Pathobiology最新文献_第6页

Current challenges in the characterization of myeloid neoplasms 髓系肿瘤特征描述目前面临的挑战

IF 5 4区医学

Pathobiology Pub Date : 2023-12-22 DOI: 10.1159/000535852

Julia T. Geyer

引用次数: 0

Contents 2023 Vol. 90 目录 2023 卷 90

IF 5 4区医学

Pathobiology Pub Date : 2023-12-01 DOI: 10.1159/000535593

Ettenheim Stückle Druck, Fernando C. Schmitt, Pedro L. Fernández, Alexander Katalinic – Institut, Jose A. Lorente, Antonio Marra – Memorial, Stefano A. Pileri – European, Q. T. Pham, Hiroshima, Ho Chi, Minh, E. Dorado-Fernández, Madrid Aso-Escario, J. Aso-Vizán, A. Zaragoza, I. Ramírez-González, Guadalajara, Madrid, M. F. Carrillo-Rodríguez, D. Cáceres-Monllor, J. Murillo-González, M. J. Brito, Almada, Lisboa, E. M. Halushka, M.K.

引用次数: 0

Essential Roles of TDO2 in Gastric Cancer: TDO2 Is Associated with Cancer Progression, Patient Survival, PD-L1 Expression, and Cancer Stem Cells. TDO2在胃癌中的重要作用:TDO2与癌症进展、患者生存、PD-L1表达和癌症干细胞相关。

IF 5 4区医学

Pathobiology Pub Date : 2023-01-01 DOI: 10.1159/000523750

Quoc Thang Pham, Daiki Taniyama, Shintaro Akabane, Tsuyoshi Takashima, Ryota Maruyama, Yohei Sekino, Kazuhiro Sentani, Wataru Yasui, Naohide Oue

{"title":"Essential Roles of TDO2 in Gastric Cancer: TDO2 Is Associated with Cancer Progression, Patient Survival, PD-L1 Expression, and Cancer Stem Cells.","authors":"Quoc Thang Pham, Daiki Taniyama, Shintaro Akabane, Tsuyoshi Takashima, Ryota Maruyama, Yohei Sekino, Kazuhiro Sentani, Wataru Yasui, Naohide Oue","doi":"10.1159/000523750","DOIUrl":"https://doi.org/10.1159/000523750","url":null,"abstract":"Introduction: Tryptophan metabolism has been shown to be involved in tumor development. Two main tryptophan-degrading enzymes, tryptophan 2,3-dioxygenase (TDO2) and indoleamine 2,3-dioxygenase 1 (IDO1), may potently promote cancer cell survival and distant metastasis in diverse types of cancer, such as lung and breast cancer. IDO1 overexpression is an independent prognosticator in gastric cancer (GC). This work aimed to uncover the expression of TDO2 and its clinicopathologic significance in GC.Methods: TDO2 expression was evaluated in public data of The Cancer Genome Atlas cohort STAD and in two different GC cohorts. Correlation between TDO2 and immune cell infiltrates as well as PD-L1 tumor staining was investigated. The biofunction of TDO2 was examined with MTT, colony formation, and spheroid formation assays by RNA interference.Results: TDO2 expression was correlated with both progressive disease and clinical outcome, and its expression was an independent predictor of prognosis in GC. TDO2 expression was correlated with infiltration of immune cells and tumor expression of PD-L1. Inhibition of TDO2 expression suppressed cell proliferation, colony formation, and cell invasion of GC cells. Additionally, suppression of TDO2 expression inhibited spheroid body-formation and viability of GC organoids.Conclusion: Our data show that TDO2 might be a crucial marker for predicting prognosis and targeted therapy in GC.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"90 1","pages":"44-55"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9180099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Disruptive and Truncating TP53 Mutations Are Associated with African-Ancestry and Worse Prognosis in Brazilian Patients with Lung Adenocarcinoma. 破坏性和截短性TP53突变与巴西肺腺癌患者的非洲祖先和更糟糕的预后有关。

