老年营养风险指数能否预测老年人骨质疏松症的发生风险？系统回顾和荟萃分析。

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Pakistan Journal of Medical Sciences Pub Date : 2025-04-01 DOI:10.12669/pjms.41.4.11539

Wanghao Liu, Xiaoying Sun

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引用次数: 0

摘要

目的：老年人是营养不良和骨质疏松的高危人群。在这篇综述中，我们研究了老年营养风险指数（GNRI）是否可以预测老年人骨质疏松症的风险。方法：检索PubMed、Embase、ScienceDirect和Web of Science的电子数据库。检索包括从数据库建立到2023年12月29日的研究。所有检查GNRI与骨质疏松症之间关系的研究均被纳入。结果：入选7项研究。所有研究均采用横断面设计。所有7项研究的荟萃分析显示，低GNRI与老年患者骨质疏松症的风险显著相关（OR: 1.33 95% CI: 1.15, 1.53）。研究间异质性高，I2值为87%。敏感性分析结果无变化。基于研究地点、糖尿病的存在、样本量、GNRI截点、确定截点的方法和骨质疏松症诊断标准的亚组分析显示出不同的结果。结论：低GNRI可作为预测老年人骨质疏松症的简单指标。目前的证据来自少数具有高偏倚风险的研究。

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Can the geriatric nutritional risk index predict the risk of osteoporosis in the elderly? A systematic review and meta-analysis.

Objective: The elderly are at a high risk of malnutrition as well as osteoporosis. In this review, we examined if the geriatric nutritional risk index (GNRI) can predict the risk of osteoporosis in the elderly.

Methods: In this PRISMA compliant systematic review we searched the electronic databases of PubMed, Embase, ScienceDirect, and Web of Science. The search included studies from inception of databases to December 29, 2023. All studies examining the association between GNRI and osteoporosis were included.

Results: Seven studies were selected. All studies were cross-sectional in design. Meta-analysis of all seven studies showed that low GNRI was significantly associated with the risk of osteoporosis in elderly patients (OR: 1.33 95% CI: 1.15, 1.53). The interstudy heterogeneity was high as the I² value was 87%. Results did not change on sensitivity analysis. Subgroup analysis based on study location, presence of diabetes, sample size, GNRI cut-off, method to determine cut-off, and diagnostic criteria for osteoporosis showed mixed results.

Conclusion: Low GNRI can be a simple marker for predicting osteoporosis in the elderly. Current evidence is from a few studies with a high risk of bias.

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来源期刊

Pakistan Journal of Medical Sciences 医学-医学：内科

CiteScore

4.10

自引率

9.10%

发文量

363

审稿时长

3-6 weeks

期刊介绍： It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.