Pakistan Journal of Medical Sciences最新文献

{"title":"Impact of ChatGPT-assisted personalized learning on teaching acute abdomen to undergraduate medical students: A randomized crossover study.","authors":"Maria Ilyas, Rehan Ahmed Khan, Rahila Yasmeen, Zainab Kamal, Noor Ul Ain","doi":"10.12669/pjms.42.8.14827","DOIUrl":"10.12669/pjms.42.8.14827","url":null,"abstract":"<p><strong>Background &objective: </strong>The application of Artificial Intelligence (AI) in medical education has emerged as a promising avenue for personalized learning experiences to the individual needs of medical students. This study investigated the impact of AI-driven personalized learning pathways on the academic performance of medical students in acute abdomen topic, comparing against traditional learning method.</p><p><strong>Methodology: </strong>This study used a randomized controlled crossover trial conducted from February 2024 to July 2024 among fourth year one hundred undergraduate medical students at Islamic International Medical College, Riphah International University, Pakistan. In this study, students enrolled in a general surgery course were randomly assigned to experimental group and control group following a pre-test. The experimental group engaged with AI-driven personalized learning pathways, powered by ChatGPT-4, the control group utilized conventional educational resources. Both groups completed a post-test to assess the effects of their respective learning interventions. Statistical analyses, including descriptive statistics, independent-samples t-tests and paired-samples t-tests were conducted using SPSS.</p><p><strong>Results: </strong>The pre-test scores of the experimental (M = 17.12, SD = 6.99) and control groups (M = 18.64, SD = 6.91) did not differ significantly (p = 0.277). Post-intervention, the experimental group showed a statistically significant improvement (M = 22.8, SD = 5.11) compared to the control group (M = 19.24, SD = 7.11), with a p-value of .005 and a moderate effect size (Cohen's d = 0.58). This suggests that AI-driven personalized learning pathways had a positive and measurable impact on the students' academic performance in the experimental group.</p><p><strong>Conclusion: </strong>AI-driven personalized learning pathways can enhance the academic performance of medical students, particularly in subject of surgery. Future research should explore the long-term effects of personalized AI-powered educational interventions.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"1943-1948"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525506/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of platelet rich plasma preparations by routine centrifuge versus two commercially available standardized centrifuges.","authors":"Syed Kamran Ahmed, Asifa Abdul Hakeem, Sadaf Saeed","doi":"10.12669/pjms.42.8.15762","DOIUrl":"10.12669/pjms.42.8.15762","url":null,"abstract":"<p><strong>Background & objective: </strong>Platelet-rich plasma (PRP) therapy is increasingly used in regenerative medicine, orthopedics, and dermatology; however, the lack of standardization in PRP preparation leads to variability in platelet yield and composition. This study aimed to compare the quality and efficiency of PRP prepared using a routine laboratory centrifuge with two commercially available standardized centrifuge systems.</p><p><strong>Methodology: </strong>This comparative cross-sectional study was conducted in the Department of Orthopedics & Traumatology and the Department of Plastic surgery at Indus Hospital & Health Network (IHHN), Karachi, over a period of six months from August, 2025 to January 2026. Non-probability consecutive sampling was employed. Thirty-six PRP samples were prepared using routine single-spin, routine double-spin, and two commercial centrifugation methods. Platelet and leukocyte counts, hemoglobin contamination, and platelet recovery were analyzed using SPSS version 26.</p><p><strong>Results: </strong>Commercial standardized centrifuge systems yielded significantly higher platelet concentrations (mean 835 ± 120 ×10⁹/L) compared to routine centrifuges (mean 25.5 ± 10.9 ×10⁹/L; p = 0.005). Platelet recovery and fold increase were also superior in commercial systems (mean 81.6% ± 5.94 vs. mean 10.65% ± 4.59). Leukocyte count and hemoglobin contamination were relatively lower in routine centrifuge methods compared to commercial PRP therapy. Among routine protocols, both single-spin and double-spin methods produced poor platelet counts when the entire supernatant fluid was examined as in our study.