Pathobiology最新文献_第10页

Critical Evaluation of Transcripts and Long Noncoding RNA Expression Levels in Prostate Cancer Following Radical Prostatectomy. 前列腺癌根治术后转录本和长非编码 RNA 表达水平的关键评估。

IF 5 4区医学

Pathobiology Pub Date : 2023-01-01 Epub Date: 2023-07-18 DOI: 10.1159/000531175

Christian Ruiz, Ilaria Alborelli, Massimilinao Manzo, Byron Calgua, Eveline Barbara Keller, Vincent Vuaroqueaux, Luca Quagliata, Cyrill A Rentsch, Giulio Cesare Spagnoli, Pierre André Diener, Lukas Bubendorf, Rudolf Morant, Serenella Eppenberger-Castori

{"title":"Critical Evaluation of Transcripts and Long Noncoding RNA Expression Levels in Prostate Cancer Following Radical Prostatectomy.","authors":"Christian Ruiz, Ilaria Alborelli, Massimilinao Manzo, Byron Calgua, Eveline Barbara Keller, Vincent Vuaroqueaux, Luca Quagliata, Cyrill A Rentsch, Giulio Cesare Spagnoli, Pierre André Diener, Lukas Bubendorf, Rudolf Morant, Serenella Eppenberger-Castori","doi":"10.1159/000531175","DOIUrl":"10.1159/000531175","url":null,"abstract":"Introduction: The clinical course of prostate cancer (PCa) is highly variable, ranging from indolent behavior to rapid metastatic progression. The Gleason score is widely accepted as the primary histologic assessment tool with significant prognostic value. However, additional biomarkers are required to better stratify patients, particularly those at intermediate risk.Methods: In this study, we analyzed the expression of 86 cancer hallmark genes in 171 patients with PCa who underwent radical prostatectomy and focused on the outcome of the 137 patients with postoperative R0-PSA0 status.Results: Low expression of the IGF1 and SRD52A, and high expression of TIMP2, PLAUR, S100A2, and CANX genes were associated with biochemical recurrence (BR), defined as an increase of prostate-specific antigen above 0.2 ng/mL. Furthermore, the analysis of the expression of 462 noncoding RNAs (ncRNA) in a sub-cohort of 39 patients with Gleason score 7 tumors revealed that high levels of expression of the ncRNAs LINC00624, LINC00593, LINC00482, and cd27-AS1 were significantly associated with BR. Our findings provide further evidence for tumor-promoting roles of ncRNAs in PCa patients at intermediate risk. The strong correlation between expression of LINC00624 and KRT8 gene, encoding a well-known cell surface protein present in PCa, further supports a potential contribution of this ncRNA to PCa progression.Conclusion: While larger and further studies are needed to define the role of these genes/ncRNA in PCa, our findings pave the way toward the identification of a subgroup of patients at intermediate risk who may benefit from adjuvant treatments and new therapeutic agents.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"400-408"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10733933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9886309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Renal Cell Carcinoma in End-Stage Renal Disease: A Retrospective Study in Patients from Hungary. 终末期肾病中的肾细胞癌：匈牙利患者的回顾性研究。

IF 5 4区医学

Pathobiology Pub Date : 2023-01-01 Epub Date: 2023-01-25 DOI: 10.1159/000529276

Dávid Semjén, Borbála Dénes, Áron Somorácz, Attila Fintha, Gertrúd Forika, Alex Jenei, Deján Dobi, Tamás Micsik, Kornélia Veronika Eizler, Nándor Giba, Fanni Sánta, Anita Sejben, Béla Iványi, Levente Kuthi

{"title":"Renal Cell Carcinoma in End-Stage Renal Disease: A Retrospective Study in Patients from Hungary.","authors":"Dávid Semjén, Borbála Dénes, Áron Somorácz, Attila Fintha, Gertrúd Forika, Alex Jenei, Deján Dobi, Tamás Micsik, Kornélia Veronika Eizler, Nándor Giba, Fanni Sánta, Anita Sejben, Béla Iványi, Levente Kuthi","doi":"10.1159/000529276","DOIUrl":"10.1159/000529276","url":null,"abstract":"Introduction: End-stage renal disease (ESRD) and acquired cystic kidney disease (ACKD) are known risk factors for renal cell carcinoma (RCC). Hereby, the clinicopathological features of RCCs developed in ESRD were investigated.Methods: A database consisting of 34 tumors from 31 patients with ESRD among 2,566 nephrectomy samples of RCC was built. The demographic, clinical, and follow-up data along with pathological parameters were analyzed. The RCCs were diagnosed according to the current WHO Classification of Urinary and Male Genital Tumors.Results: Twenty-two tumors developed in men and 12 in women, with a median age of 56 years (range: 27-75 years). The causes of ESRD were glomerulonephritis (n = 7), hypertensive kidney disease (n = 6), autosomal dominant polycystic kidney disease (n = 6), chronic pyelonephritis (n = 4), diabetic nephropathy (n = 3), chemotherapy-induced nephropathy (n = 1), and undetermined (n = 4). ACKD complicated ESRD in 12 patients. The following histological subtypes were identified: clear cell RCC (n = 19), papillary RCC (n = 5), clear cell papillary tumor (n = 5), ACKD RCC (n = 3), and eosinophilic solid and cystic RCC (n = 2). The median tumor size was 31 mm (range: 10-80 mm), and 32 tumors were confined to the kidney (pT1-pT2). There was no tumor-specific death during the period of this study. Progression was registered in 1 patient.Conclusion: In our cohort, the most common RCC subtype was clear cell RCC (55%), with a frequency that exceeded international data appreciably (14-25%). The incidence of clear cell papillary tumor and ACKD RCC (14.7% and 8.5%) was lower than data reported in the literature (30% and 40%). Our results indicate a favorable prognosis of RCC in ESRD.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"322-332"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10618765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Myeloid Sarcoma of the Breast as Blast Phase of JAK2-Mutated (Val617Phe Exon 14p) Essential Thrombocythemia: A Case Report and a Systematic Literature Review. 作为jak2突变(Val617Phe外显子14p)原发性血小板增多症的乳腺髓系肉瘤:1例报告和系统文献综述

