Pakistan Journal of Medical Sciences最新文献

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Correlation between neutrophil to lymphocyte ratio and C-reactive protein in diverse disease states in hospitalized patients. 住院病人不同疾病状态下中性粒细胞与淋巴细胞比率和 C 反应蛋白之间的相关性。
IF 1.2 4区 医学
Pakistan Journal of Medical Sciences Pub Date : 2024-10-01 DOI: 10.12669/pjms.40.9.8933
Ramsha Ghazal Arshad, Kaleem Ullah Toori
{"title":"Correlation between neutrophil to lymphocyte ratio and C-reactive protein in diverse disease states in hospitalized patients.","authors":"Ramsha Ghazal Arshad, Kaleem Ullah Toori","doi":"10.12669/pjms.40.9.8933","DOIUrl":"https://doi.org/10.12669/pjms.40.9.8933","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to find if any significant correlation exists between C-reactive protein and Neutrophil to Lymphocyte Ratio as an indirect measure of inflammation.</p><p><strong>Methods: </strong>We selected 983 patients with any inflammatory condition who presented to a tertiary care hospital and were admitted in medical wards or Intensive Care Units (ICUs) of KRL Hospital Islamabad from December 2021 to December 2022. The study was a cross sectional study and convenience sampling was done. The patients were categorized into five groups depending upon their pathophysiology. Kolmogorov Smirnov test was used to assess the normality of the data, and Spearman's coefficient was used to calculate the correlation between NLR and CRP.</p><p><strong>Results: </strong>A total of 983 patients were included. Mean CRP and NLR levels were 89.9±3.2 and 7.06±0.24, respectively. There was a significant positive correlation between CRP-NLR in the infectious, non-infectious non-inflammatory, and malignancy groups (0.420, 0.381, 0.642, <i>p</i> <0.01), and inflammatory group (0.322, <i>p</i> <0.05), and no correlation with chronic diseases.</p><p><strong>Conclusion: </strong>A significant correlation was shown to exist between CRP and NLR in patients with malignancies, non-infective non-inflammatory, inflammatory, and infective conditions and can therefore be used interchangeably to detect the presence of inflammation. Further exploration of these associations may contribute to a more nuanced understanding of the intricate relationships between different markers of inflammation and response to treatment.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of periodic nursing interventions on improving compliance behavior and health status in long-term Hemodialysis patients. 定期护理干预对改善长期血液透析患者遵医行为和健康状况的影响。
IF 1.2 4区 医学
Pakistan Journal of Medical Sciences Pub Date : 2024-10-01 DOI: 10.12669/pjms.40.9.9076
Yan Wang, Jiakang Sun, Fei Guo, Deheng Wan
{"title":"Effect of periodic nursing interventions on improving compliance behavior and health status in long-term Hemodialysis patients.","authors":"Yan Wang, Jiakang Sun, Fei Guo, Deheng Wan","doi":"10.12669/pjms.40.9.9076","DOIUrl":"https://doi.org/10.12669/pjms.40.9.9076","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of periodic nursing interventions on improving compliance behavior and health status in long-term hemodialysis patients.</p><p><strong>Method: </strong>This was retrospective study. A total of 88 patients on long-term hemodialysis admitted to Qinhuangdao Haigang Hospital from January 2022 to April 2023 were randomly divided into the control group and the intervention group, who received routine hemodialysis nursing and periodic nursing interventions, respectively. Afterward, compliance behavior and health status were compared between the two groups, along with a comprehensive assessment of the health status using renal function indexes, complication rates, and anxiety and depression scores.</p><p><strong>Result: </strong>Before nursing, no significant difference was observed in each index between the two groups (p > 0.05). After 16 months of nursing, the score of compliance behavior in the intervention group (88.68 ± 6.27) was significantly higher than that in the control group (70.91 ± 7.48) (p< 0.05), with the renal function indexes of BUN and SCr lower than those in the control group (p< 0.05). Meanwhile, the intervention group saw higher SAS and SDS scores than the control group (p< 0.05).</p><p><strong>Conclusion: </strong>Periodic nursing interventions may effectively improve the compliance behavior and health status of patients, enhance the efficacy of hemodialysis treatment, and improve the quality of life of patients.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficacy and safety of refined nursing combined with Zhao's Thunder-Fire Moxibustion in treating patients with gastric cancer of Spleen-Qi Deficiency Syndrome: A clinical study. 精制护理联合赵氏雷火灸治疗脾气虚证胃癌患者的疗效与安全性:临床研究。
