Pharmaceutical nanotechnology最新文献

{"title":"Formulation of Benzoyl Peroxide Microsponge-based Transdermal Gel for Acne Infection and Its Evaluation","authors":"Samali S Raut, Neha R Singh, Bhushan R Rane, Ashish S Jain","doi":"10.2174/2211738511666230908162410","DOIUrl":"10.2174/2211738511666230908162410","url":null,"abstract":"<p><strong>Background: </strong>Benzoyl peroxide is a peroxide with antibacterial, irritating, keratolytic, comedolytic, and anti-inflammatory properties. When benzoyl peroxide is applied topically, it breaks down and releases oxygen, which kills the germs of Propionibacterium acnes. Benzoyl peroxide's irritating impact causes an increase in epithelial cell turnover, which causes the skin to peel and aids in the healing of comedones. Treatment for acne vulgaris involves the use of benzoyl peroxide.</p><p><strong>Objective: </strong>The research is aimed at studying the formulation of Microsponge gel preparation of benzoyl peroxide by using Carbopol 934 as a gelling agent and evaluation of microsponge gel formulation for its physicochemical properties.</p><p><strong>Methods: </strong>Microsponges of anti-acne agent benzoyl peroxide drug were prepared by quasi-emulsion method, and in-vitro drug release using a suitable membrane model using a simple diffusion cell.</p><p><strong>Results: </strong>Prior to drying, the microsponge was filtered and rinsed using distilled water. Formulation containing benzoyl peroxide and Eudragit RS100 with a ratio of 1:4 showed a high 87.5% drug content and 78.20 % yield. The drug content of the microsponge gel was found to be 84%. Microbiological study on S. aureus was conducted by the cylinder cup method and found good results. The in-vitro diffusion of microsponge formulations was sustained for 8 hours. The drug release rate for Eudragit RS- 100 was reported to be 88.87% after 8 hours based on the polymer: drug ratio (4:1).</p><p><strong>Conclusion: </strong>The quasi-emulsion solvent diffusion method was used to successfully prepare benzoyl peroxide microsponges using Eudragit RS100, Ethyl Cellulose, and HPMC K4M as polymers. The formulations with the highest medication concentration were made with the porous polymer Eudragit RS100.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10570859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-Pickering Emulsion using Solid Particles of Typhonium flagelliforme Extract as a Stabilizer: Optimization using Response Surface Methodology and Elucidation of Antioxidant and Antibacterial Activities.","authors":"Hetty Lendora Maha, Irda Fidrianny, Satrialdi -, Tri Suciati","doi":"10.2174/0122117385368118250217051038","DOIUrl":"https://doi.org/10.2174/0122117385368118250217051038","url":null,"abstract":"<p><strong>Background: </strong>Typhonium flagelliforme is a plant known for its high polyphenol content, making it a good option for stabilizing nano-Pickering emulsion systems. Nano-Pickering emulsions use solid particles for better stability and functional properties than conventional ones.</p><p><strong>Objective: </strong>This study aimed to develop a nano-Pickering emulsion stabilized by TF particles using the Response Surface Methodology (RSM).</p><p><strong>Methods: </strong>The RSM was used to determine the best formulation and manufacturing process for TFbased nano-Pickering emulsion (TFNPE). The optimal formula was tested for physical stability, in vitro antioxidant activity, and antibacterial activity using the agar diffusion method against several bacteria.</p><p><strong>Results: </strong>The droplet size and distribution of TFNPE were affected by solid particle content, chitosan concentration, and sonication intensity. The optimal formula had 1.84% solid particles, 0.26% chitosan, and 50% sonication intensity. TFNPE remained stable at 4 ± 2°C for six months and showed increased antioxidant capacity (204.76 ± 3.57 mg AEAC/g) relative to TF extract (176.65 ± 2.86 mg AEAC/g). TFNPE also exhibited antibacterial activity against Cutibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis, with inhibition zones of 12.9 ± 0.5 mm, 14.81 ± 0.1 mm and 16.27 ± 0.3 mm, respectively.</p><p><strong>Conclusion: </strong>The experimental results were well fitted with the selected statistical model. These findings confirmed TFE's ability to act as a stabilizer for Pickering emulsions and determined its significant anti-acne potential due to its antioxidant and antibacterial properties.