Planta medica最新文献_第3页

Turkish Astragalus Species: Botanical Aspects, Secondary Metabolites, and Biotransformation. 土耳其黄芪品种：植物学方面、次级代谢物和生物转化。

IF 2.1 4区医学

Planta medica Pub Date : 2025-01-01 Epub Date: 2024-11-13 DOI: 10.1055/a-2444-3252

Güner Ekiz Dinçman, Zeki Aytaç, İhsan Çalış

{"title":"Turkish Astragalus Species: Botanical Aspects, Secondary Metabolites, and Biotransformation.","authors":"Güner Ekiz Dinçman, Zeki Aytaç, İhsan Çalış","doi":"10.1055/a-2444-3252","DOIUrl":"10.1055/a-2444-3252","url":null,"abstract":"Astragalus is a widespread genus comprising approximately 3500 species, both annual and perennial, found across Asia, Europe, Africa, and the Americas. In Turkey, it is represented by 63 sections and 485 taxa with a high endemism ratio (51%). In traditional medicine, the roots of various Astragalus species represent very old and well-known drugs used for antiperspirant, diuretic, and tonic purposes, as well as for the treatment of nephritis, diabetes, leukemia, and uterine cancer. The genus Astragalus is the richest source of cycloartane-type compounds, which display a diverse range of bioactivities, such as wound healing, immunomodulatory, antitumor, hepatoprotective, antimutagenic, antiviral, and antiprotozoal activities. Moreover, cycloastragenol, the main sapogenol of many cycloartane-type glycosides found in the Astragalus genus, has gained attention as a potent telomerase activator over the past decade. The preparation of cycloastragenol derivatives could be significant in the near future due to their unique bioactivity. This review covers the botanical aspects of Astragalus L., as well as the phytochemical and biological activity studies conducted on Turkish Astragalus species, with a special focus on cycloartenols. It contains 36 articles reporting the phytochemistry of 29 Astragalus species and 111 new compounds, including 104 triterpene saponins. In addition to the phytochemical studies, this review summarizes the biotransformation studies on Astragalus cycloartanes via endophytic fungi isolated from the tissues of Astragalus species.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"40-61"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142625964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Betulinic Acid Acts in Synergism with Imatinib Mesylate, Triggering Apoptosis in MDR Leukemia Cells. 白桦脂酸与甲磺酸伊马替尼协同作用，引发 mdr 白血病细胞凋亡。

IF 2.1 4区医学

Planta medica Pub Date : 2025-01-01 Epub Date: 2024-10-12 DOI: 10.1055/a-2440-4847

Claudia Stutz, Ana Paula Gregório Alves Fontão, Gustavo Werneck de Souza E Silva, Leonardo Noboru Seito, Renata Trentin Perdomo, André Luiz Franco Sampaio

{"title":"Betulinic Acid Acts in Synergism with Imatinib Mesylate, Triggering Apoptosis in MDR Leukemia Cells.","authors":"Claudia Stutz, Ana Paula Gregório Alves Fontão, Gustavo Werneck de Souza E Silva, Leonardo Noboru Seito, Renata Trentin Perdomo, André Luiz Franco Sampaio","doi":"10.1055/a-2440-4847","DOIUrl":"10.1055/a-2440-4847","url":null,"abstract":"Chronic myeloid leukemia (CML) is a myeloproliferative disease, characterized by the presence of the oncogene BCR-ABL. Imatinib mesylate (IMA) is the first-line treatment for CML, and some treatment resistance has been reported. Natural products are rich sources of bioactive compounds with biological effects, opening a possibility to alter cell susceptibility to drugs such as imatinib. Herein, we evaluated the interference of betulinic acid and ursolic acid in glycoprotein P (P-gp) activity and the possible synergistic effect when associated with IMA by the Chou-Talalay method. Ursolic acid presented an IC50 of 14.0 µM and 19.6 µM for K562 and Lucena 1, respectively, whilst betulinic acid presented an IC50 of 8.6 µM and 12.5 µM for these cell lines. Evaluation of the combination of terpenoids and imatinib mesylate revealed that ursolic acid or betulinic acid acts in synergism with IMA, as indicated by the combination indexes (CI<1). Analysis of annexin V labeling demonstrated that a combination of IMA with betulinic acid enhances the inhibition on cell proliferation via the apoptosis pathway, with caspases 3/7 activation after 24 hours of treatment and inhibition of the STAT5/survivin pathway, decreasing cell viability. The combination of natural products and IMA on a multidrug-resistant leukemia cell line is a promising strategy for CML treatment.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"19-28"},"PeriodicalIF":2.1,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472435","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Curcumin: Epigenetic Modulation and Tumor Immunity in Antitumor Therapy. 姜黄素：抗肿瘤疗法中的表观遗传调节和肿瘤免疫。

