Pakistan Journal of Medical Sciences最新文献

{"title":"Efficacy of 4-dimensional hysterosalpingo-contrast sonography and X-ray hysterosalpingography in infertility.","authors":"Meili Wu, Xue Gu, Juan Hao, Ruichao Miao","doi":"10.12669/pjms.41.1.10743","DOIUrl":"10.12669/pjms.41.1.10743","url":null,"abstract":"<p><strong>Objective: </strong>To assess and compare efficacy of 4-dimensional hysterosalpingo-contrast sonography (4D-HyCoSy) and X-ray hysterosalpingography (HSG) for fallopian tube examination.</p><p><strong>Methods: </strong>Clinical data of patients with suspected tubal infertility, who underwent examinations in Qingdao Women and Children's Hospital from September 2021 to December 2023, were retrospectively analyzed. Of them, 40 patients received laparoscopy and dye test+ 4D-HyCoSy (4D-HyCoSy group), and 36 patients received laparoscopy and dye test +HSG (HSG group).</p><p><strong>Results: </strong>The study included clinical data of 76 patients with a total of 149 fallopian tubes. Using laparoscopy and dye test observations as the gold standard, 4D-HyCoSy and X-HSG examinations identified 39 blocked tubes, 69 tubes with partial patency, and 41 tubes with patency. Compared with laparoscopy and dye test, the diagnostic concordance rate of 4D-HyCoSy was 70.51% (55/78), Kappa=0.546 (<i>P</i><0.05); and the diagnostic concordance rate of HSG was 69.01% (49/71), Kappa=0.516 (<i>P</i><0.05). Sensitivity, specificity, and accuracy of the diagnosis of obstruction, partial patency, and patency were comparable in the two groups (<i>P</i>>0.05). The incidence of pain and adverse reactions were significantly lower in the 4D-HyCoSy group compared to the HSG group (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>While both 4D-HyCoSy and HSG have high efficacy in fallopian tube examination, and are similarly accurate in evaluating tubal blockage, 4D-HyCoSy is associated with lower incidence of pain, and reduced rate of adverse reactions.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 1","pages":"151-156"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755322/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A clinical study on the screening efficacy of six thrombotic markers TAT, PIC, TM, t-PAI-C, D-D, and FDP for hypercoagulable state in pregnant women.","authors":"Tao Yu, Wenjuan Zhang, Yunshuang Wang, Ran Chen, Shuo Luo","doi":"10.12669/pjms.41.1.9755","DOIUrl":"10.12669/pjms.41.1.9755","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the screening efficacy of six thrombotic markers for hypercoagulable state (HCS) in pregnant women, including thrombin-antithrombin III complex (TAT), plasmin-alpha-2 plasmin inhibitor complex (PIC), thrombomodulin (TM), tissue-type plasminogen activator inhibitor complex(t-PAI-C), D-dimer(D-D), and fibrinogen degradation products (FDP).</p><p><strong>Methods: </strong>This was a retrospective study. Eighty-five high-risk pregnant women who underwent antenatal examination at Baoding maternal and Child Health Hospital from December 2022 to September 2023 were included as the observation group, while 85 healthy pregnant women without complications or comorbidities who underwent routine antenatal examinations at our hospital were randomly enrolled as the control group. Analyzed the screening value of these six thrombotic markers in pregnant women at risk of HCS.</p><p><strong>Results: </strong>The levels of TAT, PIC, TM, FDP, and D-D in the observation group were significantly higher than in the control group (<i>P</i> < 0.05, respectively). Pearson correlation analysis showed a weak correlation between maternal age and TAT levels (<i>r</i> = -0.179, <i>P</i>< 0.05) as well as between BMI and FDP and D-D (<i>r</i> = 0.214, 0.232, <i>P</i>< 0.05, respectively). Binary logistic regression analysis revealed that abnormal D-D levels were a risk factor for HCS in pregnant women (OR = 0.117, 95% CI: 0.621-0.639, <i>P</i>< 0.05). The area under the joint curve was 0.757, indicating that the model is of certain predictive value for HCS in pregnant women.</p><p><strong>Conclusion: </strong>TAT, PIC, TM, t-PAI-C, D-D, and FDP can used for the screening of HCS in pregnant women and have a certain predictive value for high-risk pregnant women.