Planta medica最新文献_第2页

Characterization of lipophilicity and blood partitioning of pyrrolizidine alkaloids and their N-oxides in vitro and in silico for toxicokinetic modeling.

IF 2.1 4区医学

Planta medica Pub Date : 2025-01-23 DOI: 10.1055/a-2523-3987

Anja Lehmann, Manuel Haas, Julian Taenzer, Gerd Hamscher, Charlotte Kloft, Anja These, Christoph Hethey

{"title":"Characterization of lipophilicity and blood partitioning of pyrrolizidine alkaloids and their N-oxides in vitro and in silico for toxicokinetic modeling.","authors":"Anja Lehmann, Manuel Haas, Julian Taenzer, Gerd Hamscher, Charlotte Kloft, Anja These, Christoph Hethey","doi":"10.1055/a-2523-3987","DOIUrl":"https://doi.org/10.1055/a-2523-3987","url":null,"abstract":"Lipophilicity and blood partitioning are important determinants for predicting toxicokinetics using physiologically-based toxicokinetic (PBTK) modeling. In this study, the logarithm of the n-octanol:water partition coefficient (logP) and the blood-to-plasma concentration ratio (Rb ) were for the first time experimentally determined for the pyrrolizidine alkaloids (PAs) intermedine, lasiocarpine, monocrotaline, retrorsine and their N-oxides (PANOs). Validated in vitro assays for logP (miniaturized shake-flask method) and Rb (LC-MS/MS-based depletion assay) determination were compared to an ensemble of in silico models. Experimentally determined logP indicate a higher affinity of PAs and PANOs to the aqueous compared to the organic phase. Depending on the method, in silico determined logP overpredicted the experimental values by ≥ 1 log unit for 3 out of 4 PAs (SPARC), 4 out of 6 PAs and PANOs (CLOGP), 5 out of 8 PAs and PANOs (KowWIN) and 3 out of 8 PAs and PANOs (S+logP). Rb obtained in vitro suggested a low binding affinity of PAs and PANOs towards red blood cells. For all 8 PAs and PANOs, in silico predicted Rb deviated from experimental values by less than 50%. In conclusion, for PBTK modeling of PAs and PANOs, experimental logP should be preferred, while Rb predicted by the acid/base classification model is a suitable surrogate for experimental data.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytoestrogens and Sirtuin Activation for Renal Protection: A Review of Potential Therapeutic Strategies. 植物雌激素和Sirtuin激活对肾脏保护：潜在治疗策略的综述。

IF 2.1 4区医学

Planta medica Pub Date : 2025-01-22 DOI: 10.1055/a-2464-4354

Debojyoti Mandal, Nahid Akhtar, Sana Shafi, Jeena Gupta

{"title":"Phytoestrogens and Sirtuin Activation for Renal Protection: A Review of Potential Therapeutic Strategies.","authors":"Debojyoti Mandal, Nahid Akhtar, Sana Shafi, Jeena Gupta","doi":"10.1055/a-2464-4354","DOIUrl":"10.1055/a-2464-4354","url":null,"abstract":"Significant health and socio-economic challenges are posed by renal diseases, leading to millions of deaths annually. The costs associated with treating and caring for patients with renal diseases are considerable. Current therapies rely on synthetic drugs that often come with side effects. However, phytoestrogens, natural compounds, are emerging as promising renal protective agents. They offer a relatively safe, effective, and cost-efficient alternative to existing therapies. Phytoestrogens, being structurally similar to 17-β-estradiol, bind to estrogen receptors and produce both beneficial and, in some cases, harmful health effects. The activation of sirtuins has shown promise in mitigating fibrosis and inflammation in renal tissues. Specifically, SIRT1, which is a crucial regulator of metabolic activities, plays a role in protecting against nephrotoxicity, reducing albuminuria, safeguarding podocytes, and lowering reactive oxygen species in diabetic glomerular injury. Numerous studies have highlighted the ability of phytoestrogens to activate sirtuins, strengthen antioxidant defense, and promote mitochondrial biogenesis, playing a vital role in renal protection during kidney injury. These findings support further investigation into the potential role of phytoestrogens in renal protection. This manuscript reviews the potential of phytoestrogens such as resveratrol, genistein, coumestrol, daidzein, and formononetin in regulating sirtuin activity, particularly SIRT1, and thereby providing renal protection. Understanding these mechanisms is crucial for designing effective treatment strategies using naturally occurring phytochemicals against renal diseases.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Biotechnological Strategies for Podophyllotoxin Production from Plant and Microbial Sources. 利用植物和微生物资源生产鬼臼毒素的综合生物技术战略。

