Planta medica最新文献_第3页

Andrographolide and its Derivatives in Cardiovascular Disease: A Comprehensive Review.

IF 2.1 4区医学

Planta medica Pub Date : 2025-03-07 DOI: 10.1055/a-2542-0756

Shenjie Zhang, Xiaokai Xie, Juan Zhao, Yilong Jiang, Chao Huang, Qi Li, Boyu Xia, Le Yin, Xiaomei Yuan, Qingsheng You

引用次数: 0

Galactomannan and Vicilin from Fenugreek Seeds (Trigonella foenum-graecum) Impair Early Pathogen-Host Interaction of Campylobacter jejuni with Intestinal Cells via JlpA.

IF 2.1 4区医学

Planta medica Pub Date : 2025-03-06 DOI: 10.1055/a-2536-8392

Leon Kemper, Fabian Herrmann, Simone König, Franco H Falcone, Andreas Hensel

{"title":"Galactomannan and Vicilin from Fenugreek Seeds (Trigonella foenum-graecum) Impair Early Pathogen-Host Interaction of Campylobacter jejuni with Intestinal Cells via JlpA.","authors":"Leon Kemper, Fabian Herrmann, Simone König, Franco H Falcone, Andreas Hensel","doi":"10.1055/a-2536-8392","DOIUrl":"10.1055/a-2536-8392","url":null,"abstract":"Campylobacter jejuni is the leading cause of severe enteritis worldwide. Identification of natural products against C. jejuni that inhibit early-stage host-pathogen interactions is a promising strategy, particularly by blocking bacterial adhesion to and invasion into the host cells. This should help to reduce the bacterial load in vector animals. From the seeds of Trigonella foenum-graecum, an aqueous extract (fenugreek high molecular fraction) of high-molecular compounds (polysaccharides, proteins) was obtained. The polysaccharide was characterized as galactomannan (1,4-mannose backbone, substituted at O-6 with single galactose residues and galactose oligosaccharide chains). The protein part consisted of 50 kDa vicilin as the main compound. The fenugreek high molecular fraction did not influence proliferation of C. jejuni and viability of Caco-2 cells (1 - 1000 µg/mL). The fenugreek high molecular fraction reduced bacterial adhesion to Caco-2 significantly (500 - 1000 µg/mL), which was due to an interaction with the bacterial adhesin JlpA, preventing the interaction of this outer membrane protein to its ligand HSP90α (IC50 = 23.4 µg/mL). Bacterial invasion was reduced significantly. Both polysaccharides as well as vicilin contribute to the observed antiadhesive effect. As vicilin-like proteins are widely found in plants from the Fabaceae family, a vicilin-enriched protein preparation from Pisum sativum was investigated for antiadhesive activity. These findings suggest that fenugreek seeds or vicilin-rich plant extracts could be used to develop novel strategies to control C. jejuni infections in food-producing animals, ultimately helping to decrease the prevalence of campylobacteriosis in humans.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143391503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Characterization and Comparative Analysis of Cycloartane-Type Triterpenes in Astragalus adsurgens and Astragalus membranaceus. 黄芪和膜荚黄芪中环安坦类三萜的植物化学特征和比较分析。

IF 2.1 4区医学

Planta medica Pub Date : 2025-03-01 Epub Date: 2024-11-25 DOI: 10.1055/a-2486-8873

Guanglian Zhou, Yin Chen, Bingyan Xu, Guoqing Peng, Li Wang, Jian-Ping Huang, Zhiyin Yu, Sheng-Xiong Huang

