HBV感染与妊娠：妊娠期糖尿病和早产风险增加。

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Pakistan Journal of Medical Sciences Pub Date : 2025-04-01 DOI:10.12669/pjms.41.4.9578

Xiumei Cai, Suiping Huang, Zuliang Ma

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引用次数: 0

摘要

目的：探讨乙型肝炎病毒（HBV）感染状况对妊娠结局的影响。方法：于2020年1月1日至2022年12月31日在南方医科大学顺德医院（顺德第一人民医院）进行回顾性研究。该研究纳入13980名孕妇，其中hbsag阳性组（研究组）1059名，hbsag阴性组（对照组）12921名。将对照组和研究组的妊娠结局进行比较。结果：HBsAg阳性孕妇妊娠期糖尿病发生率较高(P=0.019；或者,1.20;95% CI, 1.03-1.40)，妊娠期肝内胆汁淤积(P=0.019；或者,1.85;95% CI, 1.11-3.09)和34周前早产(P=0.013；或者,1.96;95% ci, 1.15-3.34)。HBV感染状况与妊娠期糖尿病、妊娠肝内胆汁淤积及34周前早产有显著关系。结论：HBsAg检测阳性的孕妇发生妊娠期糖尿病、妊娠期肝内胆汁淤积和34周前早产的可能性更高。乙肝病毒感染对妊娠结局的影响需要进一步澄清。

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HBV infection and pregnancy: Increased risks of gestational diabetes and preterm birth.

Objective: To investigate the effects of Hepatitis B virus (HBV) infection status on the outcomes of pregnancy.

Methods: A retrospective study was conducted at Shunde Hospital of Southern Medical University (The First People's Hospital of Shunde) from 1^st January 2020 to 31^st December2022.The study included 13,980 pregnant women, with 1,059 in the HBsAg-positive group (study group) and 12,921 in the HBsAg-negative group (control group). Pregnancy outcomes were compared between the control and study groups.

Results: Pregnant women who tested positive for HBsAg had higher rates of gestational diabetes mellitus (P=0.019; OR, 1.20; 95% CI, 1.03-1.40), intrahepatic cholestasis of pregnancy (P=0.019; OR, 1.85; 95% CI, 1.11-3.09) and preterm birth before 34 weeks (P=0.013; OR, 1.96; 95% CI, 1.15-3.34). The relationship between HBV infection status with gestational diabetes mellitus, intrahepatic cholestasis of pregnancy and preterm birth before 34 weeks was significant.

Conclusions: Pregnant women who tested positive for HBsAg faced a higher likelihood of developing gestational diabetes mellitus, intrahepatic cholestasis of pregnancy, and giving birth prematurely before 34 weeks. Further clarification is required regarding the influence of HBV infection on the outcomes of pregnancy.

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来源期刊

Pakistan Journal of Medical Sciences 医学-医学：内科

CiteScore

4.10

自引率

9.10%

发文量

363

审稿时长

3-6 weeks

期刊介绍： It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.