Planta medica最新文献

{"title":"Correction: Withaphysalin Derivatives from Iochroma arborescens Induce Antiproliferative and Antimigratory Activities in vitro.","authors":"Rodrigo Elísio de Sá, Gisele Santos de Araújo, Fabrício Dos Santos Machado, Jessica Maria Teles Souza, Ayslan Batista Barros, Francisco das Chagas Lima Pinto, Joana Deyse Lima Agostinho, Alejandro Pedro Ayala, José Delano Barreto Marinho Filho, Otília Deusdênia Loiola Pessoa, Ana Jérsia Araújo","doi":"10.1055/a-2407-3066","DOIUrl":"10.1055/a-2407-3066","url":null,"abstract":"","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"e3"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142293213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function.","authors":"André Nogueira Cardeal Dos Santos, José Ednésio da Cruz Freire, Bruna Ferreira Rodrigues, Francisco Walber Ferreira-da-Silva, José Eduardo Ribeiro Honório Júnior, José Henrique Leal Cardoso, Andrelina Noronha Coelho de Souza","doi":"10.1055/a-2426-9835","DOIUrl":"10.1055/a-2426-9835","url":null,"abstract":"","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"e2"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142392475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction: Phaeosphaeride A Isolated from an Endophytic Paraphoma sp. Alleviates ABCG2-mediated Resistance to Mitoxantrone in Breast Cancer Cells.","authors":"Alireza Tavakkoli, Hojjat Mortazavi, Mehrdad Iranshahi, Fatemeh Kalalinia, Khadijeh Jamialahmadi, Jon S Thorson, Khaled A Shaaban, Fatemeh Mosaffa","doi":"10.1055/a-2827-5623","DOIUrl":"10.1055/a-2827-5623","url":null,"abstract":"","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"e4"},"PeriodicalIF":2.1,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147444574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolomic and Cardiotoxicity Analyses of American Aconitum Compared to Related Asian and European Species.","authors":"Yi Zhao, Nathalia G Holtzman, Edward J Kennelly","doi":"10.1055/a-2933-1425","DOIUrl":"https://doi.org/10.1055/a-2933-1425","url":null,"abstract":"<p><p><i>Aconitum</i> species have been used as traditional medicines in Asian countries for millennia, and contain well-characterized bioactive diterpenoid alkaloids. In contrast, American <i>Aconitum</i> species have been less studied, despite their close phylogenetical relationship to the important Asian medicinal species. This study aims to investigate the chemistry and bioactivity of American <i>Aconitum</i>, since they also produce diterpenoid alkaloids that possess toxicity. The chemical profiles of three American <i>Aconitum</i> species, <i>A. delphiniifolium</i>, <i>A. columbianum</i>, and <i>A. uncinatum</i>, and their four individual plant parts (roots, stems, leaves, and flowers) were studied using UPLC-qTof-MS^e technique, and compared to Asian and European species. Multivariate including principal component analysis (PCA) and orthogonal partial least squares discriminant analysis (OPLS-DA) were used to analyze the chemical profiles. PCA suggests that American <i>Aconitum</i> is more chemically similar to Asian than European species. Using OPLS-DA, 29 unique marker compounds were found in American <i>Aconitum</i>, but not in the Asian or European species, we studied. Nineteen marker compounds were tentatively identified using Progenesis Qi and reference standards, including proved analgesic compounds such as talatisamine and 14-benzoyltalatisamine as well as other bioactive compounds. The results suggest that American <i>Aconitum</i> is a potential source for lead drugs. The cardiotoxicity of American <i>Aconitum</i> root extracts (200 μg/mL) was assessed using a zebrafish embryo model, and compared to the most widely used Asian species, <i>A. carmichaelii</i>. <i>Aconitum delphiniifolium</i> did not show any cardiotoxicity in this zebrafish model, as compared to <i>A. carmichaelii</i> and the control compound, aconitine. However, <i>A. columbianum</i> and <i>A. uncinatum</i> induced some morphological heart differences but not as profoundly as <i>A. carmichaelii</i>.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148796765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tetrandrine Alleviates Allergic Rhinitis via REV-ERBα-Dependent Acetylcholine.","authors":"Luomin Lin, Tingying Hao, Xiaowen Liu, Haiman Xu, Dong Dong","doi":"10.1055/a-2896-7569","DOIUrl":"https://doi.org/10.1055/a-2896-7569","url":null,"abstract":"<p><strong>Abstract: </strong>Allergic rhinitis is a prevalent chronic inflammatory disorder of the nasal mucosa, imposing substantial medical and socioeconomic burdens. Thus, there is an urgent need to develop novel agents capable of both symptom relief and immune modulation. This study elucidates the mechanism by which tetrandrine alleviates allergic rhinitis through REV-ERB<i>α</i> activation and cholinergic pathway suppression. In ovalbumin-induced allergic rhinitis mice, intranasal tetrandrine significantly reduced sneezing frequency and nasal scratching versus controls, while decreasing serum histamine and substance P levels. Mechanistically, tetrandrine dose-dependently upregulated the mRNA and protein expression of REV-ERB<i>α</i> in nasal mucosa, enhancing its transcriptional repression in Gal4 reporter assays. Genetic ablation of <i>Rev-erbα</i> abolished tetrandrine's efficacy, exacerbating allergic rhinitis symptoms and inflammatory mediators. Crucially, tetrandrine suppressed choline acetyltransferase expression in nasal mucosa, reducing the level of acetylcholine; this effect was diminished by <i>α</i>-NETA (choline acetyltransferase inhibitor) pretreatment. This confirmed the essential role of REV-ERB<i>α</i>-dependent suppression of choline acetyltransferase-mediated acetylcholine synthesis in tetrandrine's therapeutic effect on allergic rhinitis. These findings establish tetrandrine as a novel agent targeting the circadian clock pathway and the circadian-allergy crosstalk, providing a new therapeutic strategy for allergic rhinitis.