Planta medica最新文献_第3页

Galactomannan and Vicilin from Fenugreek Seeds (Trigonella foenum-graecum) Impair Early Pathogen-Host Interaction of Campylobacter jejuni with Intestinal Cells via JlpA. 葫芦巴种子中的半乳甘露聚糖和芦笋素可通过JlpA破坏空肠弯曲杆菌与肠道细胞的病原-宿主相互作用。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI: 10.1055/a-2536-8392

Leon Kemper, Fabian Herrmann, Simone König, Franco H Falcone, Andreas Hensel

{"title":"Galactomannan and Vicilin from Fenugreek Seeds (Trigonella foenum-graecum) Impair Early Pathogen-Host Interaction of Campylobacter jejuni with Intestinal Cells via JlpA.","authors":"Leon Kemper, Fabian Herrmann, Simone König, Franco H Falcone, Andreas Hensel","doi":"10.1055/a-2536-8392","DOIUrl":"10.1055/a-2536-8392","url":null,"abstract":"Campylobacter jejuni is the leading cause of severe enteritis worldwide. Identification of natural products against C. jejuni that inhibit early-stage host-pathogen interactions is a promising strategy, particularly by blocking bacterial adhesion to and invasion into the host cells. This should help to reduce the bacterial load in vector animals. From the seeds of Trigonella foenum-graecum, an aqueous extract (fenugreek high molecular fraction) of high-molecular compounds (polysaccharides, proteins) was obtained. The polysaccharide was characterized as galactomannan (1,4-mannose backbone, substituted at O-6 with single galactose residues and galactose oligosaccharide chains). The protein part consisted of 50 kDa vicilin as the main compound. The fenugreek high molecular fraction did not influence proliferation of C. jejuni and viability of Caco-2 cells (1 - 1000 µg/mL). The fenugreek high molecular fraction reduced bacterial adhesion to Caco-2 significantly (500 - 1000 µg/mL), which was due to an interaction with the bacterial adhesin JlpA, preventing the interaction of this outer membrane protein to its ligand HSP90α (IC50 = 23.4 µg/mL). Bacterial invasion was reduced significantly. Both polysaccharides as well as vicilin contribute to the observed antiadhesive effect. As vicilin-like proteins are widely found in plants from the Fabaceae family, a vicilin-enriched protein preparation from Pisum sativum was investigated for antiadhesive activity. These findings suggest that fenugreek seeds or vicilin-rich plant extracts could be used to develop novel strategies to control C. jejuni infections in food-producing animals, ultimately helping to decrease the prevalence of campylobacteriosis in humans.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"293-301"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-World Data to Document the Use of Herbal Medicinal Products in Children - Report of a Workshop in Krakow. 记录儿童使用草药产品的真实数据-克拉科夫研讨会报告。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-02-11 DOI: 10.1055/a-2523-3856

Nico Symma, Andreas Hensel, Bernd Roether, Barbara Steinhoff, Rudolf Bauer

{"title":"Real-World Data to Document the Use of Herbal Medicinal Products in Children - Report of a Workshop in Krakow.","authors":"Nico Symma, Andreas Hensel, Bernd Roether, Barbara Steinhoff, Rudolf Bauer","doi":"10.1055/a-2523-3856","DOIUrl":"10.1055/a-2523-3856","url":null,"abstract":"The workshop \"Real-world data to document the use of phytopharmaceuticals in children\" was organized by the GA Foundation Plants for Health in collaboration with multiple international scientific societies on July 14, 2024, during the International Congress on Natural Products Research in Kraków, Poland. The event focused on leveraging real-world data and real-world evidence to support the use of herbal medicinal products (syn. phytopharmaceuticals) in pediatric care. The workshop aimed to discuss the current state and future approaches for utilizing real-world data/real-world evidence in expanding the use of herbal medicinal products in children and adolescents. Therefore, the workshop highlighted the unmet needs and challenges in documenting the effectiveness and safety of herbal medicinal products in children and emphasized the coordinated exchange and collaboration among academia, industry, and regulatory authorities. After an e-symposium in May 2022 with more than 300 participants and an in-person workshop on this topic in Bonn in June 2023, this workshop in Krakow was the third event of its kind hosted by the Foundation Plants for Health. Participants concluded that interdisciplinary collaboration is highly needed to establish qualified methods of data collection and assessment of real-world data, e.g., establishing requirements to incorporate nonprescription herbal medicinal products into electronic patient records and registries that can be accessed by all stakeholders.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"167-172"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143399577","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Lipophilicity and Blood Partitioning of Pyrrolizidine Alkaloids and Their N-Oxides In Vitro and In Silico for Toxicokinetic Modeling. 吡咯利西啶类生物碱及其n -氧化物的亲脂性和血液分配特性的体外和硅毒性动力学建模。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-01-23 DOI: 10.1055/a-2523-3987