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144143286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Flavonoid Content in Apium graveolens Nanocrystals Improves Colitis in Dextran Sodium Sulfate-induced Colitis Mice.","authors":"Verda Farida, Chandra Saputra, Ardian Dewangga, Widi Kurniawan, Muhammad Novrizal Abdi Sahid, Cornelia M Keck","doi":"10.2174/0122117385358037250415034215","DOIUrl":"https://doi.org/10.2174/0122117385358037250415034215","url":null,"abstract":"<p><strong>Aim: </strong>To develop medicinal plant nanoparticles as colitis alternative/supplementary therapy.</p><p><strong>Background: </strong>Limited reports exist on the effectiveness of medicinal plant nanocrystals in treating or preventing colitis.</p><p><strong>Objectives: </strong>We investigated the effect of canonizing Apium graveolens (AG) on improving dextran sodium sulfate (DSS)- induced (4%) colitis.</p><p><strong>Methods: </strong>Nanonization was performed via the bead milling process. The nanocrystal product was characterized (i.e., particle size, zeta potential (ZP), polydispersity index (PDI) values) and freezedried. Total flavonoids and phenolic compounds in nanocrystal products were compared with ethanolic extract of AG (AGEE). Anti-colitis activity of AG-nanocrystal water suspensions (AGNS) was compared to AG bulk powder suspensions (AGBS). Colitis severity was determined via physiological, macroscopic, and microscopic colon assessment. In addition, the fecal Enterobacteriaceae population and urine glucose levels were determined.</p><p><strong>Results: </strong>The AG nanoparticle products are 200-400 nm, with PDI values 0.5-0.6, and ZP values -12 to -20 mV. The total flavonoid and phenolic compounds of AGNS were 115.12±4.32 ppm and 37.11±0.34 ppm, respectively. This value is higher compared to the content in AGEE. AGNS (350 mg/kg) improves physiological (i.e., fecal blood), macroscopic (i.e., length, diameter), and microscopic (i.e., structure and immune cell infiltration) colon conditions in a comparable level to the positive control of 5-aminosalicylic acid (100 mg/kg). AGNS have a compelling ability to restore colon microscopic and Enterobacteriaceae population compared to AGBS (700 mg/kg). AGNS (350 mg/kg) also recovered colon permeability as marked by the lower urine glucose concentration (9.90±0.15 mg/dL) compared to colitis mice (12.43±0.09 mg/dL).</p><p><strong>Conclusion: </strong>The nanonization of AG contributes to improved anti-colitis activities compared to AGBS. Nanonization of medicinal plants will reduce organic solvent extraction, which supports the sustainable development goals.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144041971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanosponge Fortified Ciclopirox-Olamine for Antifungal Efficacy with Improved Topical Delivery.","authors":"Megha Gupta, Kuldeep Vinchurkar, Dinesh Mishra, Pankaj Dixit, Sheetal Mane, Sudarshan Singh, Pooja V Nagime","doi":"10.2174/0122117385363568250417003059","DOIUrl":"https://doi.org/10.2174/0122117385363568250417003059","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Topical drug delivery systems are most promising in the management of fungal skin infections; however, they often face challenges to achieve therapeutic efficacy due to low solubility, particle size, molecular weight, and skin barriers. In this regard, nanosponge [NS] offers a novel solution with its three-dimensional porous networks, enhancing drug solubility, bioavailability, and providing prolonged release.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;The aim of this study was to develop NS fortified with Ciclopirox olamine [CPO] with enhanced drug solubility, prolonged targeted delivery, and improved therapeutic efficacy for the management of fungal skin infections.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;CPO-loaded ethyl cellulose and polyvinyl alcohol NS were synthesized using the emulsion solvent technique and subsequently evaluated for particle size, surface morphology through scanning electron microscopy [SEM], polydispersity index [PDI], zeta potential [ZP], entrapment efficiency [EE %], drug loading [DL %], drug-excipient interactions via differential scanning calorimetry, and in vitro dissolution studies. Furthermore, the antifungal test was conducted to assess the inhibitory effect on fungal growth.