furthermore, molecular docking studies revealed that certain chemical constituents of Aloe vera bind to some of the forementioned growth factors or signalling molecules. With regards to current applications, although human clinical trials have reported positive results from using Aloe vera in healing open wounds and burns and alleviating some inflammatory skin diseases, the current commercial uses of Aloe vera remain largely focused on cosmetic products. Thus, greater advances are required to promote the use of Aloe vera products in clinical settings.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Turkish Astragalus Species: Botanical Aspects, Secondary Metabolites, and Biotransformation. 土耳其黄芪品种：植物学方面、次级代谢物和生物转化。

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-13 DOI: 10.1055/a-2444-3252

Güner Ekiz Dinçman, Zeki Aytaç, İhsan Çalış

{"title":"Turkish Astragalus Species: Botanical Aspects, Secondary Metabolites, and Biotransformation.","authors":"Güner Ekiz Dinçman, Zeki Aytaç, İhsan Çalış","doi":"10.1055/a-2444-3252","DOIUrl":"https://doi.org/10.1055/a-2444-3252","url":null,"abstract":"Astragalus is a widespread genus comprising approximately 3500 species, both annual and perennial, found across Asia, Europe, Africa, and the Americas. In Turkey, it is represented by 63 sections and 485 taxa with a high endemism ratio (51%). In traditional medicine, the roots of various Astragalus species represent very old and well-known drugs used for antiperspirant, diuretic, and tonic purposes, as well as for the treatment of nephritis, diabetes, leukemia, and uterine cancer. The genus Astragalus is the richest source of cycloartane-type compounds, which display a diverse range of bioactivities, such as wound healing, immunomodulatory, antitumor, hepatoprotective, antimutagenic, antiviral, and antiprotozoal activities. Moreover, cycloastragenol, the main sapogenol of many cycloartane-type glycosides found in the Astragalus genus, has gained attention as a potent telomerase activator over the past decade. The preparation of cycloastragenol derivatives could be significant in the near future due to their unique bioactivity. This review covers the botanical aspects of Astragalus L., as well as the phytochemical and biological activity studies conducted on Turkish Astragalus species, with a special focus on cycloartenols. It contains 36 articles reporting the phytochemistry of 29 Astragalus species and 111 new compounds, including 104 triterpene saponins. In addition to the phytochemical studies, this review summarizes the biotransformation studies on Astragalus cycloartanes via endophytic fungi isolated from the tissues of Astragalus species.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Betulinic Acid Acts in Synergism with Imatinib Mesylate, Triggering Apoptosis in MDR Leukemia Cells. 白桦脂酸与甲磺酸伊马替尼协同作用，引发 mdr 白血病细胞凋亡。

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-12 DOI: 10.1055/a-2440-4847

Claudia Stutz, Ana Paula Gregório Alves Fontão, Gustavo Werneck de Souza E Silva, Leonardo Noboru Seito, Renata Trentin Perdomo, André Luiz Franco Sampaio

{"title":"Betulinic Acid Acts in Synergism with Imatinib Mesylate, Triggering Apoptosis in MDR Leukemia Cells.","authors":"Claudia Stutz, Ana Paula Gregório Alves Fontão, Gustavo Werneck de Souza E Silva, Leonardo Noboru Seito, Renata Trentin Perdomo, André Luiz Franco Sampaio","doi":"10.1055/a-2440-4847","DOIUrl":"10.1055/a-2440-4847","url":null,"abstract":"Chronic myeloid leukemia (CML) is a myeloproliferative disease, characterized by the presence of the oncogene BCR-ABL. Imatinib mesylate (IMA) is the first-line treatment for CML, and some treatment resistance has been reported. Natural products are rich sources of bioactive compounds with biological effects, opening a possibility to alter cell susceptibility to drugs such as imatinib. Herein, we evaluated the interference of betulinic acid and ursolic acid in glycoprotein P (P-gp) activity and the possible synergistic effect when associated with IMA by the Chou-Talalay method. Ursolic acid presented an IC50 of 14.0 µM and 19.6 µM for K562 and Lucena 1, respectively, whilst betulinic acid presented an IC50 of 8.6 µM and 12.5 µM for these cell lines. Evaluation of the combination of terpenoids and imatinib mesylate revealed that ursolic acid or betulinic acid acts in synergism with IMA, as indicated by the combination indexes (CI<1). Analysis of annexin V labeling demonstrated that a combination of IMA with betulinic acid enhances the inhibition on cell proliferation via the apoptosis pathway, with caspases 3/7 activation after 24 hours of treatment and inhibition of the STAT5/survivin pathway, decreasing cell viability. The combination of natural products and IMA on a multidrug-resistant leukemia cell line is a promising strategy for CML treatment.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracts of Drynariae Rhizoma Promote Bone Formation in OVX Rats through Modulating the Gut Microbiota. 旱莲草提取物通过调节肠道微生物群促进卵巢切除大鼠的骨形成