IF 1.2 4区 医学
Pakistan Journal of Medical Sciences Pub Date : 2024-10-01 DOI: 10.12669/pjms.40.9.8462
Yuelu Yang, Yueling Yang
{"title":"Efficacy and safety of refined nursing combined with Zhao's Thunder-Fire Moxibustion in treating patients with gastric cancer of Spleen-Qi Deficiency Syndrome: A clinical study.","authors":"Yuelu Yang, Yueling Yang","doi":"10.12669/pjms.40.9.8462","DOIUrl":"https://doi.org/10.12669/pjms.40.9.8462","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the efficacy and safety of refined nursing combined with Zhao's thunder-fire moxibustion in treating patients with gastric cancer (GC) of spleen-Qi deficiency syndrome.</p><p><strong>Methods: </strong>This was a retrospective study. Ninety patients with GC of spleen-Qi deficiency syndrome admitted to Baoding Hospital of Traditional Chinese Medicine from February 2022 to March 2023 were randomly divided into the observation group and the control group. Patients in the control group were intervened with XELOX chemotherapeutic regimen + routine nursing. On this basis, patients in the observation group were additionally treated with refined nursing combined with Zhao's thunder-fire moxibustion. Changes in Traditional Chinese Medicine (TCM) syndrome scores, KPS scores for physical status, and quality of life (QOL) scores were observed and compared between the two groups before and after treatment.</p><p><strong>Results: </strong>After treatment, the scores of anorexia, fatigue and weakness, postprandial abdominal bloating, loose stools, mental fatigue and laziness to speak decreased significantly in the two groups (<i>P</i>< 0.05), and each TCM syndrome score in the observation group was significantly lower than that in the control group (<i>P</i>< 0.05). After treatment, KPS and QOL scores in the observation group were significantly higher than those in the control group (<i>P</i>< 0.05). The overall nursing satisfaction was 93.3% (42/45) in the observation group, which was significantly higher than 71.1% (32/45) in the control group (<i>P</i>< 0.05).</p><p><strong>Conclusion: </strong>Refined nursing combined with Zhao's thunder-fire moxibustion can alleviate the clinical symptoms of patients with GC of spleen-Qi deficiency syndrome, reduce chemotherapeutic-induced adverse reactions, with high clinical application value.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476129/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
LDH and NLR, as inflammatory markers, the independent risk factors for COVID-19 complicated with respiratory failure in elderly patients. LDH和NLR作为炎症标志物,是老年患者COVID-19并发呼吸衰竭的独立危险因素。
IF 1.2 4区 医学
Pakistan Journal of Medical Sciences Pub Date : 2024-10-01 DOI: 10.12669/pjms.40.9.8728
Shan Wang, Jia Liu, Song Hu, Yongjun Mao
{"title":"LDH and NLR, as inflammatory markers, the independent risk factors for COVID-19 complicated with respiratory failure in elderly patients.","authors":"Shan Wang, Jia Liu, Song Hu, Yongjun Mao","doi":"10.12669/pjms.40.9.8728","DOIUrl":"https://doi.org/10.12669/pjms.40.9.8728","url":null,"abstract":"<p><strong>Objective: </strong>Lactate dehydrogenase (LDH) is an enzyme that is responsible for the production of lactic acid, which is a necessary byproduct when the body does not have enough oxygen. LDH levels in the blood can be used as a marker to predict mortality in patients with ARDS, severe COVID-19, and cancer. To analyze the clinical characteristics of COVID-19 in the elderly and the correlation between LDH and respiratory failure in COVID-19 patients, to improve the identification and management of this type of pneumonia by clinicians.</p><p><strong>Methods: </strong>This was a single-center retrospective study. We performed routine laboratory tests in 105 COVID-19 patients admitted to the affiliated hospital of Qingdao University (Qingdao, China) from October 1, 2022 to February 1, 2023. The diagnosis of respiratory failure was established based on the results of blood gas analysis upon admission.</p><p><strong>Results: </strong>The median age was 79 years. Among all univariable parameters, LDH, neutrophil to lymphocyte ratio (NLR) and Prothrombin Time (PT) were significantly independent risk factors of RF in elderly COVID-19 patients. LDH (AUC=0.829) also had a maximum specificity (96.5%), with the cutoff value of 280.5.</p><p><strong>Conclusion: </strong>The levels of LDH, NLR, and PT may serve as potential indicators for elderly COVID-19 patients combined with respiratory failure. LDH, NLR and PT assays can be beneficial for patients who need closer respiratory monitoring and more aggressive supportive care to prevent a negative prognosis.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prevalence of compassion fatigue among post-graduate trainees in Pakistan: A cross-sectional study. 巴基斯坦研究生学员中同情疲劳的普遍程度:一项横断面研究。
