Planta medica最新文献_第7页

Combating Inflammation and Oxidative Stress: Exploring the Cellular Effects of Lonicera caerulea var. kamtschatica Extract. 抗炎症和氧化应激：探索金银花提取物的细胞作用。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-01-19 DOI: 10.1055/a-2520-0013

Katarzyna Zima, Laura Banaszkiewicz, Mateusz Kacper Woźniak, Barbara Khaidakov, Krzysztof Lemke, Paulina Kowalczyk

{"title":"Combating Inflammation and Oxidative Stress: Exploring the Cellular Effects of Lonicera caerulea var. kamtschatica Extract.","authors":"Katarzyna Zima, Laura Banaszkiewicz, Mateusz Kacper Woźniak, Barbara Khaidakov, Krzysztof Lemke, Paulina Kowalczyk","doi":"10.1055/a-2520-0013","DOIUrl":"10.1055/a-2520-0013","url":null,"abstract":"Lonicera caerulea var. kamtschatica, known as blue honeysuckle or haskap berry, is rich in bioactive compounds such as polyphenols, flavonoids, and anthocyanins, which are linked to various health benefits, including anti-inflammatory and antioxidant properties. The research specifically investigates the effects of an L. caerulea var. kamtschatica extract that has been standardized to contain a minimum of 15% anthocyanins on inflammation and oxidative stress at the cellular level. In vitro studies using A549 human lung epithelial cells and peripheral blood mononuclear cells demonstrated the extract's anti-inflammatory and antioxidant properties. L. caerulea var. kamtschatica extract significantly inhibited the nuclear translocation of NF-κB p65 and reduced the production of IL-8 in A549 cells. It also downregulated the expression of proinflammatory genes (RELA and PTGS2) while upregulating antioxidant genes (CAT, HMOX1, and SOD2). In peripheral blood mononuclear cells, L. caerulea var. kamtschatica extract decreased the phosphorylation of NF-κB p65 and reduced the levels of proinflammatory cytokines IL-1β and IL-6 following lipopolysaccharide stimulation. Additionally, the extract inhibited reactive oxygen species formation and nitric oxide production, demonstrating its potential to modulate oxidative stress. Furthermore, in vitro assays indicated that L. caerulea var. kamtschatica extract could hinder the binding of SARS-CoV-2 spike protein to the hACE2 receptor, suggesting antiviral potential.These findings suggest that L. caerulea var. kamtschatica extract exerts significant anti-inflammatory and antioxidant effects, indicating its potential as a functional food ingredient or dietary supplement to combat inflammation and oxidative stress.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"208-221"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143009344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Roseoglobuloside A, a Novel Nonanolide, and Identification of Specialized Metabolites as hPTP1B1 - 400 Inhibitors from Mangrove-Dwelling Aspergillus spp. 红树曲霉hPTP1B1 - 400抑制剂的特异性代谢物鉴定——一种新型Nonanolide玫瑰红糖苷A

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-01-27 DOI: 10.1055/a-2515-9491

Carlos A Fajardo-Hernández, Ángeles G Zavala-Sierra, Verenice I Merlin-Lucas, Jesús I Morales-Jiménez, José Rivera-Chávez

{"title":"Roseoglobuloside A, a Novel Nonanolide, and Identification of Specialized Metabolites as hPTP1B1 - 400 Inhibitors from Mangrove-Dwelling Aspergillus spp.","authors":"Carlos A Fajardo-Hernández, Ángeles G Zavala-Sierra, Verenice I Merlin-Lucas, Jesús I Morales-Jiménez, José Rivera-Chávez","doi":"10.1055/a-2515-9491","DOIUrl":"10.1055/a-2515-9491","url":null,"abstract":"An approach combining enzymatic inhibition and untargeted metabolomics through molecular networking was employed to search for human recombinant full-length protein tyrosine phosphatase 1B (hPTP1 B1 - 400) inhibitors from a collection of 66 mangrove-associated fungal taxa. This strategy prioritized two Aspergillus strains (IQ-1612, section Circumdati, and IQ-1620, section Nigri) for further studies. Chemical investigation of strain IQ-1612 resulted in the isolation of a new nonanolide derivative, roseoglobuloside A (1: ), along with two known metabolites (2: and 3: ), whereas strain IQ-1620 led to the isolation of four known naphtho-γ-pyrones and one known diketopiperazine (4: -8: ). Of all isolates, compounds 2, 3: , and 7: showed a marked inhibitory effect on hPTP1B1 - 400 with an IC50 value < 20 µM, while 6: showed moderate inhibition with IC50 of 65 µM. Compounds 1: and 8: were inactive at a concentration of 100 µM, whereas 4: and 5: demonstrated significant inhibition at 20 µM. The structure of 1: was established by comprehensive spectroscopic analysis, and its relative and absolute configuration was assigned based on NOE correlations and by comparison of calculated and experimental ECD curves. Molecular docking indicated that these molecules primarily bind to two different allosteric sites, thereby inducing conformational changes that impact enzymatic activity.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"197-207"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143053194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Compounds against Mpox: Mapping Evidence and Identifying Gaps. 抗m痘的天然化合物：绘制证据并找出差距。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-03-17 DOI: 10.1055/a-2560-1844

