Planta medica最新文献_第3页

Psidium Exotic and Native Species from Brazil Abolish Depression-like Behavior and Oxidative Stress induced by Corticosterone in Mice. 巴西鹅掌楸外来种和本地种可消除皮质酮诱导的小鼠抑郁样行为和氧化应激。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-08-27 DOI: 10.1055/a-2404-3294

Ana Lúcia Bertarello Zeni, Ana Paula Dalmagro, Lucas Henrique Junges, Natália Cavichioli, Otto Rodolfo Sasse

{"title":"Psidium Exotic and Native Species from Brazil Abolish Depression-like Behavior and Oxidative Stress induced by Corticosterone in Mice.","authors":"Ana Lúcia Bertarello Zeni, Ana Paula Dalmagro, Lucas Henrique Junges, Natália Cavichioli, Otto Rodolfo Sasse","doi":"10.1055/a-2404-3294","DOIUrl":"10.1055/a-2404-3294","url":null,"abstract":"Depression is a highly prevalent neuropsychiatric disorder worldwide. One currently accepted hypothesis of this pathogenesis is the hypothalamic-pituitary-adrenal axis dysfunction, which involves oxidative stress and brain damage. Therefore, antioxidants, such as phenolic compounds, could be used in depression. In this study, we investigated the antidepressant-like and antioxidant effects of an aqueous extract of the leaves of three species of the genus Psidium, Myrtaceae family, in mice. The exotic Psidium guajava L. and the natives Psidium guineense Sw. and Psidium cattleianum Sabine (10, 1, and 0.1 mg/kg, respectively) and fluoxetine (10 mg/kg) were administered orally (p. o.) once daily for 21 days, with or without corticosterone (20 mg/kg). After behavioral assessments (tail suspension, splash, and open-field tests), the hippocampus, prefrontal cortex, liver, kidneys, and plasma were examined to determine the oxidative stress status. The three extracts and fluoxetine treatment decreased the immobility time and counteracted the oxidative stress induced by corticosterone administration. The phenolic compounds identified as major components of the extracts, quercetin in P. guajava and P. guineense and o-coumaric acid in P. cattleianum, may be involved in the biological activities. Therefore, the aqueous leaf extracts of P. guajava, P. cattleianum, and P. guineense could be potential antidepressants helpful in treating depression and other diseases with elevated nitro-oxidative stress.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1030-1039"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142081287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function. 从转化的角度看牛膝草精油萜烯对平滑肌功能的治疗潜力。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-09-03 DOI: 10.1055/a-2409-3735

André Nogueira Cardeal Dos Santos, José Ednésio da Cruz Freire, Bruna Ferreira Rodrigues, Francisco Walber Ferreira-da-Silva, José Eduardo Ribeiro Honório Júnior, José Henrique Leal Cardoso, Andrelina Noronha Coelho de Souza

{"title":"Translational Perspectives on the Therapeutic Potential of Hyptis Crenata Essential Oil Terpenes in Smooth Muscle Function.","authors":"André Nogueira Cardeal Dos Santos, José Ednésio da Cruz Freire, Bruna Ferreira Rodrigues, Francisco Walber Ferreira-da-Silva, José Eduardo Ribeiro Honório Júnior, José Henrique Leal Cardoso, Andrelina Noronha Coelho de Souza","doi":"10.1055/a-2409-3735","DOIUrl":"10.1055/a-2409-3735","url":null,"abstract":"Monoterpenes and sesquiterpenes are classes of organic compounds found in various natural products, such as the essential oil of Hyptis crenata (EOHc). The therapeutic potential of these terpenes present in EOHc is evidenced by their effect on smooth muscle and potential clinical applications. Among the highlighted monoterpenes, such as sabinene, α-pinene, and β-pinene, a relaxing effect on rat intestinal smooth muscles is observed, attributed to interaction with calcium channels. Furthermore, monoterpenoids like borneol, cineole, and linalool also demonstrate vasorelaxant properties, suggesting potential in the treatment of cardiovascular conditions. Sesquiterpenes, such as caryophyllene and aromadendrenes, exhibit relaxing effects in various smooth muscle tissues, such as rat uterus and guinea pig ileum, indicating pharmacological potential in these areas. The translational exploration of targets, such as calcium channels and G protein-coupled receptors, highlights the importance of these compounds in discovering new therapies based on natural products for treating various medical conditions.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1005-1014"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142126298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-inflammatory Principles of the Plant Family Amaryllidaceae. 天南星科植物的抗炎原理。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-07-19 DOI: 10.1055/a-2369-8104

