Planta medica最新文献

Chemical Structural Elucidation and Immunomodulatory Activity of a New Polysaccharide from Saposhnikoviae Radix. 无患子新多糖的化学结构解析和免疫调节活性

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-03 DOI: 10.1055/a-2573-7718

Yifang Cui, Haitao Fan, Sun Meng, Xinyang He, Jie Li, Guangzhong Tu, Jiang Yanyan, Bin Liu

引用次数: 0

Complex Standard Formulation as an Example for Synergism and Improved Antibacterial Activity Against Uropathogenic Escherichia coli for Urinary Tract Infections.

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-03 DOI: 10.1055/a-2563-7503

Steffen Boertz, Madhubani Dey, Fabian Herrmann, Stefan Esch, Jandirk Sendker, Ulrich Dobrindt, Andreas Hensel

{"title":"Complex Standard Formulation as an Example for Synergism and Improved Antibacterial Activity Against Uropathogenic Escherichia coli for Urinary Tract Infections.","authors":"Steffen Boertz, Madhubani Dey, Fabian Herrmann, Stefan Esch, Jandirk Sendker, Ulrich Dobrindt, Andreas Hensel","doi":"10.1055/a-2563-7503","DOIUrl":"10.1055/a-2563-7503","url":null,"abstract":"For the treatment of urinary tract infections, mixtures of different herbal materials are frequently used within traditional clinical practice. A complex formulation, widely used in Germany for the preparation of aqueous extracts with Betula sp., Agropyron repens, Solidago gigantea, and Ononis spinosa, was infused as a mixture from all four components (combined extract). In addition, the four herbs were extracted separately, and the extracts were mixed subsequently (separate extract). None of the extracts influenced the proliferation of UPEC-UTI89 and the cell viability of T24 bladder cells. The combined extract significantly reduced the activity of type-1 fimbriae of UPEC CFT073. This effect was not observed for the mixture of the separately extracted herbs. Systematic investigation of the combined extract and binary mixtures by LC-MS and bioassays indicated that a series of malonylated dammarane triterpenes from Betula spp. leaves was extracted in the presence of Solidago sp. These dammaranes are responsible for the antiadhesive effect. The combined extract of Betula sp. and Solidago gigantea BSC, as well as a dammarane-enhanced fraction (DEF), showed significant antiadhesive effects in a 2D-adhesion assay, as well as in three-dimensional RT4- bladder cell spheroids. RT-qPCR of UTI89 incubated with DEF indicated downregulation of fimC, fimD, and fimH with impact on the chaperone-usher system and correct pili formation. Increased expression of the motility gene fliC indicates a switch from a static to a motile lifestyle. The S-fimbrial gene sfaG was significantly downregulated, but this did not result in phenotypic changes. Based on an improved extraction of birch leaf constituents, the data rationalize the importance of combinations of herbal drugs.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143670335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Data to Document the Use of Herbal Medicinal Products in Children - Report of a Workshop in Krakow.

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-02-11 DOI: 10.1055/a-2523-3856

Nico Symma, Andreas Hensel, Bernd Roether, Barbara Steinhoff, Rudolf Bauer

{"title":"Real-World Data to Document the Use of Herbal Medicinal Products in Children - Report of a Workshop in Krakow.","authors":"Nico Symma, Andreas Hensel, Bernd Roether, Barbara Steinhoff, Rudolf Bauer","doi":"10.1055/a-2523-3856","DOIUrl":"10.1055/a-2523-3856","url":null,"abstract":"The workshop \"Real-world data to document the use of phytopharmaceuticals in children\" was organized by the GA Foundation Plants for Health in collaboration with multiple international scientific societies on July 14, 2024, during the International Congress on Natural Products Research in Kraków, Poland. The event focused on leveraging real-world data and real-world evidence to support the use of herbal medicinal products (syn. phytopharmaceuticals) in pediatric care. The workshop aimed to discuss the current state and future approaches for utilizing real-world data/real-world evidence in expanding the use of herbal medicinal products in children and adolescents. Therefore, the workshop highlighted the unmet needs and challenges in documenting the effectiveness and safety of herbal medicinal products in children and emphasized the coordinated exchange and collaboration among academia, industry, and regulatory authorities. After an e-symposium in May 2022 with more than 300 participants and an in-person workshop on this topic in Bonn in June 2023, this workshop in Krakow was the third event of its kind hosted by the Foundation Plants for Health. Participants concluded that interdisciplinary collaboration is highly needed to establish qualified methods of data collection and assessment of real-world data, e.g., establishing requirements to incorporate nonprescription herbal medicinal products into electronic patient records and registries that can be accessed by all stakeholders.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"167-172"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combating Inflammation and Oxidative Stress: Exploring the Cellular Effects of Lonicera caerulea var. kamtschatica Extract. 抗炎症和氧化应激：探索金银花提取物的细胞作用。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-01-19 DOI: 10.1055/a-2520-0013

