{"title":"三环萘内酯和一种山酮的融合及其抗hiv -1活性。","authors":"Ponsiri Liangsakul, Chutima Kuhakarn, Siriporn Jungsuttiwong, Ratchadaree Intayot, Sariyarach Thanasansurapong, Radeekorn Akkarawongsapat, Arthit Chairoungdua, Narong Nuntasaen, Sakchai Hongthong, Vichai Reutrakul","doi":"10.1055/a-2589-5900","DOIUrl":null,"url":null,"abstract":"<p><p>Three previously undescribed compounds, including two fused tricyclic naphthalene lactones (ventilaganones A and B, 1: and 2: ) and a xanthone (ventilagoxanthone, 3: ), along with eight known compounds (4: -11: ), were isolated from the bark of <i>Ventilago maingayi</i>. Their structures were elucidated by extensive analysis of their spectroscopic data and by comparison with those of related compounds reported in the literature. The absolute configuration of ventilaganone A (1: ) was established by single-crystal X-ray analysis. Anti-HIV-1 activity of the isolated compounds was evaluated with a reverse transcriptase (RT) assay and a syncytium reduction assay using the <sup>ΔTat/Rev</sup>MC99 virus in the 1A2 cell line. Compounds 1, 2, 4, 5: , and 8-11: showed inhibitory activity against syncytium formation, while most compounds were found to be inactive in the reverse transcriptase assay.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Fused Tricyclic Naphthalene Lactones and a Xanthone from Ventilago maingayi and their Anti-HIV-1 Activity.\",\"authors\":\"Ponsiri Liangsakul, Chutima Kuhakarn, Siriporn Jungsuttiwong, Ratchadaree Intayot, Sariyarach Thanasansurapong, Radeekorn Akkarawongsapat, Arthit Chairoungdua, Narong Nuntasaen, Sakchai Hongthong, Vichai Reutrakul\",\"doi\":\"10.1055/a-2589-5900\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Three previously undescribed compounds, including two fused tricyclic naphthalene lactones (ventilaganones A and B, 1: and 2: ) and a xanthone (ventilagoxanthone, 3: ), along with eight known compounds (4: -11: ), were isolated from the bark of <i>Ventilago maingayi</i>. Their structures were elucidated by extensive analysis of their spectroscopic data and by comparison with those of related compounds reported in the literature. The absolute configuration of ventilaganone A (1: ) was established by single-crystal X-ray analysis. Anti-HIV-1 activity of the isolated compounds was evaluated with a reverse transcriptase (RT) assay and a syncytium reduction assay using the <sup>ΔTat/Rev</sup>MC99 virus in the 1A2 cell line. Compounds 1, 2, 4, 5: , and 8-11: showed inhibitory activity against syncytium formation, while most compounds were found to be inactive in the reverse transcriptase assay.</p>\",\"PeriodicalId\":20127,\"journal\":{\"name\":\"Planta medica\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.1000,\"publicationDate\":\"2025-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Planta medica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1055/a-2589-5900\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, MEDICINAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Planta medica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/a-2589-5900","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, MEDICINAL","Score":null,"Total":0}
Fused Tricyclic Naphthalene Lactones and a Xanthone from Ventilago maingayi and their Anti-HIV-1 Activity.
Three previously undescribed compounds, including two fused tricyclic naphthalene lactones (ventilaganones A and B, 1: and 2: ) and a xanthone (ventilagoxanthone, 3: ), along with eight known compounds (4: -11: ), were isolated from the bark of Ventilago maingayi. Their structures were elucidated by extensive analysis of their spectroscopic data and by comparison with those of related compounds reported in the literature. The absolute configuration of ventilaganone A (1: ) was established by single-crystal X-ray analysis. Anti-HIV-1 activity of the isolated compounds was evaluated with a reverse transcriptase (RT) assay and a syncytium reduction assay using the ΔTat/RevMC99 virus in the 1A2 cell line. Compounds 1, 2, 4, 5: , and 8-11: showed inhibitory activity against syncytium formation, while most compounds were found to be inactive in the reverse transcriptase assay.
期刊介绍：
Planta Medica is one of the leading international journals in the field of natural products – including marine organisms, fungi as well as micro-organisms – and medicinal plants. Planta Medica accepts original research papers, reviews, minireviews and perspectives from researchers worldwide. The journal publishes 18 issues per year.
The following areas of medicinal plants and natural product research are covered:
-Biological and Pharmacological Activities
-Natural Product Chemistry & Analytical Studies
-Pharmacokinetic Investigations
-Formulation and Delivery Systems of Natural Products.
The journal explicitly encourages the submission of chemically characterized extracts.
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