Jerald J Nair, Johannes van Staden

{"title":"Anti-inflammatory Principles of the Plant Family Amaryllidaceae.","authors":"Jerald J Nair, Johannes van Staden","doi":"10.1055/a-2369-8104","DOIUrl":"10.1055/a-2369-8104","url":null,"abstract":"There is considerable interest in the utilisation of plants against inflammation. Over 50 species of the plant family Amaryllidaceae are known for such usage in traditional medicine. This review was undertaken to identify the chemical principles responsible for these anti-inflammatory effects. It describes the findings from in vitro, in vivo and in silico studies, as well as the probes made on the mechanisms of action. The literature search returned over 600 hits, of which around 130 were chosen for their relevance to the text. Over 140 compounds have thus far been screened for anti-inflammatory effects. These were mostly isoquinoline alkaloids but also included other classes of secondary metabolites such as chromones, flavonoids and triterpenoids. In vitro studies were carried out in mononuclear cells such as lymphocytes, monocytes, neutrophils and macrophages, against which no serious side effects were observed. The constituents were also effective against inflammation induced by physical and chemical stimuli in a variety of murine test subjects. Chief among the compounds were the isoquinoline alkaloids lycorine and narciclasine, which displayed potent effects against pain, swelling, asthma and arthritis, amongst others. From a mechanistic perspective, several of the compounds were shown to mediate in inflammatory pathways, notably via the modulation of both pro-inflammatory (such as NF-κB, TNF-α and IL-1) and anti-inflammatory (such as IL-10 and TGF-β) factors. Useful insights also emerged from active-site docking studies of some of the compounds. The Amaryllidaceae affords a rich and diverse platform for the discovery of potential anti-inflammatory drugs.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"900-937"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ajuga taiwanensis Extract Promotes Wound-healing via Activation of PDGFR/MAPK Pathway. 台湾刺五加提取物通过激活 PDGFR/MAPK 通路促进伤口愈合

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-08-19 DOI: 10.1055/a-2378-9274

Wei-Hsiang Hsu, Jing-Jy Cheng, Ching-Fen Wu, Yun-Lian Lin

引用次数: 0

Erigeron breviscapus: A Promising Medication for Protecting the Optic Nerve in Glaucoma. Erigeron breviscapus：保护青光眼视神经的有效药物

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-09-20 DOI: 10.1055/a-2409-2999

Yuxin Cheng, Xuanyi Chen, Guangyu Zhu, Na Li, Yue Sun, Shichun Luo, Yujie Liu, Xuejing Lu

{"title":"Erigeron breviscapus: A Promising Medication for Protecting the Optic Nerve in Glaucoma.","authors":"Yuxin Cheng, Xuanyi Chen, Guangyu Zhu, Na Li, Yue Sun, Shichun Luo, Yujie Liu, Xuejing Lu","doi":"10.1055/a-2409-2999","DOIUrl":"10.1055/a-2409-2999","url":null,"abstract":"Glaucoma is a common eye condition characterized by the loss of retinal ganglion cells and their axons, optic nerve damage, and visual field defects, which seriously affect a patient's quality of life. The pathogenesis of glaucoma is still unclear at present. It presents as damage to retinal ganglion cells, and the main treatment is primarily to reduce intraocular pressure by surgery or taking medication. However, even with well-controlled intraocular pressure, retinal ganglion cells still undergo degeneration, progressive apoptosis, and axonal loss. Therefore, protecting the optic nerve and inhibiting the apoptosis of retinal ganglion cells are the current hot topic for prevention and treatment of glaucoma. Recently, Erigeron breviscapus, originating from Yunnan province in China, has been shown to be a promising herb with neuroprotective effects to treat glaucoma. Therefore, the traditional usage, botanical characteristics, and phytochemical composition of E. breviscapus were explored through a literature review. Furthermore, we have summarized the pharmacological mechanisms of E. breviscapus and its active components in inhibiting the apoptosis of retinal ganglion cells. These research findings can not only provide guidance and recommendations for the protection of retinal ganglion cells but also further explore the potential of E. breviscapus in the treatment of glaucoma.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"992-1004"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142293214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Substantial Differences in Proanthocyanidin Contents among Ginkgo biloba Leaf Extracts in Herbal Medicinal Products Obtained from the German Market. 从德国市场上获得的草药产品中银杏叶提取物的原花青素含量存在巨大差异。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-07-25 DOI: 10.1055/a-2373-0190