Katarzyna Zima, Laura Banaszkiewicz, Mateusz Kacper Woźniak, Barbara Khaidakov, Krzysztof Lemke, Paulina Kowalczyk

{"title":"Combating Inflammation and Oxidative Stress: Exploring the Cellular Effects of Lonicera caerulea var. kamtschatica Extract.","authors":"Katarzyna Zima, Laura Banaszkiewicz, Mateusz Kacper Woźniak, Barbara Khaidakov, Krzysztof Lemke, Paulina Kowalczyk","doi":"10.1055/a-2520-0013","DOIUrl":"10.1055/a-2520-0013","url":null,"abstract":"Lonicera caerulea var. kamtschatica, known as blue honeysuckle or haskap berry, is rich in bioactive compounds such as polyphenols, flavonoids, and anthocyanins, which are linked to various health benefits, including anti-inflammatory and antioxidant properties. The research specifically investigates the effects of an L. caerulea var. kamtschatica extract that has been standardized to contain a minimum of 15% anthocyanins on inflammation and oxidative stress at the cellular level. In vitro studies using A549 human lung epithelial cells and peripheral blood mononuclear cells demonstrated the extract's anti-inflammatory and antioxidant properties. L. caerulea var. kamtschatica extract significantly inhibited the nuclear translocation of NF-κB p65 and reduced the production of IL-8 in A549 cells. It also downregulated the expression of proinflammatory genes (RELA and PTGS2) while upregulating antioxidant genes (CAT, HMOX1, and SOD2). In peripheral blood mononuclear cells, L. caerulea var. kamtschatica extract decreased the phosphorylation of NF-κB p65 and reduced the levels of proinflammatory cytokines IL-1β and IL-6 following lipopolysaccharide stimulation. Additionally, the extract inhibited reactive oxygen species formation and nitric oxide production, demonstrating its potential to modulate oxidative stress. Furthermore, in vitro assays indicated that L. caerulea var. kamtschatica extract could hinder the binding of SARS-CoV-2 spike protein to the hACE2 receptor, suggesting antiviral potential.These findings suggest that L. caerulea var. kamtschatica extract exerts significant anti-inflammatory and antioxidant effects, indicating its potential as a functional food ingredient or dietary supplement to combat inflammation and oxidative stress.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"208-221"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roseoglobuloside A, a Novel Nonanolide, and Identification of Specialized Metabolites as hPTP1B1 - 400 Inhibitors from Mangrove-Dwelling Aspergillus spp.

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI: 10.1055/a-2515-9491

Carlos A Fajardo-Hernández, Ángeles G Zavala-Sierra, Verenice I Merlin-Lucas, Jesús I Morales-Jiménez, José Rivera-Chávez

{"title":"Roseoglobuloside A, a Novel Nonanolide, and Identification of Specialized Metabolites as hPTP1B1 - 400 Inhibitors from Mangrove-Dwelling Aspergillus spp.","authors":"Carlos A Fajardo-Hernández, Ángeles G Zavala-Sierra, Verenice I Merlin-Lucas, Jesús I Morales-Jiménez, José Rivera-Chávez","doi":"10.1055/a-2515-9491","DOIUrl":"10.1055/a-2515-9491","url":null,"abstract":"An approach combining enzymatic inhibition and untargeted metabolomics through molecular networking was employed to search for human recombinant full-length protein tyrosine phosphatase 1B (hPTP1 B1 - 400) inhibitors from a collection of 66 mangrove-associated fungal taxa. This strategy prioritized two Aspergillus strains (IQ-1612, section Circumdati, and IQ-1620, section Nigri) for further studies. Chemical investigation of strain IQ-1612 resulted in the isolation of a new nonanolide derivative, roseoglobuloside A (1: ), along with two known metabolites (2: and 3: ), whereas strain IQ-1620 led to the isolation of four known naphtho-γ-pyrones and one known diketopiperazine (4: -8: ). Of all isolates, compounds 2, 3: , and 7: showed a marked inhibitory effect on hPTP1B1 - 400 with an IC50 value < 20 µM, while 6: showed moderate inhibition with IC50 of 65 µM. Compounds 1: and 8: were inactive at a concentration of 100 µM, whereas 4: and 5: demonstrated significant inhibition at 20 µM. The structure of 1: was established by comprehensive spectroscopic analysis, and its relative and absolute configuration was assigned based on NOE correlations and by comparison of calculated and experimental ECD curves. Molecular docking indicated that these molecules primarily bind to two different allosteric sites, thereby inducing conformational changes that impact enzymatic activity.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"197-207"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytoestrogens and Sirtuin Activation for Renal Protection: A Review of Potential Therapeutic Strategies. 植物雌激素和Sirtuin激活对肾脏保护：潜在治疗策略的综述。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2024-12-03 DOI: 10.1055/a-2464-4354

