Planta medica最新文献_第2页

Stachybotrins G and H, Two New Phenylspirodrimane Derivatives from the Fungus Stachybotrys chartarum. Stachybotrins G和H，两个新的从Stachybotrys chartarum中提取的苯螺旋体衍生物。

IF 2.1 4区医学

Planta medica Pub Date : 2025-05-14 DOI: 10.1055/a-2592-1627

Yi Wang, Kang Chen, Qiao Xing, Tao Zhang, Yuquan Xu

引用次数: 0

Mechanistic Insights into Propolis in Targeting Type 2 Diabetes Mellitus: A Systematic Review. 蜂胶治疗2型糖尿病的机制：系统综述。

IF 2.1 4区医学

Planta medica Pub Date : 2025-05-12 DOI: 10.1055/a-2596-0010

Chee Ning Wong, Siew-Keah Lee, Kai Bin Liew, Yik-Ling Chew, Ang-Lim Chua

{"title":"Mechanistic Insights into Propolis in Targeting Type 2 Diabetes Mellitus: A Systematic Review.","authors":"Chee Ning Wong, Siew-Keah Lee, Kai Bin Liew, Yik-Ling Chew, Ang-Lim Chua","doi":"10.1055/a-2596-0010","DOIUrl":"https://doi.org/10.1055/a-2596-0010","url":null,"abstract":"Type 2 diabetes mellitus (T2DM) is a major global health concern characterized by insulin resistance and impaired glucose metabolism. Growing interest in natural therapies has led to the exploration of propolis, a resinous bee product, for its potential anti-diabetic effects. This review examines the mechanisms by which propolis may aid in T2DM management. A literature search was conducted in SCOPUS and PubMed using the terms (Propolis) AND (diabetes OR \"insulin resistance\" OR hyperglycemia), focusing on studies published from 2014 onwards. The search yielded 384 and 207 records in SCOPUS and PubMed, respectively. After screening and full-text review, 42 studies met the inclusion criteria. Key variables analyzed included the type and source of propolis, experimental models, dosage, treatment duration, and primary and secondary outcomes. Findings highlight multiple mechanisms through which propolis may benefit T2DM, including enhancing pancreatic β-cell function, improving insulin sensitivity, regulating glucose and lipid metabolism, modulating gut microbiota, and reducing oxidative stress and inflammation. Some studies also reported protective effects on renal and hepatic function. Overall, propolis exhibits promising potential as a complementary therapy for T2DM. However, further well-designed clinical trials are necessary to confirm its efficacy, determine optimal dosing, and identify key bioactive compounds responsible for its therapeutic effects. Future research should focus on optimizing its clinical application for diabetes management.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144007974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evidence of Potential Drug Interactions Between Cannabidiol and Other Drugs: A Scoping Review to Guide Pharmaceutical Care. 大麻二酚和其他药物之间潜在药物相互作用的证据：指导药学服务的范围综述。

IF 2.1 4区医学

Planta medica Pub Date : 2025-05-08 DOI: 10.1055/a-2593-6351

Fernanda Dias Nader, Luis Phillipe Nagem Lopes, Alice Ramos-Silva, Maria Eline Matheus

{"title":"Evidence of Potential Drug Interactions Between Cannabidiol and Other Drugs: A Scoping Review to Guide Pharmaceutical Care.","authors":"Fernanda Dias Nader, Luis Phillipe Nagem Lopes, Alice Ramos-Silva, Maria Eline Matheus","doi":"10.1055/a-2593-6351","DOIUrl":"https://doi.org/10.1055/a-2593-6351","url":null,"abstract":"Cannabidiol (CBD), a non-psychoactive cannabinoid with therapeutic potential, is increasingly used in combination with other drugs, raising concerns about potential interactions and their impact on safety and efficacy. This scoping review aimed to map the current evidence on CBD interactions across different drug classes and assess their clinical significance. The study followed the Joanna Briggs Institute guidelines, utilizing a structured protocol based on the population, concept, and context (PCC) framework. Five databases were searched, and preclinical and clinical studies on CBD pharmacokinetic and pharmacodynamic interactions were included, with publications in English, Portuguese, or Spanish. Out of 136 studies analyzed, 91.91% were published after 2011, reflecting a sharp rise in interest in this area. A total of 271 interactions were identified, with 203 related to pharmacokinetics, primarily involving metabolism mediated by cytochrome P450 (CYP) enzymes, and 68 linked to pharmacodynamics, including additive effects such as sedation. Among the most relevant findings, CBD was shown to inhibit CYP enzymes like CYP3A4 and CYP2C19, potentially increasing plasma levels of co-administered drugs. However, only 5.15% of studies evaluated the clinical relevance of these interactions, indicating a substantial gap in knowledge regarding their safety implications. This review highlights the urgent need for rigorous clinical research to determine the clinical significance of CBD-drug interactions, particularly in patients undergoing polypharmacy. Understanding these interactions is crucial for optimizing therapeutic outcomes, minimizing adverse effects, and enabling safer clinical use of CBD in diverse treatment regimens.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Structural Elucidation and Immunomodulatory Activity of a New Polysaccharide from Saposhnikoviae Radix. 无患子新多糖的化学结构解析和免疫调节活性