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive Styrylchromones and a Suberin Derivative from the Staminate Flowers of Carex kobomugi.","authors":"Naohito Abe, Satoshi Endo, Shinnosuke Ayabe, Manami Haba, Masayoshi Oyama","doi":"10.1055/a-2919-5077","DOIUrl":"https://doi.org/10.1055/a-2919-5077","url":null,"abstract":"<p><strong>Abstract: </strong><i>Carex kobomugi</i> is a dioecious perennial sedge native to coastal sand dunes in temperate northeastern Asia. While previous phytochemical investigations of this species have focused exclusively on its roots and rhizomes, this study represents the first report on the chemical constituents of its flowers. From the methanolic extract of the staminate flowers, two new styrylchromones, kobochromones B (1: ) and C (2: ), and a new suberin derivative, kobosuberin (5: ), were isolated. Their structures were elucidated by spectroscopic analysis (1D/2D NMR and HRESIMS). Their cytotoxic activity was assessed against four human cancer cell lines (HCT15, MCF7, 22Rv1, and PANC1), and the normal human hepatic stellate cell line LX-2 was used as a reference normal cell line. The study revealed a unique chemical profile of the staminate flowers, contributing to the understanding of the specialized metabolites in this dioecious species.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148759345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Investigation of Origanum calcaratum Extracts and in vitro Study against Cellular Senescence.","authors":"Elio Brochsztain Mizan, Ekaterina-Michaela Tomou, Maria Anagnostou, Sofia Drakopoulou, Eleftheria Antaloudaki, Pavlos Pantelis, Dimitris-Foivos Thanos, Vassilis G Gorgoulis, Nikolaos Thomaidis, Nefeli Lagopati, Helen Skaltsa","doi":"10.1055/a-2928-9370","DOIUrl":"https://doi.org/10.1055/a-2928-9370","url":null,"abstract":"<p><p><i>Origanum calcaratum</i> is an endemic Greek species found in Cyclades, the Eastern Aegean Sea, and Northeastern Crete. The aim of this study was the thorough phytochemical analysis of <i>O. calcaratum</i> extracts and the <i>in</i> <i>vitro</i> assessment against cellular senescence. Overall, 27 constituents were identified in methanolic and hydromethanolic extracts by LC-MS and isolation techniques, predominantly phenolic compounds. Both extracts and rosmarinic acid showed noncytotoxicity to healthy cells. In Li-Fraumeni cells, they exhibited concentration-dependent senolytic activity, with rosmarinic acid and the hydromethanolic extract showing significant effects at low concentrations, while the methanolic extract was active only at higher concentrations. These findings highlight the selective senolytic potential of <i>O. calcaratum</i>, particularly the hydromethanolic extract and rosmarinic acid, supporting further investigation as antisenescence agents.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148763533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Edible Plants with Antimicrobial Potential - Report of the Expert Meetings from Ibero-American Countries.","authors":"Laura Cecilia Laurella, María do Céu Costa, Lianet Monzote Fidalgo, Suzana Guimarães Leitão, Ericsson Coy-Barrera, Claudia Sepulveda, Brenda S Konigheim, Ignacio Agudelo, María Perassolo, Luis Dyner, Héctor Alonzo Gómez Gómez, Andrea Medeiros, Horacio Pérez Sánchez, Fernando Batista da Costa, Norberto Peporine Lopes, Fredy Lopez, Sully Margot Cruz Velásquez, Armando Cáceres, Marcelo A Comini, Valeria P Sülsen","doi":"10.1055/a-2904-4000","DOIUrl":"10.1055/a-2904-4000","url":null,"abstract":"<p><strong>Abstract: </strong>Infectious diseases caused by viruses, fungi, parasites, and bacteria continue to pose significant challenges to public health globally. In this context, the Ibero-American Program of Science and Technology for Development (CYTED) Network, \"Potential Antimicrobial Agents Present in Plant Foods of Regional Interest\" (REDALIM-MIC), aims to detect antimicrobial compounds in edible plants from Ibero-American countries and to promote collaborative research on their potential applications in health and nutrition. This report summarizes the main discussions and key outcomes of expert meetings conducted within the REDALIM-MIC Network, underscoring the importance of integrated and interdisciplinary research, with particular emphasis on the potential of edible plants as innovative and sustainable sources of bioactive compounds for the prevention and control of infectious diseases. Key outcomes included the identification of promising plant species and the prioritization of bioactive extracts