Geriatric nutritional risk index as a predictor of prognosis in hepatocellular carcinoma: A systematic review and meta-analysis.

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Pakistan Journal of Medical Sciences Pub Date : 2025-04-01 DOI:10.12669/pjms.41.4.11962

Linfu Fang, Ziwei Chen

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引用次数: 0

Abstract

Objective: The geriatric nutritional risk index (GNRI) has found utility as a predictor of outcomes in several malignancies. However, does it predicts outcomes in hepatocellular cancer (HCC) is unclear. In this review, we present high-quality evidence on the prognostic ability of GNRI for HCC.

Methods: Two reviewers screened the websites of Embase, PubMed, Web of Science, and Scopus up to 20^th June 2024 for relevant articles. We examined overall survival (OS) and progression-free survival (PFS) based on low vs high GNRI in HCC.

Results: Total 13 studies were included. Meta-analysis of 11 studies showed that low GNRI was significantly associated with poor OS (HR: 1.83 95% CI: 1.47, 2.29 I²=67%) and PFS (HR: 1.51 95% CI: 1.34, 1.69 I²=27%.) in HCC patients. No publication bias was noted. Most outcomes did not change on subgroup analysis based on country of origin, sample size, Child-Pugh Grade-B %, treatment, cut-off, follow-up, and method of analysis. Results remained significant on sensitivity analysis.

Conclusions: The GNRI can predict OS and PFS in HCC patients. Given its availability and ease of calculation, the tool can be incorporated into clinical practice to rapidly predict the prognosis of HCC patients.

查看原文本刊更多论文

老年营养风险指数作为肝细胞癌预后的预测因子：一项系统回顾和荟萃分析。

目的：老年营养风险指数（GNRI）已被发现作为几种恶性肿瘤预后的预测指标。然而，它是否能预测肝细胞癌（HCC）的预后尚不清楚。在这篇综述中，我们提供了GNRI对HCC预后能力的高质量证据。方法：两名审稿人筛选Embase、PubMed、Web of Science和Scopus截至2024年6月20日的相关文章。我们研究了HCC患者基于低与高GNRI的总生存期（OS）和无进展生存期（PFS）。结果：共纳入13项研究。11项研究的荟萃分析显示，低GNRI与HCC患者较差的OS （HR: 1.83 95% CI: 1.47, 2.29 I2=67%）和PFS （HR: 1.51 95% CI: 1.34, 1.69 I2=27%）显著相关。未发现发表偏倚。在基于原产国、样本量、Child-Pugh分级b %、治疗、截止、随访和分析方法的亚组分析中，大多数结局没有改变。敏感性分析结果仍然显著。结论：GNRI可以预测HCC患者的OS和PFS。鉴于其可用性和易于计算，该工具可用于临床实践，以快速预测HCC患者的预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pakistan Journal of Medical Sciences 医学-医学：内科

CiteScore

4.10

自引率

9.10%

发文量

363

审稿时长

3-6 weeks

期刊介绍： It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.