IF 2.1 4区医学

Planta medica Pub Date : 2025-05-08 DOI: 10.1055/a-2573-7718

Yifang Cui, Haitao Fan, Meng Sun, Xinyang He, Jie Li, Guangzhong Tu, Yanyan Jiang, Bin Liu

引用次数: 0

Fused Tricyclic Naphthalene Lactones and a Xanthone from Ventilago maingayi and their Anti-HIV-1 Activity. 三环萘内酯和一种山酮的融合及其抗hiv -1活性。

IF 2.1 4区医学

Planta medica Pub Date : 2025-05-08 DOI: 10.1055/a-2589-5900

Ponsiri Liangsakul, Chutima Kuhakarn, Siriporn Jungsuttiwong, Ratchadaree Intayot, Sariyarach Thanasansurapong, Radeekorn Akkarawongsapat, Arthit Chairoungdua, Narong Nuntasaen, Sakchai Hongthong, Vichai Reutrakul

引用次数: 0

Passionflower (Passiflora incarnata): Quality of Food Supplements Versus Registered Herbal Medicinal Products. 西番莲（Passiflora incarnata）：食品补充剂与注册草药产品的质量。

IF 2.1 4区医学

Planta medica Pub Date : 2025-05-07 DOI: 10.1055/a-2591-3765

Alexa Brouns, Matthias Lechtenberg, Andreas Hensel

{"title":"Passionflower (Passiflora incarnata): Quality of Food Supplements Versus Registered Herbal Medicinal Products.","authors":"Alexa Brouns, Matthias Lechtenberg, Andreas Hensel","doi":"10.1055/a-2591-3765","DOIUrl":"https://doi.org/10.1055/a-2591-3765","url":null,"abstract":"The above-ground plant material from Passiflora incarnata is used for relief of symptoms of mental stress and to aid sleep. In Europe, passionflower products are marketed either as registered herbal medicinal products or as food supplements. Passionflower products for sleep disorders are increasingly recommended to patients by physicians or by social advertisement, but the potential consumers are in most cases not able to differentiate between food supplements or licensed herbal medicinal products. Analytical investigations by validated protocols on passionflower food supplements and registered medicinal products from different sources were performed to obtain an insight into the actual quality situation. TLC fingerprinting revealed the non-identity of five food supplements, while six products met the specification (five registered herbal medicinal products and one food supplement). A validated UHPLC method confirmed this result. LC-MS identified one food supplement containing only hyperoside and lacking other passionflower-related compounds. Quantitative determination of flavones by photometric protocol, as well as by a calibrated UHPLC, indicated that five out of six food supplements did not meet the specified content and identity, suggesting instances of food fraud. All registered herbal medicinal products conformed to the specification. As this analytical investigation is in line with other reports on the low quality of food supplements, transparent and intensified quality control is recommended. In addition, routine analyses of every batch using validated procedures by manufacturers on a batch-by-batch basis should provide a secure basis for improved product quality and for the safety of the consumer.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Datura stramonium - A Dangerous Weed and Alternative Drug of Abuse: An Overview of Poisoning Cases in 21st Century. 曼陀罗-一种危险的杂草和滥用的替代药物：21世纪中毒案件综述。

IF 2.1 4区医学

Planta medica Pub Date : 2025-05-01 Epub Date: 2025-03-14 DOI: 10.1055/a-2552-4434