IF 2.1 4区医学

Planta medica Pub Date : 2025-01-20 DOI: 10.1055/a-2504-3069

Anviksha Anviksha, Mondem Sudhakara Reddy

{"title":"Comprehensive Biotechnological Strategies for Podophyllotoxin Production from Plant and Microbial Sources.","authors":"Anviksha Anviksha, Mondem Sudhakara Reddy","doi":"10.1055/a-2504-3069","DOIUrl":"10.1055/a-2504-3069","url":null,"abstract":"Podophyllotoxin is derived from plant sources and exhibits strong anticancer activity. However, limited natural availability and environmental impacts from traditional extraction methods drive the search for alternative production approaches. This review explores diverse strategies for sustainable podophyllotoxin synthesis, including biosynthesis, semi-synthesis, and biotransformation. Biosynthetic methods involve metabolic pathway engineering in plant or microbial cells, enabling increased yields by manipulating precursor availability and gene expression. Semi-synthetic approaches modify podophyllotoxin precursors or intermediates to enhance therapeutic effects, with derivatives like etoposide and teniposide showing clinical efficacy. Biotransformation, utilising organisms such as endophytic fungi or human hepatic enzymes, enables the transformation of substrates like deoxypodophyllotoxin into podophyllotoxin or its derivatives, yielding compounds with reduced environmental impact and improved purity. The anticancer efficacy of podophyllotoxin and its derivatives stems from multiple mechanisms. These compounds disrupt cell mitosis by inhibiting microtubule assembly, impairing nucleoside transport, and blocking topoisomerase II activity, leading to DNA cleavage and cancer cell apoptosis. Podophyllotoxin and its derivatives also exhibit anti-angiogenesis and anti-metastatic effects through signalling pathway modulation. Notably, derivatives like deoxypodophyllotoxin utilise advanced delivery systems, enhancing targeted efficacy and reducing side effects. Given the varied mechanisms and growing therapeutic applications, optimising biotransformation and delivery techniques remains essential for advancing podophyllotoxin-based therapies. This comprehensive review underscores the compound's potential as a robust anticancer agent and the need for continued research to maximise its production and clinical effectiveness.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plants with Hair Growth Activity for Alopecia: A Scoping Review on Methodological Aspects. 具有毛发生长活性的植物治疗脱发：方法学方面的综述。

IF 2.1 4区医学

Planta medica Pub Date : 2025-01-20 DOI: 10.1055/a-2494-9020

Sharize Betoni Galende, Mariana Nascimento de Paula, Mariana Millan Fachi, Daniela Cristina de Medeiros Araújo, Danielly Chierrito, João Carlos Palazzo de Mello

{"title":"Plants with Hair Growth Activity for Alopecia: A Scoping Review on Methodological Aspects.","authors":"Sharize Betoni Galende, Mariana Nascimento de Paula, Mariana Millan Fachi, Daniela Cristina de Medeiros Araújo, Danielly Chierrito, João Carlos Palazzo de Mello","doi":"10.1055/a-2494-9020","DOIUrl":"10.1055/a-2494-9020","url":null,"abstract":"Alopecia is a common dermatological disorder of patchy hair loss with substantial patient burden. Phytotherapeutic compounds are increasingly used as a source of new therapeutic options. This review aimed to synthesize the evidence on plant species in hair growth and the methodological aspects of in vivo experimental models. The systematic scoping review was conducted following the PRISMA checklist, the Joanna Briggs Institute, and in accordance with Cochrane. A systematic search was carried out in the Pubmed, Scopus, Web of Science, and SciELO databases. In vivo experiments that evaluated hair growth activity using natural substances of plant origin were included. Data collection and analysis: a total of 1250 studies were identified, of which 175 were included for qualitative synthesis. Of these, 128 used mice, 37 rats, 10 rabbits, 1 guinea pig, and 1 sheep as animal models. The methodologies mapped were as follows: hair growth analysis, histological analysis, immunohistochemistry, gene expression analysis, Western blot, enzyme-linked immunosorbent assay, and biochemical analysis. Minoxidil and finasteride were the most commonly used positive controls. The studies evaluated plant species (166), algae (11), or isolated substances (31). Overall, 152 plant species and 37 isolated substances were identified. This is the first systematic scoping review on the methodological aspects of in vivo hair growth activity. We created a checklist to be completed by authors to allow data comparison and reproducibility, facilitate data interpretation by readers, and ensure better quality of evidence. This work may become a valuable tool for future research and contribute to significant advances in hair growth studies.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracts of Drynariae Rhizoma Promote Bone Formation in OVX Rats through Modulating the Gut Microbiota. 旱莲草提取物通过调节肠道微生物群促进卵巢切除大鼠的骨形成