Amin Sharifan

{"title":"Natural Compounds against Mpox: Mapping Evidence and Identifying Gaps.","authors":"Amin Sharifan","doi":"10.1055/a-2560-1844","DOIUrl":"10.1055/a-2560-1844","url":null,"abstract":"The global spread of Mpox necessitates exploration of novel treatment options. Considering the established history of herbal medicine in managing infectious diseases, this study reviewed the literature on phytotherapy for Mpox, addressing gaps in evidence-based herbal interventions. A thorough search was conducted across the Scopus, PubMed, and Cochrane databases, as well as grey literature, up to August 2024 to retrieve studies on natural compounds with potential efficacy against Mpox and its associated symptoms. Data were analysed for publication characteristics, the compounds or herbal plants investigated, and their effects on the virus. A total of 37 articles with 242 citations were identified, demonstrating a steady increase in research activity since the first study in 2011, peaking in 2023 with 21 publications and 114 citations. The majority of studies originated from Southeast Asian countries. In terms of study design, most investigations were in silico (n = 31, 84%), followed by in vitro studies (n = 4, 11%), with no in vivo or clinical interventions reported. The primary focus was on the antiviral activities of natural products, with polyphenols identified as the most prevalent lead compounds. Whilst these findings highlight the growing interest in phytotherapy for Mpox, they also underscore the predominance of computational studies. To build upon this foundation of in silico evidence, further laboratory and animal studies are imperative for translating these insights into clinical applications. The comprehensive library of compounds gathered through this research provides a valuable resource to facilitate this crucial next step in the development of herbal interventions against Mpox.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"271-273"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143649915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Characteristics and Functions of Orally Absorbed Herbal Decoction-Borne Plant MicroRNAs. 口服中药煎剂植物microrna的特性与功能。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-01-28 DOI: 10.1055/a-2527-2127

Yating Zhu, Yicheng Yu, Yao Jia, Ziqi Lin, Jinyue Lei, Diyao Wu, Tielong Xu, Longxue Li, Bin Zheng

{"title":"The Characteristics and Functions of Orally Absorbed Herbal Decoction-Borne Plant MicroRNAs.","authors":"Yating Zhu, Yicheng Yu, Yao Jia, Ziqi Lin, Jinyue Lei, Diyao Wu, Tielong Xu, Longxue Li, Bin Zheng","doi":"10.1055/a-2527-2127","DOIUrl":"10.1055/a-2527-2127","url":null,"abstract":"Herbal decoctions always contain numerous plant microRNAs, and some of these can be absorbed orally to exert cross-kingdom gene regulation. However, little is known about which specific types of herbal decoction-borne plant microRNAs are more likely to be absorbed. Thus, two antiviral herbal decoctions, Qingfei Paidu and Qingre Huashi Kangdu, were administered to human volunteers and rats, respectively, to investigate the characteristics of orally absorbed decoction-borne plant microRNAs. MIR-6240 - 3 p was identified as an absorbed plant microRNA in humans and is most highly expressed in Qingfei Paidu decoction. Therefore, the kinetics of MIR-6240 - 3 p were monitored in humans following the administration of the Qingfei Paidu decoction, and its antiviral effect on human coronavirus type 229E (HCoV-229E) was examined in vitro. There were 586 176 small RNAs identified in Qingfei Paidu decoction, of which 100 276 were orally absorbed by humans. In the Qingre Huashi Kangdu decoction, 124 026 small RNAs were detected, with 7484 being orally absorbed by rats. Logistical repression analysis revealed that absorbable plant small RNAs in both humans and rats presented higher expression levels, greater minimum free energy, and increased AU/UA frequencies compared to nonabsorbable plant small RNAs. The amount of MIR-6240 - 3 p in humans increased between 1 and 3 h after the administration of the Qingfei Paidu decoction. In addition, MIR-6240 - 3 p significantly reduced the RNA copy number and TCID50 of HCoV-229E in vitro. These results suggest that herbal decoction-borne plant small RNAs with a higher expression level, greater minimum free energy, or an increased AU/UA frequency are more likely to be orally absorbed and could potentially mediate cross-kingdom gene regulation.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"283-292"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytoestrogens and Sirtuin Activation for Renal Protection: A Review of Potential Therapeutic Strategies. 植物雌激素和Sirtuin激活对肾脏保护：潜在治疗策略的综述。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2024-12-03 DOI: 10.1055/a-2464-4354