</p><p><strong>Conclusion: </strong>Commercial standardized centrifuges produce PRP with reliable and greater platelet enrichment. Routine centrifuge, on the other hand, consistently produced poor platelet counts in the entire supernatant fluid and hence the lower one third only should be used preferably by double spin method. Different spin protocols and collection methods need to be evaluated to better document platelet enhancement in routine centrifuge use.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"2006-2012"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of factors associated with severe disease and construction of a monogram for elderly patients with community-acquired pneumonia complicated by heart failure.","authors":"Yanli Sun, Simiao Yu, Qianli Zhan, Jianlong Li","doi":"10.12669/pjms.42.8.14924","DOIUrl":"10.12669/pjms.42.8.14924","url":null,"abstract":"<p><strong>Objective: </strong>To identify independent influencing factors of severe disease among old community-acquired pneumonia(CAP) patients complicated by heart failure(HF), and to establish the nomogram model for identifying severe illness early in clinical settings.</p><p><strong>Methodology: </strong>This was a retrospective study. Altogether 140 elderly patients with concurrent CAP and HF admitted into Baoding No.1 Central Hospital between January 2022 to November 2025. According to the CURB-65 (confusion, blood urea nitrogen, respiratory rate, systolic blood pressure, age ≥65 years) score, patients were classified as the non-high-risk(<i>n =</i>100) or high-risk(<i>n =</i>40) group. Later, demographic and baseline data, infection and inflammatory markers, cardiac and other organ function parameters, coagulation parameters, systemic parameters, and clinical manifestations were compared between these two groups.</p><p><strong>Results: </strong>After preliminary screening through univariate analysis, multivariate logistic regression identified procalcitonin(PCT), B-type natriuretic peptide(BNP), and impaired consciousness as independent predictors of severe disease(<i>P<</i> 0.05, respectively). These significant predictors were incorporated into a nomogram model to estimate individual risk. The ROC curve analysis showed that the combined model yielded an area under the curve of 0.891(95% confidence interval: 0.818-0.963). Moreover, our calibration curve closely aligned with the ideal curve, indicating that our predicted risk was highly consistent with the actual risk. As for clinical utility, the DCA revealed substantial net clinical benefits of our constructed model among a broad threshold probability spectrum(0.05-1.0).</p><p><strong>Conclusion: </strong>The nomogram model incorporating PCT, BNP, and impaired consciousness demonstrates greater predictive power than those using any single parameter alone. With good calibration and favorable clinical utility.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"1999-2005"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social determinants of abdominal tuberculosis severity: An experience from a large tertiary care center.","authors":"Abdul Samad, Ali Akbar, Nazish Butt, Omar Idris","doi":"10.12669/pjms.42.8.15840","DOIUrl":"10.12669/pjms.42.8.15840","url":null,"abstract":"<p><strong>Background and objective: </strong>Abdominal tuberculosis is a concern in developing countries due to socioeconomic factors, influencing disease severity. This study at Jinnah Postgraduate Medical Centre (JPMC), Karachi, aimed to explore the link between social determinants like socioeconomic status, residence, co-morbidities, addiction patterns, and abdominal tuberculosis severity in patients.</p><p><strong>Methodology: </strong>A descriptive cross-sectional study was conducted at the Department of Gastroenterology, JPMC, Karachi. Study duration was 16 months from September 26, 2024 to January 26, 2026. A total of 503 patients diagnosed with intestinal tuberculosis were included. Data on social determinants such as socioeconomic status, residence, addiction, HIV status, diabetes, and malnutrition were collected. Disease severity was categorized as mild, moderate or severe based on clinical and radiological, endoscopic assessment. Associations between social determinants and abdominal tuberculosis severity were analyzed using Chi-square tests with a significance level of p ≤ 0.05.