Pakistan Journal of Medical Sciences最新文献

{"title":"Ultrasound characteristics of primary fallopian tube carcinoma and the misdiagnosis and missed diagnosis.","authors":"Dan Yan, Chunfang Shen, Rongrong Ru, Huijing Xu","doi":"10.12669/pjms.41.5.10600","DOIUrl":"10.12669/pjms.41.5.10600","url":null,"abstract":"<p><strong>Objective: </strong>This study retrospectively analyzed the ultrasound characteristics of primary fallopian tube carcinoma (PFTC) and the misdiagnosis and missed diagnosis.</p><p><strong>Methods: </strong>Data of 15 PFTC patients undergoing surgical treatment in Affiliated Xiaoshan Hospital, Hangzhou Normal University from August 2013 to September 2022 were collected. The clinical features, ultrasound characteristics, pathological diagnosis results and misdiagnosis and missed diagnosis by ultrasound were analyzed.</p><p><strong>Results: </strong>In 15 patients, there were 8 (53.33%) cases with vaginal bleeding, 6 (40.00%) cases with abdominal pain, five (33.33%) cases with pelvic mass, and two (13.33%) cases with vaginal discharge. There were 11 (73.33%) cases with CA125 level ≥ 35 U/ml. In 15 patients, 10 cases presented a sausage-shaped mass in adnexal region (type I PFTC) (two cases of cystic mass with papillary nodules, three cases of cystic-solid mass, five cases of hypoechoic or heterogeneous hypoechoic solid mass), four cases presented irregular hypoechoic mass in adnexal region (type II PFTC), and one case did not present the mass (type III PFTC). In 15 patients, three cases were accompanied by hydrosalpinx, two cases were accompanied by uterine fluid accumulation, and five cases were accompanied by abdominal or pelvic fluid accumulation. There were totally seven (46.66%) cases misdiagnosed or missed of diagnosis by ultrasound.</p><p><strong>Conclusion: </strong>The clinical manifestations of PFTC are diverse and lack of specificity. The ultrasound examination may have the misdiagnosis and missed diagnosis. PFTC should be highly suspected when there are characteristic ultrasound images including sausage-shaped mass companied by hydrosalpinx, uterine fluid accumulation, or abdominal or pelvic fluid accumulation. If the mass is small, it is prone to missed diagnosis.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 5","pages":"1511-1516"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of assisted reproductive technology on the risk of cerebral palsy: A systematic review and meta-analysis.","authors":"Xinyu Chen, Peihong Zhou","doi":"10.12669/pjms.41.5.11961","DOIUrl":"10.12669/pjms.41.5.11961","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to evaluate the impact of assisted reproductive technology (ART) on the risk of cerebral palsy (CP) in offspring.</p><p><strong>Methods: </strong>We searched PubMed, Embase, Web of Science and Scopus databases for observational studies that investigated the link between ART and CP as a pregnancy outcome that were published until 15th January, 2024. Only studies that provided adjusted effect sizes for the outcome of interest were included. Pooled odds ratio (OR) was reported along with 95% confidence intervals (CI).</p><p><strong>Results: </strong>Thirteen studies were included. Pregnancy that was achieved with the help of ART correlated with significantly higher risk of CP in offspring (OR 1.51, 95% CI: 1.18, 1.94) compared to natural conception. The risk of CP in singleton pregnancies achieved through ART was elevated (OR 1.31, 95% CI: 1.09, 1.58). while no such increase in the risk was detected in cases of multiple pregnancies (OR 1.07, 95% CI: 0.95, 1.20) and preterm births (OR 1.09, 95% CI: 0.93, 1.28). Studies published prior to the year 2010 showed an association of ART with elevated rates of CP (OR 1.67, 95% CI: 1.14, 2.44). No difference was detected in studies published after the year 2010 (OR 1.40, 95% CI: 0.97, 2.03).</p><p><strong>Conclusion: </strong>Our findings suggest a modest increase in the risk of CP that is linked to ART. However, the analysis is hindered by a small number of studies and notable heterogeneity. Subgroup analyses did not show significant associations for multiple or preterm pregnancies, suggesting that other factors beyond ART may be responsible. Factors such as maternal age, underlying infertility, and pregnancy complications might contribute to the observed risk of CP rather than ART itself. Higher-quality studies are required to validate our conclusions.