IF 5 4区医学

Pathobiology Pub Date : 2023-01-01 DOI: 10.1159/000525163

Mirella Pace, Elia Guadagno, Daniela Russo, Annarita Gencarelli, Annunziata Carlea, Attilio Di Spiezio, Clara Bertuzzi, Massimo Mascolo, Francesco Grimaldi, Luigi Insabato

{"title":"Myeloid Sarcoma of the Breast as Blast Phase of JAK2-Mutated (Val617Phe Exon 14p) Essential Thrombocythemia: A Case Report and a Systematic Literature Review.","authors":"Mirella Pace, Elia Guadagno, Daniela Russo, Annarita Gencarelli, Annunziata Carlea, Attilio Di Spiezio, Clara Bertuzzi, Massimo Mascolo, Francesco Grimaldi, Luigi Insabato","doi":"10.1159/000525163","DOIUrl":"https://doi.org/10.1159/000525163","url":null,"abstract":"Introduction: Myeloid sarcoma (MS) is a mass-forming proliferation of myeloid blasts. Frequently, it arises as blast phase of pre-existing myeloproliferative, myelodysplastic disorders or consequent to bone marrow transplant. Its molecular characterization has become an increasingly important requirement for the diagnostic definition of this solid leukemia.Case presentation: Our case report concerns an MS arising in the breast of a woman with a previous diagnosis of JAK2-mutated essential thrombocythemia (Val617Phe exon 14p) mimicking, on histology, a lobular carcinoma of the breast. The immunohistochemical study of the neoplasm provided the key that solved the diagnostic doubt and the immunohistochemical evaluation of NPM protein expression, which turn out to be negative, provided a clear indication on the molecular status and prognosis of the disease. A year later, the neoplasm relapsed in the pelvic area.Discussion: This diagnostic challenge led us to review the literature of the past 10 years concerning MS of the breast. To the best of our knowledge, this was the first case of MS of the breast occurring in a patient with a history of essential thrombocythemia and recurred in the pelvic region.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"90 2","pages":"123-130"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9300397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatic Fat and Macrophages Are Increased in Livers of Diabetic Patients without Non-Alcoholic Fatty Liver Disease. 无非酒精性脂肪肝的糖尿病患者肝脏脂肪和巨噬细胞增加

IF 5 4区医学

Pathobiology Pub Date : 2023-01-01 Epub Date: 2023-06-14 DOI: 10.1159/000531542

Amber Korn, Cacharel Nadeem, Emma N Bos, Hans W M Niessen, Suat Simsek, Paul A J Krijnen

{"title":"Hepatic Fat and Macrophages Are Increased in Livers of Diabetic Patients without Non-Alcoholic Fatty Liver Disease.","authors":"Amber Korn, Cacharel Nadeem, Emma N Bos, Hans W M Niessen, Suat Simsek, Paul A J Krijnen","doi":"10.1159/000531542","DOIUrl":"10.1159/000531542","url":null,"abstract":"Introduction: Diabetes mellitus (DM), especially type 2, is strongly associated with non-alcoholic fatty liver disease (NAFLD). Recent studies indicate that particularly in DM patients, \"simple\" liver steatosis can progress into more severe disease. However, little is known about putative hepatic histopathological changes in DM patients without NAFLD. In this study, we therefore analysed fat content and inflammatory cell infiltration in the livers of deceased DM and non-DM patients without NAFLD, and analysed age/sex effects hereon.Methods: Hepatic fat and inflammatory cells were studied through (immuno)histochemical analysis in liver tissue from 24 DM patients and 66 non-diabetic controls, without histopathological characteristics of NAFLD.Results: We observed a 2-fold increase in fat percentage/mm2 and a near 5-fold increase in the number of fat-containing cells/mm2 in DM patients compared to non-diabetic controls. Fat content was significantly higher in patients with type 2 DM, but not type 1 DM, compared to non-diabetic controls, while the number of CD68+ cells/mm2 was significantly elevated in both DM groups.Conclusion: Hepatic fat and number of macrophages are increased in patients with DM without NAFLD, which may reflect a higher risk on development of steatosis and steatohepatitis.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"409-416"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9624085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acknowledgement to Reviewers 审稿人致谢