IF 2.1 4区医学

Planta medica Pub Date : 2025-01-17 DOI: 10.1055/a-2462-4844

Qing Lin, Xinchen Ouyang, Qi Pan, Jiajia Huang, Zhifen Zhang, Yumei Yang, Haoyu Wang, Li Yang, Xiaofeng Zhu, Xiaoyun Li, Ronghua Zhang

{"title":"Extracts of Drynariae Rhizoma Promote Bone Formation in OVX Rats through Modulating the Gut Microbiota.","authors":"Qing Lin, Xinchen Ouyang, Qi Pan, Jiajia Huang, Zhifen Zhang, Yumei Yang, Haoyu Wang, Li Yang, Xiaofeng Zhu, Xiaoyun Li, Ronghua Zhang","doi":"10.1055/a-2462-4844","DOIUrl":"10.1055/a-2462-4844","url":null,"abstract":"Drynariae Rhizoma has been commonly used as a preventive and therapeutic agent for bone diseases. However, its pharmacological mechanisms have not been fully elucidated. Here, we aimed to investigate the effects of Drynariae Rhizoma in a bilateral ovariectomized rat model and explore the correlation with gut microbiome. We established an ovariectomized rat model, which we treated with different doses of Drynariae Rhizoma (Drynariae Rhizoma-Low, 0.27 g/kg/day; Drynariae Rhizoma-Middle, 0.81 g/kg/day; Drynariae Rhizoma-High, 2.43 g/kg/day) through intragastric administration for 12 weeks. Results showed that Drynariae Rhizoma alleviated body weight, moderated bone microstructure, and promoted the expression of bone formation-related factors in ovariectomized rats, in which Drynariae Rhizoma-High showed the most significant effects among the three doses. Furthermore, the effects of Drynariae Rhizoma on promoting bone formation were correlated to the changes in microbial richness and the restorations of several genera, among which Ruminiclostridium and Ruminococcaceae_UCG_007 were positively correlated with the bone formation-related factors, and both were enriched in the Drynariae Rhizoma-High group as biomarkers. Moreover, CMP-legionaminate biosynthesis I might be a crucial pathway of Drynariae Rhizoma to regulate gut microbiota. The content of serum short-chain fatty acids in the ovariectomized rats were regulated by Drynariae Rhizoma. Our results demonstrate that Drynariae Rhizoma promotes bone formation in ovariectomized rats, and is related to the regulation of the gut microbiota structure.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Constituents from Zanthoxylum rhoifolium. Zanthoxylum rhoifolium Lam.的新成分

IF 2.1 4区医学

Planta medica Pub Date : 2025-01-13 DOI: 10.1055/a-2486-9139

Mauro Di Stasi, Valentina Parisi, Vanessa Hernandez, Erica Gazzillo, Maria Giovanna Chini, Giuseppe Bifulco, Alessandra Braca, Giuliana Donadio, Nunziatina De Tommasi

引用次数: 0

Phytochemical Characterization and Comparative Analysis of Cycloartane-Type Triterpenes in Astragalus adsurgens and Astragalus membranaceus. 黄芪和膜荚黄芪中环安坦类三萜的植物化学特征和比较分析。

IF 2.1 4区医学

Planta medica Pub Date : 2025-01-08 DOI: 10.1055/a-2486-8873

Guanglian Zhou, Yin Chen, Bingyan Xu, Guoqing Peng, Li Wang, Jian-Ping Huang, Zhiyin Yu, Sheng-Xiong Huang

