Pathobiology最新文献

Galectin-1 expression in breast cancer stroma - prognostic value in triple-negative breast cancer. 半凝集素-1在乳腺癌基质中的表达对三阴性乳腺癌的预后价值。

IF 3.5 4区医学

Pathobiology Pub Date : 2025-05-28 DOI: 10.1159/000546206

Szintia Almási, Tibor Krenács, László Krenács, Gábor Cserni

{"title":"Galectin-1 expression in breast cancer stroma - prognostic value in triple-negative breast cancer.","authors":"Szintia Almási, Tibor Krenács, László Krenács, Gábor Cserni","doi":"10.1159/000546206","DOIUrl":"https://doi.org/10.1159/000546206","url":null,"abstract":"Introduction: Galectin-1 is a lectin with immunosuppressive effect in different solid tumors. We investigated galectin-1 expression in triple-negative breast cancer (TNBC) to determine its prognostic value.Methods: We examined 95 TNBC surgical samples in tissue microarrays with galectin-1 immunohistochemistry (intensity and percentage of staining) and looked for influences on overall and progression free survivals with the help of Kaplan-Meier estimates. Univariable and multivariable Cox regressions were also analyzed.Results: According to Kaplan-Meier curves, a significantly worse overall survival (OS) was found for TNBC patients showing intense or ≥50% galectin-1 stromal interface staining versus those lacking it. Cox regression analyses suggested that galectin-1 expression was an independent prognosticator in TNBC. According to the quantity of stromal tumor-infiltrating lymphocytes (sTILs), significant survival differences depending on galectin-1 status were only seen in the low sTILs (<30%) subset. Multivariable analysis suggested that galectin-1 expression was an independent prognosticator for progression-free survival (PFS).Discussion: The immunosuppressive effects of galectin-1 forming a shield around tumor nests may form an immune-escape mechanism and can explain the worse OS and PFS we found in TNBC. Owing to the exploratory nature of the study, the results need confirmation in order to investigate the potentials of anti-galectin-1 therapies.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"1-20"},"PeriodicalIF":3.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Duodenal foveolar adenoma - case presentation with whole exome sequencing and review of the literature. 十二指肠小窝腺瘤一例全外显子组测序报告及文献复习。

IF 3.5 4区医学

Pathobiology Pub Date : 2025-05-28 DOI: 10.1159/000546139

Ádám Ferenczi, Sofia Germano, Joana Afonso, Levente Kuthi, Tamás Lantos, Anita Sejben

{"title":"Duodenal foveolar adenoma - case presentation with whole exome sequencing and review of the literature.","authors":"Ádám Ferenczi, Sofia Germano, Joana Afonso, Levente Kuthi, Tamás Lantos, Anita Sejben","doi":"10.1159/000546139","DOIUrl":"https://doi.org/10.1159/000546139","url":null,"abstract":"Introduction: Duodenal adenomas are most commonly associated with polyposis syndromes. Foveolar adenoma is an especially rare entity with an unknown aetiology. We present a case of duodenal foveolar adenoma with coexisting metaplasia, whole exome sequencing results, and the first literature review.Case presentation: Hereby we present the case of a 58-year-old man, whose polypectomy specimen revealed a lesion composed of mainly foveolar cells with low-grade dysplasia, and was concluded as foveolar adenoma. Due to the incomplete resection, polypectomy was repeated, this time foveolar adenoma was diagnosed with high-grade dysplasia. Foveolar differentiation was proved with MUC5AC immunohistochemistry, in addition, KRAS and SMAD4 pathogenic mutations were identified.Discussion: Duodenal foveolar adenoma remains a controversial and an enigmatic entity. Our paper presents such a lesion with first low-grade, then high-grade dysplasia, and KRAS mutation, identical to gastric manifestations. The further sample of our patient suggests foveolar metaplasia as an aetiological factor that supports the literature data.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"1-10"},"PeriodicalIF":3.5,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Improved diagnosis of glioblastoma, IDH-wildtype, metastasis through molecular and DNA methylation profiling: Two case reports. 通过分子和DNA甲基化分析提高胶质母细胞瘤、idh野生型和转移的诊断：两例报告。

