The Therapeutic Potential of Topically Applied Essential Oils in Preventing or Treating Early Borrelia burgdorferi Infection: A Review.

IF 2.1 4区医学 Q3 CHEMISTRY, MEDICINAL

Planta medica Pub Date : 2025-06-20 DOI:10.1055/a-2640-4274

Keren Dolan, John Courie, Michael Tims

{"title":"The Therapeutic Potential of Topically Applied Essential Oils in Preventing or Treating Early Borrelia burgdorferi Infection: A Review.","authors":"Keren Dolan, John Courie, Michael Tims","doi":"10.1055/a-2640-4274","DOIUrl":null,"url":null,"abstract":"Lyme disease, caused by Borrelia burgdorferi, presents significant diagnostic challenges, often leading to delayed treatment and decreased therapeutic response to conventional antibiotics. This review aims to evaluate the potential of plant essential oils, known for their bacteriostatic, bactericidal, and anti-quorum sensing properties, as prophylactic, adjunct or complementary treatments during the early stages of B. burgdorferi infection. The authors explore how these essential oils can target adaptive mechanisms and interactions of B. burgdorferi, including complement regulator-acquiring surface proteins (CRASPs), immune modulation, motility, chemotaxis, biofilm formation, efflux-pump mechanisms, and cyst formation. The authors identify current research gaps and propose frameworks to substantiate the clinical efficacy of essential oils for Lyme disease treatment. This review indicates that essential oils have multifaceted therapeutic potential and could provide a viable option for early intervention in Lyme disease. Further research is necessary to confirm their clinical applicability and safety.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Planta medica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/a-2640-4274","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}

引用次数: 0

Abstract

Lyme disease, caused by Borrelia burgdorferi, presents significant diagnostic challenges, often leading to delayed treatment and decreased therapeutic response to conventional antibiotics. This review aims to evaluate the potential of plant essential oils, known for their bacteriostatic, bactericidal, and anti-quorum sensing properties, as prophylactic, adjunct or complementary treatments during the early stages of B. burgdorferi infection. The authors explore how these essential oils can target adaptive mechanisms and interactions of B. burgdorferi, including complement regulator-acquiring surface proteins (CRASPs), immune modulation, motility, chemotaxis, biofilm formation, efflux-pump mechanisms, and cyst formation. The authors identify current research gaps and propose frameworks to substantiate the clinical efficacy of essential oils for Lyme disease treatment. This review indicates that essential oils have multifaceted therapeutic potential and could provide a viable option for early intervention in Lyme disease. Further research is necessary to confirm their clinical applicability and safety.

查看原文本刊更多论文

局部应用精油预防或治疗早期伯氏疏螺旋体感染的治疗潜力：综述。

由伯氏疏螺旋体引起的莱姆病提出了重大的诊断挑战，往往导致延迟治疗和降低对常规抗生素的治疗反应。这篇综述的目的是评估植物精油的潜力，其抑菌、杀菌和抗群体感应特性，在伯氏疏螺旋体感染的早期阶段作为预防、辅助或补充治疗。作者探讨了这些精油如何靶向伯氏疏螺旋体的适应机制和相互作用，包括补体调节剂获得表面蛋白（crasp）、免疫调节、运动、趋化性、生物膜形成、外排泵机制和囊肿形成。作者确定了目前的研究空白，并提出了框架，以证实精油治疗莱姆病的临床疗效。这一综述表明，精油具有多方面的治疗潜力，可以为莱姆病的早期干预提供可行的选择。需要进一步的研究来证实其临床适用性和安全性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Planta medica 医学-药学

CiteScore

5.10

自引率

3.70%

发文量

101

审稿时长

1.8 months

期刊介绍： Planta Medica is one of the leading international journals in the field of natural products – including marine organisms, fungi as well as micro-organisms – and medicinal plants. Planta Medica accepts original research papers, reviews, minireviews and perspectives from researchers worldwide. The journal publishes 18 issues per year. The following areas of medicinal plants and natural product research are covered: -Biological and Pharmacological Activities -Natural Product Chemistry & Analytical Studies -Pharmacokinetic Investigations -Formulation and Delivery Systems of Natural Products. The journal explicitly encourages the submission of chemically characterized extracts.