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 1","pages":"189-193"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755280/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short and long-term outcome of levamisole in early versus late steroid responsive nephrotic syndrome: A single centre experience.","authors":"Saima Kashif, Khemchand N Moorani","doi":"10.12669/pjms.41.1.10184","DOIUrl":"10.12669/pjms.41.1.10184","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the effectiveness of Levamisole (Leva) in maintaining short-term and long-term remission in early steroid responders (ESRs) and late steroid responders (LSRs).</p><p><strong>Methods: </strong>This retrospective study on 106 cohorts, aged 2-14 years with frequent-relapsing (FR) and steroid-dependent nephrotic syndrome (SDNS) who received Leva over 10-years (2012-2023), was carried out at tertiary care centre, Karachi from January-August 2023. Patients were categorized based on steroid response during first episode of NS as ESRs if complete remission (CR) was achieved within two weeks of daily steroid and LSRs if CR achieved between two-four weeks. Leva was administered after inducing remission with daily steroid after labelling as FRNS and SDNS. Low-dose steroid was continued during Leva-therapy. Short-term outcome was assessed at completion of Leva and long-term outcome in terms of CR, relapse frequency, alternative immunosuppressive agents (ISAs) use and compliance was assessed at six, 12 and 36-months' follow-up while off levamisole therapy.</p><p><strong>Results: </strong>Leva was used in 106 patients (male 67%) for 20.4±8months during the study period. The mean age at Leva-initiation was 6.3±3 years. Eighty-three were FRNS and 23 SDNS. ESRs were 64 and 42 were LSRs. Overall, Leva was effective in maintaining short-term CR (73%) at end of Leva and it was effective in both ESRs (75%) and LSRs (69%, p=0.51) as well as in FRNS (72%) and SDNS (74%), P=0.08). Post-Leva follow-up duration was 36±31 months. Long-term Leva was effective in both ESRs and LSRs (p=0.51). Complete remission in 22,17 and 26%; infrequent relapses in 50,40 and 5% and alternate ISAs use in 24,39 and 55% at six,12 and 36 months follow-up respectively.</p><p><strong>Conclusion: </strong>Levamisole was effective in maintaining short-term and long-term remission in early and late initial steroid responsive nephrotic syndrome.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 1","pages":"64-70"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with eye disorders and diseases: A retrospective study.","authors":"Olgun Goktas","doi":"10.12669/pjms.41.1.9728","DOIUrl":"10.12669/pjms.41.1.9728","url":null,"abstract":"<p><strong>Objective: </strong>To retrospectively identify the factors associated with eye disorders and diseases.</p><p><strong>Methods: </strong>The retrospective study was carried out in Bursa Uludag University Family Health Center in Turkey between 1-30 September 2023. The data of individuals who were registered with the Family Health Center and whose eye disorders and diseases were known were evaluated retrospectively. Eye disorders and diseases, sociodemographic findings, existing diseases, allergies, cancer, genetic disease conditions, and steroid use were obtained.</p><p><strong>Results: </strong>Around 3658 people; 1849 males (50.5%) and 1809 females (49.5%) participated in the study. The mean age of the individuals was 26.98±10.22 years. It was determined that 1594 (43.6%) of the participants had at least one eye disorder and/or disease and 1511 (41.3%) wore glasses and/or contact lenses. In 1594 (43.6%) patients with eye disorders or diseases, 41% had refractive disorders. It was determined that the rate of eye diseases is higher in women, smokers, and obese people, those with a family history of eye diseases, those with allergic and chronic diseases, those with genetic diseases, and those who use steroids (p=0.04).</p><p><strong>Conclusion: </strong>It is noteworthy in terms of eye health that nearly half of the participants have at least one eye disorder and/or disease, and nearly half of them use glasses and/or contact lenses. It is also important that eye disorders and diseases are seen more together with smoking, obesity, allergies, genetic and chronic diseases, and steroid use. We emphasize the holistic approach of family medicine and the importance of cooperation with other clinics in terms of eye health.