{"title":"Phytochemical Characterization and Comparative Analysis of Cycloartane-Type Triterpenes in Astragalus adsurgens and Astragalus membranaceus.","authors":"Guanglian Zhou, Yin Chen, Bingyan Xu, Guoqing Peng, Li Wang, Jian-Ping Huang, Zhiyin Yu, Sheng-Xiong Huang","doi":"10.1055/a-2486-8873","DOIUrl":"10.1055/a-2486-8873","url":null,"abstract":"Astragalus adsurgens, a significant forage plant cultivated in arid regions of northwest China, remains underexplored for its triterpenoid saponins and medicinal properties compared to the extensively studied Astragalus membranaceus. To explore the phytochemical profile of A. adsurgens for its potential application in the medical field, we employed ultra-pressure liquid chromatography coupled with a tandem mass spectrometry-based method to identify cycloartane-type triterpenes. Eventually, five new cycloartane-type triterpenoids, adsurgosides A - D ( 1 - 4: ) and 3-methyl-3,4-seco-cyclostellanol (5: ), together with two known analogs, cycloastragenol (6: ) and cyclopycanthogenin (7: ), were isolated from the roots of A. adsurgens. Their structures were elucidated using 1D and 2D NMR analyses in combination with HRESIMS data. Additionally, a comparative study on the distribution patterns of these compounds revealed qualitative and quantitative variations between A. adsurgens and A. membranaceus. Our findings not only identified an alternative plant for isolating cycloartane-type triterpenoids but also offer new insights into the chemical properties of A. adsurgens.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Monotherapy or combination therapy of Oleanolic acid? From therapeutic significance and drug delivery to clinical studies: A comprehensive review. 齐墩果酸单药还是联合治疗？从治疗意义和给药到临床研究：全面回顾。

IF 2.1 4区医学

Planta medica Pub Date : 2025-01-07 DOI: 10.1055/a-2510-9958

Md Adil Shaharyar, Tanmoy Banerjee, Monalisha Sengupta, Rudranil Bhowmik, Arnab Sarkar, Pallab Mandal, Sami I Alzarea, Nilanjan Ghosh, Jamal Akhtar, Imran Kazmi, Sanmoy Karmakar

{"title":"Monotherapy or combination therapy of Oleanolic acid? From therapeutic significance and drug delivery to clinical studies: A comprehensive review.","authors":"Md Adil Shaharyar, Tanmoy Banerjee, Monalisha Sengupta, Rudranil Bhowmik, Arnab Sarkar, Pallab Mandal, Sami I Alzarea, Nilanjan Ghosh, Jamal Akhtar, Imran Kazmi, Sanmoy Karmakar","doi":"10.1055/a-2510-9958","DOIUrl":"https://doi.org/10.1055/a-2510-9958","url":null,"abstract":"Oleanolic acid (OA) is a pentacyclic triterpenoid molecule widely distributed throughout medicinal plants. This naturally occurring OA has attracted considerable interest due to its wide range of pharmacological characteristics, notably its cytotoxic effects on various human cancer cell lines, making it a potential candidate for extensive therapeutic uses. In vivo studies have shown that OA possesses hepatoprotective, cardioprotective, anti-inflammatory and anti-microbial properties. The inherent obstacles of OA, such as low permeability, limited bioavailability, and poor water solubility, have restricted its therapeutic applicability. However, recent developments in drug delivery techniques have given OA an additional advantage by overcoming issues with its solubility, stability, and bioavailability. This review briefly summarises the signalling pathways involved in the pharmacological activities of OA as monotherapy and in combination with other drugs. The review devotes a substantial portion to explaining the formulation developments, emphasising nanotechnology as a key factor in the improvement of the therapeutic potential of OA. Several investigated novel formulations have been discussed, including liposomes, nanoemulsions, phospholipids, and polymeric nanoparticles, emerging synergistically as an efficient delivery of OA and several other drugs. Based on our literature evaluation, it can be inferred that the combination therapy had a more favourable outcome than using OA alone in vivo trials, primarily due to synergistic effects. However, it is essential to note that this finding was inconsistent across all investigations. The combination of OA has not yet been considered for clinical trials. However, it is interesting that neither therapy has obtained approval from the USFDA.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aloe vera and the Proliferative Phase of Cutaneous Wound Healing: Status Quo Report on Active Principles, Mechanisms, and Applications. 芦荟与皮肤伤口愈合的增殖阶段：活性原理、机制和应用现状报告》。

IF 2.1 4区医学

Planta medica Pub Date : 2025-01-01 Epub Date: 2024-11-20 DOI: 10.1055/a-2446-2146