IF 3.5 4区医学

Pathobiology Pub Date : 2025-05-19 DOI: 10.1159/000546348

Alexandre Bertucci, Elise Kaspi, Marylin Barrie, Laurence Schenone, Amira Amri, Alexandre Astier, Isabelle Nanni, Mario Abaji, Olivier Chinot, Patrice Roll, Emeline Tabouret, Romain Appay, Diane Frankel

{"title":"Improved diagnosis of glioblastoma, IDH-wildtype, metastasis through molecular and DNA methylation profiling: Two case reports.","authors":"Alexandre Bertucci, Elise Kaspi, Marylin Barrie, Laurence Schenone, Amira Amri, Alexandre Astier, Isabelle Nanni, Mario Abaji, Olivier Chinot, Patrice Roll, Emeline Tabouret, Romain Appay, Diane Frankel","doi":"10.1159/000546348","DOIUrl":"https://doi.org/10.1159/000546348","url":null,"abstract":"Glioblastoma, the most common primary malignant brain tumor in adults, accounts for approximately 50% of primary malignant brain tumors. Extracranial metastases are extremely rare, affecting <0.5% of patients. This article describes two cases where Next-Generation Sequencing and DNA methylation profiling, confirmed extracranial metastases of glioblastoma, IDH-WT. The first case involves a 77-year-old man who developed lung and liver mass within months of diagnosis. While both biopsies revealed undifferentiated malignant tumor, identical genetic mutations on the lung biopsy and DNA methylation profiling on the liver biopsy confirmed glioblastoma metastases. The second case details a 75-year-old women diagnosed with glioblastoma, IDH-WT who presented diffuse bone infiltration. Bone marrow aspirate and bone marrow biopsy associated with NGS and methylation profiling confirmed glioblastoma metastasis. Both patients succumbed within 8 months. These cases underscore the importance of molecular diagnostics in identifying glioblastoma metastases and guiding treatment, particularly in rare presentations involving extracranial spread.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"1-13"},"PeriodicalIF":3.5,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144102404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IMMUNE SCENARIO IDENTIFICATION COMBINING MULTIPLEXED, QUANTITATIVE, AND ADVANCED IMAGING ANALYSIS COULD BE RELEVANT IN IMMUNOTHERAPY AGAINST GLIOBLASTOMA AND GRADE 4 ASTROCYTOMA. 结合多路、定量和高级成像分析的免疫情景识别可能与胶质母细胞瘤和4级星形细胞瘤的免疫治疗相关。

IF 3.5 4区医学

Pathobiology Pub Date : 2025-05-16 DOI: 10.1159/000545488

Miguel A Idoate, Mikel Ariz-Galilea, Ainhoa Urbiola-Casales, Miriam Alonso-García, Jesús Machuca-Aguado, Carlos Ortiz de Solórzano, Eloy Rivas-Infante, Rainiero Avila-Polo, Michele Biscuola

{"title":"IMMUNE SCENARIO IDENTIFICATION COMBINING MULTIPLEXED, QUANTITATIVE, AND ADVANCED IMAGING ANALYSIS COULD BE RELEVANT IN IMMUNOTHERAPY AGAINST GLIOBLASTOMA AND GRADE 4 ASTROCYTOMA.","authors":"Miguel A Idoate, Mikel Ariz-Galilea, Ainhoa Urbiola-Casales, Miriam Alonso-García, Jesús Machuca-Aguado, Carlos Ortiz de Solórzano, Eloy Rivas-Infante, Rainiero Avila-Polo, Michele Biscuola","doi":"10.1159/000545488","DOIUrl":"https://doi.org/10.1159/000545488","url":null,"abstract":"Introduction In our research on understanding glioblastoma's resistance mechanisms to immunotherapy, we extensively investigated through an innovative technology that enables the simultaneous assessment of multiple biomarkers. With this approach, we aim to gain deeper insights into the interplay between immunosuppressive cells (IC) and effector cells (EC). Methods It were studied 126 cases of glioblastoma employing tissue microarrays stained with a panel of immune infiltrate validated via multiplex immunofluorescence and quantified by advanced image analysis. All cases were categorized according to an EC/IC ratio and their respective medians. Statistical correlations between cell populations and with survival were calculated. Results M2 macrophages were the most abundant IC, followed by a variable number of EC and pro-tumoral activated microglia, and a scant quantity of FoxP3 cells. EC showed a statistically significant direct positive correlation with IC. The patients with tumors exhibiting an EC/IC ratio ≤0.063 displayed a significantly poorer outcome. Furthermore, in the context of incomplete surgical resection, significant differences were evident considering immune scenarios. Conclusions By integrating multiplex technology with advanced imaging analysis, we successfully identified 4 distinct immune scenarios in glioblastoma. We observed a favorable immune scenario characterized by a relatively high EC/IC ratio, which is especially evident in the clinical setting of incomplete tumor resection. This promising immune scenario holds significant potential for selecting suitable candidates for immunotherapy in glioblastoma.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"1-27"},"PeriodicalIF":3.5,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144094237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computer-aided diagnostics helps to accurately determine different expression levels of claudin-18.2 in gastric cancer. 计算机辅助诊断有助于准确测定胃癌中claudin-18.2的不同表达水平。

