Pakistan Journal of Medical Sciences最新文献

{"title":"Efficacy of the <i>Fuzheng Jiedu Huayu</i> decoction plus antibiotics in the management of drug-resistant bacterial pneumonia in elderly patients.","authors":"Yan Liu, Beibei Wang","doi":"10.12669/pjms.42.8.13678","DOIUrl":"10.12669/pjms.42.8.13678","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy and safety of the <i>Fuzheng Jiedu Huayu</i> decoction combined with antibiotics in elderly patients with drug-resistant bacterial pneumonia.</p><p><strong>Method: </strong>A retrospective analysis was conducted on 166 elderly patients with drug-resistant bacterial pneumonia who were admitted to Beijing Hospital of Integrated Traditional Chinese and Western Medicine between January 2022 and June 2025. Patients were assigned to either the control group(<i>n=</i> 83, treated with antibiotics alone) or the observation group(<i>n=</i> 83, treated with antibiotics plus <i>Fuzheng Jiedu Huayu</i> decoction). After 14 days of treatment, the two groups were compared in terms of traditional Chinese medicine(TCM) syndrome scores, serum inflammatory markers chest computed tomography (CT) absorption rate of pulmonary infiltrates, sputum pathogen clearance rate, overall clinical response rate (ORR), and adverse events.</p><p><strong>Results: </strong>After treatment, both groups showed significant reductions in cough, productive cough, dyspnea/wheezing, and fever scores, with the observation group demonstrating significantly lower TCM syndrome scores compared with the control group(<i>P<</i> 0.05, respectively).The observation group achieved significantly higher rates of chest CT absorption of inflammatory infiltrates (81.93% <i>vs</i>. 68.67%), ORR (84.34% <i>vs</i>. 71.08%), and sputum pathogen clearance (81.93% <i>vs</i>. 67.47%) compared with the control group(<i>P<</i> 0.05, respectively). The incidence of adverse events did not differ significantly between groups(<i>P></i> 0.05).</p><p><strong>Conclusion: </strong>The combination of the <i>Fuzheng Jiedu Huayu</i> decoction with antibiotics may significantly improve clinical symptoms, suppress inflammatory responses, enhance oxygenation, promote resolution of pulmonary inflammation, and increase pathogen clearance and clinical efficacy in elderly patients with drug-resistant bacterial pneumonia.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"2116-2122"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525532/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foley Catheter and Islamic Rulings on Purification: A Clinical-Fiqh Review and Patient-Community Survey.","authors":"Wajeed Gul Bangash, Muhammad Ghayas, Ubaid Ullah Sindhi, Abdul Razaq Khan","doi":"10.12669/pjms.42.8.15640","DOIUrl":"https://doi.org/10.12669/pjms.42.8.15640","url":null,"abstract":"<p><strong>Background & objective: </strong>Foley and suprapubic catheters are commonly used for postoperative urinary drainage and intake-output monitoring. For practicing Muslims, continuous urinary drainage raises important concerns regarding ritual purification (wuḍū), prayer validity, and recitation of the Qur'an. Our objective was to review Islamic jurisprudential (fiqh) rulings related to catheterized patients and to assess awareness, concerns, and acceptance of these rulings among patients and the wider community, with the aim of providing practical clinical guidance.</p><p><strong>Methodology: </strong>This hospital based mixed-method study comprised: (1) a clinical-fiqh review of classical and contemporary Islamic rulings regarding purification in patients with continuous urinary drainage, and (2) a structured questionnaire-based survey conducted among catheterized patients and community participants. The study was conducted jointly at the Department of Urology, Pakistan Railways General Hospital, Rawalpindi, and the Department of Islamic Studies, Riphah International University, Islamabad, from January to June 2024. A bilingual (English-Urdu) questionnaire was administered before and after counseling. This assessment was designed to evaluate the clinical impact of a structured, faith-sensitive counseling intervention delivered as part of routine patient care, rather than to conduct a standalone knowledge, attitude, or practice survey.