Pakistan Journal of Medical Sciences最新文献

{"title":"Serum Neuropeptide FFR2 is increased in pregnant women with pre-eclampsia and associated with pregnancy outcomes.","authors":"Ummu Tas, Sedat Tas, Tuncay Kume, Ozgur Yilmaz","doi":"10.12669/pjms.41.2.10591","DOIUrl":"10.12669/pjms.41.2.10591","url":null,"abstract":"<p><strong>Objectives: </strong>NPFFR2 is a biomarker produced by the placenta during pregnancy and is thought to be associated with in various physiological processes, including pain modulation, opioid receptor regulation, and cardiovascular function. Pre-eclampsia (PE) is a major public health concern due to its links with cardiovascular disease (CVD), stroke and neonatal morbidity and mortality. Consequently, timely diagnosis and efficient management of PE are essential for both maternal and neonatal health. This study aimed to conduct a comparative analysis of neuropeptide FFR2 (NPFFR2), echocardiographic evaluation results, and pregnancy outcomes in pregnant women with and without PE.</p><p><strong>Methods: </strong>This is a prospective case-control study. It included 94 pregnant participants who applied to Manisa City Hospital between October 2021 to January 2023 and were grouped into women with PE (n = 47) and those without PE (n = 47). Biochemical and NPFFR2 analyses were performed using the blood samples collected from all participants, along with echocardiography and 24 hours. Ambulatory blood pressure monitoring (ABPM). A p-value <0.05 was considered statistically significant.</p><p><strong>Results: </strong>The study group comprised 94 pregnant women with a mean age of 29.2 years and mean gestational age of 27.6 weeks. The preeclampsia group had a significantly higher NPFFR2 levels, lower gestational age at birth and higher all 24-hours ABPM findings. The left atrial-to-aortic ratio and right ventricle myocardial performance index were significantly higher and EA ratio was significantly lower in the preeclampsia group than in the control group. NPFFR2, gestational age at birth, LDL cholesterol, and body mass index were found to be independently associated with neonatal intensive care unit admission.</p><p><strong>Conclusions: </strong>The women with PE presented with increased serum NPFFR2 levels and the prognosis of pregnancy was associated with NPFFR2 levels.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"378-383"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical analysis of the correlation between nutritional risk screening and prognosis of patients with chronic obstructive pulmonary disease.","authors":"Qinghua Wu, Najuan Cui, BeiBei Wang","doi":"10.12669/pjms.41.2.9566","DOIUrl":"10.12669/pjms.41.2.9566","url":null,"abstract":"<p><strong>Objective: </strong>To explore the clinical correlation between nutritional risk screening and prognosis of patients with chronic obstructive pulmonary disease (COPD).</p><p><strong>Method: </strong>Clinical data of 80 patients with COPD admitted to Beijing Hospital of integrated Traditional Chinese and Western Medicine between August 2020 and August 2023 were retrospectively analyzed. Patients were divided into the Mortality group (n=17) and the survival group (n=63) according to the three years follow-up outcomes. The related data were compared between the two groups, the prognostic factors were analyzed, and the correlation between nutritional risk and prognostic risk factors was explored. The value of nutritional risk in prognosis prediction was analyzed by ROC curve.</p><p><strong>Result: </strong>Binary logistic regression analysis showed that complications (>2), NRS2002 score (nutritional risk), albumin (ALB), number of acute exacerbations of COPD (AECOPD) (≥2), pulmonary dysfunction (moderate to severe), and ventilator-associated pneumonia (VAP) after admission were prognostic risk factors (P<0.05). Complications, number of AECOPD, pulmonary dysfunction, and ALB were correlated with nutritional status (P<0.05). ROC curve analysis found that the AUC of NRS2002 score in prognosis prediction was 0.679(95%CI, 0.549-0.810), with a sensitivity of 88.2%, and a specificity of 47.6%, indicating the predictive value of this variable.</p><p><strong>Conclusion: </strong>Complications (>2), NRS2002 score (nutritional risk), ALB, number of AECOPD (≥2), pulmonary dysfunction (moderate to severe), and VAP after admission are prognostic risk factors. Nutritional status may be closely related to prognostic risk factors and might be used as a predictor for prognosis.