Pakistan Journal of Medical Sciences最新文献

{"title":"Computed tomography manifestations and pathological features of intra-abdominal desmoplastic small round cell tumor.","authors":"Ashan Pan, Xunze Shen, Qiande Qiu","doi":"10.12669/pjms.41.3.10154","DOIUrl":"10.12669/pjms.41.3.10154","url":null,"abstract":"<p><strong>Objective: </strong>To explore the computed tomography (CT) manifestations and pathological features of intra-abdominal desmoplastic small round cell tumor (DSRCT).</p><p><strong>Methods: </strong>Retrospective analysis was conducted on the CT manifestations and pathological features of 11 patients with intra-abdominal DSRCT in Yueqing People's Hospital, Shaoxing People's Hospital and Wenzhou People's Hospital from January 2010 to June 2022.</p><p><strong>Results: </strong>Among 11 patients, four cases were with solitary tumor and seven cases were with multiple tumors. There were five cases with elliptical shape, smooth edges and clear boundary and six cases with irregular shape and unclear boundary. The CT plain scan showed the uneven density in tumor. There were six cases with necrosis and cystic transformation in central tumor, and five cases with small patchy or strip-shaped calcification within the tumor. The enhanced CT scan showed uneven enhancement. There were seven cases of mild enhancement and four cases of moderate enhancement. Five cases showed strip or grid-like enhancement within tumor, and five cases showed increased and thickened vascular shadows around the tumor. The immunohistochemistry showed nine cases were positive for AE1/AE3, CK, Vim and Desmin, eight cases were positive for EMA, seven cases were positive for NSE, and three cases were positive for CGA, SYN, CD56 and CD99.</p><p><strong>Conclusion: </strong>In CT manifestations, the intra-abdominal DSRCT present the solitary or multiple tumors, with uneven density. There are often cystic changes and small patchy calcification within the tumor, with mild to moderate uneven enhancement.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 3","pages":"753-757"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whispers of Resilience: A phenomenological exploration of maternal journeys with children affected by Downs Syndrome in Quetta, Baluchistan.","authors":"Ambica Devi, Lubna Ansari Baig, Mehjabeen Musharaf, Hira Tariq","doi":"10.12669/pjms.41.3.9710","DOIUrl":"10.12669/pjms.41.3.9710","url":null,"abstract":"<p><strong>Background & objective: </strong>Down's syndrome, a chromosomal disorder, with an incidence of approximately one in 800 live births globally affects physical and intellectual development of a child, having greatest impact on mothers. This study explored the challenges faced by the mothers of children with Down's Syndrome related to their upbringing at different stages of life.</p><p><strong>Methods: </strong>Qualitative research was conducted using Phenomenological approach from May 2021- April 2022 in Quetta, Baluchistan. Mothers were selected through purposive sampling from institutional records of Wilderness School, Quetta, the only private school for special children. Five In depth Interviews and two Focus Group Discussions were conducted with 17 mothers using a semi structured interview guide. Data collected in audio files was transcribed verbatim into English language. Analysis was done by two researchers independently.</p><p><strong>Results: </strong>The themes included, Experience of Giving birth to a child with Down's Syndrome, Social support system, Personal Challenges, Experiencing Worrisome thoughts about child's future and Experiencing personality changes. The findings imply that giving birth and bringing up a child with DS is a life-changing process. Social stigmatization, lack of support by family, in-laws, relatives and financial constraints to afford schooling and rehabilitation make it challenging for mothers to provide adequate attention and developmental opportunities to the child. Mothers compromise on their health, career, social life, social status and relationship with other family members.</p><p><strong>Conclusion: </strong>Raising children with Down syndrome is a life changing process and the absence of prenatal diagnosis in regions like Quetta and limited counseling from concerned doctors leaves mothers unprepared. This results in care givers reliance on internet resources for developing understanding about the syndrome and child care.