Planta medica最新文献

{"title":"Comprehensive Investigation of the Metabolism Profile of Norisoboldine in Rats Using UPLC-Q-TOF-MS/MS Method.","authors":"Yuance Li, Yongmin Liu, Li Lin, Yue Dai, Yufeng Xia","doi":"10.1055/a-2785-4855","DOIUrl":"10.1055/a-2785-4855","url":null,"abstract":"<p><strong>Abstract: </strong>Linderae Radix, a traditional Chinese medicine known for its anti-inflammatory, antirheumatic, and analgesic effects, contains norisoboldine (NOR) as its primary bioactive component. NOR exhibits significant anti-inflammatory effects in preclinical studies, particularly in rheumatoid arthritis and inflammatory bowel disease. Despite the various pharmacological activity of NOR, its metabolism and biotransformation patterns <i>in vivo</i> have yet to be elucidated. This study aimed to systematically elucidate the <i>in vivo</i> metabolic pathways of NOR, the excretion patterns of its metabolites, and the primary metabolic enzyme subtypes involved. Biosamples were collected from rats following oral administration of NOR (30 mg/kg). UPLC-Q-TOF-MS/MS was used to identify NOR metabolites in plasma, tissues, and excreta. Differences in the distribution of metabolites across excretion pathways were compared. Chemical inhibition assays and human recombinant enzyme experiments were conducted to determine the key cytochrome P450 (CYP450) enzyme subtypes involved. A total of 14 metabolites were identified, including 8 phase I metabolites and 6 phase II conjugates; the major metabolic reactions were hydrolysis, glucuronidation, sulfation, and dehydrogenation. The glycosylated conjugates (M13 - M15) predominantly underwent renal excretion via urine, whereas the hydrophobic metabolites (M2 - M9) were primarily eliminated through fecal routes due to limited aqueous solubility. The identification of CYP450 enzyme subtypes indicated that CYP3A1/2 and CYP2C11 were the key functional subtypes mediating NOR biotransformation. This study provides the first comprehensive characterization of NOR metabolism, demonstrating that CYP3A1/2 and CYP2C11 catalyze its conversion into 14 metabolites. These findings provide a theoretical basis for the clinical development of NOR and metabolic research on similar compounds.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"665-676"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146011759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paediatric Use of Herbal Medicinal Products: New Insights in RWD Generation - A Report on the RWD Workshop 2025 in Naples.","authors":"Nico Symma, Andreas Hensel, Bernd Roether, Barbara Steinhoff, Rudolf Bauer","doi":"10.1055/a-2845-2840","DOIUrl":"10.1055/a-2845-2840","url":null,"abstract":"<p><strong>Abstract: </strong>Herbal medicinal products (HMPs) are widely used in European paediatric practice, but formal authorisations for their use in children remain limited. Following the 2024 workshop in Krakow, the Foundation Plants for Health (FPfH) organised a further workshop in Naples on 31 August 2025 as part of the 73rd International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA) to present updates of recent activities in the field of real-world data (RWD) and real-world evidence (RWE) for rationalising the usage of herbal medicines in children. Speakers presented concrete new data sources - private health insurance claims, patient reported outcome cohorts, and a social-media-based user survey - as well as modern methods in epidemiology. The workshop concluded that decision-relevant paediatric data on the use of HMPs can be generated efficiently by establishing new RWD data sources. For the subsequent next steps, it is necessary to engage with regulators to open usage of these data pools in regulatory practice.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"600-603"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147675890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotoxicity Studies of Milk Thistle Fruit (Silybum marianum fructus) Dry Extracts: No Hints of Mutagenicity.","authors":"Peter David Ringel, Björn Feistel, Olaf Kelber, Karen Nieber","doi":"10.1055/a-2731-9622","DOIUrl":"10.1055/a-2731-9622","url":null,"abstract":"<p><strong>Abstract: </strong>Herbal medicinal products (HMPs) prepared from the fruit of <i>Silybum marianum</i> are mainly used in the treatment of liver diseases and dyspeptic symptoms. Despite its long-standing use and good clinical safety profile, the safety assessment of such HMPs requires special attention to toxicological aspects that are difficult to detect clinically, especially genotoxic effects. The genotoxic potential of certain <i>S. marianum</i> extracts has been evaluated previously; however, some <i>in vitro</i> assays gave inconsistent results, which is why an EU list entry was not recommended by the Herbal Medicinal Product Committee (HMPC) of the European regulatory agency EMA. To provide a more comprehensive dataset for the evaluation of the genotoxic potential, six dry extracts covering the entire polarity range of extraction solvents were chosen in accordance with the \"bracketing and matrixing\" approach recommended by the HMPC. These extracts were subjected to the bacterial reverse mutation test, as specified in the OECD test guideline 471, which was performed both as a pre-incubation and plate incorporation assay. When testing up to 5 mg per plate or up to the solubility or cytotoxicity limits, none of the extracts showed signs of mutagenicity, suggesting that extracts of <i>S. marianum</i> fruit have no genotoxic potential. Within reasonable limits, these results may be extrapolated to other extracts based on the aforementioned \"bracketing and matrixing\" approach.