Debojyoti Mandal, Nahid Akhtar, Sana Shafi, Jeena Gupta

{"title":"Phytoestrogens and Sirtuin Activation for Renal Protection: A Review of Potential Therapeutic Strategies.","authors":"Debojyoti Mandal, Nahid Akhtar, Sana Shafi, Jeena Gupta","doi":"10.1055/a-2464-4354","DOIUrl":"10.1055/a-2464-4354","url":null,"abstract":"Significant health and socio-economic challenges are posed by renal diseases, leading to millions of deaths annually. The costs associated with treating and caring for patients with renal diseases are considerable. Current therapies rely on synthetic drugs that often come with side effects. However, phytoestrogens, natural compounds, are emerging as promising renal protective agents. They offer a relatively safe, effective, and cost-efficient alternative to existing therapies. Phytoestrogens, being structurally similar to 17-β-estradiol, bind to estrogen receptors and produce both beneficial and, in some cases, harmful health effects. The activation of sirtuins has shown promise in mitigating fibrosis and inflammation in renal tissues. Specifically, SIRT1, which is a crucial regulator of metabolic activities, plays a role in protecting against nephrotoxicity, reducing albuminuria, safeguarding podocytes, and lowering reactive oxygen species in diabetic glomerular injury. Numerous studies have highlighted the ability of phytoestrogens to activate sirtuins, strengthen antioxidant defense, and promote mitochondrial biogenesis, playing a vital role in renal protection during kidney injury. These findings support further investigation into the potential role of phytoestrogens in renal protection. This manuscript reviews the potential of phytoestrogens such as resveratrol, genistein, coumestrol, daidzein, and formononetin in regulating sirtuin activity, particularly SIRT1, and thereby providing renal protection. Understanding these mechanisms is crucial for designing effective treatment strategies using naturally occurring phytochemicals against renal diseases.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"146-166"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142771386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine. 网络药理学在中医治疗神经退行性疾病中的应用。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-01-08 DOI: 10.1055/a-2512-8928

Qiang Chen, Guanghui Chen, Qianyan Wang

{"title":"Application of Network Pharmacology in the Treatment of Neurodegenerative Diseases with Traditional Chinese Medicine.","authors":"Qiang Chen, Guanghui Chen, Qianyan Wang","doi":"10.1055/a-2512-8928","DOIUrl":"10.1055/a-2512-8928","url":null,"abstract":"In recent years, the incidence of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis, has exhibited a steadily rising trend, which has posed a major challenge to the global public health. Traditional Chinese medicine, with its multicomponent and multitarget characteristics, offers a promising approach to treating neurodegenerative diseases. However, comprehensively elucidating the complex mechanisms underlying traditional Chinese medicine formulations remains challenging. As an emerging systems biology method, network pharmacology has provided a vital tool for revealing the multitarget mechanisms of traditional Chinese medicine through high-throughput technologies, molecular docking, and network analysis. This paper reviews the advancements in the application of network pharmacology in treating neurodegenerative diseases using traditional Chinese medicine, analyzes the current status of relevant databases and technological methods, discusses the limitations, and proposes future directions to promote the modernization of traditional Chinese medicine and the development of precision medicine.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"226-237"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12021452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142953077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Andrographolide and its Derivatives in Cardiovascular Disease: A Comprehensive Review. 穿心莲内酯及其衍生物在心血管疾病中的研究综述。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-03-07 DOI: 10.1055/a-2542-0756

Shenjie Zhang, Xiaokai Xie, Juan Zhao, Yilong Jiang, Chao Huang, Qi Li, Boyu Xia, Le Yin, Xiaomei Yuan, Qingsheng You

引用次数: 0

Green Tea Catechins: A Promising Anticancer Approach for Leukaemia. 绿茶儿茶素：一种有希望的白血病抗癌方法。

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI: 10.1055/a-2535-2003

Łukasz Mazur, Radosław Balwierz, Krzysztof Michalak, Wojciech Michalak, Agata Jasińska-Balwierz, Mariia Shanaida, Paweł Biernat, Tomasz Baj, Izabela Jasicka-Misiak

引用次数: 0

Eleutherococcus senticosus Alleviates Aristolochic-Acid-Induced Acute Kidney Damage by Inhibiting the NLRP3/IL-1β Signaling Pathway in Mice. 刺痛棘球绦虫通过抑制NLRP3/IL-1β信号通路减轻马兜铃酸诱导的小鼠急性肾损伤

