Nano-Pickering Emulsion using Solid Particles of Typhonium flagelliforme Extract as a Stabilizer: Optimization using Response Surface Methodology and Elucidation of Antioxidant and Antibacterial Activities.
Hetty Lendora Maha, Irda Fidrianny, Satrialdi -, Tri Suciati
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引用次数: 0
Abstract
Background: Typhonium flagelliforme is a plant known for its high polyphenol content, making it a good option for stabilizing nano-Pickering emulsion systems. Nano-Pickering emulsions use solid particles for better stability and functional properties than conventional ones.
Objective: This study aimed to develop a nano-Pickering emulsion stabilized by TF particles using the Response Surface Methodology (RSM).
Methods: The RSM was used to determine the best formulation and manufacturing process for TFbased nano-Pickering emulsion (TFNPE). The optimal formula was tested for physical stability, in vitro antioxidant activity, and antibacterial activity using the agar diffusion method against several bacteria.
Results: The droplet size and distribution of TFNPE were affected by solid particle content, chitosan concentration, and sonication intensity. The optimal formula had 1.84% solid particles, 0.26% chitosan, and 50% sonication intensity. TFNPE remained stable at 4 ± 2°C for six months and showed increased antioxidant capacity (204.76 ± 3.57 mg AEAC/g) relative to TF extract (176.65 ± 2.86 mg AEAC/g). TFNPE also exhibited antibacterial activity against Cutibacterium acnes, Staphylococcus aureus, and Staphylococcus epidermidis, with inhibition zones of 12.9 ± 0.5 mm, 14.81 ± 0.1 mm and 16.27 ± 0.3 mm, respectively.
Conclusion: The experimental results were well fitted with the selected statistical model. These findings confirmed TFE's ability to act as a stabilizer for Pickering emulsions and determined its significant anti-acne potential due to its antioxidant and antibacterial properties.
期刊介绍：
Pharmaceutical Nanotechnology publishes original manuscripts, full-length/mini reviews, thematic issues, rapid technical notes and commentaries that provide insights into the synthesis, characterisation and pharmaceutical (or diagnostic) application of materials at the nanoscale. The nanoscale is defined as a size range of below 1 µm. Scientific findings related to micro and macro systems with functionality residing within features defined at the nanoscale are also within the scope of the journal. Manuscripts detailing the synthesis, exhaustive characterisation, biological evaluation, clinical testing and/ or toxicological assessment of nanomaterials are of particular interest to the journal’s readership. Articles should be self contained, centred around a well founded hypothesis and should aim to showcase the pharmaceutical/ diagnostic implications of the nanotechnology approach. Manuscripts should aim, wherever possible, to demonstrate the in vivo impact of any nanotechnological intervention. As reducing a material to the nanoscale is capable of fundamentally altering the material’s properties, the journal’s readership is particularly interested in new characterisation techniques and the advanced properties that originate from this size reduction. Both bottom up and top down approaches to the realisation of nanomaterials lie within the scope of the journal.
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