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"647-654"},"PeriodicalIF":2.1,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145985456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Genus Ruta: Traditional Uses, Pharmacology, and Safety Concerns.","authors":"Mohammad Sadegh Adel-Mehraban, Abolfazl Hakim Elahi, Niusha Esmaealzadeh, Zahra Mirali, Syed Mohd Abbas Zaidi, Roodabeh Bahramsoltani","doi":"10.1055/a-2725-3868","DOIUrl":"10.1055/a-2725-3868","url":null,"abstract":"<p><strong>Abstract: </strong>Rue (<i>Ruta</i> spp.) is a medicinal, ornamental, and culinary herb, distinguished by its strong repellent aroma, rich in various bioactive compounds. In addition to different traditional uses, rue shows anti-inflammatory, anticancer, antiviral, and antifungal properties. Thus, we aimed to comprehensively review the past and present roles of <i>Ruta</i> spp. in the management of diseases. Accordingly, we systematically reviewed PubMed, Web of Science, Scopus, and Cochrane Library with relevant keywords for ethnopharmacological, pharmacological, pre-clinical, clinical, and toxicological studies to evaluate the efficacy and safety of rue, in addition to its traditional applications. In traditional Indian and Persian Medicine, rue is mostly utilized for tonifying the stomach, managing neural complications, and regulating the menstrual cycle. Ethnopharmacological studies indicated that all parts of rue are used in more than 15 countries for different purposes such as for the diseases of respiratory system, urinary system, gastrointestinal system, and nervous system. In preclinical studies, <i>Ruta</i> spp. are examined in the management of neurologic disorders, endocrine and metabolic disorders, gastrointestinal disorders, and neuropsychologic disorders. Human studies mainly included homeopathic formulations in musculoskeletal disorders, oncology, ophthalmology, obesity, and gynecology. Although <i>Ruta</i> spp. show antioxidant effects, their systemic toxicity, cytotoxicity, and photosensitivity effects may be related to the bioactive compounds such as xanthotoxin, psoralenes, and bergapten in high doses. In conclusion, in the usual dose that is used, rue showed the potential of managing different health problems; however, more clinical studies are required.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"604-638"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145489950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genotoxicity Assessment of Hypericum perforatum Dry Extracts in the Ames Test Based on the \"Bracketing and Matrixing\" Concept.","authors":"Jens Flade, Olaf Kelber, Karen Nieber, Björn Feistel","doi":"10.1055/a-2727-1619","DOIUrl":"10.1055/a-2727-1619","url":null,"abstract":"<p><strong>Abstract: </strong>HMPs derived from <i>Hypericum perforatum</i>, herba (St. John's wort) play an important role in treating mild to moderate depressive episodes and mental exhaustion, for example. The genotoxic safety of these HMPs has already been assessed and reviewed in recent years. However, further data on the genotoxic potential of <i>Hypericum perforatum</i>, herba preparations would allow the evaluation of the therapeutic safety of the herbal drug and preparations thereof in accordance with the genotoxicity guideline of the HMPC of the EMA. Accordingly, their genotoxic potential was tested using the \"bracketing and matrixing\" concept, whereby extracts are tested at and between the extremes of their extraction solvents (ranging in strength from polar to non-polar) to cover the entire spectrum of the drug's constituents. In the present study, five dry extracts of <i>Hypericum perforatum</i>, herba, representing the full range of potential extraction solvent polarities (water, ethanol 50% (v/v), methanol 80% (v/v), ethanol 80% (v/v), and <i>n</i>-heptane) were tested using the Ames test, according to the OECD and HMPC guidelines. No mutagenic effects were observed for any of the five test strains in two independent experiments (plate incorporation test and pre-incubation test) each carried out with and without metabolic activation, even at the highest concentrations (5000 µg/plate), in accordance with the OECD guideline No. 471.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"639-646"},"PeriodicalIF":2.