Milica Aćimović

{"title":"Datura stramonium - A Dangerous Weed and Alternative Drug of Abuse: An Overview of Poisoning Cases in 21st Century.","authors":"Milica Aćimović","doi":"10.1055/a-2552-4434","DOIUrl":"10.1055/a-2552-4434","url":null,"abstract":"Datura stramonium is a well-known cosmopolitan weed known by several common names: thorn apple (due to the appearance of its fruits), Angel's trumpet (linked to its flowers), loco seed (referring to the hallucinogenic properties of its seeds), jimson weed (originating from the first recorded poisoning involving this plant), and apple of Peru (indicating the plant's origin). All parts of the plant contain the tropane alkaloids hyoscyamine, scopolamine, and atropine together with several minor alkaloids, which cause poisoning such as typical anticholinergic syndrome with neuropsychiatric effects. A review of 114 papers from various databases (Scopus, Web of Science, PubMed, and Google Scholar) revealed that poisoning incidents involving this plant have been relatively common from 2001 to 2024. The analysis indicated that all cases of poisoning from D. stramonium can be categorized into two main groups: accidental and misuse. Accidental poisonings are primarily linked to the contamination of other crops in the field, leading to mass poisoning of humans and animals. They can also result from misidentifying the plant as another edible species, children's curiosity, and self-medication. On the other hand, misuse is typically associated with recreational drug use, suicide attempts, criminal activities, and magico-religious practices. To prevent poisoning from this plant, it is essential to eliminate the weed from fields, yards, gardens, and other disturbed areas. Additionally, it is important to educate the general public about the plant's appearance and the dangers associated with its consumption, particularly in the context of self-medication and recreational drug use.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"353-370"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Possibility and Potenzial Intervention Targets of Saffron Extract in the Treatment of Atopic Dermatitis: A Review. 藏红花提取物治疗特应性皮炎的可能性及潜在干预靶点综述。

IF 2.1 4区医学

Planta medica Pub Date : 2025-05-01 Epub Date: 2025-02-13 DOI: 10.1055/a-2538-5769

Huiyang Shi, Xuan Liu, Peiyi Zhao, Wei Huang, Hebin Wang, Heying Jin, Junyou Zhu, Jianwu Wang, Tianjiao Li

{"title":"Possibility and Potenzial Intervention Targets of Saffron Extract in the Treatment of Atopic Dermatitis: A Review.","authors":"Huiyang Shi, Xuan Liu, Peiyi Zhao, Wei Huang, Hebin Wang, Heying Jin, Junyou Zhu, Jianwu Wang, Tianjiao Li","doi":"10.1055/a-2538-5769","DOIUrl":"10.1055/a-2538-5769","url":null,"abstract":"Atopic dermatitis (AD) is a chronic, recurrent inflammatory skin disorder characterized by dry skin, eczema-like lesions, and severe itching. The multifaceted etiology of AD, which is not yet fully understood, includes genetic predispositions, immune dysfunctions(such as an impaired skin barrier and abnormal immune regulation), imbalances in the skin microbiota, and environmental factors, among others. In the field of AD treatment, the combination of traditional Chinese medicine and modern medicine is becoming an emerging trend. Given the potenzial side effects and reduced efficacy of conventional therapeutic drugs, Chinese herbal medicines offer patients new treatment options because of their unique efficacy and low toxicity. Some saffron extracts derived from saffron and gardenia, such as crocin, crocetin, and safranal, have shown promising potenzial in the treatment of AD. These natural ingredients not only possess anti-inflammatory and immunomodulatory properties similar to those of traditional Chinese medicines but also demonstrate excellent effects in promoting the repair of damaged skin barriers. Therefore, this article reviews the therapeutic potenzial of saffron extract in the treatment of AD, with a special focus on its mechanisms and potenzial interventions, while emphasizing the importance of herbal medicines as alternatives to traditional treatments, providing AD patients with safer and more effective treatment options.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"338-352"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin: Epigenetic Modulation and Tumor Immunity in Antitumor Therapy. 姜黄素：抗肿瘤疗法中的表观遗传调节和肿瘤免疫。

IF 2.1 4区医学

Planta medica Pub Date : 2025-05-01 Epub Date: 2024-12-17 DOI: 10.1055/a-2499-1140

