Pathobiology最新文献

{"title":"Primary Effusion Lymphoma in an HIV-Negative Patient with Chronic Myeloid Leukemia Treated with Dasatinib.","authors":"Ivo N SahBandar,&nbsp;Chandler B Sy,&nbsp;Tayler van den Akker,&nbsp;David Kim,&nbsp;Julia T Geyer,&nbsp;Amy Chadburn,&nbsp;Ethel Cesarman,&nbsp;Giorgio Inghirami,&nbsp;John N Allan,&nbsp;Momin T Siddiqui,&nbsp;Madhu M Ouseph","doi":"10.1159/000530429","DOIUrl":"10.1159/000530429","url":null,"abstract":"<p><strong>Introduction: </strong>Primary effusion lymphoma (PEL) is a malignant lymphomatous effusion, which by definition is Kaposi sarcoma herpesvirus/human herpesvirus 8-positive. PEL typically occurs in HIV-infected patients but can also occur in HIV-negative individuals, including in organ transplant recipients. Tyrosine kinase inhibitors (TKIs) are currently the standard of care for patients with chronic myeloid leukemia (CML), BCR::ABL1-positive. Although TKIs are extremely effective in treating CML, they alter T-cell function by inhibiting peripheral T-cell migration and altering T-cell trafficking and have been associated with the development of pleural effusions.</p><p><strong>Case presentation: </strong>We report a case of PEL in a young, relatively immunocompetent patient with no history of organ transplant receiving dasatinib for CML, BCR::ABL1-positive.</p><p><strong>Discussion: </strong>We hypothesize that the loss of T-cell function secondary to TKI therapy (dasatinib) may have resulted in the unchecked cellular proliferation of Kaposi sarcoma herpesvirus (KSHV)-infected cells, leading to the emergence of a PEL. We recommend cytologic investigation and KSHV testing in patients being treated with dasatinib for CML who present with persistent or recurrent effusions.</p>","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"356-364"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9222402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interstitial Pulmonary Fibrosis and Extensive Dendriform Ossification with Persistent Viral Load: A Rare Presentation of Post-COVID-19 Condition in Need of Lung Transplantation.","authors":"Jasmin Dionne Haslbauer, Ivana Bratic-Hench, Katharina Cima, Anna Katharina Luger, Katja Schmitz, Florian Augustin, Christoph Krapf, Daniel Hoefer, Ivan Tancevski, Alexandar Tzankov, Judith Löffler-Ragg","doi":"10.1159/000525457","DOIUrl":"10.1159/000525457","url":null,"abstract":"<p><p>The incidence, presentation, and predisposing factors of post-acute sequelae of COVID-19 (PASC) are currently poorly understood. Lung explants may provide a rare insight into terminal SARS-CoV-2-associated lung damage and its pathophysiology. A 62-year-old man presented with progressively worsening respiratory symptoms after recovering from mild COVID-19 3 months earlier. No underlying pulmonary comorbidities were reported. A chest CT revealed bilateral extensive ground-glass and reticular opacities, suspicious of pulmonary fibrosis. Despite initial high-dose glucocorticoid therapy, the interstitial lung disease progressed, and after exhausting all viable therapeutic options, bilateral lung transplantation was successfully conducted. Histological analysis revealed extensive end-stage interstitial fibrosis with diffuse dendriform ossification and bronchiolar and transitional cell metaplasia. Signs of interstitial remodeling such as an increased interstitial collagen deposition, a pathological accumulation of CD163+/CD206+ M2-polarized macrophages with an increased expression of phosphorylated ERK, and an increased density of CD105+ newly formed capillaries were observed. qRT-PCR and immunohistochemistry for SARS-CoV-2 N-protein in the endothelium of medium-sized vessels confirmed a persistence of SARS-CoV-2. Our findings highlight a highly unusual presentation of SARS-CoV-2-associated lung fibrosis, implying that incomplete viral clearance in the vascular compartment may play a vital pathophysiological role in the development of PASC.</p>","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"90 2","pages":"138-146"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129030/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9719600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecularly Confirmed Female Donor-Transmitted Lobular Breast Cancer to Male following Renal Transplantation.","authors":"Jonah M Cooper,&nbsp;Benzion Samueli,&nbsp;Elad Mazor,&nbsp;Waleed Kian,&nbsp;Hadar Goldvaser,&nbsp;Gal Ben-Arie","doi":"10.1159/000524479","DOIUrl":"https://doi.org/10.1159/000524479","url":null,"abstract":"<p><strong>Introduction: </strong>Lobular breast cancer represents 10%-15% of breast cancers in women but is virtually nonexistent in men, related to the typical absence of the anatomic breast lobule structure in male breast tissue. We describe donor-transmitted metastatic lobular carcinoma to a male after kidney transplantation. Determining whether a post-transplant cancer is transplant associated, donor transmitted, or donor derived is significant for treatment, prognosis, and possibly management of other organ recipients.