{"title":"Can the geriatric nutritional risk index predict the risk of osteoporosis in the elderly? A systematic review and meta-analysis.","authors":"Wanghao Liu, Xiaoying Sun","doi":"10.12669/pjms.41.4.11539","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The elderly are at a high risk of malnutrition as well as osteoporosis. In this review, we examined if the geriatric nutritional risk index (GNRI) can predict the risk of osteoporosis in the elderly.</p><p><strong>Methods: </strong>In this PRISMA compliant systematic review we searched the electronic databases of PubMed, Embase, ScienceDirect, and Web of Science. The search included studies from inception of databases to December 29, 2023. All studies examining the association between GNRI and osteoporosis were included.</p><p><strong>Results: </strong>Seven studies were selected. All studies were cross-sectional in design. Meta-analysis of all seven studies showed that low GNRI was significantly associated with the risk of osteoporosis in elderly patients (OR: 1.33 95% CI: 1.15, 1.53). The interstudy heterogeneity was high as the I<sup>2</sup> value was 87%. Results did not change on sensitivity analysis. Subgroup analysis based on study location, presence of diabetes, sample size, GNRI cut-off, method to determine cut-off, and diagnostic criteria for osteoporosis showed mixed results.</p><p><strong>Conclusion: </strong>Low GNRI can be a simple marker for predicting osteoporosis in the elderly. Current evidence is from a few studies with a high risk of bias.</p>","PeriodicalId":19958,"journal":{"name":"Pakistan Journal of Medical Sciences","volume":"41 4","pages":"1219-1225"},"PeriodicalIF":1.2000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12022571/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Journal of Medical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.12669/pjms.41.4.11539","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0
Abstract
Objective: The elderly are at a high risk of malnutrition as well as osteoporosis. In this review, we examined if the geriatric nutritional risk index (GNRI) can predict the risk of osteoporosis in the elderly.
Methods: In this PRISMA compliant systematic review we searched the electronic databases of PubMed, Embase, ScienceDirect, and Web of Science. The search included studies from inception of databases to December 29, 2023. All studies examining the association between GNRI and osteoporosis were included.
Results: Seven studies were selected. All studies were cross-sectional in design. Meta-analysis of all seven studies showed that low GNRI was significantly associated with the risk of osteoporosis in elderly patients (OR: 1.33 95% CI: 1.15, 1.53). The interstudy heterogeneity was high as the I2 value was 87%. Results did not change on sensitivity analysis. Subgroup analysis based on study location, presence of diabetes, sample size, GNRI cut-off, method to determine cut-off, and diagnostic criteria for osteoporosis showed mixed results.
Conclusion: Low GNRI can be a simple marker for predicting osteoporosis in the elderly. Current evidence is from a few studies with a high risk of bias.
期刊介绍:
It is a peer reviewed medical journal published regularly since 1984. It was previously known as quarterly "SPECIALIST" till December 31st 1999. It publishes original research articles, review articles, current practices, short communications & case reports. It attracts manuscripts not only from within Pakistan but also from over fifty countries from abroad.
Copies of PJMS are sent to all the import medical libraries all over Pakistan and overseas particularly in South East Asia and Asia Pacific besides WHO EMRO Region countries. Eminent members of the medical profession at home and abroad regularly contribute their write-ups, manuscripts in our publications. We pursue an independent editorial policy, which allows an opportunity to the healthcare professionals to express their views without any fear or favour. That is why many opinion makers among the medical and pharmaceutical profession use this publication to communicate their viewpoint.