Anja Lehmann, Manuel Haas, Julian Taenzer, Gerd Hamscher, Charlotte Kloft, Anja These, Christoph Hethey

{"title":"Characterization of Lipophilicity and Blood Partitioning of Pyrrolizidine Alkaloids and Their N-Oxides In Vitro and In Silico for Toxicokinetic Modeling.","authors":"Anja Lehmann, Manuel Haas, Julian Taenzer, Gerd Hamscher, Charlotte Kloft, Anja These, Christoph Hethey","doi":"10.1055/a-2523-3987","DOIUrl":"10.1055/a-2523-3987","url":null,"abstract":"Lipophilicity and blood partitioning are important determinants for predicting toxicokinetics using physiologically-based toxicokinetic modeling. In this study, the logarithm of the n-octanol : water partition coefficient and the blood-to-plasma concentration ratio were, for the first time, experimentally determined for the pyrrolizidine alkaloids intermedine, lasiocarpine, monocrotaline, retrorsine, and their N-oxides. Validated in vitro assays for determination of the n-octanol : water partition coefficient (miniaturized shake-flask method) and the blood-to-plasma conentration ratio (LC-MS/MS-based depletion assay) were compared to an ensemble of in silico models. The experimentally determined octanol : water partition coefficient indicates a higher affinity of pyrrolizidine alkaloids and their N-oxides to the aqueous compared to the organic phase. Depending on the method, in silico determined n-octanol : water partition coefficients overpredicted the experimental values by ≥ 1 log unit for three out of four pyrrolizidine alkaloids (SPARC), four out of six (CLOGP), five out of eight (KowWIN), and three out of eight (S+logP) pyrrolizidine alkaloids and their N-oxides. The blood-to-plasma concentration ratio obtained in vitro suggested a low binding affinity of pyrrolizidine alkaloids and their N-oxides towards red blood cells. For all eight pyrrolizidine alkaloids and their N-oxides, in silico predicted blood-to-plasma ratios deviated from experimental values by less than 50%. In conclusion, for physiologically-based toxicokinetic modeling of pyrrolizidine alkaloids and their N-oxides, the experimental octanol : water partition coefficient should be preferred, while the blood-to-plasma concentration ratio predicted by the acid/base classification model is a suitable surrogate for experimental data.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"274-282"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Compounds against Mpox: Mapping Evidence and Identifying Gaps. 抗m痘的天然化合物：绘制证据并找出差距。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-03-17 DOI: 10.1055/a-2560-1844