IF 3.5 4区医学

Pathobiology Pub Date : 2025-04-23 DOI: 10.1159/000545769

Sabina Köfler, Katharina Mühlberger, Verena Girkinger, Drolaiz H W Liu, Bastian Dislich, Beat Gloor, Rupert Langer

{"title":"Computer-aided diagnostics helps to accurately determine different expression levels of claudin-18.2 in gastric cancer.","authors":"Sabina Köfler, Katharina Mühlberger, Verena Girkinger, Drolaiz H W Liu, Bastian Dislich, Beat Gloor, Rupert Langer","doi":"10.1159/000545769","DOIUrl":"https://doi.org/10.1159/000545769","url":null,"abstract":"Introduction Determination of claudin-18.2 expression by immunohistochemistry (IHC) is prerequisite for targeted treatment of gastric cancers (GC) with zolbetuximab. Precise assessment of IHC expression categories, however, may be challenging and prone to interobserver variability. Computer-aided diagnosis has a high potential of improving diagnostic accuracy and reproducibility. We established a computer-aided analysis tool for claudin-18.2 positivity scoring. Methods Analysis steps included the identification of tumour tissue on haematoxylin-3,3'-diaminobenzidine-stained tissue microarray (TMA) slides, cell segmentation, and membranous staining intensity estimation of claudin-18.2 (clone 43-14A). We analysed 2248 cores from 417 primary resected GC with detailed pathological data available. Results In 51.6% (1159/2248) of TMA cores, no stained tumour cells were detected. Among cases with claudin-18.2 expression, predominantly 1+ and 2+ cells, and a minority of 3+ stained cells were found, and 2+ to 3+ staining was unevenly distributed. Utilizing the SPOTLIGHT claudin-18.2 positivity threshold we identified 12% (187/1555) positive cores corresponding to 2.5% (9/365) positive cases. Lower staining intensities in tumour centre cores point to intratumoural heterogeneity. Conclusion Computer-aided diagnostics helps to accurately measure claudin-18.2 expression levels, allowing to precisely determine claudin-18.2 status in GC patients. Previously uncaptured categorization of staining intensities may enhance the understanding of claudin-18.2 threshold for patient stratification.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"1-22"},"PeriodicalIF":3.5,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Keratin 24 (KRT 24) Predicts Poor Prognosis in Breast Cancer. 角蛋白24 （krt24）预测乳腺癌预后不良。

IF 3.5 4区医学

Pathobiology Pub Date : 2025-04-19 DOI: 10.1159/000546022

Yousif A Kariri, Mansour Alsaleem, Taher A Kariri, Mohammed Alkharaiji, Mohammed Asad, Emad A Rakha