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 3","pages":"856-860"},"PeriodicalIF":1.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143658183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of Schroth Therapy combined with spinal manipulation for the treatment of adolescent idiopathic scoliosis.","authors":"He Chen, Chaonan Zhang","doi":"10.12669/pjms.41.2.11355","DOIUrl":"10.12669/pjms.41.2.11355","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effectiveness of the Schroth method combined with spinal manipulation treatment in patients with adolescent idiopathic scoliosis (AIS).</p><p><strong>Methods: </strong>This was a single-center retrospective study performed between January 2023 and February 2024, in which 150 patients with AIS were treated with Schroth method with or without spinal manipulation at Wenzhou Traditional Chinese Medicine Hospital. Patients were classified into a study group and a control group with 50 patients in each group after screening. Intervention effects, maximum Cobb angle, clavicle angle before and after the treatment, trunk rotation angle, vertebral rotation angle, and lumbar range of motion (range of motion for lumbar extension and flexion) were compared between the two groups.</p><p><strong>Results: </strong>The overall efficacy of intervention in the study group was higher than that in the control group (96.00% <i>versus</i> 84.00%) (<i>P</i><0.05). After the treatment, the maximum Cobb angle, clavicle angle, angle of trunk rotation (ATR), and vertebral rotation angle of the two groups decreased compared to pretreatment levels and were significantly smaller in the study group compared to the control group (<i>P</i><0.05). After the treatment, the degree of lumbar extension and flexion in both groups increased compared to before treatment and was markedly greater in the study group (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>In patients with AIS, combining the Schroth method and spinal manipulation treatment was more effective in reducing the maximum Cobb and clavicle angles, trunk rotation angle, and vertebral rotation angle and restoring the lumbar range of motion compared to the Schroth method alone.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"409-414"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spectrum of different categories of Primary Immunodeficiency Disorders diagnosed at Children Hospital.","authors":"Aisha Iftikhar, Mobeen Nazar, Adeela Chaudry, Ahmad Qaisar","doi":"10.12669/pjms.41.2.9511","DOIUrl":"10.12669/pjms.41.2.9511","url":null,"abstract":"<p><strong>Objective: </strong>To determine the frequency and spectrum of different categories of Primary immunodeficiency disorders (PIDD).</p><p><strong>Methodology: </strong>This was a prospective, observational analytical study, conducted in the Pediatric Medicine Department, University of Child Health Sciences (UCHS) from January 2021 to January 2023.We recruited 81 patients, initially suspected based on Jeffrey Modell Foundation(JMF) warning signs, followed by detailed evaluation. Descriptive statistics were applied.</p><p><strong>Results: </strong>Male patients exceeded female (47: 31). Median age of presentation was 17 months. Median diagnostic delay was 10.5 months. Need of I/V antibiotics was the most frequent JMF warning sign (88.5%). Consanguinity, previous hospital admissions, family history and sibling death were present in 80%, 78%, 54%, 37% of cases respectively. The most conspicuous clinical feature was persistent or recurrent thrush (51%). Patients were categorized into six main groups: B-Cell defect (29.5%), SCID (24.4%), CID (14.1%), T-Cell defect (12.8 %), Phagocytic defect (11.5%) and NK deficiency (7.7%). Main bulk of patients 37 (47.4 %) were in age-group up to one year. Most common site of infection was recurrent pneumonia (76%) and the least was septic arthritis (5.1%).</p><p><strong>Conclusion: </strong>PIDD should no longer be considered a rarity. B-Cell defect is the most common while earliest to diagnose are SCID and LAD. International health authorities should advocate EQUITABLE utilization of genetic testing across the globe.