Amin Sharifan

{"title":"Natural Compounds against Mpox: Mapping Evidence and Identifying Gaps.","authors":"Amin Sharifan","doi":"10.1055/a-2560-1844","DOIUrl":"10.1055/a-2560-1844","url":null,"abstract":"The global spread of Mpox necessitates exploration of novel treatment options. Considering the established history of herbal medicine in managing infectious diseases, this study reviewed the literature on phytotherapy for Mpox, addressing gaps in evidence-based herbal interventions. A thorough search was conducted across the Scopus, PubMed, and Cochrane databases, as well as grey literature, up to August 2024 to retrieve studies on natural compounds with potential efficacy against Mpox and its associated symptoms. Data were analysed for publication characteristics, the compounds or herbal plants investigated, and their effects on the virus. A total of 37 articles with 242 citations were identified, demonstrating a steady increase in research activity since the first study in 2011, peaking in 2023 with 21 publications and 114 citations. The majority of studies originated from Southeast Asian countries. In terms of study design, most investigations were in silico (n = 31, 84%), followed by in vitro studies (n = 4, 11%), with no in vivo or clinical interventions reported. The primary focus was on the antiviral activities of natural products, with polyphenols identified as the most prevalent lead compounds. Whilst these findings highlight the growing interest in phytotherapy for Mpox, they also underscore the predominance of computational studies. To build upon this foundation of in silico evidence, further laboratory and animal studies are imperative for translating these insights into clinical applications. The comprehensive library of compounds gathered through this research provides a valuable resource to facilitate this crucial next step in the development of herbal interventions against Mpox.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"271-273"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combating Inflammation and Oxidative Stress: Exploring the Cellular Effects of Lonicera caerulea var. kamtschatica Extract. 抗炎症和氧化应激：探索金银花提取物的细胞作用。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-01-19 DOI: 10.1055/a-2520-0013

Katarzyna Zima, Laura Banaszkiewicz, Mateusz Kacper Woźniak, Barbara Khaidakov, Krzysztof Lemke, Paulina Kowalczyk

{"title":"Combating Inflammation and Oxidative Stress: Exploring the Cellular Effects of Lonicera caerulea var. kamtschatica Extract.","authors":"Katarzyna Zima, Laura Banaszkiewicz, Mateusz Kacper Woźniak, Barbara Khaidakov, Krzysztof Lemke, Paulina Kowalczyk","doi":"10.1055/a-2520-0013","DOIUrl":"10.1055/a-2520-0013","url":null,"abstract":"Lonicera caerulea var. kamtschatica, known as blue honeysuckle or haskap berry, is rich in bioactive compounds such as polyphenols, flavonoids, and anthocyanins, which are linked to various health benefits, including anti-inflammatory and antioxidant properties. The research specifically investigates the effects of an L. caerulea var. kamtschatica extract that has been standardized to contain a minimum of 15% anthocyanins on inflammation and oxidative stress at the cellular level. In vitro studies using A549 human lung epithelial cells and peripheral blood mononuclear cells demonstrated the extract's anti-inflammatory and antioxidant properties. L. caerulea var. kamtschatica extract significantly inhibited the nuclear translocation of NF-κB p65 and reduced the production of IL-8 in A549 cells. It also downregulated the expression of proinflammatory genes (RELA and PTGS2) while upregulating antioxidant genes (CAT, HMOX1, and SOD2). In peripheral blood mononuclear cells, L. caerulea var. kamtschatica extract decreased the phosphorylation of NF-κB p65 and reduced the levels of proinflammatory cytokines IL-1β and IL-6 following lipopolysaccharide stimulation. Additionally, the extract inhibited reactive oxygen species formation and nitric oxide production, demonstrating its potential to modulate oxidative stress. Furthermore, in vitro assays indicated that L. caerulea var. kamtschatica extract could hinder the binding of SARS-CoV-2 spike protein to the hACE2 receptor, suggesting antiviral potential.These findings suggest that L. caerulea var. kamtschatica extract exerts significant anti-inflammatory and antioxidant effects, indicating its potential as a functional food ingredient or dietary supplement to combat inflammation and oxidative stress.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"208-221"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roseoglobuloside A, a Novel Nonanolide, and Identification of Specialized Metabolites as hPTP1B1 - 400 Inhibitors from Mangrove-Dwelling Aspergillus spp. 红树曲霉hPTP1B1 - 400抑制剂的特异性代谢物鉴定——一种新型Nonanolide玫瑰红糖苷A

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI: 10.1055/a-2515-9491

Carlos A Fajardo-Hernández, Ángeles G Zavala-Sierra, Verenice I Merlin-Lucas, Jesús I Morales-Jiménez, José Rivera-Chávez

