Controlling nutritional status score is a predictor of survival in hepatocellular carcinoma: A meta-analysis and meta-regression.

IF 1.2 4区医学 Q2 MEDICINE, GENERAL & INTERNAL

Pakistan Journal of Medical Sciences Pub Date : 2025-04-01 DOI:10.12669/pjms.41.4.11660

Yi Chen, Hong Cao, Jia Yao

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引用次数: 0

Abstract

Objective: The controlling nutritional status score (CONUT) has been utilized for prognostication of several cancers but its utility for hepatocellular carcinoma (HCC) is still unclear. We reviewed evidence on the ability of CONUT to predict overall survival (OS) and disease-free survival (DFS) in patients with HCC.

Methods: Online repositories of PubMed, Embase, CENTRAL, and Web of Science were searched by two reviewers for English language studies and were available before 15^th March 2024. Hazard ratio (HR) and 95% confidence intervals were calculated for both OS and DFS.

Results: A total of fourteen studies were available. Meta-analysis showed that CONUT was a significant predictor for OS (HR: 1.64 95% CI: 1.30, 2.06) and DFS (HR: 1.32 95% CI: 1.17, 1.50) in HCC. The effect size failed to change in significance on sensitivity analysis. Subgroup analysis based on country and treatment of HCC did not change the results. Subgroup analysis and meta-regression showed that a higher CONUT cut-off led to a stronger association between CONUT and OS in HCC.

Conclusions: CONUT can be an easy-to-use and rapid prognostic indicator for HCC. High CONUT scores are associated with worse OS and DFS.

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控制营养状态评分是肝细胞癌患者生存的一个预测因子：荟萃分析和荟萃回归。

目的：控制营养状态评分（CONUT）已被用于几种癌症的预后，但其在肝细胞癌（HCC）中的应用尚不清楚。我们回顾了CONUT预测HCC患者总生存期（OS）和无病生存期（DFS）能力的证据。方法：由两位审稿人检索PubMed、Embase、CENTRAL和Web of Science的在线知识库，检索2024年3月15日之前可用的英语语言研究。计算OS和DFS的风险比（HR）和95%置信区间。结果：共有14项研究。荟萃分析显示，CONUT是HCC患者OS （HR: 1.64 95% CI: 1.30, 2.06）和DFS （HR: 1.32 95% CI: 1.17, 1.50）的重要预测因子。在敏感性分析中，效应量没有显著性变化。基于国家和HCC治疗的亚组分析没有改变结果。亚组分析和meta回归显示，较高的CONUT截止值导致HCC中CONUT与OS之间的关联更强。结论：CONUT是一种简便、快速的HCC预后指标。CONUT评分越高，OS和DFS越差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pakistan Journal of Medical Sciences 医学-医学：内科

CiteScore

4.10

自引率

9.10%

发文量

363

审稿时长

3-6 weeks

期刊介绍： It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.