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145496010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nyctanthes arbor-tristis: A Multifaceted Medicinal Plant in Traditional and Contemporary Medicine.","authors":"Ayan Aggarwal, Dinesh Kumar Mehta, Ashish Bhardwaj, Rina Das","doi":"10.1055/a-2706-7358","DOIUrl":"10.1055/a-2706-7358","url":null,"abstract":"<p><p><i>Nyctanthes arbor-tristis</i>, commonly known as night-flowering jasmine or parijat, is a plant of notable importance in traditional medicine and cultural practices. It is characterized by its nocturnally blooming, fragrant flowers. Traditional medicinal systems have extensively utilized this species for its therapeutic properties, which modern clinical research has supported. This plant, renowned for its therapeutic potential, has been integral to folk medicine for addressing antibilious conditions, gynecological disorders, and liver protection, highlighting its historical significance.This review aims to conduct a comprehensive ethnopharmacological evaluation of <i>Nyctanthes arbor-tristis</i>, with a focus on its chemical composition and pharmacological properties. It seeks to explore its therapeutic potential while identifying gaps requiring further scientific investigation.The review draws on data from credible sources such as PubMed, Google Scholar, and related literature published from 2013 to 2024 using keywords such as <i>Nyctanthes arbor-tristis</i>, night-flowering jasmine, sorrow plant, harsingar, harasingaar, pavazha mattigai, paarijaata, parijathak, and parijatha.The literature reveals that <i>Nyctanthes arbor-tristis</i> contains several phytoconstituents, including steroids, terpenes, flavonoids, phenols, iridoid glycosides, and alkaloids. These compounds, distributed across its leaves, seeds, flowers, and stem bark, exhibit distinct pharmacological activities. Reported effects include anti-inflammatory, anti-oxidant, analgesic, anti-diabetic, anti-arthritic, cytotoxic, anti-microbial, anti-malarial, anthelmintic, larvicidal, bronchodilatory, hepatoprotective, immunomodulatory, neuroprotective, and wound healing activities. This plant is also widely recognized for its traditional uses and is used by various countries and communities for the treatment of sciatica, arthritis, fever, liver disorders, and parasitic infections. Additionally, various parts, such as leaves, roots, bark, and seeds, are used across cultures for their dermatological effects, sedative properties, and antispasmodic actions. Despite its potential, the existing pharmacological and phytochemical data remain insufficient, necessitating further research to understand its mechanisms of action and therapeutic applications.With its diverse bioactive compounds, <i>Nyctanthes arbor-tristis</i> shows promise as a source of natural therapeutics. However, comprehensive studies are essential to validate its ethnomedicinal applications and understand its mechanisms of action. Such efforts could facilitate the development of effective, low-side-effect natural therapeutic products, addressing a growing demand for alternative medicines in contemporary healthcare.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"440-464"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145489979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Scutellarin on the Pharmacokinetics and Pharmacodynamics of Warfarin in Rats.","authors":"Jiahui Sun, Mengnan Qin, Lin Wei, Xuepeng Shi, Bing Shao, Gaofeng Liu, Chunjuan Yang","doi":"10.1055/a-2748-8868","DOIUrl":"10.1055/a-2748-8868","url":null,"abstract":"<p><strong>Abstract: </strong>The study aims to investigate the pharmacodynamics and pharmacokinetics to elucidate the mechanism of enhanced anticoagulant effect of scutellarin and its preparations on warfarin. Evaluation of pharmacodynamic effects is undertaken by measuring coagulation parameters prothrombin time (PT) and activated partial thromboplastin time (APTT). The UHPLC-ESI-MS/MS method is used to determine the plasma concentrations of R/S-warfarin to investigate the influence on the pharmacokinetics. Changes in the plasma protein binding rate of warfarin is studied by ultrafiltration. The results of pharmacodynamics showed that there was no significant difference in PT, international normalized ratio (INR), and APTT between the scutellarin control and the blank control group. Compared to the warfarin control group, scutellarin co-administered with the warfarin group has a significant increase in PT and INR after 8 h, and APTT had no change. The pharmacokinetic results showed that there was an increase in peak concentration (<i>C</i> _max) and area under curve (<i>AUC</i> _0-t and <i>AUC</i> _0-∞) and a significant prolongation of half time (<i>t</i> _1/2) and a decrease in apparent clearance (<i>CL</i>/<i>F</i>) of R-warfarin compared with the warfarin control group. Compared with the warfarin group, the protein binding rates were decreased in all doses of scutellarin co-administered with the warfarin groups, respectively. Scutellarin can enhance the anticoagulant effect of warfarin by both inhibition of the R-warfarin metabolism and reduction in the protein binding rate of warfarin.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"567-573"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145708892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutmeg: A Review on Basic Source, Traditional Use, Chemical Components, Pharmacological Activities, Mechanism, and Quality Control.","authors":"Junni Qi, Yanqiu Bai, Qier Mu, Jisiguleng Wu, Chula Sa","doi":"10.1055/a-2623-1165","DOIUrl":"10.1055/a-2623-1165","url":null,"abstract":"<p><strong>Abstract: </strong><i>Myristica fragrans</i> (<i>M. fragrans</i>) is a species within the Myristicaceae family and the Myristica genus. It is an evergreen tree plant native to Maluku and the Banda Islands. Nutmeg (dried kernel of <i>M. fragrans</i>) could be used not only as a spice but also as a valuable medicinal herb used in traditional ethnomedicines, including Ayurvedic medicine, Tibetan medicine, Mongolian medicine, and Chinese medicine. From previous studies, it has been found that its chemical components