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"569-574"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803810/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis, characterization, and application of methylene blue functionalized reduced graphene oxide for photodynamic therapy in root canal treatment.","authors":"Rizwan Jouhar, Mohamad Syahrizal Halim, Muhammad Adeel Ahmed, Faheem Shah, Sayed A Quadri","doi":"10.12669/pjms.41.2.11001","DOIUrl":"10.12669/pjms.41.2.11001","url":null,"abstract":"<p><strong>Background & objective: </strong>Root canal infections are challenging to eradicate with conventional methods due to their complexity. Traditional chemical irrigants often fail to reach all bacterial colonies. Methylene blue (MB), used in photoactivated disinfection (PAD), generates reactive oxygen species (ROS) upon light activation, effectively killing bacteria. This study aimed to synthesize, characterize, and explore MB-functionalized reduced graphene oxide (MB/rGO) for enhanced photoactivated disinfection in root canal treatment.</p><p><strong>Methods: </strong>This in-vitro study was conducted from April 2024 to September 2024 at Universiti Sains Malaysia and King Faisal University. Graphene oxide (GO) was reduced by dispersing GO in deionized water with sonication, followed by adding sodium hydroxide (NaOH) under vigorous stirring. The suspension obtained was centrifuged, washed, and dried to yield reduced graphene oxide (rGO). For functionalization, rGO was dispersed in ethanol and mixed with methylene blue (MB) solution, followed by stirring and drying to obtain MB-functionalized rGO. The antibacterial and antifungal activities of MB alone and in combination with rGO, with or without laser exposure, were tested using the agar well diffusion method. The paired sample t-test was used to compare the inhibition zones for different treatment groups of <i>E. faecalis</i> and <i>C. albicans</i>.</p><p><strong>Results: </strong>FTIR analysis confirmed successful functionalization by identifying specific functional groups of rGO and MB. Similarly, Raman spectroscopy indicated that GO-MB had an intermediate level of defects, and SEM analysis confirmed slight morphological changes with MB molecules attached to the rGO surface. Moreover, the antimicrobial test revealed that MB/rGO with laser performed significantly better (<i>p</i>=0.042) than MB/rGO without laser and MB with laser group (<i>p</i>=0.034) against <i>E. faecalis</i>.</p><p><strong>Conclusions: </strong>The functionalization of MB with rGO and its application with laser treatment significantly enhanced antimicrobial and antifungal activity, suggesting potential benefits for endodontic treatments and other dental applications.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"519-524"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383132","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the use of protective face masks affect temporomandibular joint function?","authors":"Sena Ozdemir Gorgu, Yasin Yildirim, Pınar Kaya, Gizem Ergezen, Eda Uzuner","doi":"10.12669/pjms.41.2.10588","DOIUrl":"10.12669/pjms.41.2.10588","url":null,"abstract":"<p><strong>Objective: </strong>Long-term mask use can trigger or exacerbate various health issues. This prospective experimental study evaluated the impact of protective face masks on masseter muscle activity and temporomandibular joint (TMJ) function reported by participants.</p><p><strong>Methods: </strong>This prospective, experimental tudy was conducted to investigate the effect of face masks on TMJ function, we used surface electromyography to assess masseter muscle activity at rest, during maximum contraction of the masseter muscle, and while reading a text. We also evaluated the intensity of the masseter muscle pain using an algometer. The participants underwent these evaluations at the Istanbul Medipol University between July and October 2022.</p><p><strong>Results: </strong>The study included 24 female participants with an average age of 28.5±5.40 years. After at least five hours of daily N95 mask use, a significant increase in masseter muscle activity was observed at rest and during speech (p=0.01; p=0.04, respectively). However, no significant changes in the maximum contraction of masseter muscle or pain threshold were observed (p>0.05).</p><p><strong>Conclusion: </strong>This study found that the use of N95 mask is associated with restricted TMJ movements and discomfort, and an increase in its use is associated with restricted TMJ movements, discomfort, and increased masseter muscle activity. Questions regarding mask-wearing-related habits should be included in the routine lifestyle assessment of patients who report TMJ complaints.