{"title":"Phytochemical Characterization and Comparative Analysis of Cycloartane-Type Triterpenes in Astragalus adsurgens and Astragalus membranaceus.","authors":"Guanglian Zhou, Yin Chen, Bingyan Xu, Guoqing Peng, Li Wang, Jian-Ping Huang, Zhiyin Yu, Sheng-Xiong Huang","doi":"10.1055/a-2486-8873","DOIUrl":"10.1055/a-2486-8873","url":null,"abstract":"Astragalus adsurgens, a significant forage plant cultivated in arid regions of northwest China, remains underexplored for its triterpenoid saponins and medicinal properties compared to the extensively studied Astragalus membranaceus. To explore the phytochemical profile of A. adsurgens for its potential application in the medical field, we employed ultra-pressure liquid chromatography coupled with a tandem mass spectrometry-based method to identify cycloartane-type triterpenes. Eventually, five new cycloartane-type triterpenoids, adsurgosides A - D ( 1 - 4: ) and 3-methyl-3,4-seco-cyclostellanol (5: ), together with two known analogs, cycloastragenol (6: ) and cyclopycanthogenin (7: ), were isolated from the roots of A. adsurgens. Their structures were elucidated using 1D and 2D NMR analyses in combination with HRESIMS data. Additionally, a comparative study on the distribution patterns of these compounds revealed qualitative and quantitative variations between A. adsurgens and A. membranaceus. Our findings not only identified an alternative plant for isolating cycloartane-type triterpenoids but also offer new insights into the chemical properties of A. adsurgens.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"109-118"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New Constituents from Zanthoxylum rhoifolium. Zanthoxylum rhoifolium Lam.的新成分

IF 2.1 4区医学

Planta medica Pub Date : 2025-03-01 Epub Date: 2024-11-25 DOI: 10.1055/a-2486-9139

Mauro Di Stasi, Valentina Parisi, Vanessa Hernandez, Erica Gazzillo, Maria Giovanna Chini, Giuseppe Bifulco, Alessandra Braca, Giuliana Donadio, Nunziatina De Tommasi

引用次数: 0

Plants with Hair Growth Activity for Alopecia: A Scoping Review on Methodological Aspects. 具有毛发生长活性的植物治疗脱发：方法学方面的综述。

IF 2.1 4区医学

Planta medica Pub Date : 2025-03-01 Epub Date: 2024-12-02 DOI: 10.1055/a-2494-9020

Sharize Betoni Galende, Mariana Nascimento de Paula, Mariana Millan Fachi, Daniela Cristina de Medeiros Araújo, Danielly Chierrito, João Carlos Palazzo de Mello

{"title":"Plants with Hair Growth Activity for Alopecia: A Scoping Review on Methodological Aspects.","authors":"Sharize Betoni Galende, Mariana Nascimento de Paula, Mariana Millan Fachi, Daniela Cristina de Medeiros Araújo, Danielly Chierrito, João Carlos Palazzo de Mello","doi":"10.1055/a-2494-9020","DOIUrl":"10.1055/a-2494-9020","url":null,"abstract":"Alopecia is a common dermatological disorder of patchy hair loss with substantial patient burden. Phytotherapeutic compounds are increasingly used as a source of new therapeutic options. This review aimed to synthesize the evidence on plant species in hair growth and the methodological aspects of in vivo experimental models. The systematic scoping review was conducted following the PRISMA checklist, the Joanna Briggs Institute, and in accordance with Cochrane. A systematic search was carried out in the Pubmed, Scopus, Web of Science, and SciELO databases. In vivo experiments that evaluated hair growth activity using natural substances of plant origin were included. Data collection and analysis: a total of 1250 studies were identified, of which 175 were included for qualitative synthesis. Of these, 128 used mice, 37 rats, 10 rabbits, 1 guinea pig, and 1 sheep as animal models. The methodologies mapped were as follows: hair growth analysis, histological analysis, immunohistochemistry, gene expression analysis, Western blot, enzyme-linked immunosorbent assay, and biochemical analysis. Minoxidil and finasteride were the most commonly used positive controls. The studies evaluated plant species (166), algae (11), or isolated substances (31). Overall, 152 plant species and 37 isolated substances were identified. This is the first systematic scoping review on the methodological aspects of in vivo hair growth activity. We created a checklist to be completed by authors to allow data comparison and reproducibility, facilitate data interpretation by readers, and ensure better quality of evidence. This work may become a valuable tool for future research and contribute to significant advances in hair growth studies.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"89-108"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comprehensive Biotechnological Strategies for Podophyllotoxin Production from Plant and Microbial Sources. 利用植物和微生物资源生产鬼臼毒素的综合生物技术战略。