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 1","pages":"176-181"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755293/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical efficacy of bladder function training combined with pelvic floor biofeedback electrical stimulation on neurogenic bladder and its impact on urodynamics.","authors":"Jiawei Gu, Jun Zang","doi":"10.12669/pjms.41.1.9655","DOIUrl":"10.12669/pjms.41.1.9655","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the clinical efficacy of bladder function training combined with pelvic floor biofeedback electrical stimulation in the treatment of neurogenic bladder and its impact on urodynamics.</p><p><strong>Methods: </strong>This was a clinical comparative study. A total of 120 patients with neurogenic bladder after spinal cord injury admitted to Beijing Rehabilitation Hospital of Capital Medical University and Beijing Shijingshan Hospital from January 2023 to December 2023 were randomly divided into two groups (n= 60/group). The study group treated with bladder function training combined with pelvic floor biofeedback electrical stimulation and the control group receiving conventional treatment and bladder function training. The differences in the clinical efficacy, voiding diary, voiding symptom score, urodynamics parameters, etc. were between the two groups were compared and analyzed.</p><p><strong>Results: </strong>The difference of the efficacy in the study and control groups was statistically significant(p=0.02). After treatment, the study group showed significant improvement compared to the control group in terms of daily mean voiding frequency, daily mean single urine volume, daily maximum single urine volume, and catheterization frequency(P=0.00). Meanwhile, the study group also saw significantly lower residual urine volume (RUV) than the control group, with statistically significant differences(p=0.00), while MBC, Qmax, and BP were significantly higher in the study group than in the control group, with statistically significant differences(p=0.00).</p><p><strong>Conclusion: </strong>The application of bladder function training combined with pelvic floor biofeedback electrical stimulation is significantly effective for treating neurogenic bladder, which can significantly improve the storage and voiding functions of patients, alleviate lower urinary tract symptoms, and improve patients' quality of life.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 1","pages":"251-256"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe gastrointestinal symptoms during first year after laparoscopic cholecystectomy.","authors":"Saleh Abdulrahman Almulhim, Mounther Mohammed AlNaim, Abdul Qadeer Memon, Abdulrhman Khalid Aldrweesh, Omar Ahmed Aldamigh, Faisal Abdulaziz Alhadi, Shahd Salah Albooshal, Abdullah Ahmed Alabdrabulridha, Ahmed Hassan Kamal, Abdulrahman Saleh Al-Mulhim","doi":"10.12669/pjms.41.1.10125","DOIUrl":"10.12669/pjms.41.1.10125","url":null,"abstract":"<p><strong>Background & objective: </strong>Many patients after cholecystectomy, develop gastrointestinal (GI) symptoms and are worried. The objective of this study was to find out the risk factors for severe GI symptoms following laparoscopic cholecystectomy (LC) during first year of follow-up.</p><p><strong>Methods: </strong>It is a multi-center prospective observational study. In this study, patients who underwent LC for gallstones as elective or emergency at different hospitals of Al-Ahsa region of the Kingdom of Saudi Arabia from January 2020 to December 2021were evaluated for the development of severe GI symptoms postoperatively. They were followed-up for one year after the surgery.