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"608-613"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contribution from the SAARC Region to Ophthalmic Research: A Bibliometric Analysis.","authors":"Yousaf Jamal Mahsood, Rima Khan, Hira Wakil, Saima Farooq, Rashid Zia","doi":"10.12669/pjms.41.2.10581","DOIUrl":"10.12669/pjms.41.2.10581","url":null,"abstract":"<p><strong>Objective: </strong>To review the contributions to the ophthalmic research from the SAARC region in the top twenty ophthalmology journals.</p><p><strong>Methods: </strong>This was a bibliometric study and the top 20 ophthalmology journals, as ranked by the Scimago Journal Rankings (SJR) from 2021 and 2022 (two years), were selected for analysis. Only original research articles were included in the analysis. Articles were analysed based on authorship, corresponding authorship, and research centres within the South Asian Association for Regional Cooperation (SAARC) region (Afghanistan, Bangladesh, Bhutan, India, Maldives, Nepal, Pakistan, and Sri Lanka). The main research topics were also examined. This data was recorded on Microsoft excel sheet and then descriptive analysis were calculated.</p><p><strong>Results: </strong>Of the total 4952 articles reviewed, 208 (4.2%) had authorship from the SAARC region. Of the 38079 authors in total, 1133 (2.97%) were from the SAARC region and 715 (63.1%) were male. The authors from India contributed the most (n=1074, 94.8%) articles. Of the 155 corresponding authors from SAARC, 150 (96.78%) were from India. Research centres from India were the leading contributors, (n=166, 93.26%). Out of all the publications, medical retina accounted for 1546 (31.22%) of the total articles.</p><p><strong>Conclusions: </strong>Compared to its share of the world's population, the SAARC region's research contribution to the top twenty ophthalmology journals is nominal.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"614-621"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803768/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The predictive value of placental growth factor combined with uterine ultrasound arterial blood flow characteristics for preeclampsia.","authors":"Fengmei Xiao, Caiqiu Li, Xiaoying Wang, Jun Li","doi":"10.12669/pjms.41.2.11349","DOIUrl":"10.12669/pjms.41.2.11349","url":null,"abstract":"<p><strong>Objective: </strong>To study the predictive value of placental growth factor (PLGF) combined with uterine ultrasound artery blood flow characteristics in preeclampsia (PE).</p><p><strong>Methods: </strong>The retrospective cohort study included singleton pregnant women who admitted for prenatal examinations at the Yongkang First People's Hospital between February 2021 to November 2023. Based on whether the pregnant women had PE and the severity of PE, they were divided into Control group, Severe PE group and Mild PE group. Levels of PLGF and ultrasound arterial blood flow parameters were compared between the groups, and the sensitivity and specificity of the above indicators were calculated.</p><p><strong>Results: </strong>This study included one hundred pregnant women with PE in the analysis, with 29 in the Severe PE group and 71 in the Mild PE group. Additionally, 100 healthy pregnant women without PE were included in the control group. Levels of PLGF, resistance index (RI), pulsatility index (PI), and systolic/diastolic blood flow ratio (S/D) were statistically different between the groups (<i>P</i><0.05). Logistic analysis showed that PLGF, RI, PI, and S/D were risk factors for the onset of PE (<i>P</i><0.05). Receiver operating characteristic (ROC) curve analysis showed that the combined prediction value of PLGF, RI, PI, and S/D for PE was significantly higher than the individual prediction of each indicator (<i>P</i><0.05).</p><p><strong>Conclusions: </strong>PE was significantly associated with decreased levels of PLGF and increased RI, PI, and S/D in pregnant women. These indexes can serve as important indicators for predicting the onset of preeclampsia, especially when they are combined.