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"432-436"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Positive Cases for Dense Fine Speckled (DFS) Immunofluorescence Pattern and Anti-DFS70 Antibodies.","authors":"Melahat Gurbuz, Betul F Yıldırım, Yeliz Cetinkol","doi":"10.12669/pjms.41.2.10336","DOIUrl":"10.12669/pjms.41.2.10336","url":null,"abstract":"<p><strong>Objective: </strong>The detection of anti-nuclear antibodies (ANA) is crucial in diagnosing systemic autoimmune rheumatic diseases (SARDs). The Dense Fine Speckled (DFS) nuclear pattern is one of the most common indirect immunofluorescence (IIF) patterns detected during routine ANA screening in patients with various clinical conditions. The aim of this study was to analyze the data of patients who were positive for DFS/antiDFS in our patient population and to show the possible clinical relationship.</p><p><strong>Methods: </strong>In this retrospective study, 7406 patient serum samples sent to our laboratory for routine ANA screening between May 2022-2023 were evaluated for the presence of anti-DFS.</p><p><strong>Results: </strong>In a group of patients referred for routine ANA screening using the indirect immunofluorescence method, the frequency of DFS pattern was found to be 4.55% (337/7406), with ANA positivity detected at a rate of 25.68% (1902/7406). Out of 221 patients with DFS pattern, 181 tested positive for anti-DFS antibodies in both the IIF-ANA and immunoblot (IB) tests. Additionally, 11 of these patients tested positive for other antibodies against different extractable nuclear antigens (anti-ENAs). Conversely, only seven out of the 40 patients who tested negative for anti-DFS antibodies showed positive results for other anti-ENAs.</p><p><strong>Conclusion: </strong>The DFS pattern is often positive in individuals. In patients exhibiting this pattern, anti-DFS70 antibody may be detected alone or in combination with SARD-associated autoantibodies. Therefore, we propose that in this patient cohort, it would be more prudent to screen for additional concomitant autoantibodies with anti-ENA rather than confirming isolated anti-DFS.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"580-584"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of β-thalassemias in the premarital hemoglobinopathy screening program: A retrospective study.","authors":"Olgun Goktas","doi":"10.12669/pjms.41.2.10024","DOIUrl":"10.12669/pjms.41.2.10024","url":null,"abstract":"<p><strong>Objective: </strong>To retrospectively evaluate β-thalassemias in the premarital hemoglobinopathy screening program in primary care.</p><p><strong>Methods: </strong>The retrospective study was carried out in Bursa Uludag University Family Health Center in Turkey between 1-30 September 2023. In the study, the data of individuals who applied to the Family Health Center for premarital health examination within the four years between January 1, 2019, and December 31, 2022, were taken from the database and evaluated retrospectively. Family history of hemoglobinopathy, sociodemographic findings, existing diseases, allergies, cancer, and genetic disease conditions were obtained. Complete blood count, and high-performance liquid chromatography (HPLC) results were examined. <i>P-values</i> below 0.05 were considered statistically significant. Analyzes were made in the SPSS 25.0 program.</p><p><strong>Results: </strong>A total of 327 people, 171 men (52.3%) and 156 (47.7%) women, participated in the study. It was determined that the age of the individuals was 30.17±6.16. The average Mentzer index levels were found to be 12.95±4.56. Places of birth are Mediterranean with 8.3% and other regions with 91.7%. β-thalassemia type detected in family medicine was suspected with a rate of 1.5% and carrier with a rate of 0.6%. The rate of patients referred to a hematologist was found to be 2.1%. The rate of patients with a definitive diagnosis was determined as 1.8%. It was determined that β-thalassemia definitive diagnosis rates were higher in groups whose place of birth was the Mediterranean region, with a family history of thalassemia, with a diagnosis of cancer, and with a genetic, allergic, and chronic disease diagnosis (p=0.01).