经皮椎体后凸成形术联合不同抗骨质疏松药物治疗骨质疏松性椎体压缩性骨折。

IF 1.2 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Weiliang Du, Wenshuai Li, Lixing Kang, Linfeng Wang
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引用次数: 0

摘要

目的:探讨经皮椎体后凸成形术(PKP)联合不同抗骨质疏松药物治疗骨质疏松性椎体压缩性骨折(OVCF)的疗效,评价联合治疗后的骨密度、疼痛、腰椎功能恢复及椎体再骨折发生率。方法:对河北医科大学第三医院2021年1月至2022年10月间行PKP治疗的138例OVCF患者的病历进行回顾性分析。其中,PKP后补钙加alfacalciferol组41例(a组),PKP后补钙加降钙素组58例(b组),PKP后补钙加降钙素加阿仑膦酸钠组39例(c组)。比较三组患者在PKP前后的骨密度、疼痛、腰椎功能恢复及椎体再骨折发生率。结果:PKP术后6个月和12个月,b组和c组骨密度t值显著高于a组(ppppp)。结论:在经皮后凸成形术后骨质疏松性椎体压缩性骨折的治疗中,钙治疗联合降钙素和阿仑膦酸钠治疗具有积极作用,可有效改善骨密度、疼痛和功能状态,减少椎体骨折的发生率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Percutaneous Kyphoplasty combined with different anti-osteoporosis drugs for the treatment of osteoporotic vertebral compression fractures.

Objective: To explore the effectiveness of percutaneous kyphoplasty (PKP) combined with different anti-osteoporosis drugs in the treatment of osteoporotic vertebral compression fractures (OVCF) by assessing bone mineral density, pain, lumbar functional recovery, and incidence of vertebral refractures after the combined therapy.

Methods: In this single-center retrospective study, medical records of 138 patients with OVCF who underwent PKP in the Third Hospital of Hebei Medical University between January 2021 and October 2022 were retrospectively analyzed. Among them, 41 patients treated with calcium and alfacalciferol supplementation after PKP (Group-A), 58 patients treated with calcium and calcitonin after PKP (Group-B), and 39 patients treated with calcium, calcitonin, and alendronate sodium after PKP (Group-C). Bone mineral density, pain, lumbar functional recovery, and incidence of vertebral refractures in the three groups were compared before and after PKP.

Results: At six and 12 months after PKP, bone density T-values of Group-B and Group-C were significantly higher than Group-A (P<0.05). The visual analogue scale (VAS) scores of Group-B and Group-C were significantly lower than Group-A (P<0.05). At 12 months after PKP, T-value of bone density in Group-C was significantly higher, while the VAS score was significantly lower than Group-B; At six months after PKP, the Cobb angle in Group-B and Group-C was significantly lower than Group-A (P<0.05). At 12 months after PKP, Oswestry disability index (ODI) and Cobb angle of Group-B and Group-C were significantly lower than Group-A, and the lowest in Group-C. The extent of vertebral loss in Group-C was significantly lower than Groups A and B (P<0.05).

Conclusions: In the treatment of osteoporotic vertebral compression fractures after percutaneous kyphoplasty, a combination of calcium therapy with calcitonin and alendronate sodium had a positive effect, which may effectively improve bone density, pain, and functional status, and reduce the incidence of vertebral body fractures.

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来源期刊
Pakistan Journal of Medical Sciences
Pakistan Journal of Medical Sciences 医学-医学:内科
CiteScore
4.10
自引率
9.10%
发文量
363
审稿时长
3-6 weeks
期刊介绍: It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad. Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.
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