are lignans, neolignans, volatile oils, and other chemical components. Modern pharmacological studies have shown that nutmeg extract and its chemical constituents possess a wide range of pharmacological activities such as neurological and digestive pharmacological effects, as well as cardioprotective, anti-inflammatory, analgesic, potential anticancer, antimicrobial, antioxidant activities, and other pharmacological effects, which are closely related to its rich ethnomedical uses. There were more studies on the pharmacological activities and chemical constituents of nutmeg, but few studies had been carried out in terms of incorporating the experience of traditional medicine and systematic quality control studies. Based on botanical books, Chinese classic texts, medical monographs, and academic search engines (Pubmed, Web of Science, CNKI, Science Direct, and Wiley Online Library), this paper reviewed various aspects of nutmeg, such as its basic source, traditional use, chemical components, pharmacological activities, and mechanism of action, as well as quality control, with a view to laying a foundation for the study of the potential pharmacological activities and quality control of nutmeg and providing a theoretical basis for the further development of nutmeg.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"539-566"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moutan Cortex: A Review of Origins, Phytochemical Characterization Strategies, and Anti-fibrosis-related Pharmacological Mechanisms and Applications.","authors":"Wei Zheng, Yingting Li, Xingyi Wu, Luping Yuan","doi":"10.1055/a-2706-7513","DOIUrl":"10.1055/a-2706-7513","url":null,"abstract":"<p><strong>Abstract: </strong>Traditional medicine has long acknowledged the therapeutic effects of Moutan cortex (MC), derived from the dried root bark of the tree peony. In recent times, scientific investigations have shed light on its bioactive components and the mechanisms underlying its health-promoting effects. Here, we review the origin of MC, encompassing its worldwide resource distribution, plant morphological characteristics, and medicinal values. Additionally, a multi-dimensional analysis is carried out on the present research strategies concerning the components of MC, aiming to provide insights into the identification of the active components in MC. Simultaneously, this article focuses on the anti-fibrotic pharmacological mechanisms of the two crucial active components, paeonol and paeoniflorin, derived from MC. We comprehensively summarize the multiple mechanisms and pathways through which these components exhibit anti-fibrotic actions within specific pathological sites. Moreover, it reviews the advancements in patents and clinical research associated with paeonol and paeoniflorin, emphasizing their substantial potential for translational applications. Elucidating the key active components derived from MC and their pharmacological mechanisms holds critical scientific and practical value across multiple fields.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"520-538"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145286717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Herbal Products and Their Active Constituents on Angiogenesis in Diabetic Wounds.","authors":"Anna Herman","doi":"10.1055/a-2735-8069","DOIUrl":"10.1055/a-2735-8069","url":null,"abstract":"<p><p>Angiogenesis plays a key role in tissue regeneration by delivering oxygen and nutrients to the injury site. In diabetes mellitus, various factors, including hyperglycemia, neuropathy, increased reactive oxygen species, and proinflammatory cytokines, decrease the levels of proangiogenic factors and increase levels of antiangiogenic factors, hamper angiogenesis, and hinder wound healing. Reconstruction of the vasculature of the wound bed is crucial for promoting diabetic wound healing and improving the quality of life of patients. Given the urgent need for innovative therapies to promote angiogenesis and accelerate the repair of diabetic wounds, researchers have increasingly focused on identifying herbal products and their active constituents with promising proangiogenic activity.The aim of this review is to present verified data on the current knowledge on the effect of herbal products and their active constituents on angiogenesis processes in diabetic wounds.The electronic databases were searched for articles published from 2014 to the present. The 38 articles comparing topically used herbal products/active constituents on angiogenesis in diabetic wound healing treatment versus control treatments (placebo or active therapy) were selected.Herbal products and their active constituents are rich sources of novel angio-modulators that may affect the angiogenesis process in diabetic wound healing via different mechanisms of action, including stimulation of VEGF and HRMs and activation of the Nrf2, PI3K/AKT, and HIF-1<i>α</i> signaling pathways. Topical applications of herbal products and their active constituents, especially when incorporated into wound dressings, show promising proangiogenic activity and represent a potential alternative for the treatment of diabetic wounds.</p>","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"483-493"},"PeriodicalIF":2.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145409632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}