Planta medica最新文献

{"title":"Selection of Promising Candidates for Herbal Veterinary Medicinal Products: A Strategic Approach.","authors":"Jelena Arsenijević, Céline Renouard, Kristina Bacova, Cigdem Bilgi, Carole Cousin, Antonio Di Loria, Milica Drobac, Frans V D Dungen, Georgios Efthimiou, Ivona Foitova, Attila Hunyadi, Anne-Marie Jacques, Olga Kosakowsk, Radoslava Kristofova, Lise Laborieux, Mirjana Marčetić, Monika Pogány Simonova, Zeynep Semen, Sylwia Styczyńska, Theresa Schlittenlacher, Liliana Vargas-Murga, Michael Walkenhorst, Begum Yurdakok-Dikmen, Marta Mendel","doi":"10.1055/a-2891-9080","DOIUrl":"10.1055/a-2891-9080","url":null,"abstract":"<p><strong>Abstract: </strong>The growing urgency to reduce antimicrobial and antiparasitic use in livestock has renewed scientific interest in medicinal plants as sustainable components of veterinary healthcare. However, the absence of a dedicated regulatory framework for herbal veterinary medicinal products (HVMPs) in the European Union continues to hinder their wider application.</p><p><strong>Abstract: </strong>The need for a science-based, multi-criteria framework to identify medicinal plant species as sources of active substances of herbal origin, with the highest potential for future inclusion in a dedicated EU registration pathway for HVMPs, resulted in the establishment of a multidisciplinary expert panel. The panel evaluated over 100 medicinal plant species with documented veterinary application, using a structured scoring system integrating regulatory, pharmacopoeial, toxicological, and sustainability sources. These included regulations and documents related to veterinary, pharmaceutical, food, and feed data, as well as considerations for conservation. Weighted scores reflecting all these aspects were applied to rank the species.</p><p><strong>Abstract: </strong>The assessment resulted in the creation of List A, which contains the most promising candidates for future HVMPs, and List B, which compiles plant species whose simplified registration is currently not considered a priority or is not advisable based on the available data. Eighty-three species received positive overall scores. These medicinal plants demonstrate strong regulatory recognition, pharmacopoeial inclusion, and well-documented safety profiles, highlighting their suitability for evidence-based veterinary use.</p><p><strong>Abstract: </strong>The proposed framework offers a clear, reproducible method for prioritizing botanical species for regulatory consideration as HVMPs. It supports EU initiatives to enhance sustainable animal health, antimicrobial stewardship, and innovation in veterinary phytotherapy.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.1,"publicationDate":"2026-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148252813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"There is No Caffeine in Damiana-Dismantling Filter Bubbles and Echo Chambers in Scientific Referencing.","authors":"Guido Frank Pauli, Shao-Nong Chen, Daniela Rebollar-Ramos, Sol Cristians, Ana Hernandez-Ochoa, Thomas Brendler","doi":"10.1055/a-2865-0932","DOIUrl":"10.1055/a-2865-0932","url":null,"abstract":"<p><strong>Abstract: </strong>The scientific literature is increasingly challenged by miscitation, publication bias, and the uncritical perpetuation of false information. One such case concerns the purported presence of caffeine in damiana, a botanical ingredient marketed for \"sexual well-being\". While consumer perception and regulatory implications make caffeine content highly relevant, a systematic review of the literature indicates that claims of caffeine in damiana (<i>Turnera diffusa</i>) largely stem from erroneous or circular referencing, including citations of studies where caffeine was never reported. To address this discrepancy experimentally, we conducted NMR analyses on authenticated aerial and seed material of <i>T. diffusa</i> and seeds of <i>T. ulmifolia</i>. No caffeine was detected, with a detection limit of < 4 nM, corresponding to < 4 µg caffeine per daily serving of damiana. These findings confirm that damiana is effectively caffeine-free. Beyond correcting a specific phytochemical misconception, this study highlights how flawed referencing practices can perpetuate modern \"scientific myths\", emphasizing the need for more rigorous citation ethics and the value of experimental data. Addressing such errors is critical not only for scientific accuracy but also for consumer trust and evidence-based regulatory decision-making.