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The optimized formulation using ethyl cellulose and polyvinyl alcohol at 1.75 mg and 2 mg, respectively, emerged as the most effective, with a particle size of 526.1 nm and PDI of 0.332, indicating a uniform distribution. Moreover, the formulation demonstrated a high drug loading efficiency and sustained drug release over a 7 h period, achieving a drug release of 77.83 %. The pH of the gel formulations ranged from 5.35 to 7.40, the viscosity ranged from 3759 to 4710 cps, and the spreadability was adequate for topical application. Additionally, the optimized NS exhibited superior antifungal activity against Candida albicans and Aspergillus Niger, compared to drug alone and commercial fungicidal creams. Moreover, the in vitro studies confirmed the gel's effectiveness and its ability to sustain drug release, following Higuchi kinetics.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;The formulated CPO-loaded NS gels exhibit enhanced solubility, stability, and sustained drug release, significantly improving topical drug delivery with exceptional therapeutic efficacy. This novel approach underscores the potential of NSs for efficient and targeted medication delivery in both the pharmaceutical and cosmetic industries. Furthermore, their effective preparation method, excellent physicochemical properties, and antifungal activity make NSs a promising strategy for the oral delivery of poorly soluble drugs. The fungal skin infections are generally not serious but can be uncomfortable and persistent. With proper hygiene and appropriate treatment, most infections can be effectively managed. Therefore, understanding the types of fungi involved and recognizing symptoms early with an effective delivery system can lead to qu","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144049540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano Milling Application of Mutamba (West Indian Elm) Leaves Extract to Enhance its In vitro Bioactivity.","authors":"Yuda Prasetya Nugraha, Juniar Kalpika Resmi, Muhammad Luthfi Shidik, Rachmat Mauludin, Muhamad Insanu, Sophi Damayanti, Benny Permana, Siti Farah Rahmawati, Neng Fisheri Kurniati, Nizar Happyana, Ade Danova, Heni Rachmawati","doi":"10.2174/0122117385338502250417020845","DOIUrl":"https://doi.org/10.2174/0122117385338502250417020845","url":null,"abstract":"<p><strong>Background: </strong>Guazuma ulmifolia or mutamba has been traditionally used for many years as a slimming agent. Various studies reported the antihyperlipidemic activity of mutamba leaves extract due to its flavonoid content.</p><p><strong>Objective: </strong>This research was conducted to improve the bioactivity of mutamba leaves extract by applying ball-milling technology.</p><p><strong>Methods: </strong>Unground dried mutamba leaves were extracted in ethanol 40%. The resulting extract (ME) was nano-milled and characterized for its physicochemical parameters. The ball milling process was optimized by performing in various durations, ball and powder ratios, and rotation speed.</p><p><strong>Results: </strong>The optimized process of ball milling produced nano-extract (NanoME) with a particle size of 492,57±55,96 nm, confirmed with particle size and SEM. Compared with ME, the crystallinity and thermal behavior of NanoME did not change by particle size reduction. The reduction of particle size also did not improve the HMG-CoA reductase inhibitor activity. ME and NanoME showed comparable activity compared to Pravastatin. However, the bioactivities of NanoME, including DPPH antioxidant activities, improved 8-fold compared to ME.</p><p><strong>Conclusion: </strong>The improvement of these activities was attributed to the increase in their flavonoid content. This study emphasizes the role of particle size reduction or nano-extract preparation in increasing the biological activity of plant extracts.