</p><p><strong>Case report: </strong>A 74-year-old Caucasian male presented to the emergency department with lower abdominal pain and macro-hematuria. Past medical history included two renal transplantations. Computed tomography identified a 4-5-cm space-occupying lesion in the native left kidney. A left native nephrectomy was performed. Histology pathologic examination demonstrated lobular (as opposed to ductal) breast carcinoma. Fluorescent in situ hybridization probes to identify X- and Y-chromosomes showed tumor cells with an XX genotype, whereas the surrounding host cells were of XY genotype. These findings confirmed the female-sex origin (donor) of the tumor within the XY native male (current patient) tissues.</p><p><strong>Discussion/conclusion: </strong>Due to discordance between the donor and recipient sex, fluorescent in situ hybridization as a molecular technique correctly identified the origin of an individual's cancer in the post-transplant setting. The metastatic breast cancer behaved more indolently than usually seen. Expanded criteria donors (ECD) are those who cannot donate under standard criteria for organ transplantation; expanded criteria widen the potential organ donor pool at the expense of increased risk for post-transplant complications (e.g., graft failure, the transmission of malignancy). The case provides a potential area of future research into considering allowing ECDs with a distant history of cancer with very low transmission risk when the biochemical environment of the recipient would, in the unlikely event of transmission, induce the tumor to pursue an indolent clinical course.</p>","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"90 1","pages":"63-68"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10617750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum.","authors":"","doi":"10.1159/000526108","DOIUrl":"10.1159/000526108","url":null,"abstract":"","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"90 1","pages":"69-70"},"PeriodicalIF":3.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11210556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9931138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Critical Evaluation of Transcripts and Long Noncoding RNA Expression Levels in Prostate Cancer Following Radical Prostatectomy.","authors":"Christian Ruiz, Ilaria Alborelli, Massimilinao Manzo, Byron Calgua, Eveline Barbara Keller, Vincent Vuaroqueaux, Luca Quagliata, Cyrill A Rentsch, Giulio Cesare Spagnoli, Pierre André Diener, Lukas Bubendorf, Rudolf Morant, Serenella Eppenberger-Castori","doi":"10.1159/000531175","DOIUrl":"10.1159/000531175","url":null,"abstract":"<p><strong>Introduction: </strong>The clinical course of prostate cancer (PCa) is highly variable, ranging from indolent behavior to rapid metastatic progression. The Gleason score is widely accepted as the primary histologic assessment tool with significant prognostic value. However, additional biomarkers are required to better stratify patients, particularly those at intermediate risk.</p><p><strong>Methods: </strong>In this study, we analyzed the expression of 86 cancer hallmark genes in 171 patients with PCa who underwent radical prostatectomy and focused on the outcome of the 137 patients with postoperative R0-PSA0 status.</p><p><strong>Results: </strong>Low expression of the IGF1 and SRD52A, and high expression of TIMP2, PLAUR, S100A2, and CANX genes were associated with biochemical recurrence (BR), defined as an increase of prostate-specific antigen above 0.2 ng/mL. Furthermore, the analysis of the expression of 462 noncoding RNAs (ncRNA) in a sub-cohort of 39 patients with Gleason score 7 tumors revealed that high levels of expression of the ncRNAs LINC00624, LINC00593, LINC00482, and cd27-AS1 were significantly associated with BR. Our findings provide further evidence for tumor-promoting roles of ncRNAs in PCa patients at intermediate risk. The strong correlation between expression of LINC00624 and KRT8 gene, encoding a well-known cell surface protein present in PCa, further supports a potential contribution of this ncRNA to PCa progression.