</p><p><strong>Results: </strong>The sample was nearly evenly split by gender and had a mean age of 47.7 years. Most participants came from urban areas and low to middle socio-economic backgrounds. Notably, 20.3% were HIV-positive, 4.2% had diabetes, and nearly one-third (32.7%) were malnourished. Addictive behaviors were common, with 27.8% chewing tobacco and 15% smoking. The severity of intestinal TB was classified as mild (39.9%), moderate (30.7%), or severe (29.4%), based on predefined criteria. While gender, socio-economic status, residence, and HIV status were not significantly associated with disease severity, diabetes (<i>p</i> = 0.029), malnutrition (<i>p</i> = 0.001), type of addiction (<i>p</i> = 0.001), and geographic location (<i>p</i> = 0.001) showed significant correlations.</p><p><strong>Conclusion: </strong>Abdominal tuberculosis severity is significantly influenced by factors like diabetes, malnutrition, type of addiction, and geographic location but not with socioeconomic status, gender, and residence.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"2094-2099"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525504/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can frailty predict complications and mortality in patients undergoing total knee arthroplasty? A systematic review and meta-analysis.","authors":"Bo Jin, Jianyue Wang, Yungen Hu, Weifan Ren","doi":"10.12669/pjms.42.8.16131","DOIUrl":"10.12669/pjms.42.8.16131","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the value of frailty in predicting postoperative complications and mortality in patients undergoing total knee arthroplasty (TKA).</p><p><strong>Methodology: </strong>PubMed, Scopus, EMBASE and CENTRAL databases were screened up to 20^th November 2025 for observational and randomized studies evaluating postoperative outcomes in frail TKA patients. Data on postoperative complications, readmission and reoperation rates, length of hospital stay and mortality were extracted. A random-effects model was used to calculate pooled risk ratios (RRs) and odds ratios (ORs) with 95% confidence intervals (CIs).</p><p><strong>Results: </strong>Sixteen studies with over 14 million patients were included. Frail patients had a significantly higher risk of 30-day mortality with RR 4.40 (95% CI: 2.18-8.91; p < 0.00001); overall postoperative complications with RR 1.85 (95% CI: 1.35-2.52; p= 0.0001); 30-day readmission with RR: 2.24 (95% CI: 1.74-2.87; p < 0.00001) and 30-day reoperation with RR: 1.81 (95% CI: 1.48-2.22; p < 0.0001). Frailty was also linked to an increased risk of surgical site infections with RR 1.56 ( 95% CI: 0.86-2.83) and prolonged hospital stay with mean difference MD 0.86 days (95% CI: 0.55-1.16; p<0.00001). Individual complications, such as myocardial infarction, renal complications and pulmonary embolism, were consistently more frequent in frail patients. Heterogeneity was moderate to high in some outcomes, attributed to differences in frailty assessment tools and study designs.</p><p><strong>Conclusion: </strong>Within the limitations, frailty is a strong, independent predictor of increased postoperative complications, mortality and prolonged hospital stays in patients undergoing TKA. Incorporating frailty assessments into preoperative evaluations can enhance risk stratification and guide interventions to improve perioperative care in this vulnerable population.<b>Prospero Registration Number:</b> CRD420251035972.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"2138-2151"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic value of platelet-lymphocyte ratio for pediatric sepsis: A systematic review and meta-analysis.","authors":"Li Chen, Qiuping Yang","doi":"10.12669/pjms.42.8.19637","DOIUrl":"10.12669/pjms.42.8.19637","url":null,"abstract":"<p><strong>Objectives: </strong>Early diagnosis of pediatric sepsis remains challenging due to limitations of conventional biomarkers. The platelet-to-lymphocyte ratio (PLR), derived from routine blood tests, has emerged as a potential diagnostic marker. This study aimed to evaluate the diagnostic accuracy of PLR for pediatric sepsis.</p><p><strong>Methodology: </strong>A systematic search of PubMed, Embase, Web of Science, and Scopus was conducted from inception to March 15, 2026. Studies assessing the diagnostic performance of PLR in pediatric sepsis and reporting sufficient data to construct 2×2 contingency tables were included. Pooled sensitivity and specificity were calculated using a random-effects model. Summary receiver operating characteristic (SROC) analysis and Deeks' funnel plot were performed.