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"426-431"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803773/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Wii Fit-based Exercises versus proprioceptive training on balance and fall risk in patients with diabetic neuropathy.","authors":"Syed Shakil Ur Rehman, Danish Hassan, Maryam Ikram, Mehwish Ikram","doi":"10.12669/pjms.41.2.8775","DOIUrl":"10.12669/pjms.41.2.8775","url":null,"abstract":"<p><strong>Objective: </strong>To determine the effects of Wii Fit-based exercises and proprioceptive training on balance and fall risk in diabetic neuropathy patients.</p><p><strong>Methods: </strong>This randomized clinical trial was conducted in Riphah Rehabilitation Centre, Lahore, between March 2022 to August 2022 (duration six months). Thirty-four participants were included, twenty males and fourteen females. Participants were randomly allocated into two groups. Group-A received Wii Fit-based exercises thrice a week for six weeks and Group-B received Proprioceptive training thrice a week for six weeks. Pre and post-measurements of balance and risk fall were assessed through Berg Balance Scale (BBS), Modified Fall Efficacy Scale (MFES), and Timed Up and Go test (TUG).</p><p><strong>Results: </strong>Thirty-four participants (20 males and 14 females) were allocated in each group, with a mean age of 62±9.21. The normality test (Shaphiro-Wilk Test, p>0.05) of BBS, MFES, and TUG summarized that data was normally distributed. Six weeks of treatment sessions have shown no significant difference between both groups (p>0.05). However, the within-group comparisons showed significant results that indicate the clinical effects of both treatments (p<0.05).</p><p><strong>Conclusion: </strong>It was concluded that there was no difference between Wii Fit exercises and proprioceptive training on balance and risk of falls in diabetic neuropathic patients. <b><i>Trial Registration Number:</i></b> This study was registered at ClinicalTrials.gov ID: NCT05282602 on date 16/03/2022.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"393-398"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803812/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling gender disparities among medical faculty in a developing country: A case study of a public sector teaching hospital, Peshawar, Pakistan.","authors":"Mudir Khan, Brekhna Jamil, Bushra Mehboob, Uzma Bibi","doi":"10.12669/pjms.41.2.9616","DOIUrl":"10.12669/pjms.41.2.9616","url":null,"abstract":"<p><strong>Objective: </strong>To explore the gendered experiences of medical faculty in tertiary care hospitals in Pakistan.</p><p><strong>Method: </strong>A qualitative exploratory study was conducted using a semi-structured interview guide in Lady Reading Hospital, Peshawar from 1st April to 30th September 2023. A purposive sampling technique was employed, and data was interpreted using Ackers's theory of Gendered Organization. Two Focus Group Discussions (FGDs) and six interviews were conducted and transcribed for data analysis. Braun and Clark's thematic analysis was used for data analysis.</p><p><strong>Results: </strong>Five themes and twelve sub-themes emerged after data analysis. Most male faculty accepted that gender disparity exists in medical institutions and found an element of ignorance in their responses. On the other hand, most females declared the existence of gender bias in administration, career opportunities, working environment, and basic facilities. Findings revealed the dependency of females on males. A huge gap was also found in policy regarding gender disparity.</p><p><strong>Conclusion: </strong>Gender disparity exists everywhere because of patriarchal structures. Study unmasked the workplace realities of both genders within medical institutes. Mainly found that females become more victims of this issue. Women lag behind due to the disparity prevalent among both genders.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"548-553"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803772/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Guided Percutaneous Catheter Drainage in Periappendiceal abscess Management: Retrospective Insights.","authors":"Ying-Bin Ding, Wei-Na Wang, Xue-Lei Zhan","doi":"10.12669/pjms.41.2.10211","DOIUrl":"10.12669/pjms.41.2.10211","url":null,"abstract":"<p><strong>Objective: </strong>To retrospectively evaluate the comparative efficacy and safety of percutaneous catheter drainage (PCD) combined with antibiotic therapy versus emergency laparoscopic surgery (ELS) for treating periappendiceal abscesses.