{"title":"Roseoglobuloside A, a Novel Nonanolide, and Identification of Specialized Metabolites as hPTP1B1 - 400 Inhibitors from Mangrove-Dwelling Aspergillus spp.","authors":"Carlos A Fajardo-Hernández, Ángeles G Zavala-Sierra, Verenice I Merlin-Lucas, Jesús I Morales-Jiménez, José Rivera-Chávez","doi":"10.1055/a-2515-9491","DOIUrl":"10.1055/a-2515-9491","url":null,"abstract":"An approach combining enzymatic inhibition and untargeted metabolomics through molecular networking was employed to search for human recombinant full-length protein tyrosine phosphatase 1B (hPTP1 B1 - 400) inhibitors from a collection of 66 mangrove-associated fungal taxa. This strategy prioritized two Aspergillus strains (IQ-1612, section Circumdati, and IQ-1620, section Nigri) for further studies. Chemical investigation of strain IQ-1612 resulted in the isolation of a new nonanolide derivative, roseoglobuloside A (1: ), along with two known metabolites (2: and 3: ), whereas strain IQ-1620 led to the isolation of four known naphtho-γ-pyrones and one known diketopiperazine (4: -8: ). Of all isolates, compounds 2, 3: , and 7: showed a marked inhibitory effect on hPTP1B1 - 400 with an IC50 value < 20 µM, while 6: showed moderate inhibition with IC50 of 65 µM. Compounds 1: and 8: were inactive at a concentration of 100 µM, whereas 4: and 5: demonstrated significant inhibition at 20 µM. The structure of 1: was established by comprehensive spectroscopic analysis, and its relative and absolute configuration was assigned based on NOE correlations and by comparison of calculated and experimental ECD curves. Molecular docking indicated that these molecules primarily bind to two different allosteric sites, thereby inducing conformational changes that impact enzymatic activity.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"197-207"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Characteristics and Functions of Orally Absorbed Herbal Decoction-Borne Plant MicroRNAs. 口服中药煎剂植物microrna的特性与功能。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-01-28 DOI: 10.1055/a-2527-2127

Yating Zhu, Yicheng Yu, Yao Jia, Ziqi Lin, Jinyue Lei, Diyao Wu, Tielong Xu, Longxue Li, Bin Zheng

{"title":"The Characteristics and Functions of Orally Absorbed Herbal Decoction-Borne Plant MicroRNAs.","authors":"Yating Zhu, Yicheng Yu, Yao Jia, Ziqi Lin, Jinyue Lei, Diyao Wu, Tielong Xu, Longxue Li, Bin Zheng","doi":"10.1055/a-2527-2127","DOIUrl":"10.1055/a-2527-2127","url":null,"abstract":"Herbal decoctions always contain numerous plant microRNAs, and some of these can be absorbed orally to exert cross-kingdom gene regulation. However, little is known about which specific types of herbal decoction-borne plant microRNAs are more likely to be absorbed. Thus, two antiviral herbal decoctions, Qingfei Paidu and Qingre Huashi Kangdu, were administered to human volunteers and rats, respectively, to investigate the characteristics of orally absorbed decoction-borne plant microRNAs. MIR-6240 - 3 p was identified as an absorbed plant microRNA in humans and is most highly expressed in Qingfei Paidu decoction. Therefore, the kinetics of MIR-6240 - 3 p were monitored in humans following the administration of the Qingfei Paidu decoction, and its antiviral effect on human coronavirus type 229E (HCoV-229E) was examined in vitro. There were 586 176 small RNAs identified in Qingfei Paidu decoction, of which 100 276 were orally absorbed by humans. In the Qingre Huashi Kangdu decoction, 124 026 small RNAs were detected, with 7484 being orally absorbed by rats. Logistical repression analysis revealed that absorbable plant small RNAs in both humans and rats presented higher expression levels, greater minimum free energy, and increased AU/UA frequencies compared to nonabsorbable plant small RNAs. The amount of MIR-6240 - 3 p in humans increased between 1 and 3 h after the administration of the Qingfei Paidu decoction. In addition, MIR-6240 - 3 p significantly reduced the RNA copy number and TCID50 of HCoV-229E in vitro. These results suggest that herbal decoction-borne plant small RNAs with a higher expression level, greater minimum free energy, or an increased AU/UA frequency are more likely to be orally absorbed and could potentially mediate cross-kingdom gene regulation.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"283-292"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytoestrogens and Sirtuin Activation for Renal Protection: A Review of Potential Therapeutic Strategies. 植物雌激素和Sirtuin激活对肾脏保护：潜在治疗策略的综述。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2024-12-03 DOI: 10.1055/a-2464-4354