IF 1.2 4区 医学
Pakistan Journal of Medical Sciences Pub Date : 2024-10-01 DOI: 10.12669/pjms.40.9.9265
Saima Norin, Usman Mahboob, Naheed Mahsood, Sohail Raziq
{"title":"Prevalence of compassion fatigue among post-graduate trainees in Pakistan: A cross-sectional study.","authors":"Saima Norin, Usman Mahboob, Naheed Mahsood, Sohail Raziq","doi":"10.12669/pjms.40.9.9265","DOIUrl":"https://doi.org/10.12669/pjms.40.9.9265","url":null,"abstract":"<p><strong>Objective: </strong>To determine the prevalence of compassion fatigue, compassion satisfaction and burnout and identify the socio-demographic and work-related factors associated with compassion fatigue among FCPS Part-II trainees in Pakistan.</p><p><strong>Method: </strong>A cross-sectional study of FCPS-II trainees was conducted using stratified sampling at multiple centers over six months. Data was collected through an online, self-administered survey, which consisted of the 30-item ProQOL-V and a socio-demographic and work-related characteristics questionnaire. Informed consent was obtained from all participants. Data was analysed using SPSS 26 for descriptive stats, one-sample t-test, Pearson correlation, and multivariate linear regression at a 95% significance level.</p><p><strong>Results: </strong>Out of 460, only 392 trainees completely filled the online survey (completion rate: 90.74%). The study found that 78.80% of postgraduate trainees experienced moderate levels of compassion fatigue (CF) (Mean = 27.6, SD = 6.3), with moderate burnout (BO) (75.50%, Mean = 26.6, SD = 5.9), while moderately high Compassion satisfaction (CS) (90.60%, Mean = 33.3, SD = 5.5). Compared to normative data, compassion fatigue levels were significantly elevated among post-graduate trainees (p < 0.001). Significant correlations were observed between CF and BO (r =0.59), CF and CS (r = -0.20), and BO and CS (r = -0.63). Factors associated with higher CF included family dependents (p = 0.029), longer working hours (p < 0.001), and inadequate sleep (p < 0.001). Trainees in \"Poor\" work environments reported higher CF levels than those in \"Excellent\" environments (p < 0.001). Additionally, engaging in self-care activities such as exercise, prayer, and socialising were associated with lower CF levels (p < 0.05).</p><p><strong>Conclusion: </strong>The study revealed that many postgraduate trainees experience moderate compassion fatigue and burnout, with a strong positive correlation between CF and BO. Compassion satisfaction inversely related to both CF and BO, highlighting the need to boost CS. Factors like longer work hours, poor sleep, family dependents and unfavorable work conditions were linked to higher Compassion Fatigue. Conversely, engaging in self-care practices like prayer, meditation, exercise, and socialising is associated with decreased compassion fatigue levels. These results stress the importance of tailored interventions to enhance trainees' well-being and ultimately improve patient care quality.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476145/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early oral colonization of streptococcus mutans and lactobacilli species in infants: Investigating the relationship with maternal and environmental factors, from birth through the sixth month. 婴儿变异链球菌和乳酸杆菌的早期口腔定植:调查婴儿从出生到 6 个月期间与母体和环境因素的关系。
IF 1.2 4区 医学
Pakistan Journal of Medical Sciences Pub Date : 2024-10-01 DOI: 10.12669/pjms.40.9.9602
Cansu Ay, Huseyin Karayılmaz, Ayse Cengiz
{"title":"Early oral colonization of streptococcus mutans and lactobacilli species in infants: Investigating the relationship with maternal and environmental factors, from birth through the sixth month.","authors":"Cansu Ay, Huseyin Karayılmaz, Ayse Cengiz","doi":"10.12669/pjms.40.9.9602","DOIUrl":"https://doi.org/10.12669/pjms.40.9.9602","url":null,"abstract":"<p><strong>Objective: </strong>To assess the presence of <i>Streptococcus Mutans</i> (<i>S.mutans</i>) and <i>Lactobacillus</i> species (<i>LB</i>) of newborn-mother pairs using the real time polymerase chain reaction (qRT-PCR).</p><p><strong>Method: </strong>Subjects were selected from the patients followed in the Neonatology Clinic of Akdeniz University's Faculty of Medicine between the years 2017-2018. First samples collected within 48 hours after birth, and second samples were at six months. The samples were analyzed for the presence of <i>S.mutans</i> and <i>LB</i> using qRT-PCR. Mothers' smoking habits, education level, occupation, oral hygiene habits, DMFT scores and dietary history; Babies' delivery type, birth weight, feeding type, oral hygiene practices, feeding habits, bottle usage, pacifier usage, consumption of sugary foods, were also recorded. The effect of factors related to both mothers and infants was examined comparatively.