喜马拉雅金丝桃多环聚丙烯化酰基间苯三酚。

IF 2.1 4区医学 Q3 CHEMISTRY, MEDICINAL

Planta medica Pub Date : 2025-05-20 DOI:10.1055/a-2596-3029

Guang-Hui Liu, Fan Wu, Xue-Yan Huo, Hong-Bing Sun, Zhuo-Lin Jin, Yu-Cheng Gu, Da-Le Guo, Yan Zhou

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引用次数: 0

摘要

从喜马拉雅金丝桃（Hypericum himaicum）全株中分离得到6个具有邻二醇（1-6）片段的多环聚戊烯酰化酰基间苯三酚（PPAPs）。通过HRMS、1D和2D NMR数据的综合分析确定了它们的结构，并通过Mo2(OAc)4诱导的圆二色性（ICD）、ECD和NMR计算确定了它们的绝对构型。化合物1可降低lps诱导的RAW264.7巨噬细胞NO、TNF-α、IL-6的分泌，下调COX-2、iNOS蛋白表达，抑制ROS的释放。进一步研究发现其抗炎作用可能与抑制NF-κB和NLRP3信号通路有关。

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Polycyclic Polyprenylated Acylphloroglucinols from Hypericum himalaicum.

Six previously undescribed polycyclic polyprenylated acylphloroglucinols (PPAPs) with a vicinal diol moiety (1: -6: ) were isolated from the whole plant of Hypericum himalaicum. Their structures were established through a comprehensive analysis of HRMS and 1D and 2D NMR data, while the absolute configurations were determined using the Mo₂(OAc)₄-induced circular dichroism (ICD), ECD, and NMR calculations. Compound 1: attenuated the secretion of NO, TNF-α, and IL-6, downregulated the protein expression of COX-2 and iNOS, and inhibited the release of ROS in LPS-induced RAW264.7 macrophages. Further investigation revealed that the anti-inflammatory effects may be attributed to the inhibition of the NF-κB and NLRP3 signaling pathways.

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来源期刊

Planta medica 医学-药学

CiteScore

5.10

自引率

3.70%

发文量

101

审稿时长

1.8 months

期刊介绍： Planta Medica is one of the leading international journals in the field of natural products – including marine organisms, fungi as well as micro-organisms – and medicinal plants. Planta Medica accepts original research papers, reviews, minireviews and perspectives from researchers worldwide. The journal publishes 18 issues per year. The following areas of medicinal plants and natural product research are covered: -Biological and Pharmacological Activities -Natural Product Chemistry & Analytical Studies -Pharmacokinetic Investigations -Formulation and Delivery Systems of Natural Products. The journal explicitly encourages the submission of chemically characterized extracts.