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 5","pages":"1526-1535"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive factors of stigma in stroke patients based on logistic regression and decision tree mode.","authors":"Wenwen Ma, Kunjuan Jing, Ruotong Zhang, Xuefei Li, Zheng Li","doi":"10.12669/pjms.41.5.9946","DOIUrl":"10.12669/pjms.41.5.9946","url":null,"abstract":"<p><strong>Objective: </strong>Logistic regression and decision tree model were used to analyze the predictive factors of stigma in stroke patients, and to explore the application value of the two models.</p><p><strong>Methods: </strong>This was a retrospective study. The data of 342 stroke patients were collected from Baoding No.1 Central Hospital from December 2023 to March 2024. Data were retrospectively retrieved from the hospital information and management system. The regression model and decision tree model of influencing factors of stroke patients' sense of stigma were established, to analyze the influencing factors of the sense of stigma, and to compare the predictive effects, advantages and disadvantages of the two models.</p><p><strong>Results: </strong>Logistic regression analysis showed that threat assessment (OR=2.7761) was a risk factor for stigma, while irrelevant cognitive appraisal (OR=0.321), social support (OR=0.098) and resilience (OR=0.438) were protective factors. The results of the decision tree model showed that the patients' psychological resilience was the most important factor affecting the sense of stigma, followed by social support and threat assessment. The AUC of the decision tree model and Logistic regression model were 0.854 and 0.880, respectively, and the accuracy were 78.7% and 79.6%, respectively.</p><p><strong>Conclusion: </strong>Threat, irrelevant cognitive appraisal, social support and resilience might be the predictive factors of stigma in stroke patients. The AUC and accuracy of the decision tree model were slightly lower than that of the Logistic regression model.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 5","pages":"1482-1487"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130943/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Analysis of causes and preventive measures of complications after decompressive craniectomy for Craniocerebral Trauma.","authors":"Zhenling Jia, Jia Li, Yuchao Shan, Dongjing Xu, Jing Li","doi":"10.12669/pjms.41.5.10382","DOIUrl":"10.12669/pjms.41.5.10382","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the incidence and risk factors of postoperative complications in patients treated with decompressive craniectomy for craniocerebral injury.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on the clinical data of 80 patients with craniocerebral injury who underwent decompressive craniectomy in Baoding NO.1 Central Hospital from May 2022 to January 2024, with statistics of the incidence of postoperative complications collected for the analysis of the related risk factors.</p><p><strong>Results: </strong>In this study, the incidence of postoperative complications was 37.50%, including intracranial infection (n=5; 6.25%), delayed intracranial hemorrhage (n=6; 7.50%), subdural effusion (n=15; 18.75%), cerebrospinal fluid leakage (n=3; 3.75%), and hydrocephalus (n=7; 8.75%). Additionally, the location and volume of hematoma were independent risk factors for complications after decompressive craniectomy for craniocerebral trauma(p<0.05).</p><p><strong>Conclusion: </strong>Due to the high incidence of complications after decompressive craniectomy for craniocerebral trauma, relevant measures should be taken according to the risk factors to reduce the incidence of postoperative complications, along with prompt postoperative treatment, thereby improving the efficacy of surgery.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 5","pages":"1376-1380"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of prognostic values of IL-6 and PCT levels with the severity of pneumonia caused by <i>Mycoplasma pneumoniae</i> in children.","authors":"Xinxin Bao, Qiuhong Wang, Haiying Geng, Xiaohua Yuan","doi":"10.12669/pjms.41.5.10448","DOIUrl":"10.12669/pjms.41.5.10448","url":null,"abstract":"<p><strong>Objective: </strong>To explore the correlation of interleukin 6 (IL-6) and procalcitonin (PCT) with severity of <i>Mycoplasma pneumoniae pneumonia</i> (MPP) in children and their prognostic value.