</p><p><strong>Conclusion: </strong>While larger and further studies are needed to define the role of these genes/ncRNA in PCa, our findings pave the way toward the identification of a subgroup of patients at intermediate risk who may benefit from adjuvant treatments and new therapeutic agents.</p>","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"400-408"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10733933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9886309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal Cell Carcinoma in End-Stage Renal Disease: A Retrospective Study in Patients from Hungary.","authors":"Dávid Semjén,&nbsp;Borbála Dénes,&nbsp;Áron Somorácz,&nbsp;Attila Fintha,&nbsp;Gertrúd Forika,&nbsp;Alex Jenei,&nbsp;Deján Dobi,&nbsp;Tamás Micsik,&nbsp;Kornélia Veronika Eizler,&nbsp;Nándor Giba,&nbsp;Fanni Sánta,&nbsp;Anita Sejben,&nbsp;Béla Iványi,&nbsp;Levente Kuthi","doi":"10.1159/000529276","DOIUrl":"10.1159/000529276","url":null,"abstract":"<p><strong>Introduction: </strong>End-stage renal disease (ESRD) and acquired cystic kidney disease (ACKD) are known risk factors for renal cell carcinoma (RCC). Hereby, the clinicopathological features of RCCs developed in ESRD were investigated.</p><p><strong>Methods: </strong>A database consisting of 34 tumors from 31 patients with ESRD among 2,566 nephrectomy samples of RCC was built. The demographic, clinical, and follow-up data along with pathological parameters were analyzed. The RCCs were diagnosed according to the current WHO Classification of Urinary and Male Genital Tumors.</p><p><strong>Results: </strong>Twenty-two tumors developed in men and 12 in women, with a median age of 56 years (range: 27-75 years). The causes of ESRD were glomerulonephritis (n = 7), hypertensive kidney disease (n = 6), autosomal dominant polycystic kidney disease (n = 6), chronic pyelonephritis (n = 4), diabetic nephropathy (n = 3), chemotherapy-induced nephropathy (n = 1), and undetermined (n = 4). ACKD complicated ESRD in 12 patients. The following histological subtypes were identified: clear cell RCC (n = 19), papillary RCC (n = 5), clear cell papillary tumor (n = 5), ACKD RCC (n = 3), and eosinophilic solid and cystic RCC (n = 2). The median tumor size was 31 mm (range: 10-80 mm), and 32 tumors were confined to the kidney (pT1-pT2). There was no tumor-specific death during the period of this study. Progression was registered in 1 patient.</p><p><strong>Conclusion: </strong>In our cohort, the most common RCC subtype was clear cell RCC (55%), with a frequency that exceeded international data appreciably (14-25%). The incidence of clear cell papillary tumor and ACKD RCC (14.7% and 8.5%) was lower than data reported in the literature (30% and 40%). Our results indicate a favorable prognosis of RCC in ESRD.</p>","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"322-332"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10614572/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10618765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myeloid Sarcoma of the Breast as Blast Phase of JAK2-Mutated (Val617Phe Exon 14p) Essential Thrombocythemia: A Case Report and a Systematic Literature Review.","authors":"Mirella Pace,&nbsp;Elia Guadagno,&nbsp;Daniela Russo,&nbsp;Annarita Gencarelli,&nbsp;Annunziata Carlea,&nbsp;Attilio Di Spiezio,&nbsp;Clara Bertuzzi,&nbsp;Massimo Mascolo,&nbsp;Francesco Grimaldi,&nbsp;Luigi Insabato","doi":"10.1159/000525163","DOIUrl":"https://doi.org/10.1159/000525163","url":null,"abstract":"<p><strong>Introduction: </strong>Myeloid sarcoma (MS) is a mass-forming proliferation of myeloid blasts. Frequently, it arises as blast phase of pre-existing myeloproliferative, myelodysplastic disorders or consequent to bone marrow transplant. Its molecular characterization has become an increasingly important requirement for the diagnostic definition of this solid leukemia.</p><p><strong>Case presentation: </strong>Our case report concerns an MS arising in the breast of a woman with a previous diagnosis of JAK2-mutated essential thrombocythemia (Val617Phe exon 14p) mimicking, on histology, a lobular carcinoma of the breast. The immunohistochemical study of the neoplasm provided the key that solved the diagnostic doubt and the immunohistochemical evaluation of NPM protein expression, which turn out to be negative, provided a clear indication on the molecular status and prognosis of the disease. A year later, the neoplasm relapsed in the pelvic area.