</p><p><strong>Results: </strong>One thousand and two patients who underwent LC, 139(13.87%) developed severe GI symptoms after LC. The patients affected were mostly females 103(74.1%). After LC, the GI symptoms observed were increased frequency of defecation 113(81.3%), loose stools 102 (73.4%), urgency 63(45.3%) and bloating 60 (43.16%) patients. Forty-seven (33.8%) patients had two GI symptoms at a time, followed by 36 (25.9%) who had three. The median time of the start of GI symptoms was two weeks after surgery and the symptoms ended at 12 weeks after surgery. Forty-five (32.4%) patients had less than three-weeks' duration, followed by 35(25%) having less than 15 weeks. A BMI more than 40 showed a significant association. A higher frequency of cholecystitis attacks and a delayed onset of GI symptoms showed a significant severity of GI symptoms, resulting in delayed resolution. The bowel symptoms were more prominent in the emergency group. Age and gender had no significance.</p><p><strong>Conclusion: </strong>Early laparoscopic cholecystectomy of patients with cholelithiasis who have a smaller number of attacks of cholecystitis have less frequency of severe GI symptoms after the surgery.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 1","pages":"107-112"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The burden of cutaneous fungal infections in a tertiary care hospital in Pakistan.","authors":"Najam-Us-Saher, Saadia Tabassum, Madiha Sajid, Yumna Khabir, Aisha Faheem","doi":"10.12669/pjms.41.1.9061","DOIUrl":"10.12669/pjms.41.1.9061","url":null,"abstract":"<p><strong>Objective: </strong>In Pakistan, the real extent of fungal infection is unknown. Our objective was to estimate the burden of major fungal diseases here to emphasize their public health importance.</p><p><strong>Methods: </strong>In this retrospective study, the medical records (January 2019 - December 2019) of 863 patients diagnosed with superficial fungal infection (SFI) were reviewed at the dermatology department of Aga Khan University Hospital (AKUH) Karachi. Stata 17.0 was used to analyze the data. Chi-squared test or Fisher's exact test was used to evaluate association between variables. Descriptive analyses include means, frequencies, standard deviations, and percentage tests whereas Poisson regression with robust standard error was used to examine the association of age, gender, diabetes, and type of SFI with recurrence of SFI.</p><p><strong>Results: </strong>In this study, the most common SFI was tinea cruris (234/863, 27.1%) in men (n=62, 21.7%) and females (n=172, 29.8%) followed by pityriasis versicolor (n=77, 26.9%) in males and tinea corporis (n=115, 19.9%) in females. Tinea cruris recurrence rates were similar between males and females (34/234, 14.5%).</p><p><strong>Conclusion: </strong>These findings show that fungal infections are a public health problem in Pakistan and that additional research is needed to assess their frequency in the general population. Clinicians must be taught and made aware of these infections to enhance diagnosis and treatment.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 1","pages":"269-274"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wrist ganglion cyst enveloping radial artery.","authors":"Jia-Fu Zhu, Kai-Chen","doi":"10.12669/pjms.41.1.9776","DOIUrl":"10.12669/pjms.41.1.9776","url":null,"abstract":"<p><p>Wrist ganglion cysts typically do not show noticeable symptoms but can affect aesthetics and even compress adjacent blood vessels and nerves. Compression therapy can eliminate cysts. However, caution is needed when treating cysts around the radial artery. This study examined a rare case of a wrist ganglion cyst that, after repeated compression and recurrence, enveloped the radial artery. This not only caused wrist swelling and pain but also increased the difficulty and risk of surgical treatment.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 1","pages":"338-340"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of <i>Centratherum anthelminticum</i> seeds on Glycated hemoglobin, Cardiovascular disease risks and dyslipidemia in Type-2 diabetic patients in Karachi: A non-blind randomized controlled trial.","authors":"Hina Akram Mudassir, Syed Muhammed Talha Arshad, Munazzah Naheed, Sadia Anwer","doi":"10.12669/pjms.41.1.8496","DOIUrl":"10.12669/pjms.41.1.8496","url":null,"abstract":"<p><strong>Objective: </strong>To explore the effect of <i>Centratherum antheminticum</i> seeds powder {<i>Cap</i> _CASP 500 mg} capsule in diabetes Type-2 (T2DM) patients in Karachi.