</p><p><strong>Methods: </strong>One hundred twenty children with MPP and 100 healthy children who underwent physical examination at the Clinical Laboratory Department of Nantong University Maternal and Child Health Hospital from November 2023 to December 2023 were selected as the study subjects, and were divided into the experimental group and the control group. The experimental group was divided into mild MPP group (n=70 ) and severe MPP group (n=50 ) according to the severity of the disease. According to the condition after one course of treatment, separated MPP children into good prognosis group (n=96) and poor prognosis group (n=24). The IL-6 and PCT levels of the experimental/control group before treatment and the good/bad prognosis group after treatment were compared, respectively. The lung function of children with MPP before and after treatment was also examined, and the changes of respiratory rate (RR), tidal volume (VT), expiratory time (Te), peak time (TPTEF), and peak volume (VPTEF) were observed. The correlation between pulmonary function and IL-6, PCT in MPP children was analyzed by Pearson analysis. Receiver operation curve was adopted to analyze the predictive value of IL-6, PCT for poor prognosis.</p><p><strong>Results: </strong>IL-6 and PCT were increased in the severe MPP group compared to the mild MPP group (P<0.001) and tended to decrease in the good prognosis group compared to the poor prognosis group (P<0.001). Fifty-nine of the 70 cases in the good prognosis group were patients with mild MPP, suggesting that patients with mild MPP have a better prognosis. The results of respiratory function showed an increase in RR (P<0.001) and a decrease in VT (P=0.007), TPTEF/Te (P<0.001), VPTEF/VT (P<0.001) in the severe MPP group compared to the mild MPP group. The results of correlation analysis revealed that IL-6, PCT were negatively correlated with VT, TPTEF/Te and VPTEF/VT (P<0.001). ROC curve analysis revealed that IL-6 and PCT co-diagnosis had a better predictive ability for poor prognosis in children with MPP (AUC=0.843).</p><p><strong>Conclusion: </strong>IL-6 and PCT are positively related to the severity of MPP, the combined detection of IL-6 and PCT has certain clinical usefulness to evaluate and assess prognosis of MPP children.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 5","pages":"1305-1310"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A programme of faculty development in medical education for junior doctors: The start of a journey to clinical educator.","authors":"Charles Thurston, Anna Schmid, Chaudhry Aqeel Safdar","doi":"10.12669/pjms.41.5.11936","DOIUrl":"10.12669/pjms.41.5.11936","url":null,"abstract":"<p><strong>Objective: </strong>Interest in medical education for early career doctors is on the rise, but medical education training is insufficient. Medical education faculty development programmes for Junior/Foundation year doctors (JDs) are needed.</p><p><strong>Methods: </strong>A group of clinical educators designed a development programme and interested Junior doctors were recruited to a pilot. A pre-programme questionnaire established teaching practices and needs of JDs. It had two parts. First included a full day of hands-on workshop, imparting educational principles, teaching skills, developing a lesson plan and practicing structured feedback. The second part invited them to deliver faculty observed skills sessions to medical students, with feedback. Faculty reflection and peer review informed evaluation of the course.</p><p><strong>Results: </strong>Twelve JDs were recruited, with nine attending (75% retention). Eight completed pre-course questionnaire (89%, n=8/9). This showed frequent bedside teaching (87%, n=7/8), confidence (75%, n=6/8) but 'not often' satisfaction with their teaching (75%, n=6/8). JDs' engagement with post-course evaluation was low (25%). Faculty reflection was a positive approach and generated ideas for improvement.</p><p><strong>Conclusions: </strong>JDs had high levels of engagement with students, but confidence did not translate into satisfaction, with knowledge and skills gaps. Reflection and peer review provided good insights into the programme and its need. Such programmes are feasible to continue faculty development of JDs, who regularly teach medical students on the wards and can provide clinical educationalist of tomorrow.