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response Surface Optimization, Fabrication and In-vitro Investigation of Elastic Nanovesicles Loaded with Flunarizine.","authors":"Mahmood A Haiss, Shaimaa N Abd Alhammid","doi":"10.2174/0122117385392040250404114249","DOIUrl":"https://doi.org/10.2174/0122117385392040250404114249","url":null,"abstract":"<p><strong>Background: </strong>Different variables have been used for the preparation of elastic nanovesicles. In this work, the ethanol injection method has been used to prepare flunarizine spanlastic nanovesicles and study the potential of these variables on vesicle size, encapsulation efficiency, and vesicle elasticity.</p><p><strong>Objective: </strong>The objective of this study was to encapsulate flunarizine dihydrochloride (FHC), a medication with low solubility in water, within nano-elastic vesicles made from Span 60. These vesicles, known as nano-spanlastics, were developed to provide non-invasive trans-nasal delivery and offer a potential therapeutic option for migraines. The ideal formula for flunarizine spanlastic nanovesicles should have the lowest possible particle size and PdI, highest possible zeta potential, vesicle elasticity, drug entrapment, and dissolving efficiency.</p><p><strong>Methods: </strong>An experimental design was followed during the preparation of flunarizine-loaded nanospanlastics utilizing the ethanol injection method and a number of edge activators (EAs). To investigate how the independent parameters affected the features of elastic vesicles and choose the best formula, Design-Expert®, software was used. The screening of 18 formulation and process aspects affecting vesicle size, polydispersity index, deformability index, zeta potential, drug entrapment, and in-vitro release was made easier by the experimental design.</p><p><strong>Results: </strong>The selected Flunarizine spanlastic nanovesicles exhibited a vesicle size of 135 ± 2.81 nm, PdI 0.2462 ± 0.01, ZP -28 ± 0.92 mV, relative deformability of 13.96 ± 0.76 g, EE% of 78.37 ± 1.42, and dissolution efficiency of about 90%.</p><p><strong>Conclusion: </strong>The successful preparation of Flunarizine-loaded spanlastic nanovesicles using ethanol injection method significantly improved the drug's solubility. Flunarizine spanlastic formulations made up of Span 60 and EAs (Tween 40 and SDC) were prepared using various weight ratios of Span 60: EA. The study presented a viable and successful method for nasal delivery of the medication for migraine treatment.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Preparation Techniques for Polymeric Nanoparticles and their Application in Drug Delivery.","authors":"Harish Bhardwaj, Soniya Sarthi, Rajendra Kumar Jangde","doi":"10.2174/0122117385366838250314110525","DOIUrl":"https://doi.org/10.2174/0122117385366838250314110525","url":null,"abstract":"<p><p>Nanotechnology has advanced significantly in recent decades, with the production and design of nanomaterials becoming a focal point of research. Nanomedicine, a key component of this field, involves the development of nanoscale materials for applications in imaging and drug delivery. Current research predominantly focuses on the synthesis of precisely characterized nanomaterials, particularly in terms of their size and morphology, as these parameters play a critical role in determining the behavior of nanomaterials in vivo. This paper reviews various methods for the preparation of polymeric nanoparticles, including solvent evaporation, nanoprecipitation, emulsification/ solvent diffusion, salting out, dialysis, supercritical fluid technology (SCF), and monomer polymerization techniques. Additionally, it discusses approaches such as emulsion, mini-emulsion, microemulsion, interfacial polymerization, controlled/living radical polymerization, and ionic gelation/ coacervation. Each preparation method is described in terms of its characteristics, advantages, limitations, and potential applications. The paper also explores pharmaceutical considerations and challenges associated with novel drug delivery systems. Recent literature examples are presented to highlight the impact of preparation techniques on the physicochemical properties of nanoparticles.