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Antioxidant Mangosteen on Clinical and Biochemical Parameters of Periodontitis-A Systematic Review.","authors":"Cristina Estornut, Nicla Flacco, Sergio Estornut, Martín Pérez-Leal","doi":"10.1055/a-2779-9057","DOIUrl":"10.1055/a-2779-9057","url":null,"abstract":"<p><strong>Abstract: </strong>Periodontitis is a common chronic inflammatory disease that leads to the progressive destruction of periodontal tissues. Traditional treatments focus on mechanical debridement; however, antioxidants are increasingly being considered as adjuvant therapies to improve clinical outcomes. Mangosteen (<i>Garcinia mangostana</i> L.), a tropical fruit and chemically characterized natural source of xanthones, exhibits potent antioxidant, anti-inflammatory, and antimicrobial properties, making it a promising candidate in phytotherapeutic periodontal interventions.</p><p><strong>Abstract: </strong>This systematic review aimed to assess the clinical and biochemical effects of mangosteen-based treatments in patients with periodontitis, compared to placebo or conventional therapies.</p><p><strong>Abstract: </strong>Following PRISMA guidelines, a comprehensive search was conducted in PubMed, Web of Science, and Scopus. Eligible studies included randomized controlled trials, cohort studies, and clinical trials that evaluated the effects of mangosteen on periodontal parameters-probing pocket depth (PPD), plaque index (PI), gingival index (GI), clinical attachment level (CAL), and bleeding on probing (BOP)-as well as biochemical markers such as IL-6, TNF-<i>α</i>, MMP-8, MMP-9, total antioxidant capacity (TAOC), and oxidative stress indicators.</p><p><strong>Abstract: </strong>Ten studies met the inclusion criteria, involving 422 patients. The use of 4% mangosteen gel as an adjuvant to scaling and root planing (SRP) showed significant clinical improvements in PPD, GI, CAL, and BOP. Biochemically, reductions in IL-6 and MMP-9 and increased TAOC were observed. However, heterogeneity in formulations and methodologies limited comparability.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"717-729"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145857530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Neuroprotection by Cannabis sativa and Tilia × viridis: Attenuation of Hippocampal Neurons Glutamate-Induced Oxidative Stress and LPS-Driven Microglial Inflammation.","authors":"Elina Malen Saint Martin, María Laura Barreiro-Arcos, María Belén Gomez, Giuliana Colonna Soldavini, Carla Marrassini, Laura Cogoi, Ignacio Peralta, Analía Reinés, María Rosario Alonso, Claudia Anesini","doi":"10.1055/a-2751-0171","DOIUrl":"10.1055/a-2751-0171","url":null,"abstract":"<p><strong>Abstract: </strong>Throughout history, <i>Cannabis sativa</i> has been linked to the therapeutic management of epilepsy and <i>Tilia</i> × <i>viridis</i> has a tradition of use as a sedative.</p><p><strong>Abstract: </strong>This study aimed to evaluate the protective effect of an ethanolic extract of <i>C. sativa</i> (CSRD), an aqueous extract of <i>T.</i> × <i>viridis</i> (TE), and their combination against oxidative stress induced by glutamate in a murine hippocampal neuronal (HT-22) cell line, as well as their anti-inflammatory activity in male Wistar rats' microglial cells stimulated with LPS. A phytochemical analysis was also conducted. Glutamate-induced reactive oxygen species (ROS) were quantified using 2',7'-dichlorodihydrofluorescein diacetate via fluorescence microscopy. Cell viability was assessed using the MTT assay. Distinct microglial cell phenotypes were identified via immunofluorescence.