IF 5 4区医学

Pathobiology Pub Date : 2023-01-01 Epub Date: 2023-04-08 DOI: 10.1159/000530587

Rodrigo de Oliveira Cavagna, Icaro Alves Pinto, Flávia Escremim de Paula, Gustavo Noriz Berardinelli, Débora Sant'Anna, Iara Santana, Vinicius Duval da Silva, Eduardo Caetano Albino Da Silva, José Elias Miziara, Josiane Mourão Dias, Augusto Antoniazzi, Alexandre Jacinto, Pedro De Marchi, Miguel Angel Molina-Vila, Leticia Ferro Leal, Rui Manuel Reis

{"title":"Disruptive and Truncating TP53 Mutations Are Associated with African-Ancestry and Worse Prognosis in Brazilian Patients with Lung Adenocarcinoma.","authors":"Rodrigo de Oliveira Cavagna, Icaro Alves Pinto, Flávia Escremim de Paula, Gustavo Noriz Berardinelli, Débora Sant'Anna, Iara Santana, Vinicius Duval da Silva, Eduardo Caetano Albino Da Silva, José Elias Miziara, Josiane Mourão Dias, Augusto Antoniazzi, Alexandre Jacinto, Pedro De Marchi, Miguel Angel Molina-Vila, Leticia Ferro Leal, Rui Manuel Reis","doi":"10.1159/000530587","DOIUrl":"10.1159/000530587","url":null,"abstract":"Introduction: TP53 is the most frequently mutated gene in lung tumors, but its prognostic role in admixed populations, such as Brazilians, remains unclear. In this study, we aimed to evaluate the frequency and clinicopathological impact of TP53 mutations in non-small cell lung cancer (NSCLC) patients in Brazil.Methods: We analyzed 446 NSCLC patients from Barretos Cancer Hospital. TP53 mutational status was evaluated through targeted next-generation sequencing (NGS) and the variants were biologically classified as disruptive/nondisruptive and as truncating/nontruncating. We also assessed genetic ancestry using 46 ancestry-informative markers. Analysis of lung adenocarcinomas from the cBioportal dataset was performed. We further examined associations of TP53 mutations with patients' clinicopathological features.Results: TP53 mutations were detected in 64.3% (n = 287/446) of NSCLC cases, with a prevalence of 60.4% (n = 221/366) in lung adenocarcinomas. TP53 mutations were associated with brain metastasis at diagnosis, tobacco consumption, and higher African ancestry. Disruptive and truncating mutations were associated with a younger age at diagnosis. Additionally, cBioportal dataset revealed that TP53 mutations were associated with younger age and Black skin color. Patients harboring disruptive/truncating TP53 mutations had worse overall survival than nondisruptive/nontruncating and wild-type patients.Conclusion: TP53 mutations are common in Brazilian lung adenocarcinomas, and their biological characterization as disruptive and truncating mutations is associated with African ancestry and shorter overall survival.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"344-355"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9257625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Tissue Fixation with a Formic Acid-Deprived Formalin Better Preserves DNA Integrity over Time. 组织固定与甲酸剥夺福尔马林更好地保存DNA完整性随着时间的推移。

IF 5 4区医学

Pathobiology Pub Date : 2023-01-01 DOI: 10.1159/000525523

Enrico Berrino, Laura Annaratone, Paolo Detillo, Dora Grassini, Alberto Bragoni, Anna Sapino, Benedetta Bussolati, Giovanni Bussolati, Caterina Marchiò