</p><p><strong>Results: </strong>A total of 500 participants were enrolled, including 250 catheterized patients and 250 community members. Baseline awareness of Islamic rulings related to catheterization was 22%, which increased to 91% following counseling (p < 0.001). Most participants reported fear of missing prayers or reciting the Qur'an incorrectly. Jurisprudential review demonstrated consensus that catheterized patients are classified as <i>ma'dhūr</i> (legally excused) and may perform prayer according to prescribed concessions.</p><p><strong>Conclusion: </strong>Catheterized Muslim patients should be counseled in accordance with established Islamic rulings on purification to prevent unnecessary spiritual distress. Integrating clinical care with fiqh-based guidance supports holistic patient well-being without compromising medical management.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"1949-1953"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525539/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of a non-contrast CT-based radiomics model in patients with Type-B aortic dissection after thoracic endovascular aortic repair.","authors":"Jiajun Zou, Xinyi Shi, Jianqi Ni, Qin Jin, Haofeng Ding, Yifeng Shen","doi":"10.12669/pjms.42.8.16527","DOIUrl":"10.12669/pjms.42.8.16527","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the value of a non-contrast computed tomography (CT)-based radiomics model in predicting adverse prognosis in patients with type B aortic dissection (TBAD) after thoracic endovascular aortic repair (TEVAR).</p><p><strong>Methodology: </strong>A retrospective analysis included data from 107 patients with TBAD undergoing TEVAR at the First Hospital of Jiaxing from January 2010 to May 2024. Patients were randomly divided into a training (n=86) and a validation cohort (n=21) at an 8:2 ratio. Radiomic features were extracted from non-contrast CT images to build a radiomic model. Univariate and multivariate logistic regression analyses identified independent clinical risk factors for constructing a clinical model. Lasso regression was used for data dimensionality reduction and model building. A clinical-radiomic model was established by integrating clinical risk factors with radiomic features. The discriminative ability, calibration, and clinical utility of the three models were evaluated using ROC curves (specificity and sensitivity), calibration curves, and clinical decision curve analysis (DCA), respectively.</p><p><strong>Results: </strong>Ten radiomic features were selected in the training cohort. Clinical, radiomic, and clinical-radiomic models were generated using eight machine learning algorithms and exhibited good predictive performance. The clinical-radiomic model had the highest AUC values (0.943 in the training cohort, 0.875 in the validation cohort) compared to the clinical and radiomic models. Calibration curves and the Hosmer-Lemeshow test confirmed good calibration of all three models in both sets. DCA revealed that the nomogram model provided favorable clinical net benefits within a certain threshold range.</p><p><strong>Conclusions: </strong>A non-contrast CT-based radiomics machine learning model has high value for predicting adverse prognosis after TEVAR.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"1954-1967"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The High Cost of Misdiagnosis: The Challenges of Differentiating Grade-4 Astrocytoma from Glioblastoma in Resource-Constrained Countries.","authors":"Hasan Saeed, Haseeb Mehmood Qadri","doi":"10.12669/pjms.42.8.16057","DOIUrl":"10.12669/pjms.42.8.16057","url":null,"abstract":"","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"2195-2196"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525517/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Striving or surviving? Influence of bullying on psychological well-being and coping approaches among undergraduate dental students.","authors":"Preh Ayub, Junaid Sarfraz, Saleem Raza, Yousif Ali Shah","doi":"10.12669/pjms.42.8.15956","DOIUrl":"10.12669/pjms.42.8.15956","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the frequency of bullying and its association with depression, anxiety, stress, and coping strategies among undergraduate dental students.