{"title":"Keratin 24 (KRT 24) Predicts Poor Prognosis in Breast Cancer.","authors":"Yousif A Kariri, Mansour Alsaleem, Taher A Kariri, Mohammed Alkharaiji, Mohammed Asad, Emad A Rakha","doi":"10.1159/000546022","DOIUrl":"https://doi.org/10.1159/000546022","url":null,"abstract":"Background: Keratin (KRT) 24 is a cytoskeletal protein that plays a major role in the formation of intermediate filaments to provide mechanical stability. KRT24 overexpression facilitates tumour-cell migration, invasion and metastasis in several types of cancers. This study evaluates the clinicopathological significance of KRT24 expression in large breast cancer (BC) cohorts with long-term follow-up.Methods: KRT24 mRNA expression was assessed in publicly available BC datasets (n=13,025). KRT24 protein expression was evaluated immunohistochemically using well-characterised operable BC cohort (n=832), and associations with clinicopathological features and patients' outcomes were evaluated.Results: The KRT24 expression, at both transcriptomic and protein levels was associated with features indicative of poor prognosis, including high histological grade, ER negativity and HER2 positivity, and with poor patient outcomes. High KRT24 protein expression in chemotherapy-treated patients was significantly correlated with a shorter survival, a higher risk of distant metastases and BC-related deaths. Additionally, patients with high KRT24 mRNA expression exhibited dysregulation of several differentially expressed genes and enriched pathways, including the cytokine-cytokine receptor-interaction pathway, IL-17 signaling pathway, and oestrogen signaling pathway.Conclusion: KRT24 expression is associated with poor prognosis in BC. It also plays a predictive role in advanced BC, and may represent a potential therapeutic target for patients with this aggressive disease.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"1-22"},"PeriodicalIF":3.5,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial Intelligence-Driven Quantification of Tumor-Stroma Ratio and Fibroblasts Enables Precise Classification of Stroma Quality and Quantity in Predicting Colorectal Cancer Recurrence. 人工智能驱动的肿瘤-间质比和成纤维细胞的量化，使间质质量和数量的精确分类能够预测结直肠癌的复发。

IF 3.5 4区医学

Pathobiology Pub Date : 2025-04-19 DOI: 10.1159/000546021

Jun Yong Kim, Hoein Jeong, Aaron Valero Puche, Sanghoon Song, Soo Ick Cho, Minsun Jung

{"title":"Artificial Intelligence-Driven Quantification of Tumor-Stroma Ratio and Fibroblasts Enables Precise Classification of Stroma Quality and Quantity in Predicting Colorectal Cancer Recurrence.","authors":"Jun Yong Kim, Hoein Jeong, Aaron Valero Puche, Sanghoon Song, Soo Ick Cho, Minsun Jung","doi":"10.1159/000546021","DOIUrl":"https://doi.org/10.1159/000546021","url":null,"abstract":"The tumor microenvironment (TME) significantly influences the progression and prognosis of colorectal cancer (CRC). Key components, including the tumor-stroma ratio (TSR) and cancer-associated fibroblasts (CAFs), have been recognized as important prognostic markers in CRC. However, the conventional assessment of TSR and CAF density is often subjective and labor-intensive, limiting its clinical application. In this study, we employed an artificial intelligence (AI)-powered whole slide image (WSI) analyzer, Lunit SCOPE IO, to objectively quantify TSR and CAF density in stage II and III CRC specimens from 207 treatment-naïve patients. Our analysis revealed that both TSR (log-rank p<0.0001) and CAF (log-rank p=0.017) density were independently associated with disease-free survival (DFS), providing superior prognostic accuracy compared to conventional risk factors. Notably, incorporating TSR and CAF density with traditional high-risk criteria allowed for the reclassification of additional patients as high-risk, significantly improving DFS prediction and reducing false-negative rates. These findings highlight the potential of integrating AI-based histopathological analysis into routine clinical practice to enhance diagnostic precision, improve risk stratification, and ultimately optimize patient management in CRC.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"1-20"},"PeriodicalIF":3.5,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144037252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metastatic Prostatic Adenocarcinoma to the Penis with Diffuse P16 Expression: Recognizing a Diagnostic Pitfall. 伴P16弥漫性表达的阴茎转移性前列腺腺癌：认识诊断缺陷

IF 3.5 4区医学

Pathobiology Pub Date : 2025-04-18 DOI: 10.1159/000545971

Levente Kuthi, Márton Csaba Gráczia, Imola Adamik, Zsombor Melegh, Zsófia Küronya, Mahmut Akgul

