Zanthoxylum rhoifolium Lam.的新成分

IF 2.1 4区医学 Q3 CHEMISTRY, MEDICINAL

Planta medica Pub Date : 2025-01-13 DOI:10.1055/a-2486-9139

Mauro Di Stasi, Valentina Parisi, Vanessa Hernandez, Erica Gazzillo, Maria Giovanna Chini, Giuseppe Bifulco, Alessandra Braca, Giuliana Donadio, Nunziatina De Tommasi

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引用次数: 0

摘要

对 Zanthoxylum rhoifolium 的极性和中等极性茎皮和叶提取物进行的植物化学研究获得了 29 个化合物，包括三个新的倍半萜（1: -3: ）和一个新的α-酮苷（4: ）。所有化合物都通过一维和二维核磁共振以及 HRESIMS 数据进行了表征。此外，还采用密度泛函理论（DFT）/核磁共振相结合的方法进行了精确的结构分析，以阐明化合物的构型。然后，通过肉汤稀释法对粗提取物进行了测试，以确定它们对革兰氏阳性和革兰氏阴性细菌的最小抑菌浓度（MIC）；在这些实验条件下，没有观察到有趣的抗菌活性。

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New Constituents from Zanthoxylum rhoifolium.

The phytochemical study of Zanthoxylum rhoifolium apolar and medium polarity stem bark and leaf extracts afforded 29 compounds, including three new sesquiterpenes (1 - 3: ) and one new α-ionone glycoside (4: ). All compounds were characterized by means of 1D and 2D NMR and HRESIMS data. Furthermore, a precise structural analysis was performed, employing a combined density functional theory (DFT)/NMR approach to elucidate the compounds configurations. The crude extracts were then tested against a panel of gram-positive and gram-negative bacteria by broth dilution methods to determine their minimal inhibitory concentration. In these experimental conditions, no interesting antimicrobial activity was observed.

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来源期刊

Planta medica 医学-药学

CiteScore

5.10

自引率

3.70%

发文量

101

审稿时长

1.8 months

期刊介绍： Planta Medica is one of the leading international journals in the field of natural products – including marine organisms, fungi as well as micro-organisms – and medicinal plants. Planta Medica accepts original research papers, reviews, minireviews and perspectives from researchers worldwide. The journal publishes 18 issues per year. The following areas of medicinal plants and natural product research are covered: -Biological and Pharmacological Activities -Natural Product Chemistry & Analytical Studies -Pharmacokinetic Investigations -Formulation and Delivery Systems of Natural Products. The journal explicitly encourages the submission of chemically characterized extracts.