</p><p><strong>Methods: </strong>A randomized selection of 40 T2DM patients from Sindh Government Hospital New Karachi with their consents was done for a non-blinded controlled trial from October to December 2019 and divided into P_Group (Positive Control, metformin 500 mg) & T_Group (Test, <i>Cap</i> _CASP + was also included, using the same dosage of CapCASP on twenty healthy volunteers. The data were analyzed using an online graph pad student's t-test and a one-way ANOVA (SPSS version 24) metformin 500mg each). Both groups had (n = 20). C_Group (healthy control), was also included with twenty healthy volunteers with same dose of <i>Cap</i> _CASP. The biochemical tests (lipid profile, HbA1c, fasting blood glucose) of both groups were done in biochemistry lab Federal Urdu University of Arts, Science & Technology and results were analyzed by one-way ANOVA (SPSS version 24) and online graph pad student´s t-test.</p><p><strong>Results: </strong>CASP showed potent (<i>in-vitro</i>) anti-diabetic activity (72.81%) than standard acarbose (standard drug). Most of <i>in-vivo</i> parameters in T_Group showed significant improvements. Body weight (<i>p</i><0.01) & (<i>p</i><0.05), HbA1c & fasting blood glucose (<i>p</i><0.0001), coronary risk index (CRI), atherogenic index (A Indx) (<i>p</i><0.05, <i>p</i><0.0001) & atherogenic dyslipidemia ratio (A-DLR) (<i>p</i><0.0001 & <i>p</i><0.01) were reduced after six and twelve weeks. Reduction in serum cholesterol and triglycerides (<i>p</i>< 0.05 & <i>p</i>< 0.01) after six as well as (<i>p</i>< 0.01) after twelve weeks. Very low density lipoprotein reduced after both (<i>p</i>< 0.05) six and (<i>p</i>< 0.0001) twelve weeks. High density lipoprotein increased (<i>p</i>< 0.01) & low density lipoprotein decreased (<i>p</i>< 0.05) after twelve weeks.</p><p><strong>Conclusion: </strong>When given standard care to T2D patients, the CASP intervention demonstrated both anti-diabetic and anti-lipidemic effects.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 1","pages":"257-262"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurological disorders in Pregnancy: Radiological insights and Obstetric implications.","authors":"Rukhsana Aziz, Sumaira Yasmin, Nasreen Aman, Huma Shams","doi":"10.12669/pjms.41.1.9680","DOIUrl":"10.12669/pjms.41.1.9680","url":null,"abstract":"<p><strong>Objective: </strong>To explore the radiological findings of neurological disorders in obstetrics patients, their obstetric and fetal outcome.</p><p><strong>Method: </strong>The cross-sectional study was conducted at Lady Ready Hospital (LRH), Peshawar from June 2022 till March, 2023. Sixty two obstetric patients with neurological symptoms were included. Their clinical records were explored. MRI/MRV brain were performed in patients requiring brain imaging and followed till the end of pregnancy.</p><p><strong>Results: </strong>Seizures were the commonest symptom found in 74.2% patients followed by hemiparesis; 8.1%. About 92% had never experienced hypertension and 62.3% had pregnancy-induced hypertension in current pregnancy. Twenty eight patients underwent MRI, revealing Dural sinus thrombosis (DST) in 42.9%, posterior reversible encephalopathy syndrome (PRES) in 17.9%, infarcts in 14.3% and hemorrhage in 7.1%. Normal baby was born in 69% patients; stillbirth, preterm birth and miscarriage were found in 25.9%, 3.2% and 1.6% respectively. Apgar scores of 7-10, 4-6 and 0-3 were found in 67.2%, 6.9% and 25.9% respectively. Fits were observed in 10.3% babies and 32.8% required neonatal intensive care unit (NICU) care. Fits and ischemic infarct were commoner in prenatal. DST and PRES were commoner in postnatal patients. All PRES patients presented with fits. DST patients presented with fits, headache, hemiparesis and altered consciousness. All PRES patients delivered normal alive babies. DST mothers delivered alive babies at term in 81.8%, dead pre-term baby and miscarriage in 9.1% each.</p><p><strong>Conclusion: </strong>Pregnancy-related neurological problems should be taken carefully and evaluated, since even seemingly insignificant symptoms like headaches may be signs of serious illnesses like PRES or DST.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 1","pages":"182-188"},"PeriodicalIF":1.2,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755281/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143047652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}