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 5","pages":"1546-1548"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Kidney injury of glomerular origin in Asian population: Causes and outcomes - Meta-Analysis.","authors":"Sakina Abbas, Aleena Aftab, Ahya Aziz, Rubina Naqvi","doi":"10.12669/pjms.41.5.11858","DOIUrl":"10.12669/pjms.41.5.11858","url":null,"abstract":"<p><strong>Objective: </strong>To collect all studies on acute kidney injury of glomerular origin, published from Asia, even with their limitations, and look for causes and outcome in this particular population.</p><p><strong>Method: </strong>As of June 2024, a comprehensive literature search was conducted in the databases of PubMed, Cochrane Library, Web of Science, Embase, Google Scholar and PubMed Central, for full-text articles in English language, describing original articles on acute kidney injury of glomerular origin published from Asia. There was no time limit set for searching year of publication. Combinations of key words used were 'acute kidney injury' or 'acute renal failure' or 'acute kidney injury of glomerular origin' or 'glomerular diseases causing acute kidney injury' along with using 'Asia'. Data was extracted and analyzed.</p><p><strong>Results: </strong>Of the 21 studies subjected to detailed analysis, 10(47.61%) had been published from China, 4 (19 %) from India, 2(9.52%) from Hong Kong and 1 (4.76 %) each from Iran, Korea, Pakistan, Saudi Arabia and Sri Lanka. Overall, there were 4,077 patients with acute kidney injury of glomerular origin. There were 7(33 %) studies addressing isolated lupus nephritis, two had isolated AAV, 1 Anti-GBM disease, two acute GN, two Crescentic GN, two PIGN, while 5 (24%) studies included different varieties including lupus and other categories in their population. Majority of studies were retrospective cohorts except one prospective. Pattern of defining and classifying acute kidney injury varied in the studies. Need for renal replacement varied widely from 7-80 %. Complete recovery varied from 9 to 96 % and mortality 3-38 % in the analyzed studies.</p><p><strong>Conclusions: </strong>The number of acute kidney injury patients was considerable. Despite variations in definitions, study designs and outcomes, the meta-analysis provides useful information about the pattern of the major causes of glomerular diseases causing acute kidney injury in Asia.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 5","pages":"1536-1545"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130953/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic efficacy of budesonide suspension combined with poractant alfa injection for neonatal respiratory distress syndrome and its effect on serum ferritin and PAI-1 expressions.","authors":"Yunbo Xu, Wenchao Chen","doi":"10.12669/pjms.41.5.10496","DOIUrl":"10.12669/pjms.41.5.10496","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the therapeutic efficacy of budesonide suspension combined with poractant alfa injection for neonatal respiratory distress syndrome (NRDS) and the underlying action mechanisms.</p><p><strong>Methods: </strong>Sixty NRDS patients treated in Huangshi Maternity and Children's Health Hospital from May 2021 to May 2023 were enrolled and were divided into control and observation groups, which were treated with poractant alfa injection and budesonide suspension combined with poractant alfa injection, respectively.</p><p><strong>Results: </strong>After 72 hours of treatment, the total efficacy in observation group was significantly higher than control group. Compared with control treatment, in observation group the partial pressure of oxygen was significantly increased, the partial pressure of carbon dioxide, peak inspiratory pressure, respiratory rate, fraction of inspired oxygen and serum tumor necrosis factor-α, interleukin-6, high-sensitivity C-reactive protein, serum ferritin and plasminogen activator inhibitor-1 levels were significantly decreased.</p><p><strong>Conclusion: </strong>Compared with poractant alfa injection, budesonide suspension combined with poractant alfa injection is more effective in treatment of NRDS. The action mechanisms may be related to its further reduction of inflammatory response and inhibition of serum ferritin and plasminogen activator inhibitor-1 expressions.