</p><p><strong>Results: </strong>Fifteen studies with 1,980 patients were included. The pooled sensitivity and specificity of PLR for diagnosing pediatric sepsis were 0.81 (95% CI: 0.73-0.87) and 0.72 (95% CI: 0.60-0.82), respectively. The SROC curve demonstrated an area under the curve of 0.79, indicating moderate diagnostic accuracy. Significant heterogeneity was observed. Subgroup analysis showed better performance in larger studies (≥150 patients) and studies using higher PLR cut-offs (>50). Deeks' funnel plot showed no evidence of publication bias (p = 0.536).</p><p><strong>Conclusions: </strong>Evidence from studies with high-risk of bias indicates that PLR may have moderate diagnostic accuracy for pediatric sepsis and may serve as a simple, cost-effective adjunctive biomarker. Since, most studies were on neonatal population, evidence may not be generalized to older pediatric populations. Further large-scale prospective studies are needed to establish standardized cut-off values and validate its clinical utility.<b>Registration No:</b> PROSPERO (No. CRD420261338676).</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"2162-2173"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CD56-Positive Acute Myeloid Leukemia Complicated by Hemophagocytic Lymphohistiocytosis: A case report and narrative review.","authors":"Xianjie Fu, Ming Li, Chuancai Liu, Yaohui Wu, Junbin Hu, Cong Lu","doi":"10.12669/pjms.42.8.16163","DOIUrl":"10.12669/pjms.42.8.16163","url":null,"abstract":"<p><p>At present, there are no reported cases of CD56+ acute myeloid leukemia (AML) combined with hemophagocytic lymphohistiocytosis (HLH). Meanwhile, there is no standardized treatment plan for AML combined with HLH. This article reports a 27 years old female patient with CD56+ AML who received treatment with an HLH-94-based regimen combined with B cell lymphoma 2 (BCL-2) inhibitor venetoclax. After treatment, the patient's body temperature returned to normal and laboratory parameters related to HLH improved. Two weeks after chemotherapy, bone marrow reassessment showed 3% blast cells and undetectable MLL-AF9 fusion transcripts; complete remission was subsequently documented on May 23, 2024. To our knowledge, this represents a rarely reported case of CD56+AML with HLH. The result suggests that BCL-2 targeted therapy combined with HLH-94 regimen may be a safe and promising strategy for treating CD56+AML with HLH, and may provide a basis for the selection of treatment strategies for such patients in clinical practice.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"2189-2194"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Outcome of tPA Therapy in Patients with Acute Ischemic Stroke (0-three hours).","authors":"Amna Tariq, Muhammad Adnan Aslam, Qasim Bashir, Sabina Nayab, Aamir Hayat","doi":"10.12669/pjms.42.8.13372","DOIUrl":"10.12669/pjms.42.8.13372","url":null,"abstract":"<p><strong>Objective: </strong>To determine the frequency of good functional outcome and significant neurological improvement for patients treated with tPA within first three hours of onset of acute ischemic stroke.</p><p><strong>Methodology: </strong>This cross-sectional study was conducted at Neurology Department, Services Hospital, Lahore, from October 2024 to April 2025. Total 51 patients with acute ischemic stroke who received tPA within three hours of symptom onset were included. Neurological improvement was assessed using NIHSS, and functional outcome with Modified Rankin Scale at baseline and after 90 days; ≥4-point improvement in NIHSS was considered as significant neurological improvement, while mRS scores of 0-2 indicated good functional outcome. Data were analyzed using SPSS v26.</p><p><strong>Results: </strong>Mean NIHSS score improved from 12.31 ± 5.42 at baseline to 7.96 ± 7.05 at 90 days (p < 0.001), while mean mRS improved from 4.02 ± 1.04 to 2.90 ± 1.81 (p < 0.001). Significant neurological improvement was seen in 54.9% of patients, and 49.0% achieved good functional outcomes. No statistically significant associations were found between gender, age, time of tPA administration, or stroke subtype and outcomes (p > 0.05).</p><p><strong>Conclusion: </strong>These findings suggest that while intravenous tPA therapy led to meaningful neurological and functional improvement in many patients, baseline demographics and time to tPA administration within the three hours window did not significantly influence the likelihood of achieving favourable outcomes.