IF 2.1 4区医学

Planta medica Pub Date : 2025-03-01 Epub Date: 2024-12-17 DOI: 10.1055/a-2504-3069

Anviksha Anviksha, Mondem Sudhakara Reddy

{"title":"Comprehensive Biotechnological Strategies for Podophyllotoxin Production from Plant and Microbial Sources.","authors":"Anviksha Anviksha, Mondem Sudhakara Reddy","doi":"10.1055/a-2504-3069","DOIUrl":"10.1055/a-2504-3069","url":null,"abstract":"Podophyllotoxin is derived from plant sources and exhibits strong anticancer activity. However, limited natural availability and environmental impacts from traditional extraction methods drive the search for alternative production approaches. This review explores diverse strategies for sustainable podophyllotoxin synthesis, including biosynthesis, semi-synthesis, and biotransformation. Biosynthetic methods involve metabolic pathway engineering in plant or microbial cells, enabling increased yields by manipulating precursor availability and gene expression. Semi-synthetic approaches modify podophyllotoxin precursors or intermediates to enhance therapeutic effects, with derivatives like etoposide and teniposide showing clinical efficacy. Biotransformation, utilising organisms such as endophytic fungi or human hepatic enzymes, enables the transformation of substrates like deoxypodophyllotoxin into podophyllotoxin or its derivatives, yielding compounds with reduced environmental impact and improved purity. The anticancer efficacy of podophyllotoxin and its derivatives stems from multiple mechanisms. These compounds disrupt cell mitosis by inhibiting microtubule assembly, impairing nucleoside transport, and blocking topoisomerase II activity, leading to DNA cleavage and cancer cell apoptosis. Podophyllotoxin and its derivatives also exhibit anti-angiogenesis and anti-metastatic effects through signalling pathway modulation. Notably, derivatives like deoxypodophyllotoxin utilise advanced delivery systems, enhancing targeted efficacy and reducing side effects. Given the varied mechanisms and growing therapeutic applications, optimising biotransformation and delivery techniques remains essential for advancing podophyllotoxin-based therapies. This comprehensive review underscores the compound's potential as a robust anticancer agent and the need for continued research to maximise its production and clinical effectiveness.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"66-88"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142847388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracts of Drynariae Rhizoma Promote Bone Formation in OVX Rats through Modulating the Gut Microbiota. 旱莲草提取物通过调节肠道微生物群促进卵巢切除大鼠的骨形成

IF 2.1 4区医学

Planta medica Pub Date : 2025-03-01 Epub Date: 2024-11-05 DOI: 10.1055/a-2462-4844

Qing Lin, Xinchen Ouyang, Qi Pan, Jiajia Huang, Zhifen Zhang, Yumei Yang, Haoyu Wang, Li Yang, Xiaofeng Zhu, Xiaoyun Li, Ronghua Zhang