</p><p><strong>Methodology: </strong>A cross-sectional study was conducted among 124 dental undergraduates at Bibi Aseefa Dental College, Larkana, Pakistan (August 2025-January 2026). Bullying exposure was assessed using an adapted 15-item Negative Acts Questionnaire-Revised (NAQ-R), while psychological distress was measured using the 21 items Depression, Anxiety, and Stress Scale (DASS-21), Coping strategies were evaluated using the 24 items Brief-COPE inventory and were categorized as adaptive and maladaptive. Data were analyzed using descriptive statistics, Chi-square tests, and Spearman's correlation, with a p-value < 0.05 considered statistically significant.</p><p><strong>Results: </strong>Most students reported high bullying exposure (74.2%). Moderate to extremely severe depression was observed in 50.8%, severe to extremely severe anxiety in 54.0%, and moderate to severe stress in 29.9% of participants. Bullying exposure was significantly associated with depression (χ² = 18.2, p = 0.020), stress (χ² = 16.6, p = 0.035), and anxiety (χ² = 29.2, p < 0.001). Spearman's correlation revealed that bullying was positively correlated with anxiety (ρ = 0.427, p < 0.001) and maladaptive coping (ρ = 0.403, p < 0.001), while maladaptive coping strongly correlated with anxiety (ρ = 0.648, p < 0.001). Adaptive coping showed weaker positive correlations with anxiety, suggesting increased coping efforts in response to distress. Multivariable analysis identified high bullying exposure (OR ≈6.0, p<0.001) and maladaptive coping (OR ≈ 1.18, p<0.001) as significant independent predictors of moderate to severe anxiety.</p><p><strong>Conclusion: </strong>Bullying is highly prevalent among dental students and strongly associated with anxiety, depression, and maladaptive coping. Targeted interventions, including bullying prevention, mental health support, and resilience training, are essential to safeguard student well-being.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"2045-2051"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525524/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scar tenderness as a sensitive marker for uterine scar dehiscence or uterine rupture.","authors":"Maria, Erum Majid, Tanzila Fahim, Bader Faiyaz Zuberi, Saima Mujtaba","doi":"10.12669/pjms.42.8.7502","DOIUrl":"10.12669/pjms.42.8.7502","url":null,"abstract":"<p><strong>Objective: </strong>To determine the sensitivity, specificity, and diagnostic accuracy of caesarean scar tenderness in predicting uterine dehiscence or rupture during per-operative findings.</p><p><strong>Methodology: </strong>This cross-sectional study was conducted in the Department of Obstetrics & Gynaecology, JPMC, Karachi, from November 2021 to July 2024. Women with singleton pregnancies having previous caesarean were given Trial of Labor After Caesarean (TOLAC) after informed consent using consecutive sampling. Exclusion criteria included uterine abnormalities, hypertension, diabetes mellitus, multiple pregnancies, and pre-eclampsia. Data were collected on demographic details, clinical findings, and operative outcomes. Statistical analysis was performed using SPSS Version 27.</p><p><strong>Results: </strong>A total of 385 women were included in the study. Scar tenderness was present in 67.8% of women. Uterine rupture was found in 22.3% of cases, while scar dehiscence was present in 49.9%. The sensitivity of scar tenderness in predicting uterine rupture and dehiscence was 85.6%, and the specificity was 78.5%. The positive predictive value (PPV) was 91.2%, and the negative predictive value (NPV) was 67.7%. The overall diagnostic accuracy was 83.6%.</p><p><strong>Conclusions: </strong>Scar tenderness is a useful clinical predictor of uterine scar complications during TOLAC, particularly in low-resource settings.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"1980-1986"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525533/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sepiolite and Zirconia Nanoparticles Doped with Erythrosine: Adhesive Bond Strength and Antimicrobial Performance in Primary Carious Dentin.","authors":"Abeer Ali Alshami, Hiba F Kattan","doi":"10.12669/pjms.42.8.16412","DOIUrl":"10.12669/pjms.42.8.16412","url":null,"abstract":"<p><strong>Objective: </strong>Antimicrobial effectiveness against Lactobacillus and micro tensile bond strength (μTBS) of etch and rinse adhesive (ERA) modified using Erythrosine (Ery), Ery-doped Zirconium oxide nanoparticles (ZrO₂NPs), and Ery-doped Sepiolite Nanoparticles (SepNPs) bonded to caries-affected dentin (CAD) in primary dentition.