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 5","pages":"1488-1493"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of sacubitril-valsartan combined with rosuvastatin calcium in the treatment of unstable angina pectoris and its effects on blood lipids and hemorheology.","authors":"Yang Peng, Yuxiang Wen, Han Wei","doi":"10.12669/pjms.41.5.10658","DOIUrl":"10.12669/pjms.41.5.10658","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical efficacy of sacubitril-valsartan (SV) combined with rosuvastatin calcium (RC) in the treatment of patients with unstable angina pectoris (UAP).</p><p><strong>Methods: </strong>This was retrospective study. Eighty patients with UAP admitted to The First Affiliated Hospital of Yangtze University from December 2022 to December 2023 were included and divided into observation group (n=40) and control group (n=40) according to treatment regimens. Patients in the control group received RC, while the observation group received SV combined with RC. Clinical efficacy, adverse reactions, and blood lipid, hemorheology, and cardiac function before and six months after treatment were compared between the two groups.</p><p><strong>Results: </strong>The total efficacy of the observation group was higher than the control group (P<0.05). After six months of treatment, the levels of TG, TC, and LDL-C decreased in both groups, with the observation group showing more significant decrease, while the HDL-C level increased, with the observation group showing more significant increase (P<0.05); The hemorheological indicators of both groups decreased compared to before treatment, and the degree of decrease was more significant in the observation group (P<0.05); Both groups showed significant improvement in cardiac function levels compared to before treatment, with the observation group showing more pronounced improvement (P<0.05). The incidence of adverse reactions in both were not statistically significant different (P=0.712).</p><p><strong>Conclusion: </strong>The use of SV combined with RC in treatment of UPA has significant clinical effects, improving patients' blood lipids, hemorheology, and cardiac function indicators without increasing adverse reactions.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 5","pages":"1360-1364"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of obesity and other key risk factors on adverse outcomes in COVID-19 patients in critical care settings.","authors":"Mehwish Iftikhar, Amna Rizvi, Saba Zartash, Arsalan Nawaz","doi":"10.12669/pjms.41.5.9302","DOIUrl":"10.12669/pjms.41.5.9302","url":null,"abstract":"<p><strong>Background & objective: </strong>Although the global emergency caused by COVID-19 was officially declared over in 2023, the pandemic by no means has completely disappeared. Study explored the interconnection between obesity and critical outcomes in intensive care. Focusing on the infiltration of viruses and increased risk with obesity and other factors, this study provides insights for tailored interventions. This study is devised to establish the effect of obesity and other associated factors with outcomes of patients having COVID 19 infection in the critical care setting.</p><p><strong>Methods: </strong>This observational study was performed in the COVID-19 ICU of Services Hospital Lahore from December 10, 2020 to February 10, 2021. One hundred fifty consecutive COVID-PCR positive, conscious patients with Age (18-80 years) and BMI (18 to ≥ 40) were included. Patients with inability to provide informed consent and pregnancy were excluded. BMI was categorized into non-obese (18-29.9) and obese (≥ 30), with outcomes assessed during ICU stay. Analysis involved descriptive statistics and logistic regression to predict outcomes.</p><p><strong>Results: </strong>Study showed an average age of 59.73 years, BMI 30.14 kg/m², and 80.66% baseline O2 levels. BMI's had significant impact on COVID-19 outcomes, emphasizing its association with severity, comorbidities, ARDS, and mortality (p<0.05). Logistic regression indicates BMI, SpO2, and HCO3 significantly predict outcomes, with increased BMI elevating mortality risk, while decreased SpO2 and HCO3 increase mortality likelihood (p<0.05).</p><p><strong>Conclusion: </strong>These findings highlight considering obesity as a critical factor in COVID-19 prognosis. This research has contributed valuable insights needed to grapple with the complexities of the pandemic.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 5","pages":"1337-1343"},"PeriodicalIF":1.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12130940/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144226234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}