Stefan Germer, Thomas Ritter, Mario Wurglics

{"title":"Substantial Differences in Proanthocyanidin Contents among Ginkgo biloba Leaf Extracts in Herbal Medicinal Products Obtained from the German Market.","authors":"Stefan Germer, Thomas Ritter, Mario Wurglics","doi":"10.1055/a-2373-0190","DOIUrl":"10.1055/a-2373-0190","url":null,"abstract":"Pharmacologic activity of proanthocyanidins in Ginkgo biloba leaf extract has recently been reported. The objective of the present study was to screen proanthocyanidin contents in herbal medicinal products containing Ginkgo extracts. A recently published HPLC method for quantification of proanthocyanidins in G. biloba leaf extract EGb 761 was adopted to also be suitable for finished herbal medicinal products. The method was applied to 14 products from the German market. For each product, a set of three individual batches was purchased and analyzed. Substantial differences in proanthocyanidins contents were found among distinct products, ranging from 0.30 to 5.86%. The batch-to-batch variability within each product was low. The highest concentrations are in a similar range as, for example, the amount of Ginkgo terpene trilactones specified in the monograph for G. biloba leaf extract in the European Pharmacopeia. Although it has not yet been established whether and to what extent proanthocyanidins contribute to the overall pharmacological or clinical efficacy of Ginkgo extracts, a potential impact on the purported benefits of different contents in proanthocyanidins cannot be ruled out. Quality assessment of different Ginkgo extracts in the future may include proanthocyanidins.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"1040-1047"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141760296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and Development of a Self-nanoemulsifying Drug Delivery System for Co-delivery of Curcumin and Naringin for Improved Wound Healing Activity in an Animal Model. 设计和开发用于姜黄素和柚皮苷联合给药的 SNEDDS，提高动物模型的伤口愈合活性。

IF 2.1 4区医学

Planta medica Pub Date : 2024-10-01 Epub Date: 2024-07-30 DOI: 10.1055/a-2376-6380

Ajmal Hayat, Ismail Shah, Abdul Jabbar, Shafi Ullah, Muhammad Raza Shah, Muhammad Shafique, Aziz Balouch, Farah Gul

{"title":"Design and Development of a Self-nanoemulsifying Drug Delivery System for Co-delivery of Curcumin and Naringin for Improved Wound Healing Activity in an Animal Model.","authors":"Ajmal Hayat, Ismail Shah, Abdul Jabbar, Shafi Ullah, Muhammad Raza Shah, Muhammad Shafique, Aziz Balouch, Farah Gul","doi":"10.1055/a-2376-6380","DOIUrl":"10.1055/a-2376-6380","url":null,"abstract":"The present study endeavored to design and develop a self-nanoemulsifying drug delivery system to improve the solubility and dermatological absorption of curcumin and naringin. Curcumin and naringin-loaded self-nanoemulsifying drug delivery system formulations were developed using aqueous phase titration. Phase diagrams were used to pinpoint the self-nanoemulsifying drug delivery system zones. Tween 80 and Labrasol (surfactants), Transcutol (cosurfactant), and cinnamon oil were chosen from a large pool of surfactants, cosurfactants, and oils based on their solubility and greatest nano-emulsion region. Fourier transform infrared spectroscopy, zeta sizer, and atomic force microscopy were used to characterize the optimized formulations and test for dilution and thermodynamic stability. The optimized curcumin-naringin-self-nanoemulsifying drug delivery system demonstrated the following characteristics: polydispersity index (0.412 ± 0.03), % transmittance (97%), particle size (212.5 ± 05 nm), zeta potential (- 25.7 ± 1.80 mV) and having a smooth and spherical droplet shape, as shown by atomic force microscopy. The ability of their combined formulation to cure wounds was tested in comparison to pure curcumin suspension, empty self-nanoemulsifying drug delivery system, and standard fusidic acid. Upon topical administration, the optimized curcumin-naringin-self-nanoemulsifying drug delivery system demonstrated significant wound healing activity in comparison with a pure curcumin suspension, empty self-nanoemulsifying drug delivery system, and standard fusidic acid. Based upon this result, we assume that skin penetration was increased by using the optimized curcumin-naringin-self-nanoemulsifying drug delivery system with enhanced solubility.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"959-970"},"PeriodicalIF":2.1,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cnicus benedictus: Folk Medicinal Uses, Biological Activities, and In Silico Screening of Main Phytochemical Constituents Cnicus benedictus：民间药用、生物活性和主要植物化学成分的硅学筛选