{"title":"Tissue Fixation with a Formic Acid-Deprived Formalin Better Preserves DNA Integrity over Time.","authors":"Enrico Berrino, Laura Annaratone, Paolo Detillo, Dora Grassini, Alberto Bragoni, Anna Sapino, Benedetta Bussolati, Giovanni Bussolati, Caterina Marchiò","doi":"10.1159/000525523","DOIUrl":"https://doi.org/10.1159/000525523","url":null,"abstract":"Introduction: Optimization of pre-analytic procedures and tissue processing is a basic requirement for reliable and reproducible data to be obtained. Tissue fixation in formalin represents the extensively favored method for surgical tissue specimen processing in diagnostic pathology; however, formalin fixation exerts a blasting effect on DNA and RNA.Methods: A formic acid-deprived formaldehyde solution was prepared by removing acids with an ion-exchange basic resin and the concentrated, acid-deprived formaldehyde (ADF) solution was employed to prepare a 4% ADF solution in 0.1 M phosphate buffer, pH 7.2-7.4. Human (n = 27) and mouse (n = 20) tissues were fixed in parallel and similar conditions in either ADF or neutral buffered formalin (NBF). DNAs and RNAs were extracted, and fragmentation analyses were performed.Results: Besides no significant differences in terms of extraction yield and absorbance ratio, ADF fixation reduced DNA fragmentation, i.e., the largest fragments (>5,000 bp) were significantly more prevalent in the DNAs purified from ADF-fixed tissues (p < 0.001 in both cohorts). Moreover, we observed that DNA preservation is more stable in ADF-fixed tissue compared to NBF-fixed tissues.Conclusion: Although DNA fragmentation in FFPE tissues is a multifactor process, we showed that the removal of formic acid is responsible for a significant improvement in DNA preservation.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"90 3","pages":"155-165"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9578500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Blood Liquid Biopsy in an Advanced Medullary Thyroid Carcinoma: A Case Study with Rearranged during Transfection Heterogeneity. 晚期甲状腺髓样癌的血液活检:转染异质性中重排的一例研究。

IF 5 4区医学

Pathobiology Pub Date : 2023-01-01 DOI: 10.1159/000527184

Josep Gumà, Karla Beatríz Peña, Francesc Riu, Clara Lucia-Gozálvez, Ana Vidaller, Vanesa Maldonado, David Parada

{"title":"Blood Liquid Biopsy in an Advanced Medullary Thyroid Carcinoma: A Case Study with Rearranged during Transfection Heterogeneity.","authors":"Josep Gumà, Karla Beatríz Peña, Francesc Riu, Clara Lucia-Gozálvez, Ana Vidaller, Vanesa Maldonado, David Parada","doi":"10.1159/000527184","DOIUrl":"https://doi.org/10.1159/000527184","url":null,"abstract":"Introduction: Liquid biopsy is an innovative and efficient method for studying circulating tumor DNA. In conjunction with innovative techniques such as next-generation sequencing, it can provide real-time information on prognostic and predictive factors.Case presentation: We report a case of advanced, unresectable medullary thyroid carcinoma with various rearranged during transfection (RET) and Kirsten rat sarcoma viral (KRAS) mutations in both blood liquid and tissue biopsies. After the initial failure of treatment with a tyrosine kinase inhibitor (TKI), a liquid biopsy analyzed by next-generation sequencing showed the presence of six different RET mutations and KRAS. Tissue biopsy also revealed two RET mutations. Due to these biopsy findings, the treatment was changed to another TKI, and the patient is now clinically stable.Discussion/conclusion: Liquid biopsy makes it possible to analyze different genetic alterations that may have implications as predictive factors. It also reveals tumor heterogeneity and its implications for prognostic factors.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"90 4","pages":"281-288"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9968930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Genetic Factors in Familial Manifestation of Primary Mediastinal Large B-Cell Lymphoma over Two Generations. 两代原发性纵隔大 B 细胞淋巴瘤家族表现的遗传因素

IF 5 4区医学

Pathobiology Pub Date : 2023-01-01 Epub Date: 2023-07-25 DOI: 10.1159/000532053

Darius Juskevicius, Pontus Lundberg, Alexandar Tzankov, Stefan Dirnhofer, Frank Stenner