</p><p><strong>Methodology: </strong>The present in vitro study was approved by the Institutional Review Board and Ethical Committee of Princess Nourah Binte Abdul Rahman University, IRB# 25-0063. The study duration was two months, November 20, 2025 - January 20, 2026. Primary CAD was removed. All the specimens were divided into four groups based on the application of ERA modification. Group-1 (Conventional ERA), Group-2 (Ery-modified ERA), Group-3 (Ery-doped ZrO₂NPs modified ERA), and Group-4 (Ery-doped SepNPs modified ERA). Composite build-up was performed on all the specimens after adhesive application, and the specimens were exposed to μTBS testing and fracture analysis. All adhesives (modified and unmodified) were further tested for antimicrobial efficiency against Lactobacillus. The statistical analysis was conducted using a one-way analysis of variance (ANOVA) and a Tukey post hoc test.</p><p><strong>Results: </strong>Group-4 (Ery-doped SepNPs-ERA) treated samples displayed the minimum survival of microorganisms (0.30 ± 0.04 CFU/mL) and the highest bond integrity (15.02±0.61MPa). However, Group-1 (Unmodified ERA) exhibited the highest bacterial survival count (0.65 ± 0.11 CFU/mL) and the lowest μTBS (10.95 ± 0.55 MPa).</p><p><strong>Conclusion: </strong>Ery-doped ZrO₂NPs and Ery-doped SepNPs modified adhesive presented satisfactory antimicrobial activity against Lactobacillus and μTBS as compared to the unmodified adhesive when bonded to primary dentin.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"2059-2065"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The link between low maternal cholesterol levels and increased risk of fetal patent ductus arteriosus and septal defects: Large-scale cohort retrospective study.","authors":"Zhaodong Liu, Shuhua Lai, Guangcheng Xing, Caihong Jiang, Yulong Zhang, Jianying Yan","doi":"10.12669/pjms.42.8.19548","DOIUrl":"10.12669/pjms.42.8.19548","url":null,"abstract":"<p><strong>Objective: </strong>To investigate whether low maternal cholesterol levels during pregnancy are associated with an increased risk of neonatal Patent Ductus Arteriosus (PDA) and Atrial or Ventricular Septal Defect (ASD/VSD).</p><p><strong>Methodology: </strong>Medical records of 36,633 pregnant women who received care and delivered at Fujian Maternity and Child Health Hospital, China, from 2016 to 2020 were retrospectively analyzed. Maternal serum lipid levels were measured one week before delivery, and Congenital heart disease (CHD) was diagnosed by echocardiography within three days of birth. Logistic regression models were adjusted for neonatal sex, maternal age, gestational diabetes and hypertension, gravidity, parity, and preterm birth.</p><p><strong>Results: </strong>Among 36,633 mother-child pairs, 906 (2.5%) cases of CHD were identified. Lower maternal TC, LDL-C, and HDL-C levels were significantly associated with increased CHD risk. Each 1 mmol/L increase in TC was associated with an 11% decrease in CHD risk (OR: 0.89, 95% CI 0.85, 0.95). LDL-C showed a similar protective effect (OR: 0.88, 95% CI 0.82, 0.95), while HDL-C demonstrated the strongest association (OR: 0.61, 95% CI 0.51, 0.73). The relationship between TG and CHD risk was not significant after adjustment (OR: 0.97, 95% CI 0.92, 1.02; p=0.224). For PDA specifically, TC, LDL-C, and HDL-C remained significantly protective; for ASD/VSD, only TC demonstrated significance (OR: 0.91, 95% CI 0.83, 0.99). TG showed no significant association with any CHD subtype.</p><p><strong>Conclusion: </strong>This study indicates that lower maternal levels of TC, LDL-C, and HDL-C may be significantly associated with an increased risk of PDA, while lower TC levels could be associated with ASD/VSD risk. The relationship between maternal TG levels and CHD could not be demonstrated. Future prospective multicenter and intervention studies are needed to validate the results.