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aptamer-Decorated Nanocarrier for Selectively Targeting Cancer Cells.","authors":"Thangavel Lakshmipriya, Subash C B Gopinath","doi":"10.2174/0122117385372567250304072634","DOIUrl":"https://doi.org/10.2174/0122117385372567250304072634","url":null,"abstract":"","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Nanoparticle-Based Targeted Drug Delivery Systems for Breast Cancer.","authors":"Roshni Kunte, Prafulla Sabale, Suchita Waghmare, Manasi Nikam Jiwankar, Vidya Sabale","doi":"10.2174/0122117385339882241206095441","DOIUrl":"https://doi.org/10.2174/0122117385339882241206095441","url":null,"abstract":"<p><p>Cancer is a leading cause of death and life-threatening disease globally. It is connected to persistent tissue damage and unregulated cellular proliferation. In females, breast cancer plays a crucial role in death rates. Chemotherapy, alongside surgery, radiation, and hormone therapy, is a first-line treatment, but its non-specific action harms both cancerous and healthy cells, causing severe side effects. The treatment options for breast cancer are based on the disease stage, which spans from stages 0 to IV. To mitigate this issue, novel strategies focusing on specific targets have been introduced in recent times. Advanced nanocarriers are focused on tumor-specific drug delivery using active targeting based on ligand-receptor identification, this approach has the potential to demonstrate enhanced efficacy compared to passive targeting strategies in the context of therapy for human breast cancer. Surface alteration can assist overcome this issue. This overview focuses on modified nano-sized carriers, including liposomes, micelles, polymeric nanocarriers, carbon dots, and gold nanoparticles. It has been studied to improve therapeutics efficacy, bioavailability, and pharmacokinetics features via mechanisms. The primary aim is no longer confined to merely enveloping cancer medications in novel formulations for diverse delivery pathways; instead, the emphasis lies on precise cancer targeting. This review focuses on the stages of breast cancer, obstacles, types of breast cancer therapies, techniques, and various nanocarriers using ligand-mediated drug delivery systems and their mechanisms.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano Drug Delivery Carriers (Nanocarriers): A Promising Targeted Strategy in Tuberculosis and Pain Treatment.","authors":"Rahul Pal, Prachi Pandey, Himmat Singh Chawra, Zuber Khan","doi":"10.2174/0122117385367493250224103839","DOIUrl":"https://doi.org/10.2174/0122117385367493250224103839","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) and chronic pain are global health concerns that affect millions of people, often requiring long-term, effective treatment strategies. The conventional therapies used to manage these conditions come with significant limitations. In TB, long treatment durations, poor compliance, drug resistance, and toxicity of first-line drugs are key challenges. Similarly, pain management faces issues, such as inadequate targeting, systemic side effects, and tolerance to analgesics, limiting traditional therapy efficacy.</p><p><strong>Objective: </strong>The objective of this review is to explore the potential of nanocarriers as a targeted drug delivery strategy for improving treatment outcomes in TB and pain management. It aims to explore how these advanced systems improve drug bioavailability (BA), control release, reduce side effects, and enhance therapeutic outcomes.</p><p><strong>Methods: </strong>This systematic review used databases like PubMed, Elsevier, Scopus, Google Scholar, Google Patents, and ResearchGate, etc., to collect original review articles from the past 15 years (September 1, 2007 to September 1, 2024).</p><p><strong>Results: </strong>The review also revealed that these advanced systems offer promising solutions for overcoming the limitations of conventional therapies, such as poor patient compliance and drug toxicity. Nanocarriers represent a transformative approach in both TB and pain management, with the potential to revolutionize treatment paradigms and improve patient outcomes.</p><p><strong>Conclusion: </strong>In conclusion, nanocarriers represent a highly promising approach for advancing treatment strategies in both TB and pain management. The review underscores that nanocarrier systems, such as nanoemulsion, nanosuspension, nanocrystal, liposomes, niosomes, dendrimer, and polymeric nanoparticles, offer substantial improvements in drug delivery by enhancing BA, ensuring targeted release, and reducing systemic side effects.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}