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-05 DOI: 10.1055/a-2462-4844

Qing Lin, Xinchen Ouyang, Qi Pan, Jiajia Huang, Zhifen Zhang, Yumei Yang, Haoyu Wang, Li Yang, Xiaofeng Zhu, Xiaoyun Li, Rong-Hua Zhang

{"title":"Extracts of Drynariae Rhizoma Promote Bone Formation in OVX Rats through Modulating the Gut Microbiota.","authors":"Qing Lin, Xinchen Ouyang, Qi Pan, Jiajia Huang, Zhifen Zhang, Yumei Yang, Haoyu Wang, Li Yang, Xiaofeng Zhu, Xiaoyun Li, Rong-Hua Zhang","doi":"10.1055/a-2462-4844","DOIUrl":"https://doi.org/10.1055/a-2462-4844","url":null,"abstract":"Drynariae Rhizoma (DR) has been commonly used as a preventive and therapeutic agent for bone diseases. However, its pharmacological mechanisms have not been fully elucidated. Here, we aimed to investigate the effects of DR in a bilateral ovariectomized (OVX) rat model and explore the correlation with the gut microbiome. We established an OVX rat model and treated with different doses of DR (DR-L, 0.27 g/kg/day; DR-M, 0.81 g/kg/day; DR-H, 2.43 g/kg/day) through intragastric administration for 12 weeks. Results showed that DR alleviated body weight, moderated bone microstructure, and promoted the expression of bone formation related factors in OVX rats, in which DR-H behaved the most significant effects among the three doses. Furthermore, the effects of DR on promoting bone formation were correlated to the changes in microbial richness and the restorations of several genera, among which Ruminiclostridium and Ruminococcaceae_UCG_007 were positively correlated with the bone formation related factors, and both of them enriched in DR-H group as biomarker. Moreover, CMP-legionaminate biosynthesis I might be a crucial pathway of DR regulates gut microbiota, and the content of serum short-chain fatty acids in OVX rats were regulated by DR. Our results demonstrated that DR promoted bone formation in OVX rats, and it was related to the regulation of the gut microbiota structure.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory Activity of Labdane and Norlabdane Diterpenoids from Leonurus sibiricus Related to Modulation of MAPKs Signaling Pathway. 西比露中的拉布丹和诺拉布丹二萜类化合物的抗炎活性与调节 MAPKs 信号通路有关

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-04 DOI: 10.1055/a-2440-5166