Debojyoti Mandal, Nahid Akhtar, Sana Shafi, Jeena Gupta

{"title":"Phytoestrogens and Sirtuin Activation for Renal Protection: A Review of Potential Therapeutic Strategies.","authors":"Debojyoti Mandal, Nahid Akhtar, Sana Shafi, Jeena Gupta","doi":"10.1055/a-2464-4354","DOIUrl":"10.1055/a-2464-4354","url":null,"abstract":"Significant health and socio-economic challenges are posed by renal diseases, leading to millions of deaths annually. The costs associated with treating and caring for patients with renal diseases are considerable. Current therapies rely on synthetic drugs that often come with side effects. However, phytoestrogens, natural compounds, are emerging as promising renal protective agents. They offer a relatively safe, effective, and cost-efficient alternative to existing therapies. Phytoestrogens, being structurally similar to 17-β-estradiol, bind to estrogen receptors and produce both beneficial and, in some cases, harmful health effects. The activation of sirtuins has shown promise in mitigating fibrosis and inflammation in renal tissues. Specifically, SIRT1, which is a crucial regulator of metabolic activities, plays a role in protecting against nephrotoxicity, reducing albuminuria, safeguarding podocytes, and lowering reactive oxygen species in diabetic glomerular injury. Numerous studies have highlighted the ability of phytoestrogens to activate sirtuins, strengthen antioxidant defense, and promote mitochondrial biogenesis, playing a vital role in renal protection during kidney injury. These findings support further investigation into the potential role of phytoestrogens in renal protection. This manuscript reviews the potential of phytoestrogens such as resveratrol, genistein, coumestrol, daidzein, and formononetin in regulating sirtuin activity, particularly SIRT1, and thereby providing renal protection. Understanding these mechanisms is crucial for designing effective treatment strategies using naturally occurring phytochemicals against renal diseases.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"146-166"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine. 网络药理学在中医治疗神经退行性疾病中的应用。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-01-08 DOI: 10.1055/a-2512-8928

Qiang Chen, Guanghui Chen, Qianyan Wang

{"title":"Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine.","authors":"Qiang Chen, Guanghui Chen, Qianyan Wang","doi":"10.1055/a-2512-8928","DOIUrl":"10.1055/a-2512-8928","url":null,"abstract":"In recent years, the incidence of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, has exhibited a steadily rising trend, which has posed a major challenge to the global public health. Traditional Chinese medicine, with its multicomponent and multitarget characteristics, offers a promising approach to treating neurodegenerative diseases. However, comprehensively elucidating the complex mechanisms underlying traditional Chinese medicine formulations remains challenging. As an emerging systems biology method, network pharmacology has provided a vital tool for revealing the multitarget mechanisms of traditional Chinese medicine through high-throughput technologies, molecular docking, and network analysis. This paper reviews the advancements in the application of network pharmacology in treating neurodegenerative diseases using traditional Chinese medicine, analyzes the current status of relevant databases and technological methods, discusses the limitations, and proposes future directions to promote the modernization of traditional Chinese medicine and the development of precision medicine.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"226-237"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Andrographolide and its Derivatives in Cardiovascular Disease: A Comprehensive Review. 穿心莲内酯及其衍生物在心血管疾病中的研究综述。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-03-07 DOI: 10.1055/a-2542-0756

Shenjie Zhang, Xiaokai Xie, Juan Zhao, Yilong Jiang, Chao Huang, Qi Li, Boyu Xia, Le Yin, Xiaomei Yuan, Qingsheng You

引用次数: 0