IF 2.1 4区医学

Planta medica Pub Date : 2024-12-17 DOI: 10.1055/a-2499-1140

Xin Wan, Dong Wang

{"title":"Curcumin: Epigenetic Modulation and Tumor Immunity in Antitumor Therapy.","authors":"Xin Wan, Dong Wang","doi":"10.1055/a-2499-1140","DOIUrl":"https://doi.org/10.1055/a-2499-1140","url":null,"abstract":"Curcumin is the main ingredient of the Chinese herbal turmeric rhizome, used to treat tumors, diabetes, inflammation, neurodegenerative diseases, cardiovascular diseases, metabolic syndrome, and liver diseases. The antitumor effects of curcumin have received even more attention. One of the main mechanisms of antitumor effects includes inhibition of tumor invasion and migration, induction of tumor cell apoptosis, and inhibition of various cell signaling pathways. It has been found that the antitumor biological activity of curcumin in the body is associated with epigenetic mechanisms. That also implies that curcumin may act as a potential epigenetic modulator to influence the development of tumor diseases. The immune system plays an essential role in the development of tumorigenesis. Tumor immunotherapy is currently one of the most promising research directions in the field of tumor therapy. Curcumin has been found to have significant regulatory effects on tumor immunity and is expected to be a novel adjuvant for tumor immunity. This paper summarizes the antitumor effects of curcumin from four aspects: molecular and epigenetic mechanisms of curcumin against a tumor, mechanisms of curcumin modulation of tumor immunotherapy, reversal of chemotherapy resistance, and novel drug delivery system of curcumin, which provide new directions for the development of new antitumor drugs.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of Echinacea purpurea Extracts as Immunostimulants: Impact on Macrophage Activation. 紫锥菊提取物作为免疫刺激剂的评估：对巨噬细胞活化的影响

IF 2.1 4区医学

Planta medica Pub Date : 2024-12-01 Epub Date: 2024-10-17 DOI: 10.1055/a-2436-9664

Sara F Vieira, Samuel M Gonçalves, Virgínia M F Gonçalves, Maria E Tiritan, Cristina Cunha, Agostinho Carvalho, Rui L Reis, Helena Ferreira, Nuno M Neves

{"title":"Evaluation of Echinacea purpurea Extracts as Immunostimulants: Impact on Macrophage Activation.","authors":"Sara F Vieira, Samuel M Gonçalves, Virgínia M F Gonçalves, Maria E Tiritan, Cristina Cunha, Agostinho Carvalho, Rui L Reis, Helena Ferreira, Nuno M Neves","doi":"10.1055/a-2436-9664","DOIUrl":"10.1055/a-2436-9664","url":null,"abstract":"Echinacea purpurea has been traditionally used to strengthen the immune system. Therefore, herein, we investigated the potential of E. purpurea aqueous extracts (AEs) obtained from flowers (F), leaves (L), or roots (R) as an immune booster in human primary monocyte-derived macrophages (hMDMs). Additionally, to identify the main class of compounds (phenolic/carboxylic acids vs. alkylamides) responsible for the bioactivity, the three AEs were fractioned by semi-preparative high-performance liquid chromatography (HPLC). The AEs and the isolated phenolic/carboxylic acidic fractions were not cytotoxic for hMDMs for all tested concentrations, as confirmed by the metabolic activity and DNA content assays. Moreover, AE drastically induced the production of the interleukin (IL)-6 and tumor necrosis factor (TNF)-α, with a minimal effect on IL-1β and prostaglandin E2 (PGE2), supporting their potential for macrophage activation. Interestingly, in the presence of the phenolic/carboxylic acidic fractions, this efficacy considerably decreased, suggesting a complementary effect between compounds. AE also triggered the phosphorylation of the extracellular signal-regulated kinase (ERK) 1/2 and p38 signaling pathways and upregulated the cyclooxygenase (COX)-2 expression in hMDMs. Overall, AE-F was demonstrated to be the most powerful immunostimulant extract that can be related to their higher number in identified bioactive compounds compared to AE-L and AE-R. These results highlight the efficiency of E. purpurea AE to enhance the function of a key cell type of the immune system and their potential as immunostimulant formulations for patients with a compromised immune system due to certain diseases (e.g., acquired immunodeficiencies) and treatments (e.g., chemotherapy).","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1143-1155"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medicinal Plant Microbiomes: Factors Affecting Bacterial and Fungal Community Composition. 药用植物微生物群：影响细菌和真菌群落组成的因素

IF 2.1 4区医学

Planta medica Pub Date : 2024-12-01 Epub Date: 2024-10-24 DOI: 10.1055/a-2420-0270