for further phytochemical characterization and pharmacological evaluation. The potential application of these findings in the development of scientific evidence-based functional claims for foods and novel therapeutics, as well as the importance of strengthening regional collaboration, was also recognized. The REDALIM-MIC Network focuses on detecting antimicrobial compounds in edible plant species, evaluating their immunomodulatory properties, assessing their nutritional and health value, and fostering collaboration among Ibero-American institutions to support innovative, food-based approaches for preventing and managing infectious diseases. During the meetings, key topics such as regulatory frameworks, analytical techniques, quality control, methodologies, and cell-based assays for the evaluation of their antimicrobial activity were discussed. In addition, good agricultural practices and biotechnological tools for sustainable production were addressed.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148369509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin-lightening Metabolites in Achillea filipendulina: Comparative Phytochemical and Bioactivity Profiling of Extracts from Shoot Cultures and Field-grown Plants.","authors":"Karolina Czech, Małgorzata Kozyra, Agnieszka Szopa, Wirginia Kukula-Koch, Katarzyna Gaweł-Bęben","doi":"10.1055/a-2910-9128","DOIUrl":"10.1055/a-2910-9128","url":null,"abstract":"<p><strong>Abstract: </strong><i>Achillea filipendulina</i>, a polyphenol-rich species, was used to establish <i>in vitro</i> shoot cultures and to compare their phytochemical and biological properties with those of field-grown material. <i>In vitro</i> shoots cultivated on agar medium (AFiv) and in Plantform bioreactors (AFB) were extracted with ethanol, 50% ethanol, or water and evaluated alongside extracts from field-grown plants (AFH). HPLC-ESI-QTOF-MS/MS profiling revealed 37 phenolic constituents. At the same time, quantitative analysis by LC-MS confirmed that chlorogenic acid was the major compound, reaching the highest concentrations in AFH and AFB ethanol-based extracts. In contrast, AFiv samples contained lower but consistently detectable levels. Similarly, <i>p</i>-hydroxybenzoic acid, quercetin, and rutin were quantified above LOQ in nearly all samples, with their highest amounts in AFH EtOH and 50% EtOH extracts and the lowest levels in AFiv H₂O extracts, demonstrating clear solvent- and biomass-dependent variation.</p><p><strong>Abstract: </strong>AFH extracts showed the strongest antioxidant activity (IC₅₀ 50% EtOH=30.1; TPC = 1.32 mg GAE/g DW), while AFiv and AFB displayed lower TPC (0.36 - 0.38 and 0.19 - 0.30 mg GAE/g DW) and weaker activity (IC₅₀ = 254 µg/mL and ≥ 1000 µg/mL). In tyrosinase assays, AFiv extracts were the most potent, inhibiting murine tyrosinase by 56.8 - 62.8% and human tyrosinase by 17.6 - 29.9%, comparable to kojic acid, whereas AFH and AFB demonstrated weaker or selective inhibition.</p><p><strong>Abstract: </strong>Cytotoxicity testing showed that AFH extracts reduced HaCaT viability by 25 - 38%, while AFiv and AFB were non-cytotoxic and exhibited reduced or no cytotoxicity toward melanoma cells. Moreover, technological validation of the most potent AFiv 50EtOH extract within model O/W and W/O emulsions demonstrated exceptional 30-day physicochemical stability and compatibility.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148437608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Diversity and Biological Activities of the Artemisia L. Genus Beyond Antimalarial Effects.","authors":"Olga Karoutzou, Leandros A Skaltsounis","doi":"10.1055/a-2805-3483","DOIUrl":"10.1055/a-2805-3483","url":null,"abstract":"<p><strong>Abstract: </strong>The genus <i>Artemisia</i> L. constitutes one of the largest and most widely distributed groups within the Asteraceae family, renowned for its pharmacological significance. Used in traditional medicine for over two millennia, <i>Artemisia</i> species have been employed to treat a broad spectrum of ailments, with modern pharmacological studies increasingly validating these traditional uses. Interest in the genus surged following the groundbreaking discovery of the antimalarial sesquiterpene lactone artemisinin from <i>Artemisia annua</i> L. Beyond antimalarial activity, <i>Artemisia</i> species exhibit diverse pharmacological effects including anti-inflammatory, antiproliferative, cytotoxic, antimicrobial, and antiviral properties, largely attributed to secondary metabolites such as sesquiterpene lactones, furofuran lignans, polyacetylenes, and methylated flavonoids. This present study covers the bioactivities of extracts, essential oils, and isolated compounds from <i>Artemisia</i> genus reported between 1998 and 2025. Representative compounds from the most characteristic classes of <i>Artemisia</i> secondary metabolites are linked to biological activities, incorporating <i>in vitro</i> and <i>in vivo</i> studies, pharmacokinetics, clinical data, and toxicity profiles, while for each compound species-specific origin is reported.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"854-868"},"PeriodicalIF":2.1,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146143211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}