Zhuang Min Lee, Bey Hing Goh, Kooi Yeong Khaw

{"title":"Aloe vera and the Proliferative Phase of Cutaneous Wound Healing: Status Quo Report on Active Principles, Mechanisms, and Applications.","authors":"Zhuang Min Lee, Bey Hing Goh, Kooi Yeong Khaw","doi":"10.1055/a-2446-2146","DOIUrl":"10.1055/a-2446-2146","url":null,"abstract":"Aloe vera is commonly used as traditional medicine for cutaneous wound healing. Nonetheless, the wound healing mechanisms of Aloe vera remain unclear. This review aims to provide insight into the molecular mechanisms of Aloe vera in promoting cutaneous wound healing, with particular emphasis on the mechanisms that stimulate cell proliferation and migration. Aloe vera has been shown to upregulate growth factors such as keratinocyte growth factor-1 (KGF-1), transforming growth factor-β (TGF-β), cyclin D1, insulin-like growth factor 1 (IGF-1), vascular endothelial growth factor (VEGF), basic fibroblastic growth factor (bFGF), and microfibril-associated glycoprotein 4 (MFAP4), as well as collagen, fibrillin, elastin, α-smooth muscle actin (α-SMA), integrins, and platelet endothelial cell adhesion molecule 1 (PECAM-1, also known as CD31), while downregulating the expression of matrix metalloproteinases (MMPs). In addition, Aloe vera was also found to upregulate PI3K/Akt and MAPK pathways, as well as the TGF-β signalling pathway via Smad proteins. Furthermore, molecular docking studies revealed that certain chemical constituents of Aloe vera bind to some of the forementioned growth factors or signalling molecules. With regards to current applications, although human clinical trials have reported positive results from using Aloe vera in healing open wounds and burns and alleviating some inflammatory skin diseases, the current commercial uses of Aloe vera remain largely focused on cosmetic products. Thus, greater advances are required to promote the use of Aloe vera products in clinical settings.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"4-18"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142682321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory Activity of Labdane and Norlabdane Diterpenoids from Leonurus sibiricus Related to Modulation of MAPKs Signaling Pathway. 西比露中的拉布丹和诺拉布丹二萜类化合物的抗炎活性与调节 MAPKs 信号通路有关

IF 2.1 4区医学

Planta medica Pub Date : 2025-01-01 Epub Date: 2024-10-12 DOI: 10.1055/a-2440-5166

Nguyen Minh Trang, Le Ba Vinh, Nguyen Viet Phong, Seo Young Yang

{"title":"Anti-Inflammatory Activity of Labdane and Norlabdane Diterpenoids from Leonurus sibiricus Related to Modulation of MAPKs Signaling Pathway.","authors":"Nguyen Minh Trang, Le Ba Vinh, Nguyen Viet Phong, Seo Young Yang","doi":"10.1055/a-2440-5166","DOIUrl":"10.1055/a-2440-5166","url":null,"abstract":"Leonurus sibiricus, a widely cultivated herbaceous plant in Asian countries, exhibits diverse medicinal applications. Recent studies emphasize its pharmacological properties and efficacy in promoting bone health. In addition to the known compounds and their pharmacological activities, in this study, we isolated and elucidated two new labdane-type diterpenoids, (3R,5R,6S,10S)-3,6-dihydroxy-15-ethoxy-7-oxolabden-8(9),13(14)-dien-15,16-olide (1: ) and (4R,5R,10S)-18-hydroxy-14,15-bisnorlabda-8-en-7,13-dione (2: ), a new natural phenolic compound, and a known compound from L. sibiricus using advanced spectroscopic techniques, including circular dichroism spectroscopy, high-resolution mass spectrometry, and 1- and 2-dimensional NMR. Among these, compound 1: demonstrated potent inhibition of nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) mRNA expression levels, followed by compound 2: . Whereas compounds 3: and 4: did not exhibit effectiveness in RAW264.7 macrophages. Moreover, compound 1: suppressed pro-inflammatory markers induced by lipopolysaccharide (LPS) stimulation. Compound 1: also suppressed iNOS and cyclooxygenase-2 (COX-2) protein levels and downregulated pro-inflammatory cytokines. Additionally, compound 1: showed inhibition of the phosphorylation of p38, JNK, and ERK, key mediators of the MAPK signaling pathway. These findings indicate that a natural-derived product, compound 1,: might be a potential candidate as an anti-inflammation mediator.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"29-39"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0