</p><p><strong>Discussion: </strong>This diagnostic challenge led us to review the literature of the past 10 years concerning MS of the breast. To the best of our knowledge, this was the first case of MS of the breast occurring in a patient with a history of essential thrombocythemia and recurred in the pelvic region.</p>","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"90 2","pages":"123-130"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9300397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatic Fat and Macrophages Are Increased in Livers of Diabetic Patients without Non-Alcoholic Fatty Liver Disease.","authors":"Amber Korn, Cacharel Nadeem, Emma N Bos, Hans W M Niessen, Suat Simsek, Paul A J Krijnen","doi":"10.1159/000531542","DOIUrl":"10.1159/000531542","url":null,"abstract":"<p><strong>Introduction: </strong>Diabetes mellitus (DM), especially type 2, is strongly associated with non-alcoholic fatty liver disease (NAFLD). Recent studies indicate that particularly in DM patients, \"simple\" liver steatosis can progress into more severe disease. However, little is known about putative hepatic histopathological changes in DM patients without NAFLD. In this study, we therefore analysed fat content and inflammatory cell infiltration in the livers of deceased DM and non-DM patients without NAFLD, and analysed age/sex effects hereon.</p><p><strong>Methods: </strong>Hepatic fat and inflammatory cells were studied through (immuno)histochemical analysis in liver tissue from 24 DM patients and 66 non-diabetic controls, without histopathological characteristics of NAFLD.</p><p><strong>Results: </strong>We observed a 2-fold increase in fat percentage/mm2 and a near 5-fold increase in the number of fat-containing cells/mm2 in DM patients compared to non-diabetic controls. Fat content was significantly higher in patients with type 2 DM, but not type 1 DM, compared to non-diabetic controls, while the number of CD68+ cells/mm2 was significantly elevated in both DM groups.</p><p><strong>Conclusion: </strong>Hepatic fat and number of macrophages are increased in patients with DM without NAFLD, which may reflect a higher risk on development of steatosis and steatohepatitis.</p>","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":" ","pages":"409-416"},"PeriodicalIF":5.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9624085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgement to Reviewers","authors":"","doi":"10.1159/000527864","DOIUrl":"https://doi.org/10.1159/000527864","url":null,"abstract":"<br />Pathobiology 2022;89:418","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"244 1","pages":""},"PeriodicalIF":5.0,"publicationDate":"2022-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138516372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contents, Vol. 89, 2022","authors":"Fernando C. Schmitt","doi":"10.1159/000528321","DOIUrl":"https://doi.org/10.1159/000528321","url":null,"abstract":"Kemal Behzatoğlu – Acibadem University Atakent Hospital, Istanbul, Turkey Lukas Bubendorf – University Hospital Basel, Basel, Switzerland Nicolò Costantino Brembilla – University of Geneva, Geneva, Switzerland Enrique de Álava – Virgen del Rocío University Hospital, Sevilla, Spain Reynaldo Falcón-Escobedo – Autonomous University of San Luis Potosí, San Luis Potosí, Mexico Pedro L. Fernández – Hospital Germans Trias i Pujol, Badalona, Spain Julia T. Geyer – Weill Cornell Medicine, New York, NY, USA Irene Gullo – University of Porto, Porto, Portugal Gerald Hoefler – Medizinische Universität Graz, Graz, Austria Akira Horii – Tohoku University School of Medicine, Sendai, Japan Elisabeth Hyjek – University of Chicago, Chicago, IL, USA Alexander Katalinic – Institut für Krebsepidemiologie e.V., Lübeck, Germany Sigurd F. Lax – Medical University Graz, Graz, Austria Jose A. Lorente – University of Granada, Granada, Spain Antonio Marra – Memorial Sloan-Kettering Cancer Center, New York, NY Aurel Perren – Universität Bern, Bern, Switzerland Stefano A. Pileri – European Institute of Oncology, Milan, Italy Marc Reymond – Universitätsklinikum Tübingen, Tübingen, Germany Raquel Seruca – University of Porto, Porto, Portugal Puay Hoon Tan – Singapore General Hospital, Singapore Andrea Tannapfel – Ruhr-Universität Bochum, Bochum, Germany Giancarlo Troncone – University of Naples Federico II, Naples, Italy Wataru Yasui – Hiroshima University, Hiroshima, Japan Kurt Zatloukal – Medical University of Graz, Graz, Austria Pathobiology","PeriodicalId":19805,"journal":{"name":"Pathobiology","volume":"33 1","pages":"I - IV"},"PeriodicalIF":5.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72641182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}