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"1914-1918"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative biochemical and computational analysis identifies LOX-1 and IL-6R as therapeutic targets in oxidative, inflammatory and lipid dysregulation of ischemic stroke.","authors":"Sabahat Fatima, Muhammad Sarwar, Madeeha Shahzad Lodhi, Sumaira Sharif","doi":"10.12669/pjms.42.8.15732","DOIUrl":"10.12669/pjms.42.8.15732","url":null,"abstract":"<p><strong>Background and objective: </strong>Ischemic stroke (IS) being one of the leading causes of mortality and morbidity globally is initiated by complex interactions among lipid peroxidation, oxidative stress and metabolic dysfunction. This study aimed to identify therapeutic targets for these pathological pathways is critical for improving diagnostic and treatment strategies.</p><p><strong>Methodology: </strong>This case control study comprising 150 patients and one hundred healthy controls was conducted at DHQ Hospital, Gujranwala from June 2022 to June 2023. Biochemical analyses quantified apolipoproteins, oxidized lipoproteins (oxLDL, oxHDL), sdLDL, antioxidant factors (SOD), inflammatory (IL-6) and metabolic markers (ferritin, LDH) using ELISA and spectrophotometric assays. Moreover, molecular docking and 100 ns molecular dynamics (MD) simulations conducted to evaluate inhibitory potential and structural stability of selected small molecule ligands targeting major lipid related (LOX-1) and inflammatory (IL-6R) receptors.</p><p><strong>Results: </strong>The stroke patients demonstrated significantly elevated levels of biochemical markers and a marked reduction in SOD activity (p< 0.05). Multivariate regression modeling highlighted oxHDL, apoCIII, ferritin, and LDH as robust independent predictors of ischemic stroke. IL-6 displayed positive correlation with oxidized lipoproteins and apolipoproteins, supporting a link between inflammatory signaling and lipid abnormalities. Computational studies identified strong ligand receptor binding with docking energies ranging from -5.9 to -8.0 kcal/mol.</p><p><strong>Conclusion: </strong>Overall, integrated biochemical and computational approach highlights inflammatory activation, oxidative lipid damage, and iron dysregulation as vital contributors to stroke. Key receptors involved in lipid oxidation and cytokine signaling emerge as promising dual therapeutic targets, and the identified ligands show potential as lead candidates for future drug development against ischemic stroke.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"1919-1926"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Latent Class Analysis of eHealth Literacy in Patients with Acute Coronary Syndrome: Associations with Secondary Prevention Medication Adherence and Care Dependency.","authors":"Mengxi He, Ru Ye, Linglong Chen, Aidi Pan","doi":"10.12669/pjms.42.8.14802","DOIUrl":"10.12669/pjms.42.8.14802","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the latent classes of eHealth literacy in patients with acute coronary syndrome(ACS) and their associations with secondary prevention medication adherence and care dependency.</p><p><strong>Methodology: </strong>This was a retrospective study. A cross-sectional survey was conducted on 142 ACS patients admitted to the Emergency Department of Wenzhou People's Hospital from January 2024 to November 2025, via convenience sampling method. Data were retrospectively extracted from the hospital's electronic medical record(EMR) system. Latent class analysis (LCA), univariate analysis, and multivariate logistic regression analysis were applied to identify the latent classes of eHealth literacy and examine their associations with secondary prevention medication adherence and care dependency.</p><p><strong>Results: </strong>Three eHealth literacy subgroups were identified: low (23.24%), moderate (50.00%), and high (26.76%). Age, education, stress, insurance, medication adherence, and care dependency were significant influencing factors(P< 0.05).</p><p><strong>Conclusion: </strong>Acute coronary syndrome(ACS) patients showed heterogeneity in eHealth literacy latent classes. eHealth literacy was positively correlated with medication adherence and negatively correlated with care dependency, which were influenced by age, education, stress, insurance type, medication adherence and care dependency.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"42 8","pages":"2072-2077"},"PeriodicalIF":1.6,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13525523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148857653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}