</p><p><strong>Abstract: </strong>Extracts partially reversed glutamate-induced loss of cell viability (52% to 200% for CSRD; 22% to 82% for TE). Their combination produced a greater effect, reversing glutamate-induced toxicity by 133% to 284% and fully restoring cell viability to control levels. Moreover, the combined treatment reduced intracellular ROS levels (52% to 58%). Notably, the combination also exhibited the most pronounced anti-inflammatory effects, significantly reducing the proportion of reactive phenotype 1 cells, while increasing the population of anti-inflammatory phenotype 2 cells and preserving the trophic phenotype 3 subpopulation. In conclusion, this study not only validates the ethnobotanical uses of <i>C. sativa</i> and <i>T.</i> × <i>viridis</i> but also reveals a potent synergy when combined. This provides a strong foundation for the development of phytomedicines with translational potential for managing complex pathologies like epilepsy or neuroinflammation associated with neurodegenerative diseases.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"730-745"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146106789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phaeosphaeride A Isolated from an Endophytic Paraphoma sp. Alleviates ABCG2-mediated Resistance to Mitoxantrone in Breast Cancer Cells.","authors":"Alireza Tavakkoli, Hojjat Mortazavi, Mehrdad Iranshahi, Fatemeh Kalalinia, Khadijeh Jamialahmadi, Jon S Thorson, Khaled A Shaaban, Fatemeh Mosaffa","doi":"10.1055/a-2805-4670","DOIUrl":"10.1055/a-2805-4670","url":null,"abstract":"<p><strong>Abstract: </strong>The efficacy of breast cancer chemotherapies is frequently limited by multidrug resistance (MDR), partly through efflux by ABC transporters, including ABCG2. This study evaluated whether phaeosphaeride A (PPA), a fungal metabolite isolated from a <i>Paraphoma</i> sp. endophyte of <i>Ferula xylorhachis</i>, can modulate ABCG2-mediated resistance to mitoxantrone (MTX). The endophyte was cultured and extracted with ethyl acetate, and the extract was purified by column chromatography and HPLC to yield PPA, whose structure was confirmed by NMR and MS analyses. Cytotoxicity of MTX, PPA, and their combination was assessed in MCF-7- and ABCG2-overexpressing MCF-7/MX cells. MTX showed marked differential cytotoxicity (IC₅₀ = 1.6 µM, 95% CI: 1.4 - 1.9 in MCF-7 vs. > 25 µM in MCF-7/MX; p < 0.0001), whereas PPA exhibited comparable activity in both lines (23.2 µM, 95% CI: 18.0 - 30.1 vs. 36.1 µM, 95% CI: 28.7 - 46.0; p = 0.01). Co-treatment with PPA IC₅₀ significantly reduced MTX IC₅₀ to 0.4 µM (95% CI: 0.3 - 0.6) in MCF-7 and 1.9 µM (95% CI: 1.2 - 2.7) in MCF-7/MX, restoring MTX sensitivity in resistant cells to near MCF-7 levels. Flow cytometry showed that PPA (IC₅₀) increased intracellular MTX accumulation with stronger effects in MCF-7/MX cells (p < 0.0001) than in MCF-7 (p < 0.05). In combination with MTX, PPA (IC₅₀) increased Sub-G1 apoptotic populations in both lines.</p><p><strong>Abstract: </strong>These findings demonstrate that PPA is unlikely to be a substrate of ABCG2 but functionally inhibits ABCG2-mediated efflux, contributing to the restoration of MTX sensitivity, although there may be additional mechanisms involved. PPA could be a promising MDR-reversal agent in ABCG2-driven chemotherapy resistance.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"746-755"},"PeriodicalIF":2.1,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146119907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Life and Work of Ernst Reinhard (1926 - 2005).","authors":"","doi":"10.1055/a-2841-0945","DOIUrl":"https://doi.org/10.1055/a-2841-0945","url":null,"abstract":"","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":"92 7","pages":"680-681"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148227424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phytochemical Diversity and Pharmacological Potential of Genista Species in Algeria: A Systematic Review.","authors":"Safia Bouchliti, Batoul Alallam, Vuanghao Lim, Reda Djebbar, Lilya Boucelha, Juzaili Azizi, Wen-Nee Tan","doi":"10.1055/a-2779-8721","DOIUrl":"10.1055/a-2779-8721","url":null,"abstract":"<p><strong>Abstract: </strong><i>Genista</i>, a genus in the Fabaceae family mainly found in the Mediterranean, includes 25 species in Algeria where 11 are native. Locally, these species are used medicinally to treat gastrointestinal disorders, hyperglycemia, and respiratory infections and as diuretics. This systematic review investigates the phytochemical diversity and pharmacological potential of the Algerian <i>Genista</i> species. A comprehensive literature search was conducted in ScienceDirect, Scopus, Web of Science, PubMed, and Google Scholar up to December 2024, with no start date restrictions. The inclusion criteria focused on studies involving <i>Genista</i> species collected from Algeria that investigated the identification and/or quantification of specific phytochemical profiles and/or pharmacological activities, using extracts, residues, fractions, or essential oils. Thirty-two studies met the criteria, covering nine <i>Genista</i> species and identifying 132 compounds across major classes such as phenolic acids, flavonoids, terpenoids, alkaloids, saponins, and fatty acids. Total phenolic content (TPC) reached 690.32 mg gallic acid equivalent (GAE)/g, and total flavonoid content (TFC) was up to 318 mg quercetin equivalent (QE)/g. The highest antioxidant activity showed an IC₅₀ of 3.65 µg/mL. Antibacterial effects were strongest against <i>Staphylococcus aureus</i>, with a 19 mm inhibition zone and minimum inhibitory concentration (MIC) values as low as 10 µg/mL. Hepatoprotective effects showed over 80% inhibition, while cytotoxicity had IC₅₀ values as low as 5 µg/mL. Anti-inflammatory activity reached 96.54%. These findings highlight the diverse pharmacological activities of the genus and its potential for therapeutic applications. However, many bioactivities, such as antidiabetic, antispasmodic, gastroprotective, and immunomodulatory effects, remain underexplored, highlighting the need for further rigorous research.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"682-716"},"PeriodicalIF":2.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146011863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygonatum sibiricum Alleviates Salivary Gland Dysfunction in Sjögren's Syndrome via CHRM3/AQP5 Axis Potentiation.","authors":"Fangping Wu, Xinjie Wu, Lewei Dai, Jianan Peng, Ruoxuan Li, Yangqin Zhou, Mancang Gu, Wenwen Lu, Bo Pan","doi":"10.1055/a-2867-4341","DOIUrl":"10.1055/a-2867-4341","url":null,"abstract":"<p><strong>Abstract: </strong>Hydroxychloroquine (HCQ), a commonly used drug for Sjögren's syndrome (SS), is ineffective, highlighting the need for better treatments for salivary gland damage in SS. The study evaluated the effects of <i>Polygonatum sibiricum</i> (HJ) on SS using non-obese diabetic (NOD) mice treated with HJ, HCQ, or both for six weeks. Body weight, saliva levels, and submandibular gland histology were assessed. Various techniques were used to analyze apoptosis and oxidative stress. Network pharmacology identified therapeutic targets, and lentivirus technology was used to suppress CHRM3 gene expression to understand HJ's mechanisms against SS. HJ treatment significantly mitigates salivary gland damage, resulting in increased body weight, reduced water intake, and improved saliva flow rates. Histological evaluations revealed HJ reduced lymphocytic infiltration, restored glandular architecture, and alleviated oxidative stress. In addition, the study has the following key mechanistic finding: HJ upregulated the expression of the target proteins CHRM3 and AQP5 in submandibular glands. Additionally, HJ can significantly enhance the expression of CHRM3 and AQP5 in human salivary gland (HSG) cells after silencing CHRM3. This study revealed that HJ may act as a novel SS treatment by activating the CHRM3/AQP5 axis, promoting water channel transport, alleviating salivary gland damage, and enhancing saliva secretion. Moreover, the combination of HJ and HCQ could significantly improve the therapeutic benefit. These findings provide a new therapeutic strategy for SS.