Daniel Zagal, James G Graham, Jonathan Bisson, Stefan J Green, Guido F Pauli

{"title":"Medicinal Plant Microbiomes: Factors Affecting Bacterial and Fungal Community Composition.","authors":"Daniel Zagal, James G Graham, Jonathan Bisson, Stefan J Green, Guido F Pauli","doi":"10.1055/a-2420-0270","DOIUrl":"10.1055/a-2420-0270","url":null,"abstract":"This exploratory study was designed to identify factors implicating microbial influence on medicinal plant metabolomes. Utilizing a whole-microbiome approach, amplicon sequencing was used to identify the makeup of fungal and bacterial assemblages from endophytic (interior) and epiphytic (external) environments in two different sets of congeneric host-plant pairs, with collection of multiple samples of two medicinal plant species (Actaea racemosa, Rhodiola rosea) and two generic analogs (Actaea rubra, Rhodiola integrifolia). Diversity analysis of microbial assemblages revealed the influence of three primary factors driving variance in microbial community composition: host-plant taxonomy, the compartmentalization of microbial communities within discrete plant parts, and the scale of distance (microhabitat heterogeneity) between sampling locations. These three factors accounted for ~ 60% of variance within and between investigated microbiomes. Across all our collections, bacterial populations were more diverse than fungi (per compartment), and microbial density in epiphytic compartments (aerial parts, rhizosphere) were higher than those of endophytes (leaf and root). These comparative data point to key loci associated with variation between congeneric pairs and plant genera, providing insight into the complex and contrasting relationships found within this multi-kingdom coevolutionary relationship. Although reflective of only a limited set of botanical source materials, these data document the richness of a relatively unexplored component of the plant world and highlight the relevance of a whole-microbiome ecology-driven approach to botanical research and directed natural product investigations.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1130-1142"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11816503/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aescin Inhibits Herpes simplex Virus Type 1 Induced Membrane Fusion. Aescin 抑制单纯疱疹病毒 1 型诱导的膜融合

IF 2.1 4区医学

Planta medica Pub Date : 2024-12-01 Epub Date: 2024-10-23 DOI: 10.1055/a-2441-6570

Diana Ulrich, Andreas Hensel, Nica Classen, Wali Hafezi, Jandirk Sendker, Joachim Kühn

{"title":"Aescin Inhibits Herpes simplex Virus Type 1 Induced Membrane Fusion.","authors":"Diana Ulrich, Andreas Hensel, Nica Classen, Wali Hafezi, Jandirk Sendker, Joachim Kühn","doi":"10.1055/a-2441-6570","DOIUrl":"10.1055/a-2441-6570","url":null,"abstract":"Infections with Herpes simplex virus can cause severe ocular diseases and encephalitis. The present study aimed to investigate potential inhibitors of fusion between HSV-1 and the cellular membrane of the host cell. Fusion and entry of HSV-1 into the host cell is mimicked by a virus-free eukaryotic cell culture system by co-expression of the HSV-1 glycoproteins gD, gH, gL, and gB in presence of a gD receptor, resulting in excessive membrane fusion and polykaryocyte formation. A microscopic read-out was used for the screening of potential inhibitors, whereas luminometric quantification of cell-cell fusion was used in a reporter fusion assay. HSV-1 gB was tagged at its C-terminus with mCherry to express mCherry-gB in both assay systems for the visualization of the polykaryocyte formation. Reporter protein expression of SEAP was regulated by a Tet-On 3 G system. The saponin mixture aescin was identified as the specific inhibitor (IC50 7.4 µM, CC50 24.3 µM, SI 3.3) of membrane fusion. A plaque reduction assay on Vero cells reduced HSV-1 entry into cells and HSV-1 cell-to-cell spread significantly; 15 µM aescin decreased relative plaque counts to 41%, and 10 µM aescin resulted in a residual plaque size of 11% (HSV-1 17 syn+) and 2% (HSV-1 ANG path). Release of the HSV-1 progeny virus was reduced by one log step in the presence of 15 µM aescin. Virus particle integrity was mainly unaffected. Analytical investigation of aescin by UHPLC-MS revealed aescin IA and -IB and isoaescin IA and -IB as the main compounds with different functional activities. Aescin IA had the lowest IC50, the highest CC50, and an SI of > 4.6.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1156-1166"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142505900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pharmacological Effects of Paeonia lactiflora Focusing on Painful Diabetic Neuropathy. 芍药对糖尿病痛性神经病变的药理作用

IF 2.1 4区医学

Planta medica Pub Date : 2024-12-01 Epub Date: 2024-10-29 DOI: 10.1055/a-2441-6488