{"title":"Metastatic Prostatic Adenocarcinoma to the Penis with Diffuse P16 Expression: Recognizing a Diagnostic Pitfall.","authors":"Levente Kuthi, Márton Csaba Gráczia, Imola Adamik, Zsombor Melegh, Zsófia Küronya, Mahmut Akgul","doi":"10.1159/000545971","DOIUrl":"https://doi.org/10.1159/000545971","url":null,"abstract":"Introduction: Prostate cancer (PCa) is the most common malignant tumor in men, with acinar adenocarcinoma as the predominant subtype. While PCa metastases typically affect bones, penile metastases are exceedingly rare. Penile tumors are generally squamous cell carcinoma (SCC), with p16 overexpression often used as a surrogate marker for oncogenic human papillomavirus (HPV) infection.Case presentation: We report the case of an 85-year-old male with a history of PCa (grade group 5) treated with irradiation and hormonal therapy, who presented with a progressive penile lesion initially misdiagnosed as HPV-associated SCC. Immunohistochemistry revealed diffuse panCK, p16, NKX3.1, AR, and ERG positivity, with Rb1 protein loss confirming metastatic PCa. PSA levels remained within the normal range, complicating the diagnosis.Conclusion: This case emphasizes the importance of thorough clinico-pathological correlation in unusual metastatic presentations and highlights that p16 overexpression, even in penile tumors, may indicate Rb1 inactivation rather than HPV-related SCC.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"1-8"},"PeriodicalIF":3.5,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cytological Features of the Emerging Entity Papillary Renal Neoplasm with Reverse Polarity: A Case Report Highlighting the Relevance of Fine-Needle Aspiration in Renal Masses. 反极性肾乳头状肿瘤的细胞学特征：一个强调细针穿刺与肾肿块相关性的病例报告。

IF 3.5 4区医学

Pathobiology Pub Date : 2025-04-15 DOI: 10.1159/000545894

João Castro, Júlia Azevedo, Cláudia Lobo, Ângelo Rodrigues, Isaac Braga, Rui Freitas, Rui Silva-Santos, Ana Peixoto, Rui Henrique, Luís Leça, João Lobo

{"title":"Cytological Features of the Emerging Entity Papillary Renal Neoplasm with Reverse Polarity: A Case Report Highlighting the Relevance of Fine-Needle Aspiration in Renal Masses.","authors":"João Castro, Júlia Azevedo, Cláudia Lobo, Ângelo Rodrigues, Isaac Braga, Rui Freitas, Rui Silva-Santos, Ana Peixoto, Rui Henrique, Luís Leça, João Lobo","doi":"10.1159/000545894","DOIUrl":"10.1159/000545894","url":null,"abstract":"Introduction: Papillary renal neoplasm with reverse polarity (PRNRP) is an emerging entity characterized by distinctive histomorphological and molecular features. Often identified incidentally in imaging studies, its accurate diagnosis is essential considering its favorable prognosis. However, its cytological features need further characterization, since only one single publication with 2 cases diagnosed in fine-needle aspiration biopsies have been reported to date.Case presentation: We report the case of a 70-year-old man recently diagnosed with primary lung adenocarcinoma. Fine-needle aspiration biopsy of a 15-mm nodule in the left kidney revealed cytological features consistent with a papillary neoplasm with eosinophilic features. Immunocytochemistry showed positivity for PAX-8, CK7, and GATA3 and negativity for TTF-1. Next-generation sequencing (NGS) identified a KRAS G12V mutation. Altogether, these findings enabled the diagnosis of PRNRP. The patient underwent conservative management of the renal tumor, which did not recur at 8 months since diagnosis.Conclusion: PRNRP is a recently described tumor which can be managed conservatively. We describe the third case of PRNRP diagnosed on fine-needle aspiration biopsy, which enabled several diagnostic studies, including immunocytochemistry and NGS confirmation. With this case, we highlight the increasing role of fine-needle aspiration biopsy in the clinical management of a subset of patients with small renal masses.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"1-6"},"PeriodicalIF":3.5,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144031570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retraction Statement. 撤销声明。

IF 3.5 4区医学

Pathobiology Pub Date : 2025-04-14 DOI: 10.1159/000544903

引用次数: 0