Debojyoti Mandal, Nahid Akhtar, Sana Shafi, Jeena Gupta

{"title":"Phytoestrogens and Sirtuin Activation for Renal Protection: A Review of Potential Therapeutic Strategies.","authors":"Debojyoti Mandal, Nahid Akhtar, Sana Shafi, Jeena Gupta","doi":"10.1055/a-2464-4354","DOIUrl":"10.1055/a-2464-4354","url":null,"abstract":"Significant health and socio-economic challenges are posed by renal diseases, leading to millions of deaths annually. The costs associated with treating and caring for patients with renal diseases are considerable. Current therapies rely on synthetic drugs that often come with side effects. However, phytoestrogens, natural compounds, are emerging as promising renal protective agents. They offer a relatively safe, effective, and cost-efficient alternative to existing therapies. Phytoestrogens, being structurally similar to 17-β-estradiol, bind to estrogen receptors and produce both beneficial and, in some cases, harmful health effects. The activation of sirtuins has shown promise in mitigating fibrosis and inflammation in renal tissues. Specifically, SIRT1, which is a crucial regulator of metabolic activities, plays a role in protecting against nephrotoxicity, reducing albuminuria, safeguarding podocytes, and lowering reactive oxygen species in diabetic glomerular injury. Numerous studies have highlighted the ability of phytoestrogens to activate sirtuins, strengthen antioxidant defense, and promote mitochondrial biogenesis, playing a vital role in renal protection during kidney injury. These findings support further investigation into the potential role of phytoestrogens in renal protection. This manuscript reviews the potential of phytoestrogens such as resveratrol, genistein, coumestrol, daidzein, and formononetin in regulating sirtuin activity, particularly SIRT1, and thereby providing renal protection. Understanding these mechanisms is crucial for designing effective treatment strategies using naturally occurring phytochemicals against renal diseases.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"146-166"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green Tea Catechins: A Promising Anticancer Approach for Leukaemia.

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI: 10.1055/a-2535-2003

Łukasz Mazur, Radosław Balwierz, Krzysztof Michalak, Wojciech Michalak, Agata Jasińska-Balwierz, Mariia Shanaida, Paweł Biernat, Tomasz Baj, Izabela Jasicka-Misiak

引用次数: 0

Eleutherococcus senticosus Alleviates Aristolochic-Acid-Induced Acute Kidney Damage by Inhibiting the NLRP3/IL-1β Signaling Pathway in Mice.

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-01-24 DOI: 10.1055/a-2517-9234

Jian-Hui Zhang, Mei-Zhu Gao, Qian Chen, Ting Chen, Dan-Dan Ruan, Min Wu, Fang-Meng Huang, Jie-Wei Luo, Yao-Bin Zhu, Li Chen

{"title":"Eleutherococcus senticosus Alleviates Aristolochic-Acid-Induced Acute Kidney Damage by Inhibiting the NLRP3/IL-1β Signaling Pathway in Mice.","authors":"Jian-Hui Zhang, Mei-Zhu Gao, Qian Chen, Ting Chen, Dan-Dan Ruan, Min Wu, Fang-Meng Huang, Jie-Wei Luo, Yao-Bin Zhu, Li Chen","doi":"10.1055/a-2517-9234","DOIUrl":"10.1055/a-2517-9234","url":null,"abstract":"Eleutherococcus senticosus (ES) exerts various pharmacological effects, including renoprotection in a rat model of renal ischemia-reperfusion injury. However, the mechanisms of these effects remain unclear. Therefore, we investigated the effects and mechanisms of ES on aristolochic acid (AA)-induced acute kidney injury in mice. The experimental mice were divided into the control group, the model group (AA-induced acute kidney injury model), the model + ES group (Eleutherococcus senticosus boiled-free granules treated by gavage for two weeks), the model + fasudil group (fasudil administered intraperitoneally for three days), and the model + ES + fasudil group. After AA intervention in normal mice, the expression of ASC and NLRP3 and the levels of IL-1β, IL-18, and TNF-α were significantly elevated in mouse renal tissues (P < 0.05). However, AA-induced renal dysfunction was ameliorated by both ES and fasudil, which was confirmed by the decrease in serum creatinine and blood urea nitrogen levels, as well as by renal histopathological abnormalities such as renal tubule dilation and tubular formation. In addition, the inflammatory response of AA-induced renal inflammation was inhibited by both ES and fasudil, and the expression of ASC and NLRP3 and the levels of IL-1β, IL-18, and TNF-α were significantly higher in mouse renal tissues after the treatment of either ES or fasudil (P < 0.05). ES may be a potential treatment agent for aristolochic-acid-triggered nephropathy, with inhibition of the NLRP3/IL-1β as one plausible underlying mechanism.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"189-196"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Compounds against Mpox: Mapping Evidence and Identifying Gaps.

