Ipek Guney Varal, Ezgi Deniz Acar Celik, Pelin Dogan, Gaffari Tunc, Ayse Oren
{"title":"平均血小板体积水平对早产儿生发基质出血-脑室内出血的预后价值。","authors":"Ipek Guney Varal, Ezgi Deniz Acar Celik, Pelin Dogan, Gaffari Tunc, Ayse Oren","doi":"10.12669/pjms.41.4.11642","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>Germinal matrix hemorrhage and intraventricular hemorrhage (GMH-IVH) is currently the most significant cause of brain damage and mortality seen in preterm infants. The aim of this study was to evaluate the predictive value of mean platelet volume (MPV) in diagnosing GMH-IVH and mortality.</p><p><strong>Method: </strong>A retrospective-cohort study of preterm infants with a gestational age <32 weeks or with birthweight <1500gr who were admitted to the Neonatal Intensive Care Unit was conducted between January 2020 and January 2022. These infants were then classified into two groups according to the presence of GMH-IVH.</p><p><strong>Results: </strong>Overall, 136 preterm infants were enrolled. The MPV levels were significantly higher in the GMH-IVH group (p <0.001). A MPV cutoff of >9.95 was determined to be predictive for GMH-IVH with sensitivity of 62% and specificity of 80% (p < 0.001). Mortality was significantly higher in the GMH-IVH group (p<0.001). A MPV cutoff of >10.55 fL was determined to predict mortality with 77% sensitivity and 70% specificity (p < 0.001).</p><p><strong>Conclusions: </strong>The MPV value is significantly higher in infants with GMH-IVH and therefore can be used in the prediction of GMH-IVH and mortality in preterm infants.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 4","pages":"1145-1150"},"PeriodicalIF":1.2000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022600/pdf/","citationCount":"0","resultStr":"{\"title\":\"The prognostic value of mean platelet volume levels in germinal matrix hemorrhage- intraventricular hemorrhage in preterm infants.\",\"authors\":\"Ipek Guney Varal, Ezgi Deniz Acar Celik, Pelin Dogan, Gaffari Tunc, Ayse Oren\",\"doi\":\"10.12669/pjms.41.4.11642\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>Germinal matrix hemorrhage and intraventricular hemorrhage (GMH-IVH) is currently the most significant cause of brain damage and mortality seen in preterm infants. The aim of this study was to evaluate the predictive value of mean platelet volume (MPV) in diagnosing GMH-IVH and mortality.</p><p><strong>Method: </strong>A retrospective-cohort study of preterm infants with a gestational age <32 weeks or with birthweight <1500gr who were admitted to the Neonatal Intensive Care Unit was conducted between January 2020 and January 2022. These infants were then classified into two groups according to the presence of GMH-IVH.</p><p><strong>Results: </strong>Overall, 136 preterm infants were enrolled. The MPV levels were significantly higher in the GMH-IVH group (p <0.001). A MPV cutoff of >9.95 was determined to be predictive for GMH-IVH with sensitivity of 62% and specificity of 80% (p < 0.001). Mortality was significantly higher in the GMH-IVH group (p<0.001). A MPV cutoff of >10.55 fL was determined to predict mortality with 77% sensitivity and 70% specificity (p < 0.001).</p><p><strong>Conclusions: </strong>The MPV value is significantly higher in infants with GMH-IVH and therefore can be used in the prediction of GMH-IVH and mortality in preterm infants.</p>\",\"PeriodicalId\":19958,\"journal\":{\"name\":\"Pakistan Journal of Medical Sciences\",\"volume\":\"41 4\",\"pages\":\"1145-1150\"},\"PeriodicalIF\":1.2000,\"publicationDate\":\"2025-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022600/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pakistan Journal of Medical Sciences\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.12669/pjms.41.4.11642\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"MEDICINE, GENERAL & INTERNAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Journal of Medical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12669/pjms.41.4.11642","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
The prognostic value of mean platelet volume levels in germinal matrix hemorrhage- intraventricular hemorrhage in preterm infants.
Objective: Germinal matrix hemorrhage and intraventricular hemorrhage (GMH-IVH) is currently the most significant cause of brain damage and mortality seen in preterm infants. The aim of this study was to evaluate the predictive value of mean platelet volume (MPV) in diagnosing GMH-IVH and mortality.
Method: A retrospective-cohort study of preterm infants with a gestational age <32 weeks or with birthweight <1500gr who were admitted to the Neonatal Intensive Care Unit was conducted between January 2020 and January 2022. These infants were then classified into two groups according to the presence of GMH-IVH.
Results: Overall, 136 preterm infants were enrolled. The MPV levels were significantly higher in the GMH-IVH group (p <0.001). A MPV cutoff of >9.95 was determined to be predictive for GMH-IVH with sensitivity of 62% and specificity of 80% (p < 0.001). Mortality was significantly higher in the GMH-IVH group (p<0.001). A MPV cutoff of >10.55 fL was determined to predict mortality with 77% sensitivity and 70% specificity (p < 0.001).
Conclusions: The MPV value is significantly higher in infants with GMH-IVH and therefore can be used in the prediction of GMH-IVH and mortality in preterm infants.
期刊介绍：
It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad.
Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.
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