IF 2.1 4区医学

Planta medica Pub Date : 2025-04-01 Epub Date: 2025-01-24 DOI: 10.1055/a-2517-9234

Jian-Hui Zhang, Mei-Zhu Gao, Qian Chen, Ting Chen, Dan-Dan Ruan, Min Wu, Fang-Meng Huang, Jie-Wei Luo, Yao-Bin Zhu, Li Chen

{"title":"Eleutherococcus senticosus Alleviates Aristolochic-Acid-Induced Acute Kidney Damage by Inhibiting the NLRP3/IL-1β Signaling Pathway in Mice.","authors":"Jian-Hui Zhang, Mei-Zhu Gao, Qian Chen, Ting Chen, Dan-Dan Ruan, Min Wu, Fang-Meng Huang, Jie-Wei Luo, Yao-Bin Zhu, Li Chen","doi":"10.1055/a-2517-9234","DOIUrl":"10.1055/a-2517-9234","url":null,"abstract":"Eleutherococcus senticosus (ES) exerts various pharmacological effects, including renoprotection in a rat model of renal ischemia-reperfusion injury. However, the mechanisms of these effects remain unclear. Therefore, we investigated the effects and mechanisms of ES on aristolochic acid (AA)-induced acute kidney injury in mice. The experimental mice were divided into the control group, the model group (AA-induced acute kidney injury model), the model + ES group (Eleutherococcus senticosus boiled-free granules treated by gavage for two weeks), the model + fasudil group (fasudil administered intraperitoneally for three days), and the model + ES + fasudil group. After AA intervention in normal mice, the expression of ASC and NLRP3 and the levels of IL-1β, IL-18, and TNF-α were significantly elevated in mouse renal tissues (P < 0.05). However, AA-induced renal dysfunction was ameliorated by both ES and fasudil, which was confirmed by the decrease in serum creatinine and blood urea nitrogen levels, as well as by renal histopathological abnormalities such as renal tubule dilation and tubular formation. In addition, the inflammatory response of AA-induced renal inflammation was inhibited by both ES and fasudil, and the expression of ASC and NLRP3 and the levels of IL-1β, IL-18, and TNF-α were significantly higher in mouse renal tissues after the treatment of either ES or fasudil (P < 0.05). ES may be a potential treatment agent for aristolochic-acid-triggered nephropathy, with inhibition of the NLRP3/IL-1β as one plausible underlying mechanism.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"189-196"},"PeriodicalIF":2.1,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143040977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phytochemical Characterization and Comparative Analysis of Cycloartane-Type Triterpenes in Astragalus adsurgens and Astragalus membranaceus. 黄芪和膜荚黄芪中环安坦类三萜的植物化学特征和比较分析。

IF 2.1 4区医学

Planta medica Pub Date : 2025-03-01 Epub Date: 2024-11-25 DOI: 10.1055/a-2486-8873

Guanglian Zhou, Yin Chen, Bingyan Xu, Guoqing Peng, Li Wang, Jian-Ping Huang, Zhiyin Yu, Sheng-Xiong Huang

{"title":"Phytochemical Characterization and Comparative Analysis of Cycloartane-Type Triterpenes in Astragalus adsurgens and Astragalus membranaceus.","authors":"Guanglian Zhou, Yin Chen, Bingyan Xu, Guoqing Peng, Li Wang, Jian-Ping Huang, Zhiyin Yu, Sheng-Xiong Huang","doi":"10.1055/a-2486-8873","DOIUrl":"10.1055/a-2486-8873","url":null,"abstract":"Astragalus adsurgens, a significant forage plant cultivated in arid regions of northwest China, remains underexplored for its triterpenoid saponins and medicinal properties compared to the extensively studied Astragalus membranaceus. To explore the phytochemical profile of A. adsurgens for its potential application in the medical field, we employed ultra-pressure liquid chromatography coupled with a tandem mass spectrometry-based method to identify cycloartane-type triterpenes. Eventually, five new cycloartane-type triterpenoids, adsurgosides A - D ( 1 - 4: ) and 3-methyl-3,4-seco-cyclostellanol (5: ), together with two known analogs, cycloastragenol (6: ) and cyclopycanthogenin (7: ), were isolated from the roots of A. adsurgens. Their structures were elucidated using 1D and 2D NMR analyses in combination with HRESIMS data. Additionally, a comparative study on the distribution patterns of these compounds revealed qualitative and quantitative variations between A. adsurgens and A. membranaceus. Our findings not only identified an alternative plant for isolating cycloartane-type triterpenoids but also offer new insights into the chemical properties of A. adsurgens.","PeriodicalId":20127,"journal":{"name":"Planta medica","volume":" ","pages":"109-118"},"PeriodicalIF":2.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142716850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0