{"title":"Genetic Factors in Familial Manifestation of Primary Mediastinal Large B-Cell Lymphoma over Two Generations.","authors":"Darius Juskevicius, Pontus Lundberg, Alexandar Tzankov, Stefan Dirnhofer, Frank Stenner","doi":"10.1159/000532053","DOIUrl":"10.1159/000532053","url":null,"abstract":"Introduction: Primary mediastinal large B-cell lymphoma (PMBL) is a rarely occurring lymphoid malignancy which typically affects young adults and presents itself as an anterior mediastinal mass. Gene expression profiling as well as somatic genetic analysis revealed that it is closely related to classical Hodgkin lymphoma, whereas morphologically, it tends to resemble diffuse large B-cell lymphoma. Familial clustering of PMBL is rare - only two reports have been published to date. While it is generally accepted that positive family history is associated with increased risk of developing a lymphoma, genetic risk factors which might predispose to PMBL are largely unknown.Case presentation: We performed germline and tumor genetic analyses by whole-exome sequencing and array-CGH of a family, in which the father and the son both developed a PMBL. Germline investigations of both affected patients and of their two unaffected family members have not been able to provide a single risk factor associated with lymphoma predisposition. In addition, genes that were previously implicated in increased risk for PMBL, namely MLL (KMT2A) and TIRAP, were found to be intact in all investigated family members. Somatic genetic investigations identified known as well as novel genetic aberrations in tumors of the affected subjects.Conclusion: We conclude that predisposition to a PMBL might be inherited through a combination of low- or moderate-risk factors and provide a shortlist of the most likely selected candidates, which can be used in future studies.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"422-428"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10733924/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9867626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

miR-142-3p Suppresses Invasion and Adhesion of Mesothelioma Cells by Downregulating ITGAV. miR-142-3p通过下调ITGAV抑制间皮瘤细胞的侵袭和粘附

IF 5 4区医学

Pathobiology Pub Date : 2023-01-01 DOI: 10.1159/000528670

Ihiro Endo, Vishwa Jeet Amatya, Kei Kushitani, Tetsuya Nakagiri, Kohei Aoe, Yukio Takeshima

{"title":"miR-142-3p Suppresses Invasion and Adhesion of Mesothelioma Cells by Downregulating ITGAV.","authors":"Ihiro Endo, Vishwa Jeet Amatya, Kei Kushitani, Tetsuya Nakagiri, Kohei Aoe, Yukio Takeshima","doi":"10.1159/000528670","DOIUrl":"https://doi.org/10.1159/000528670","url":null,"abstract":"Introduction: Malignant mesothelioma is an aggressive cancer associated with asbestos exposure. Currently, the efficacy of therapeutics is limited in malignant mesothelioma, and developing more effective therapies is the need of the hour. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), have attracted attention as therapeutic targets. To explore potential therapeutic targets, we focused on miR-142-3p expression, which was found to be significantly downregulated in mesothelioma cell lines in our previous study.Methods: Mesothelioma cell lines and tissues were validated for expression of miR-142-3p or integrin subunit alpha-V (ITGAV). We transfected mesothelioma cell lines with miR-142-3p mimic and ITGAV siRNA and analyzed their biological functions.Results: We found that miR-142-3p was significantly downregulated in mesothelioma tissues. Transfection with miR-142-3p mimic significantly suppressed cell proliferation, migration, and invasion. Bioinformatics analysis of potential targets of miR-142-3p identified ITGAV. Membrane ITGAV expression in mesothelioma cell lines was confirmed using immunocytochemistry. ITGAV was significantly upregulated in mesothelioma tissues. Moreover, transfection of miR-142-3p mimics into mesothelioma cell lines significantly suppressed ITGAV expression, indicating that miR-142-3p targets ITGAV. Next, ITGAV siRNA transfection into mesothelioma cell lines inhibited cell proliferation, migration, and invasion. Further investigation of cell adhesion mechanisms showed that the miR-142-3p/ITGAV axis specifically affects mesothelioma cell adhesion via vitronectin in the extracellular matrix.Conclusion: This study proposed that the miR-142-3p/ITGAV axis is involved in tumor progression in malignant mesothelioma.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"90 4","pages":"270-280"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9959931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Protocadherin B9 Is Associated with Human Esophageal Squamous Cell Carcinoma Progression. 原钙粘蛋白B9与人食管鳞状细胞癌进展相关

IF 5 4区医学

Pathobiology Pub Date : 2023-01-01 DOI: 10.1159/000523817

Yuto Fujiki, Akira Ishikawa, Shintaro Akabane, Shoichiro Mukai, Ryota Maruyama, Yuji Yamamoto, Aya Kido, Narutaka Katsuya, Daiki Taniyama, Kazuhiro Sentani, Naohide Oue, Wataru Yasui