IF 5 4区医学

Pathobiology Pub Date : 2022-12-13 DOI: 10.1159/000527864

引用次数: 0

Contents, Vol. 89, 2022 目录，第89卷，2022年

IF 5 4区医学

Pathobiology Pub Date : 2022-12-01 DOI: 10.1159/000528321

Fernando C. Schmitt

{"title":"Contents, Vol. 89, 2022","authors":"Fernando C. Schmitt","doi":"10.1159/000528321","DOIUrl":"https://doi.org/10.1159/000528321","url":null,"abstract":"Kemal Behzatoğlu – Acibadem University Atakent Hospital, Istanbul, Turkey Lukas Bubendorf – University Hospital Basel, Basel, Switzerland Nicolò Costantino Brembilla – University of Geneva, Geneva, Switzerland Enrique de Álava – Virgen del Rocío University Hospital, Sevilla, Spain Reynaldo Falcón-Escobedo – Autonomous University of San Luis Potosí, San Luis Potosí, Mexico Pedro L. Fernández – Hospital Germans Trias i Pujol, Badalona, Spain Julia T. Geyer – Weill Cornell Medicine, New York, NY, USA Irene Gullo – University of Porto, Porto, Portugal Gerald Hoefler – Medizinische Universität Graz, Graz, Austria Akira Horii – Tohoku University School of Medicine, Sendai, Japan Elisabeth Hyjek – University of Chicago, Chicago, IL, USA Alexander Katalinic – Institut für Krebsepidemiologie e.V., Lübeck, Germany Sigurd F. Lax – Medical University Graz, Graz, Austria Jose A. Lorente – University of Granada, Granada, Spain Antonio Marra – Memorial Sloan-Kettering Cancer Center, New York, NY Aurel Perren – Universität Bern, Bern, Switzerland Stefano A. Pileri – European Institute of Oncology, Milan, Italy Marc Reymond – Universitätsklinikum Tübingen, Tübingen, Germany Raquel Seruca – University of Porto, Porto, Portugal Puay Hoon Tan – Singapore General Hospital, Singapore Andrea Tannapfel – Ruhr-Universität Bochum, Bochum, Germany Giancarlo Troncone – University of Naples Federico II, Naples, Italy Wataru Yasui – Hiroshima University, Hiroshima, Japan Kurt Zatloukal – Medical University of Graz, Graz, Austria Pathobiology","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"33 1","pages":"I - IV"},"PeriodicalIF":5.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72641182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prelims 预备考试

IF 5 4区医学

Pathobiology Pub Date : 2022-10-03 DOI: 10.1159/000526725

引用次数: 0

Front & Back Matter 正面和背面

IF 5 4区医学

Pathobiology Pub Date : 2022-10-01 DOI: 10.1159/000527327

引用次数: 0

Immunohistochemistry in Breast Cancer: Practice Points and Pitfalls 乳腺癌的免疫组织化学:实践要点和缺陷

IF 5 4区医学

Pathobiology Pub Date : 2022-06-02 DOI: 10.1159/000525093

E. Rakha, P. Tan

引用次数: 0

Receptor Status after Neoadjuvant Therapy of Breast Cancer: Significance and Implications 乳腺癌新辅助治疗后受体状态:意义和启示

IF 5 4区医学

Pathobiology Pub Date : 2022-05-30 DOI: 10.1159/000521880

A. Shaaban, E. Provenzano

{"title":"Receptor Status after Neoadjuvant Therapy of Breast Cancer: Significance and Implications","authors":"A. Shaaban, E. Provenzano","doi":"10.1159/000521880","DOIUrl":"https://doi.org/10.1159/000521880","url":null,"abstract":"Neoadjuvant chemotherapy (NACT) is now established in routine management of early breast cancer. Alterations in oestrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) following NACT are reported, with wide variation in results across series. In larger series, changes in ER status are identified in 5–23%, whilst changes in PR status are more frequent (14.5–67%). HER2 status changes less frequently with loss being more common than gain, and higher rates of change with immunohistochemistry are observed compared to in situ hybridization and following HER2-targeted therapy compared with chemotherapy alone. Triple negative is the most stable molecular subtype with combined ER, and HER2-positive cancers show the highest rate of change. Neoadjuvant endocrine therapy is used less commonly than NACT, and whilst loss of ER is rare, changes in PR status can occur in up to 40% of cases. There is relatively little published data on the impact of change in receptor status on survival outcomes. In patients whose tumours become ER or HER2 positive post-NACT, endocrine or anti-HER2 therapy can be initiated, although evidence from clinical trials is lacking. Most guidelines do not currently recommend routine retesting; however it should be considered in some circumstances.","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"33 1","pages":"297 - 308"},"PeriodicalIF":5.0,"publicationDate":"2022-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76200717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10