</p><p><strong>Results: </strong><i>S.mutans</i> DNA was detectable in 87% and <i>LB</i> DNA was detected in 37% mothers, while it was undetected in 63% mothers at the first sampling. <i>S.mutans</i> was detected in 37% and, while <i>LB</i> was detected in 5% of the newborns in the first 48 hours of their life. At the second sampling, the <i>S.mutans</i> and <i>LB</i> levels in infants have increased, while there has been no significant change in mothers. A significant relationship was found only between the increase in <i>S.mutans</i> in infants and the presence of erupted teeth.</p><p><strong>Conclusion: </strong><i>S.mutans</i> and <i>LB</i> were able to colonize on the oral mucosal surfaces of edentulous newborns, with the counts of both bacteria increasing significantly with tooth eruption.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142485792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of clinical application effects of Esketamine combining Sufentanil in labor analgesia and their impacts on postpartum depression. 艾司他敏联合舒芬太尼在分娩镇痛中的临床应用效果及其对产后抑郁的影响分析。
IF 1.2 4区 医学
Pakistan Journal of Medical Sciences Pub Date : 2024-10-01 DOI: 10.12669/pjms.40.9.8689
Haoyu Jiang, Shoubo Quan, Yahai Su, Jingyi Li, Xuefeng Zhang
{"title":"Analysis of clinical application effects of Esketamine combining Sufentanil in labor analgesia and their impacts on postpartum depression.","authors":"Haoyu Jiang, Shoubo Quan, Yahai Su, Jingyi Li, Xuefeng Zhang","doi":"10.12669/pjms.40.9.8689","DOIUrl":"https://doi.org/10.12669/pjms.40.9.8689","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical effects of Esketamine combining Sufentanil in labor analgesia and their impacts on postpartum depression.</p><p><strong>Methods: </strong>This was a retrospective study. One hundred and fifty primiparae with spontaneous labor were selected at SSL Central Hospital of Dongguan City from July 10, 2021 to May 10, 2022 as the research objects and randomly divided into two groups (each n=75). While the control group underwent epidural infusion of Sufentanil for analgesia, the study group was administered Esketamine combining Sufentanil. Compared analgesic effects, time of birth course, adverse reactions, pain intensity, scores assigned to depression and anxiety before analgesia and after delivery were made for pregnant women in both groups.</p><p><strong>Results: </strong>The response rates of the study and control groups reached 100% and 93%, respectively, with statistically significant differences (p=0.02). The time of the first, second, and third stages of labor in the study group were all significantly lower than that of the control group; showing statistical significance (p=0.00). Regarding adverse reactions showed no statistically significant differences (p=0.44). Moreover, the study group showed noticeably lower pain intensity than those of the control group during delivery, 20 minutes and one hour after delivery; and their differences were statistically significant (p=0.00). After delivery, both the SAS and SDS of the study group were respectively lower than those of the control group, with statistically significant differences as well (p=0.00).</p><p><strong>Conclusions: </strong>Applying Esketamine combining Sufentanil in epidural painless delivery produces rather favorable analgesic effects, shortens the time of the birth process, and improves postpartum anxiety and depression without leading to more adverse reactions.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Management of early recurrence following successful endoscopic detorsion in sigmoid volvulus. 成功进行乙状结肠腹腔镜分离术后早期复发的处理方法。
IF 1.2 4区 医学
Pakistan Journal of Medical Sciences Pub Date : 2024-10-01 DOI: 10.12669/pjms.40.9.10078
Nurhak Aksungur, Esra Disci, Rifat Peksoz, Sabri Selcuk Atamanalp