</p><p><strong>Conclusion: </strong>Although it is not located in the Mediterranean region, the high prevalence of β-thalassemia in our population and its relationship with diseases are important. We emphasize the importance of a premarital screening program for the diagnosis of β-thalassemia due to its increasing frequency and complications in the globalizing world.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"590-597"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Helicobacter pylori infection, clarithromycin-resistant genes and CYP2C19 gene polymorphisms in asymptomatic school-age children in Baigou New Town, Baoding City, Hebei Province.","authors":"Jie Zhang, Weicheng Yuan, Yutong Xing, Xinyu Ma, Fan Xuan","doi":"10.12669/pjms.41.2.9838","DOIUrl":"10.12669/pjms.41.2.9838","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prevalence of Helicobacter pylori (Hp) infection, clarithromycin (CAM)-resistant genes and CYP2C19 gene polymorphisms in asymptomatic school-age children in Baigou New Town, Baoding City, Hebei Province, China.</p><p><strong>Methods: </strong>This retrospective study recruited 1,068 primary school students from Baigou New Town, Baoding City, Hebei Province, China, in November 2023 to screen for Hp infection and detect clarithromycin-resistant genes using stool samples. Additionally, blood samples were collected for CYP2C19 gene polymorphism analysis.</p><p><strong>Results: </strong>The stool antigen test for Hp yielded a positive rate of 18.4% (197/1,068). Among the 197 Hp-positive patients, 36.5% were resistant to CAM. The polymorphism analysis revealed that, in the 23S rRNA V region, the overall mutation rate was 62.5% for the A2143G site, 77.7% for T2182C, 50% for A2143G and T2182C, 2.7% for A2142C and 1.3% for A2142G. Moreover, the analysis classified the study participants into three CYP2C19 phenotypes (i.e., extensive, intermediate and poor metabolisers; extensive metabolisers (EM), intermediate metabolisers (IM) and poor metabolisers (PM), respectively), and the prevalence was 45.6%, 44.6% and 9.6% for EM, IM and PM, respectively.</p><p><strong>Conclusion: </strong>The local area showed a high CAM resistance, indicating that CAM is not preferred for Hp eradication. CYP2C19 gene polymorphism analysis revealed that the EM phenotype was highly prevalent. Therefore, a comprehensive analysis of CYP2C19 gene polymorphisms is recommended to identify ideal proton-pump inhibitors for Hp eradication.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"484-487"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803778/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of ablative fractional carbon dioxide laser combined with 1064 nm-Nd: YAG laser in the treatment of postburn hypertrophic scar.","authors":"Lingqiao Li, Weichang Shen, Guozhong Lyu","doi":"10.12669/pjms.41.2.11088","DOIUrl":"10.12669/pjms.41.2.11088","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of ablative fractional carbon dioxide laser (AFCO2L) combined with 1064 nm-Nd: YAG laser in treating hypertrophic scars (HTS) in burn patients.</p><p><strong>Methods: </strong>This study retrospectively analyzed the medical records of 119 patients with postburn HTS admitted to The First People's Hospital of Changzhou from March 2021 to October 2023. According to the treatment method, patients who received 1064 nm-Nd: YAG laser treatment were included in the YAG group, while patients who were treated by a combination of 1064 nm-Nd: YAG laser and AFCO2L comprised the combined group. Treatment effects, skin properties, and patients' satisfaction with aesthetics were compared between the two groups.</p><p><strong>Results: </strong>The total efficacy of the combination group was significantly higher than that of the YAG group (<i>P</i><0.05). After the treatment, skin elasticity, skin moisture, and pigmentation scores of the combined group were significantly higher than those of the YAG group (<i>P</i><0.05). The level of satisfaction with the aesthetics was significantly higher in patients who received the combined treatment than those treated with YAG alone (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>A combination of AFCO2L and 1064 nm-Nd: YAG laser in the treatment of HTS is associated with a more significant effect, more significant improvement of skin properties, less pigmentation, and overall increased patient satisfaction with the aesthetics compared to the treatment with 1064 nm-Nd: YAG laser alone.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"536-541"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}