{"title":"Extracts of Drynariae Rhizoma Promote Bone Formation in OVX Rats through Modulating the Gut Microbiota.","authors":"Qing Lin, Xinchen Ouyang, Qi Pan, Jiajia Huang, Zhifen Zhang, Yumei Yang, Haoyu Wang, Li Yang, Xiaofeng Zhu, Xiaoyun Li, Ronghua Zhang","doi":"10.1055/a-2462-4844","DOIUrl":"10.1055/a-2462-4844","url":null,"abstract":"Drynariae Rhizoma has been commonly used as a preventive and therapeutic agent for bone diseases. However, its pharmacological mechanisms have not been fully elucidated. Here, we aimed to investigate the effects of Drynariae Rhizoma in a bilateral ovariectomized rat model and explore the correlation with gut microbiome. We established an ovariectomized rat model, which we treated with different doses of Drynariae Rhizoma (Drynariae Rhizoma-Low, 0.27 g/kg/day; Drynariae Rhizoma-Middle, 0.81 g/kg/day; Drynariae Rhizoma-High, 2.43 g/kg/day) through intragastric administration for 12 weeks. Results showed that Drynariae Rhizoma alleviated body weight, moderated bone microstructure, and promoted the expression of bone formation-related factors in ovariectomized rats, in which Drynariae Rhizoma-High showed the most significant effects among the three doses. Furthermore, the effects of Drynariae Rhizoma on promoting bone formation were correlated to the changes in microbial richness and the restorations of several genera, among which Ruminiclostridium and Ruminococcaceae_UCG_007 were positively correlated with the bone formation-related factors, and both were enriched in the Drynariae Rhizoma-High group as biomarkers. Moreover, CMP-legionaminate biosynthesis I might be a crucial pathway of Drynariae Rhizoma to regulate gut microbiota. The content of serum short-chain fatty acids in the ovariectomized rats were regulated by Drynariae Rhizoma. Our results demonstrate that Drynariae Rhizoma promotes bone formation in ovariectomized rats, and is related to the regulation of the gut microbiota structure.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"127-141"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Characteristics and Functions of Orally Absorbed Herbal Decoction-Borne Plant MicroRNAs.

IF 2.1 4区医学

Planta medica Pub Date : 2025-02-26 DOI: 10.1055/a-2527-2127

Yating Zhu, Yicheng Yu, Yao Jia, Ziqi Lin, Jinyue Lei, Diyao Wu, Tielong Xu, Longxue Li, Bin Zheng

{"title":"The Characteristics and Functions of Orally Absorbed Herbal Decoction-Borne Plant MicroRNAs.","authors":"Yating Zhu, Yicheng Yu, Yao Jia, Ziqi Lin, Jinyue Lei, Diyao Wu, Tielong Xu, Longxue Li, Bin Zheng","doi":"10.1055/a-2527-2127","DOIUrl":"10.1055/a-2527-2127","url":null,"abstract":"Herbal decoctions always contain numerous plant microRNAs, and some of these can be absorbed orally to exert cross-kingdom gene regulation. However, little is known about which specific types of herbal decoction-borne plant microRNAs are more likely to be absorbed. Thus, two antiviral herbal decoctions, Qingfei Paidu and Qingre Huashi Kangdu, were administered to human volunteers and rats, respectively, to investigate the characteristics of orally absorbed decoction-borne plant microRNAs. MIR-6240 - 3 p was identified as an absorbed plant microRNA in humans and is most highly expressed in Qingfei Paidu decoction. Therefore, the kinetics of MIR-6240 - 3 p were monitored in humans following the administration of the Qingfei Paidu decoction, and its antiviral effect on human coronavirus type 229E (HCoV-229E) was examined in vitro. There were 586 176 small RNAs identified in Qingfei Paidu decoction, of which 100 276 were orally absorbed by humans. In the Qingre Huashi Kangdu decoction, 124 026 small RNAs were detected, with 7484 being orally absorbed by rats. Logistical repression analysis revealed that absorbable plant small RNAs in both humans and rats presented higher expression levels, greater minimum free energy, and increased AU/UA frequencies compared to nonabsorbable plant small RNAs. The amount of MIR-6240 - 3 p in humans increased between 1 and 3 h after the administration of the Qingfei Paidu decoction. In addition, MIR-6240 - 3 p significantly reduced the RNA copy number and TCID50 of HCoV-229E in vitro. These results suggest that herbal decoction-borne plant small RNAs with a higher expression level, greater minimum free energy, or an increased AU/UA frequency are more likely to be orally absorbed and could potentially mediate cross-kingdom gene regulation.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Lipophilicity and Blood Partitioning of Pyrrolizidine Alkaloids and Their N-Oxides In Vitro and In Silico for Toxicokinetic Modeling.