IF 2.1 4区医学

Planta medica Pub Date : 2025-03-25 DOI: 10.1055/a-2560-1844

Amin Sharifan

{"title":"Natural Compounds against Mpox: Mapping Evidence and Identifying Gaps.","authors":"Amin Sharifan","doi":"10.1055/a-2560-1844","DOIUrl":"10.1055/a-2560-1844","url":null,"abstract":"The global spread of Mpox necessitates exploration of novel treatment options. Considering the established history of herbal medicine in managing infectious diseases, this study reviewed the literature on phytotherapy for Mpox, addressing gaps in evidence-based herbal interventions. A thorough search was conducted across the Scopus, PubMed, and Cochrane databases, as well as grey literature, up to August 2024 to retrieve studies on natural compounds with potential efficacy against Mpox and its associated symptoms. Data were analysed for publication characteristics, the compounds or herbal plants investigated, and their effects on the virus. A total of 37 articles with 242 citations were identified, demonstrating a steady increase in research activity since the first study in 2011, peaking in 2023 with 21 publications and 114 citations. The majority of studies originated from Southeast Asian countries. In terms of study design, most investigations were in silico (n = 31, 84%), followed by in vitro studies (n = 4, 11%), with no in vivo or clinical interventions reported. The primary focus was on the antiviral activities of natural products, with polyphenols identified as the most prevalent lead compounds. Whilst these findings highlight the growing interest in phytotherapy for Mpox, they also underscore the predominance of computational studies. To build upon this foundation of in silico evidence, further laboratory and animal studies are imperative for translating these insights into clinical applications. The comprehensive library of compounds gathered through this research provides a valuable resource to facilitate this crucial next step in the development of herbal interventions against Mpox.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Angelicone Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota.

IF 2.1 4区医学

Planta medica Pub Date : 2025-03-24 DOI: 10.1055/a-2565-6197

Chengwei Ruan, Weiwei Gao, Guoguo Wang, Fan Wenting, Wei-Feng Zhang, Shuang Tao, Zheng Wu

{"title":"Angelicone Ameliorates Ulcerative Colitis in Mice via Modulating Gut Microbiota.","authors":"Chengwei Ruan, Weiwei Gao, Guoguo Wang, Fan Wenting, Wei-Feng Zhang, Shuang Tao, Zheng Wu","doi":"10.1055/a-2565-6197","DOIUrl":"https://doi.org/10.1055/a-2565-6197","url":null,"abstract":"Ulcerative colitis (UC) is a persistent, periodically reoccurring inflammatory condition that impacts the gastrointestinal tract. Angelicone, a principal compound extracted from Angelica sinensis, may offer a potential alternative therapeutic approach for UC through the downregulation of inflammatory mediators. Nonetheless, the pharmacological impacts and molecular pathways of angelicone in UC management, particularly in relation to gut microbiota, remain unexplored. The current study scrutinized the modifications in gut microbiota in mice afflicted with UC, induced by 3% dextran sodium sulfate (DSS), utilizing 16S rRNA sequencing. The study demonstrated that angelicone (100mg/kg) substantially enhanced clinical indices, mitigated colonic damage, decreased cytokine levels, and reestablished the integrity of the intestinal epithelial barrier in UC mice. Furthermore, we discerned distinct bacterial genera that were responsive to angelicone treatment. Importantly, angelicone augmented the abundance of gut microbiota and partially reinstated the disrupted intestinal microbial composition, inclusive of the phyla Proteobacteria, Firmicutes, and Bacteroidetes. To summarize, our research offers novel perspectives into the intervention mechanisms of angelicone in the treatment of UC.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0