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147778541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond Curcumin: Structural Modification Strategies to Improve Stability, Bioavailability, and Antiproliferative Activity.","authors":"Paulina Kobylka, Marek Murias, Karol Kandulski, Malgorzata Kucinska","doi":"10.1055/a-2860-5232","DOIUrl":"https://doi.org/10.1055/a-2860-5232","url":null,"abstract":"<p><strong>Abstract: </strong>Curcumin is a versatile natural compound that has been extensively studied for its potential activity in cancer models. However, its clinical development faces challenges, including poor water solubility, chemical instability under physiological conditions, rapid metabolism, and limited systemic bioavailability. These issues have driven efforts to modify the curcumin structure to enhance stability, pharmacokinetics, and target interaction, while preserving or improving its antiproliferative effects. This review highlights key medicinal chemistry strategies for creating analogs beyond curcumin, including (i) monocarbonyl variants that replace the <i>β</i>-diketone group to improve stability, (ii) aromatic ring modifications that adjust electronic properties, lipophilicity, and cellular entry, (iii) prodrug designs that conceal phenolic groups to increase solubility or permeability, and (iv) hybrid molecules and conjugates for dual targeting or better delivery. Additionally, we discuss metal-curcumin(oid) complexes as promising options to modify stability, redox activity, and biological effects in cancer models. We also propose a basic evaluation toolkit to support more consistent comparisons among analogs, emphasizing the need to report chemical stability, microsomal metabolism, selectivity, and <i>in vivo</i> exposure, alongside <i>in vitro</i> viability/proliferation readouts and, where available, orthogonal cytotoxicity endpoints. Rather than treating beyond-curcumin chemistry as a catalog of potency-improving modifications, this review frames the major scaffold classes in terms of developability, evidentiary burden, and translational pragmatism. Overall, successful translation will depend less on isolated IC₅₀ gains and more on standardized profiling and alignment of mechanism claims with achievable exposure.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":""},"PeriodicalIF":2.0,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147932381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biotransformation of Two Guaiane-type Sesquiterpene Lactones with Filamentous Fungi and Extremophile Bacteria.","authors":"Gabriela I Furque, Carina N Casero, Marcela Kurina-Sanz, Carlos G Nieto-Peñalver, María E Farias, José M Padrón, Viviana E Nicotra","doi":"10.1055/a-2770-3688","DOIUrl":"10.1055/a-2770-3688","url":null,"abstract":"<p><strong>Abstract: </strong>There is an urgent need for new naturally occurring and/or naturally derived chemical structures for drug development. The biotransformation of two bioactive guaiane-type sesquiterpene lactones, ludartin and estafietin, by filamentous fungi of the genera <i>Aspergillus</i> and <i>Penicillium</i> and by extremophile bacteria of the genera <i>Rhodococcus, Acinetobacter, Streptomyces</i>, and <i>Citricoccus</i> led to the isolation of three new and four known derivatives. The structures were determined based on data obtained from HRESIMS and 1D/2D NMR spectroscopy. The predominant reactions from both eukaryotic and prokaryotic biocatalysts were stereoselective epoxide opening and chemical and regio- and stereoselective double bond reduction, though the fungi were more efficient than the bacteria. Substrates and six selected metabolites were subjected to <i>in vitro</i> evaluation for antiproliferative effects against six human solid tumor cell lines. The derivative 3<i>α</i>,4<i>β</i>-dihydroxy-estafietin showed significant activity against HBL-100, HeLa, and SW1573 cell lines, justifying a more specific, in-depth evaluation of its scope as an anticancer candidate molecule.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"655-664"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146011798","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}