{"title":"Protocadherin B9 Is Associated with Human Esophageal Squamous Cell Carcinoma Progression.","authors":"Yuto Fujiki, Akira Ishikawa, Shintaro Akabane, Shoichiro Mukai, Ryota Maruyama, Yuji Yamamoto, Aya Kido, Narutaka Katsuya, Daiki Taniyama, Kazuhiro Sentani, Naohide Oue, Wataru Yasui","doi":"10.1159/000523817","DOIUrl":"https://doi.org/10.1159/000523817","url":null,"abstract":"Introduction: Esophageal cancer is the sixth leading cause of cancer-related death worldwide. However, molecular targeted therapy and novel therapeutic targets are needed for esophageal squamous cell cancer (ESCC). In a previous study, we reported that protocadherin (PCDH) B9 plays an important role in several cancers. Therefore, in this study, we examined the clinical significance of PCDHB9 expression in ESCC.Methods: PCDHB9 expression was examined using immunohistochemistry in 128 cases and using quantitative reverse transcription-polymerase chain reaction in 16 cases of ESCC. PCDHB9 function in ESCC cells was examined using RNA interference.Results: High PCDHB9 expression was identified in 5 of 16 (31.3%). In total, 51 (40%) ESCC cases showed strong PCDHB9 expression, whereas nonneoplastic mucosa rarely showed its expression. High PCDHB9 expression was significantly associated with T classification, N grade, and stage in ESCC. In ESCC cell lines, PCDHB9 knockdown affected cell growth, migration, and adhesion. Further, the expression of integrin (ITG) A3, ITGA4, ITGA5, ITGB1, ITGB6, vimentin, snail family transcriptional repressor 1, and cadherin 2 (NCAD) was significantly reduced and cadherin 1 was significantly increased in PCDHB9 knockdown ESCC cells.Conclusion: These results suggest that PCDHB9 plays a tumor-promoting role and is a potential biomarker and therapeutic target in ESCC.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"90 1","pages":"13-21"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10612690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Case of Acute Plastic Deformation of the Forearm in a Medieval Hispano-Mudejar Skeleton (13-14th Centuries AD). 一具中世纪伊斯帕诺-穆德哈尔（Hispano-Mudejar）骸骨（公元 13-14 世纪）的前臂急性塑性变形病例。

IF 5 4区医学

Pathobiology Pub Date : 2023-01-01 Epub Date: 2022-05-03 DOI: 10.1159/000524452

Enrique Dorado-Fernández, José Aso-Escario, Alberto Aso-Vizán, Ildefonso Ramírez-González, Manuel F Carrillo-Rodríguez, David Cáceres-Monllor, Jorge Murillo-González

{"title":"A Case of Acute Plastic Deformation of the Forearm in a Medieval Hispano-Mudejar Skeleton (13-14th Centuries AD).","authors":"Enrique Dorado-Fernández, José Aso-Escario, Alberto Aso-Vizán, Ildefonso Ramírez-González, Manuel F Carrillo-Rodríguez, David Cáceres-Monllor, Jorge Murillo-González","doi":"10.1159/000524452","DOIUrl":"10.1159/000524452","url":null,"abstract":"Introduction: Acute plastic deformation refers to a traumatic bending or bowing without a detectable cortical defect.Case presentation and discussion: We describe a rare case from an individual that was exhumed from the Hispano-Mudejar necropolis in Uceda (Guadalajara, Spain) dated between the 13th and 14th centuries AD. The case corresponds to an adult woman, with a bowing involvement of the left ulna and radius. After making the differential diagnosis with various pathologies likely to present with this alteration, we reached the diagnosis of acute plastic deformation of the forearm through external and radiological examination and comparison with the healthy contralateral forearm.Conclusions: Acute plastic deformation is a rare traumatic injury, not described until the last century and only rarely described in palaeopathological contexts. We contribute a new case, the first being sufficiently documented, contributing to the knowledge and diagnosis of this type of trauma in the ancient bone, while deepening the knowledge of the living conditions of the medieval Mudejar population of Uceda.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"90 1","pages":"56-62"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10612701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0