</p><p><strong>Methods: </strong>A retrospective study was conducted on 90 patients diagnosed with periappendiceal abscesses at Harbin Hospital of Traditional Chinese Medicine between March 2022 and December 2023. The study compared clinical outcomes between two groups: one receiving percutaneous catheter drainage (PCD) with antibiotic therapy and the other undergoing emergency laparoscopic surgery. The comparison encompassed key outcomes such as operative time, gastrointestinal function recovery, length of hospital stays, postoperative complication rate, recurrence rate, and the need for additional interventions.</p><p><strong>Results: </strong>The PCD group exhibited a significantly shorter operative time (<i>P</i>=0.02) and fewer postoperative complications (<i>P</i>=0.008) compared to the ELS group. During outpatient follow-up, six patients in the PCD group had a recurrence of appendicitis, which was statistically significant compared to the ELS group.</p><p><strong>Conclusion: </strong>Ultrasound-guided PCD has been shown to be effective and safe in the management of periappendiceal abscesses in our single-center clinical study. It offers several benefits over ELS, such as reduced operative time and a decreased incidence of postoperative complications. Our results suggest that PCD, in conjunction with antibiotic therapy, is a feasible alternative to surgery, significantly reducing patient discomfort and healthcare resource consumption. However, these findings are specific to our center, and further multicenter studies are required to confirm these results and to establish guidelines for the optimal application of PCD in clinical practice.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"564-568"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of risk factors for death during treatment of hemodynamically unstable pelvic fractures.","authors":"Dazhi Wang, Jungang Xiao, Kaifu Zheng","doi":"10.12669/pjms.41.2.9808","DOIUrl":"10.12669/pjms.41.2.9808","url":null,"abstract":"<p><strong>Objective: </strong>To analyze the risk factors associated with the occurrence of death during the treatment of patients with hemodynamically unstable pelvic fractures.</p><p><strong>Methods: </strong>The present study is a retrospective research design, which selected 136 patients with hemodynamically unstable pelvic fractures admitted to China Resource & WISCO General Hospital from March 2020 to March 2022 as the subjects of the study. They were divided into a survival group (113 cases) and a death group (23 cases) according to whether the patients died during treatment. The general clinical data and laboratory test indexes of the two groups were compared to analyze the risk factors affecting the death of pelvic fracture patients. Receiver operator characteristic (ROC) curves were plotted, and the area under the curve was calculated.</p><p><strong>Results: </strong>The two groups were significantly different in aspects of age, systolic blood pressure, rapid emergency medicine score, injury severity score (ISS), sequential organ failure assessment (SOFA) score, prothrombin time, activated partial thromboplastin time, and percentages of patients with bleeding volume > 2,000 mL, shock index > 2, and minimum oxygenation index < 200 (P<0.05). Logistic regression analysis suggested that shock index > 2, ISS, SOFA score, and bleeding volume > 2,000 mL were independent risk factors for patient death. ROC analysis showed that the area under the curve for shock index > 2, ISS, SOFA score, and bleeding volume > 2,000 mL was 0.656, 0.732, 0.907, and 0.798, respectively.</p><p><strong>Conclusions: </strong>Severe shock, increased ISS and SOFA score, and bleeding are independent risk factors for death in patients with hemodynamically unstable pelvic fractures. Implementation of rapid and efficient targeted management during treatment of high-risk patients with these factors is key to reducing their risk of death.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"559-563"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post liver transplant metabolic syndrome: Frequency, predictors and outcome.","authors":"Zoha Rahim, Kashif Malik, Shahid Sarwar, Adnan Salim","doi":"10.12669/pjms.41.2.10774","DOIUrl":"10.12669/pjms.41.2.10774","url":null,"abstract":"<p><strong>Objective: </strong>To determine frequency of post-transplant metabolic syndrome (PTMS) after liver transplantation (LT), its pre-transplant predictors and its association with cardiovascular events.