{"title":"Management of early recurrence following successful endoscopic detorsion in sigmoid volvulus.","authors":"Nurhak Aksungur, Esra Disci, Rifat Peksoz, Sabri Selcuk Atamanalp","doi":"10.12669/pjms.40.9.10078","DOIUrl":"https://doi.org/10.12669/pjms.40.9.10078","url":null,"abstract":"<p><strong>Objectives: </strong>Following endoscopic detorsion, sigmoid volvulus (SV) recurs in 3%-86% of patients, approximately 13% of which are early recurrence presenting during the first admission period. Although semielective surgery is the traditional approach, elective surgery following repetitive endoscopy or percutaneous endoscopic sigmoidopexy (PES) are other alternatives in the management of early SV recurrence. Our aim was to discuss the role of semielective surgery in above-mentioned rare clinical entity.</p><p><strong>Methods: </strong>Among our 1,076-case series, we retrospectively evaluated the records of 612 patients (56.9%) treated between June 1966 and June 1986, while we prospectively utilized the data of 464 patients (43.1%) managed between June 1986 and January 2024. We recorded the treatment option and prognosis for each patient.</p><p><strong>Results: </strong>Early SV recurrence was determined in 34 (5.5%) of the 621 patients with successful nonoperative detorsion. We treated all of these patients by semielective surgery. The surgical procedures were detorsion in one patient (2.9%), mesopexy in 11 (32.4%), sigmoidectomy with primary anastomosis in 17 (50.0%), and sigmoidectomy with stoma in five (14.7%). In this series, mortality and morbidity rates were 2.9% (one patient) and 14.7% (five patients), respectively.</p><p><strong>Conclusion: </strong>Semielective surgery is the traditional approach tried by most surgeons, which allows for the recovery of the general status of the patients, bowel preparation, and antibiotic prophylaxis. However, repetitive endoscopy followed by elective surgery or PES are current alternatives for some selected patients. Unfortunately, the relatively low effectuation rate of elective surgery following successful repetitive endoscopic detorsion and recurrence-related poor prognosis are still important handicaps of the latter procedure.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical effects of IPCH after the surgery for ovarian cancer at the middle or advanced stage and its impacts on tumor markers and immune functions. 中晚期卵巢癌术后 IPCH 的临床效果及其对肿瘤标志物和免疫功能的影响。
IF 1.2 4区 医学
Pakistan Journal of Medical Sciences Pub Date : 2024-10-01 DOI: 10.12669/pjms.40.9.8720
Heyue Li, Yan Zhang, Hong Tang, Linxia Li
{"title":"Clinical effects of IPCH after the surgery for ovarian cancer at the middle or advanced stage and its impacts on tumor markers and immune functions.","authors":"Heyue Li, Yan Zhang, Hong Tang, Linxia Li","doi":"10.12669/pjms.40.9.8720","DOIUrl":"https://doi.org/10.12669/pjms.40.9.8720","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical effects of intraperitoneal chemohyperthermia (IPCH) in the treatment of postoperative patients with advanced stage ovarian cancer, and its impacts on tumor markers and immune functions.</p><p><strong>Methods: </strong>This is a retrospective study. One hundred and twenty patients with advanced stage ovarian cancer received in Shanghai 7th People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from May 10, 2022 to June 10, 2023 were selected and randomly divided into control and study groups (n=60 each group). Patients in the control group were administered routine intravenous chemotherapy, the study group underwent IPCH besides routine intravenous chemotherapy based on the control group. Comparatively analyzed the clinical effects, adverse reaction occurrence rates, and variations in relevant observation targets, the tumor marker after and before the treatment.</p><p><strong>Results: </strong>Total efficacy in the study and control groups are proved to be with statistically significant differences. The occurrence of adverse reactions proved that no significant differences is seen between both groups. After the treatment, CEA, CA19-9, and CA125 levels in patients of the study group are apparently lower than those in the control group, showing statistically significant differences; expression levels of CD3<sup>+</sup>, CD4<sup>+</sup> and CD4<sup>+</sup>/CD8<sup>+</sup>, in the study group were enormously above those in the control group after the treatment, with statistically significant differences.</p><p><strong>Conclusions: </strong>IPCH has the potential to effectively enhance comprehensively clinical therapeutic effects among postoperative patients with ovarian cancer, significantly improve patients' immune states, and evidently reduce expression levels of various tumor markers.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11476136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142472257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of nurse informaticists in the implementation of Electronic Health Records (EHRs) at resource-limited settings. 护士信息学家在资源有限的环境中实施电子健康记录(EHR)中的作用。
IF 1.2 4区 医学
Pakistan Journal of Medical Sciences Pub Date : 2024-10-01 DOI: 10.12669/pjms.40.9.9686
Kiran Bano Asif, Haroon Khan
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