IF 2.7 4区医学

Planta medica Pub Date : 2024-09-12 DOI: 10.1055/a-2401-6049

Katarzyna Ziętal, Dagmara Mirowska-Guzel, Alicja Nowaczyk, Kamilla Blecharz-Klin

引用次数: 0

Correction: Withaphysalin Derivatives from Iochroma arborescens Induce Antiproliferative and Antimigratory Activities in vitro. 更正：Iochroma arborescens 的 Withaphysalin 衍生物在体外诱导抗增殖和抗移植物活性。

IF 2.1 4区医学

Planta medica Pub Date : 2024-09-12 DOI: 10.1055/a-2407-3066

Rodrigo Elísio de Sá, Fabrício Dos Santos Machado, Gisele Santos Araújo, Jéssica Maria Teles Souza, Ayslan Batista Barros, Francisco das Chagas Lima Pinto, Joana Deyse Lima Agostinho, Alejandro Pedro Ayala, José Delano Barreto Marinho Filho, Otilia Pessoa, Ana Jérsia Araújo

引用次数: 0

In Vitro Anti-inflammatory Effects of Larch Turpentine, Turpentine Oil, Eucalyptus Oil, and Their Mixture as Contained in a Marketed Ointment 市场上销售的软膏中含有的落叶松松节油、松节油、桉叶油及其混合物的体外抗炎效果

IF 2.7 4区医学

Planta medica Pub Date : 2024-09-11 DOI: 10.1055/a-2388-7527

Kurt Appel, Thorsten Rose, Christian Zimmermann, Nils Günnewich

{"title":"In Vitro Anti-inflammatory Effects of Larch Turpentine, Turpentine Oil, Eucalyptus Oil, and Their Mixture as Contained in a Marketed Ointment","authors":"Kurt Appel, Thorsten Rose, Christian Zimmermann, Nils Günnewich","doi":"10.1055/a-2388-7527","DOIUrl":"https://doi.org/10.1055/a-2388-7527","url":null,"abstract":"An ointment containing larch turpentine, turpentine oil, and eucalyptus oil has been used for almost a century for the symptomatic treatment of mild, localized, purulent inflammations of the skin. Its clinical efficacy in the treatment of skin infections has been shown in clinical trials, but the mode of action of the active ingredients on inflammation is not known. We studied the anti-inflammatory properties of the active ingredients of the ointment and their mixture in a human monocyte cell model, in which the cells were stimulated with lipopolysaccharide and incubated with the test substances. The cytotoxic threshold of each test substance and the mixture was identified using the alamarBlue assay, and their anti-inflammatory activity was assessed by measuring the release of interleukins IL-1β, IL-6, IL-8, monocyte chemoattractant protein-1, prostaglandin E2, and TNF-α. Cell toxicity was observed at a mixture concentration of 10 µg/mL. All immunological assays were carried out at nontoxic concentrations. Larch turpentine decreased IL-1β, monocyte chemoattractant protein-1, and prostaglandin E2 release at a concentration of 3.9 µg/mL and TNF-α at concentrations > 1.95 µg/mL, whereas eucalyptus oil and turpentine oil had no relevant inhibitory effects. The mixture dose-dependently inhibited IL-1β, IL-6, monocyte chemoattractant protein-1, prostaglandin E2, and TNF-α release at concentrations > 1 µg/mL. IL-8 release was only marginally affected. The anti-inflammatory activity of the herbal ingredients and their mixture was confirmed in this model. This effect seems to be mediated mainly by larch turpentine, with turpentine oil and eucalyptus oil exerting an additive or possibly synergistic function. ","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":"61 1","pages":""},"PeriodicalIF":2.7,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142182738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0