</p><p><strong>Methods: </strong>In this observational, analytical cross-sectional study done at Gastroenterology Department, Shaikh Zayed Post Graduate Medical Institute Lahore from January 2021 to March 2023, pre-transplant data of patients having LT for > 1 year including etiology of liver disease, presence of metabolic syndrome (MS), diabetes mellitus (DM), hypertension (HTN) and obesity were noted. Post-transplant evaluation was done to document DM, HTN, Dyslipidemia, obesity, PTMS and cardiovascular events after LT. Student's t test and chi square were used for correlation and linear regression for multivariate analysis.</p><p><strong>Results: </strong>Total of 111 post LT patients with mean age 45.2 (±10.45) and male to female ratio 6.4/1 (96/15) were included. Before LT, 15(13.5%) patients had DM, 11 (9.9%) had HTN, 48(43.2%) were obese and MS was present in 13 (11.7%) patients. Median duration since LT was three years. Post LT, PTMS developed in 60(54.1%) patients, 64(57.7%) had DM, 27(24.3%) had HTN, dyslipidemia was noted in 60(54.1%) patients and 69(62.2%) were obese. Presence of DM (OR 15.21; p< 0.001), HTN (OR 10.00; p=0.01) and MS (OR 12.50; p=0.003) before transplant was significantly associated with development of PTMS. No significant difference in development of cardiovascular events was noted in patients with and without PTMS.</p><p><strong>Conclusion: </strong>Post transplant metabolic syndrome develops in majority of LT patients, risk is higher in those with diabetes mellitus, hypertension and metabolic syndrome before liver transplantation.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"531-535"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803791/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143382920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive Value of Transabdominal Ultrasonography in Detecting Extrahepatic Bile Duct Obstructive Lesions Compared with Endoscopic Retrograde Cholangiopancreatography.","authors":"Abdulkhaleq Ayedh Binnuhaid, Sultan Abdulwadoud Alshoabi, Fahad H Alhazmi, Awadia Gareeballah, Faisal A Alrehily, Abdulaziz A Qurashi","doi":"10.12669/pjms.41.2.9613","DOIUrl":"10.12669/pjms.41.2.9613","url":null,"abstract":"<p><strong>Background & objective: </strong>Transabdominal ultrasonography (TAUS) remains the initial imaging modality in diagnosis of bile duct obstructive lesions. The purpose of this study was to investigate the predictive value of TAUS in detecting bile duct obstructive lesions in comparison with endoscopic retrograde cholangiopancreatography (ERCP) as the standard method.</p><p><strong>Methods: </strong>This retrospective descriptive study analyzed the electronic records of the patients diagnosed with obstructive jaundice from April 2017 to November 2022 at Alsafwa Consultative Medical Center in Almukalla City, Hadhramout, Yemen. All patients involved were diagnosed by TAUS and the diagnosis was confirmed by ERCP. A comparison of the diagnoses was performed.</p><p><strong>Results: </strong>TAUS and ERCP demonstrated high compatibility in bile duct obstructive lesions, with substantial agreement in detecting cholangiocarcinoma, bile duct stricture, stones, pancreatic cancer, and ampulla of Vater mass (compatibility ranging from 71.4% to 100%, Cohen's Kappa = 0.748, <i>p</i> < 0.001). Pearson correlation indicated strong agreement between the two methods (r=0.856). TAUS showed high sensitivity, and positive predictive value (PPV), particularly for bile duct stones (99.4% sensitivity, 86.7% PPV), and pancreatic carcinoma (94.3% sensitivity, 82.5% PPV), with significant effectiveness in identifying other conditions like bile duct stricture (42.6% sensitivity, 88.5% PPV) and cholangiocarcinoma (70.6% sensitivity, 100% PPV). (<i>p</i><0.001). Overall, TAUS and ERCP displayed excellent compatibility across various diagnoses, with near-perfect agreement in determining the causes in the ampulla of Vater and bile duct (Kappa= 0.899, p<0.001).</p><p><strong>Conclusion: </strong>TAUS is a reliable and highly valuable imaging modality for detecting and determining the cause and level of bile duct obstruction in patients with obstructive jaundice which offers a non-invasive approach, radiation free, with minimal risk of serious complications.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 2","pages":"384-392"},"PeriodicalIF":1.2,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143383038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}