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"2032-2037"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidrug resistant bacterial infection in liver transplant recipients: A Deterrent and obstacle.","authors":"Nazish Misbah, Jahanzaib Haider, Muhammad Hassan, Mehreen Fatima","doi":"10.12669/pjms.42.8.15347","DOIUrl":"10.12669/pjms.42.8.15347","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the microbiological spectrum of multi-drug resistant (MDR) bacterial infections within the first 30 days post-living donor liver transplantation (LDLT) and identify the associated risk factors contributing to their emergence.</p><p><strong>Methodology: </strong>This retrospective cohort study reviewed the medical records of patients who underwent LDLT from January 2020 to December 2024 at the Liver Transplant and Hepatopancreatobiliary Surgery Unit of Dow University Hospital, Karachi. Patients were categorized into MDR and no-MDR groups based on culture-confirmed MDR bacterial infection with clinical features of sepsis. Types of MDR bacterial infections were noted. Baseline, pre-transplant, intraoperative, and post-transplant variables were recorded. Pearson Chi-square test, Mann-Whitney U test, and univariate and multivariate logistic regression analyses were performed for statistical inference.</p><p><strong>Results: </strong>Of 151 LDLT recipients, 75 (49.7%) developed MDR bacterial infections within 30 days. Among these, gram negative MDR organisms were predominated, with carbapenem-resistant Enterobacteriaceae (21.2%) and carbapenem-resistant <i>Acinetobacter baumannii</i> (20.5%) most frequent, followed by vancomycin-resistant <i>Enterococci</i> (13.2%). On univariate analysis, MDR infection was associated with pre-transplant ICU admission, renal dysfunction, prolonged postoperative ICU stay, mechanical ventilation >48 h, hemodialysis and/or sustained low-efficiency dialysis (SLED), postoperative complications, longer invasive device duration, prolonged hospital stay, central line-associated blood stream infection (CLABSI), and intra-abdominal infections. On multivariate analysis, only CLABSI [Wald χ²=17.696 (OR 0.021; 95% CI: 0.003-0.127; p<0.001)] and intra-abdominal infections [Wald χ²=25.567 (OR 0.008; 95% CI: 0.001-0.050; p<0.001)] remained independently associated with MDR infection.</p><p><strong>Conclusion: </strong>Nearly half of LDLT recipients developed MDR infections, predominantly due to gram-negative organisms. CLABSI and intra-abdominal infections emerged as the key predictors of MDR bacterial infections.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"2078-2087"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interaction of intestinal microbiota and diabetes mellitus: A database-based quantitative analysis and visualization.","authors":"Qian Wang, Liwen Zhan, Ying Wen, Chenyang Wang","doi":"10.12669/pjms.42.8.13682","DOIUrl":"10.12669/pjms.42.8.13682","url":null,"abstract":"<p><strong>Objective: </strong>To comprehensively characterize the composition and structure of intestinal microbiota in Type-II diabetes mellitus (T2DM) patients and identify microbial taxa associated with metabolic parameters, particularly body mass index (BMI), using integrated multi-database analysis and quantitative visualization approaches.</p><p><strong>Methodology: </strong>This retrospective study was conducted at The Hospital of the 82nd Group Army of the PLA from 2024 to 2025, using data from public repositories. Using multi omics sample analysis methods, quantitative analysis and visualization of the interactions between gut microbiota and diabetes mellitus were discovered and explained. The original data was obtained from the NCBI and GMrepo databases. The abundance of gut microbiota was analyzed and visualized in diabetic patients of various BMI indexes, sexes, and ages.</p><p><strong>Results: </strong>A comprehensive analysis of 2,457 bacterial species and 550 genera revealed Bacteroides as the most abundant genus (11.29%), followed by <i>Faecalibacterium</i> (4.70%). Bacteroides, particularly <i>B. fragilis</i>, correlated with BMI and was consistently abundant across ages. In diabetic patients, females exhibited higher microbial abundance than males, with Bacteroides representing 20.95% and 18.49%, respectively.</p><p><strong>Conclusion: </strong>This study offers a comprehensive view of the interplay between intestinal microbiota and diabetes mellitus in patients.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"2052-2058"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}