Vanessa Wiegand, Ying Gao, Nicole Teusch

{"title":"Pharmacological Effects of Paeonia lactiflora Focusing on Painful Diabetic Neuropathy.","authors":"Vanessa Wiegand, Ying Gao, Nicole Teusch","doi":"10.1055/a-2441-6488","DOIUrl":"10.1055/a-2441-6488","url":null,"abstract":"Painful diabetic neuropathy (PDN) is a highly prevalent complication in patients suffering from diabetes mellitus. Given the inadequate pain-relieving effect of current therapies for PDN, there is a high unmet medical need for specialized therapeutic options. In traditional Chinese medicine (TCM), various herbal formulations have been implemented for centuries to relieve pain, and one commonly used plant in this context is Paeonia lactiflora (P. lactiflora). Here, we summarize the chemical constituents of P. lactiflora including their pharmacological mechanisms-of-action and discuss potential benefits for the treatment of PDN. For this, in silico data, as well as preclinical and clinical studies, were critically reviewed and comprehensively compiled. Our findings reveal that P. lactiflora and its individual constituents exhibit a variety of pharmacological properties relevant for PDN, including antinociceptive, anti-inflammatory, antioxidant, and antiapoptotic activities. Through this multifaceted and complex combination of various pharmacological effects, relevant hallmarks of PDN are specifically addressed, suggesting that P. lactiflora may represent a promising source for novel therapeutic approaches for PDN.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1115-1129"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preclinical Evidence of Mulberry Leaf Polysaccharides on Diabetic Kidney Disease: a Systematic Review and Meta-Analysis. 桑叶多糖治疗糖尿病肾病的临床前证据：系统综述和荟萃分析。

IF 2.1 4区医学

Planta medica Pub Date : 2024-12-01 Epub Date: 2024-10-02 DOI: 10.1055/a-2432-2732

Yisu Wang, Baifan Chen, Jinghong Zhang, Dan Wang, Yuan Ruan

{"title":"Preclinical Evidence of Mulberry Leaf Polysaccharides on Diabetic Kidney Disease: a Systematic Review and Meta-Analysis.","authors":"Yisu Wang, Baifan Chen, Jinghong Zhang, Dan Wang, Yuan Ruan","doi":"10.1055/a-2432-2732","DOIUrl":"10.1055/a-2432-2732","url":null,"abstract":"Mulberry leaf polysaccharides (MLPs) have a variety of biological activities. Preliminary scattered evidence of preclinical studies have reported their potenzial effects on diabetic kidney disease (DKD). Here, we intended to assess the preclinical evidence of MLPs and explore their potenzial mechanisms on DKD, offering a scientific reference for the therapeutic use of MLPs. The study has been registered under the CRD42022309117 registration number at PROSPERO. Comprehensive search was conducted across eight databases from their establishment till January 2024, and eight studies with 270 animals were included in the meta-analysis. The primary outcome measurements in the MLP group, including serum creatinine (Scr) (P = 0.0005), blood urea nitrogen (BUN) (P = 0.02), 24-hour urinary protein (UP) (P = 0.001), and urinary microalbumin (UAlb) (P < 0.0001), were significantly reduced compared to the control group. Additionally, MLP treatment was significantly correlated with fasting blood glucose (FBG), total cholesterol (TC), protein expression of TGF-β1, CTGF mRNA, and the kidney index (all P values < 0.05) and delayed the progression of local pathological changes in the kidney. Subgroup analysis revealed significant species differences in the efficacy of MLPs. Also, it showed that the dosage of streptozotocin potenzially affected the Scr and UAlb results, while the duration of MLP treatment influenced UAlb results. MLPs may exert potenzial renal protection by delaying renal fibrosis, inhibiting inflammatory reactions, suppressing the growth hormone-insulin-like growth factor-insulin-like growth factor binding protein axis, and regulating the insulin receptor pathway. In summary, MLPs have multifaceted renal protective effects, suggesting their potenzial for treating DKD.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1100-1114"},"PeriodicalIF":2.1,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11617037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142366230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Basic Requirements and Framework Conditions of Real-World Data (RWD) on Herbal Medicinal Products. 草药产品真实世界数据 (RWD) 的基本要求和框架条件。

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-01 Epub Date: 2024-09-25 DOI: 10.1055/a-2409-3125

Salome Sophie Hölzle, Thorsten Reineke, Stefan Hoch, Bernd Roether, Matthew Francis, Christelle Anquez-Traxler, Nico Symma

引用次数: 0

Correction: Immunomodulatory activity and inhibitory effects of Viscum album on cancer cells, its safety profiles and recent nanotechnology development. 更正：白花蛇舌草的免疫调节活性和对癌细胞的抑制作用、其安全性概况以及最新的纳米技术发展。

IF 2.1 4区医学

Planta medica Pub Date : 2024-11-01 Epub Date: 2024-10-10 DOI: 10.1055/a-2423-9185

Ibrahim Jantan, Nermeen Yosri, Nurkhalida Kamal, Ahmed Mediani, Sameh AbouZid, Ahmed Swillam, Mahmoud Swilam, Ahmed M Ayyat

引用次数: 0