Nguyen Minh Trang, Le Ba Vinh, Nguyen Viet Phong, Seo Young Yang

{"title":"Anti-Inflammatory Activity of Labdane and Norlabdane Diterpenoids from Leonurus sibiricus Related to Modulation of MAPKs Signaling Pathway.","authors":"Nguyen Minh Trang, Le Ba Vinh, Nguyen Viet Phong, Seo Young Yang","doi":"10.1055/a-2440-5166","DOIUrl":"10.1055/a-2440-5166","url":null,"abstract":"Leonurus sibiricus, a widely cultivated herbaceous plant in Asian countries, exhibits diverse medicinal applications. Recent studies emphasize its pharmacological properties and efficacy in promoting bone health. In addition to the known compounds and their pharmacological activities, in this study, we isolated and elucidated two new labdane-type diterpenoids, (3R,5R,6S,10S)-3,6-dihydroxy-15-ethoxy-7-oxolabden-8(9),13(14)-dien-15,16-olide (1: ) and (4R,5R,10S)-18-hydroxy-14,15-bisnorlabda-8-en-7,13-dione (2: ), a new natural phenolic compound, and a known compound from L. sibiricus using advanced spectroscopic techniques, including circular dichroism spectroscopy, high-resolution mass spectrometry, and 1- and 2-dimensional NMR. Among these, compound 1: demonstrated potent inhibition of nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) mRNA expression levels, followed by compound 2: . Whereas compounds 3: and 4: did not exhibit effectiveness in RAW264.7 macrophages. Moreover, compound 1: suppressed pro-inflammatory markers induced by lipopolysaccharide (LPS) stimulation. Compound 1: also suppressed iNOS and cyclooxygenase-2 (COX-2) protein levels and downregulated pro-inflammatory cytokines. Additionally, compound 1: showed inhibition of the phosphorylation of p38, JNK, and ERK, key mediators of the MAPK signaling pathway. These findings indicate that a natural-derived product, compound 1,: might be a potential candidate as an anti-inflammation mediator.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Basic Requirements and Framework Conditions of Real-World Data (RWD) on Herbal Medicinal Products. 草药产品真实世界数据 (RWD) 的基本要求和框架条件。

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-01 Epub Date: 2024-09-25 DOI: 10.1055/a-2409-3125

Salome Sophie Hölzle, Thorsten Reineke, Stefan Hoch, Bernd Roether, Matthew Francis, Christelle Anquez-Traxler, Nico Symma

引用次数: 0

Correction: Immunomodulatory activity and inhibitory effects of Viscum album on cancer cells, its safety profiles and recent nanotechnology development. 更正：白花蛇舌草的免疫调节活性和对癌细胞的抑制作用、其安全性概况以及最新的纳米技术发展。

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-01 Epub Date: 2024-10-10 DOI: 10.1055/a-2423-9185

Ibrahim Jantan, Nermeen Yosri, Nurkhalida Kamal, Ahmed Mediani, Sameh AbouZid, Ahmed Swillam, Mahmoud Swilam, Ahmed M Ayyat

引用次数: 0

Immunomodulatory Activity and Inhibitory Effects of Viscum album on Cancer Cells, Its Safety Profiles and Recent Nanotechnology Development. 白花蛇舌草的免疫调节活性和对癌细胞的抑制作用、其安全性概况以及最新的纳米技术发展。

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-01 Epub Date: 2024-09-23 DOI: 10.1055/a-2412-8471

Nermeen Yosri, Nurkhalida Kamal, Ahmed Mediani, Sameh AbouZid, Ahmed Swillam, Mahmoud Swilam, Ahmed M Ayyat, Ibrahim Jantan

{"title":"Immunomodulatory Activity and Inhibitory Effects of Viscum album on Cancer Cells, Its Safety Profiles and Recent Nanotechnology Development.","authors":"Nermeen Yosri, Nurkhalida Kamal, Ahmed Mediani, Sameh AbouZid, Ahmed Swillam, Mahmoud Swilam, Ahmed M Ayyat, Ibrahim Jantan","doi":"10.1055/a-2412-8471","DOIUrl":"10.1055/a-2412-8471","url":null,"abstract":"Viscum album has been employed traditionally to treat various ailments including as add-on therapy for cancer treatment. V. album formulations have been employed as adjuvants in cancer treatment due to their immunomodulatory activities as well as to alleviate the side effects of conventional cancer therapies. The present review provides updated information from the past 10 years on the immunomodulatory activity and inhibitory effects of V. album on cancer cells, its safety profile, and recent nanotechnology development. V. album extracts and their bioactive phytochemicals, particularly lectins, viscotoxins, and polyphenols, have demonstrated immunomodulatory activity and inhibitory effects against various types of cancer, with low cytotoxicity and side effects, in experimental studies and demonstrated promising anticancer activity in clinical studies in cancer patients. V. album extracts have been shown to enhance immune function by promoting cytokine secretion and inducing both innate and adaptive immune responses, which can help improve immune surveillance against cancer cells. The development of V. album nanoparticles has boosted their biological activities, including inhibitory activity on cancer cells, and could possibly reduce undesired side effects of the plant. Further prospective studies on the plant as a source of new medicinal agents for use as an adjuvant in the treatment of cancer must be performed to provide sufficient efficacy and safety data.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1059-1079"},"PeriodicalIF":2.1,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0