Xin Wan, Dong Wang

{"title":"Curcumin: Epigenetic Modulation and Tumor Immunity in Antitumor Therapy.","authors":"Xin Wan, Dong Wang","doi":"10.1055/a-2499-1140","DOIUrl":"10.1055/a-2499-1140","url":null,"abstract":"Curcumin (turmeric) is the main ingredient of the Chinese herbal turmeric rhizome, used to treat tumors, diabetes, inflammation, neurodegenerative diseases, cardiovascular diseases, metabolic syndrome, and liver diseases. The antitumor effects of curcumin have received even more attention. One of the main mechanisms of the antitumor effects includes inhibition of tumor invasion and migration, induction of tumor cell apoptosis, and inhibition of various cell signaling pathways. It has been found that the antitumor biological activity of curcumin in the body is associated with epigenetic mechanisms. That also implies that curcumin may act as a potential epigenetic modulator to influence the development of tumor diseases. The immune system plays an essential role in the development of tumorigenesis. Tumor immunotherapy is currently one of the most promising research directions in the field of tumor therapy. Curcumin has been found to have significant regulatory effects on tumor immunity and is expected to be a novel adjuvant for tumor immunity. This paper summarizes the antitumor effects of curcumin from four aspects: molecular and epigenetic mechanisms of curcumin against a tumor, mechanisms of curcumin modulation of tumor immunotherapy, reversal of chemotherapy resistance, and a novel drug delivery system of curcumin, which provide new directions for the development of new antitumor drugs.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"320-337"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pseudopeptides of Marine Vibrio spp. from Taiwan and Their Combined Treatment Effects with Commercial Antibiotics. 台湾海洋弧菌的假多肽及其与市售抗生素的联合治疗效果。

IF 2.1 4区医学

Planta medica Pub Date : 2025-05-01 Epub Date: 2025-02-11 DOI: 10.1055/a-2536-8292

Mao-Xuan Hong, Bo-Wei Wang, Li-Hua Lo, Gamaralalage Eranga Dilshan Jayalath, Wei-Tsen Lin, Yu-Liang Yang, Sung-Pin Tseng, Yen-Hsu Chen, Wan-Chi Tsai, Wei-Chieh Cheng, Chih-Chuang Liaw

{"title":"Pseudopeptides of Marine Vibrio spp. from Taiwan and Their Combined Treatment Effects with Commercial Antibiotics.","authors":"Mao-Xuan Hong, Bo-Wei Wang, Li-Hua Lo, Gamaralalage Eranga Dilshan Jayalath, Wei-Tsen Lin, Yu-Liang Yang, Sung-Pin Tseng, Yen-Hsu Chen, Wan-Chi Tsai, Wei-Chieh Cheng, Chih-Chuang Liaw","doi":"10.1055/a-2536-8292","DOIUrl":"10.1055/a-2536-8292","url":null,"abstract":"Vibrio strains, identified by 16S rDNA, were isolated from the marine environment surrounding Taiwan, revealing diverse bioactive effects, such as iron-chelating and antimicrobial activities. Notably, the hierarchical clustering dendrogram of mass spectrum profiles of the Vibrio strains using matrix-assisted laser desorption ionization time-of-flight, in contrast to the phylogenetic tree based on 16S rDNA sequencing analysis, exhibited a strong correlation with their observed bioactivities. Within this set, global natural products social molecular network analysis by LC-HRMS/MS highlighted that three strains, Vibrio tubiashii DJW05 - 1, Vibrio japonicus DJW05 - 8, and Vibrio fortis DJW21 - 4, shared similar bioactive pseudopeptides in the same cluster. Subsequent chromatographical isolation and purification yielded an unprecedented unsaturated diketopiperazine, (Z)-3-(2-methylpropylidene)-2,3-dihydropyrrolo[1,2-a]pyrazine-1,4-dione (1: ), along with a series of diketopiperazines, and a potential new annotated pseudopeptide (2: ), as well as three pseudopeptides, including andrimid (10: ), moiramide B (11: ), and moiramide C (12: ), and several alkaloids from V. tubiashii DJW05 - 1. Further investigation into the combined applications of the major antimicrobial compound and commercial antibiotics revealed that andrimid (10: ) displayed significant inhibitory effects against gram-positive Staphylococcus aureus, and gram-negative Escherichia coli, Salmonella typhimurium, and Acinetobacter baumannii, but not Pseudomonas aeruginosa. Nevertheless, the potential for synergistic and additive effects of andrimid (10: ) with certain antibiotics remains, presenting valuable prospects for medicinal applications.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"371-381"},"PeriodicalIF":2.1,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0