IF 2.1 4区医学

Planta medica Pub Date : 2025-02-21 DOI: 10.1055/a-2523-3987

Anja Lehmann, Manuel Haas, Julian Taenzer, Gerd Hamscher, Charlotte Kloft, Anja These, Christoph Hethey

{"title":"Characterization of Lipophilicity and Blood Partitioning of Pyrrolizidine Alkaloids and Their N-Oxides In Vitro and In Silico for Toxicokinetic Modeling.","authors":"Anja Lehmann, Manuel Haas, Julian Taenzer, Gerd Hamscher, Charlotte Kloft, Anja These, Christoph Hethey","doi":"10.1055/a-2523-3987","DOIUrl":"10.1055/a-2523-3987","url":null,"abstract":"Lipophilicity and blood partitioning are important determinants for predicting toxicokinetics using physiologically-based toxicokinetic modeling. In this study, the logarithm of the n-octanol : water partition coefficient and the blood-to-plasma concentration ratio were, for the first time, experimentally determined for the pyrrolizidine alkaloids intermedine, lasiocarpine, monocrotaline, retrorsine, and their N-oxides. Validated in vitro assays for determination of the n-octanol : water partition coefficient (miniaturized shake-flask method) and the blood-to-plasma conentration ratio (LC-MS/MS-based depletion assay) were compared to an ensemble of in silico models. The experimentally determined octanol : water partition coefficient indicates a higher affinity of pyrrolizidine alkaloids and their N-oxides to the aqueous compared to the organic phase. Depending on the method, in silico determined n-octanol : water partition coefficients overpredicted the experimental values by ≥ 1 log unit for three out of four pyrrolizidine alkaloids (SPARC), four out of six (CLOGP), five out of eight (KowWIN), and three out of eight (S+logP) pyrrolizidine alkaloids and their N-oxides. The blood-to-plasma concentration ratio obtained in vitro suggested a low binding affinity of pyrrolizidine alkaloids and their N-oxides towards red blood cells. For all eight pyrrolizidine alkaloids and their N-oxides, in silico predicted blood-to-plasma ratios deviated from experimental values by less than 50%. In conclusion, for physiologically-based toxicokinetic modeling of pyrrolizidine alkaloids and their N-oxides, the experimental octanol : water partition coefficient should be preferred, while the blood-to-plasma concentration ratio predicted by the acid/base classification model is a suitable surrogate for experimental data.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143029261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine. 网络药理学在中医治疗神经退行性疾病中的应用。

IF 2.1 4区医学

Planta medica Pub Date : 2025-02-18 DOI: 10.1055/a-2512-8928

Qiang Chen, Guanghui Chen, Qianyan Wang

{"title":"Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine.","authors":"Qiang Chen, Guanghui Chen, Qianyan Wang","doi":"10.1055/a-2512-8928","DOIUrl":"10.1055/a-2512-8928","url":null,"abstract":"In recent years, the incidence of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, has exhibited a steadily rising trend, which has posed a major challenge to the global public health. Traditional Chinese medicine, with its multicomponent and multitarget characteristics, offers a promising approach to treating neurodegenerative diseases. However, comprehensively elucidating the complex mechanisms underlying traditional Chinese medicine formulations remains challenging. As an emerging systems biology method, network pharmacology has provided a vital tool for revealing the multitarget mechanisms of traditional Chinese medicine through high-throughput technologies, molecular docking, and network analysis. This paper reviews the advancements in the application of network pharmacology in treating neurodegenerative diseases using traditional Chinese medicine, analyzes the current status of relevant databases and technological methods, discusses the limitations, and proposes future directions to promote the modernization of traditional Chinese medicine and the development of precision medicine.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0