Pharmaceutical nanotechnology最新文献_第2页

Therapeutic and Diagnostic Implications of Carbon Dot: An Advancement in the Avenue towards Cancer, Diabetes and Neurodegenerative Disorders. 碳点的治疗和诊断意义：迈向癌症、糖尿病和神经退行性疾病之路的新进展。

Pharmaceutical nanotechnology Pub Date : 2024-09-27 DOI: 10.2174/0122117385314533240824090949

Sreejan Manna, Sabyasachi Banerjee, Arnab De, Subhasis Banerjee, Stabak Das, Pallabita Rakshit, S K Ashok Kumar, Kalyan Kumar Sen, Sourav De

{"title":"Therapeutic and Diagnostic Implications of Carbon Dot: An Advancement in the Avenue towards Cancer, Diabetes and Neurodegenerative Disorders.","authors":"Sreejan Manna, Sabyasachi Banerjee, Arnab De, Subhasis Banerjee, Stabak Das, Pallabita Rakshit, S K Ashok Kumar, Kalyan Kumar Sen, Sourav De","doi":"10.2174/0122117385314533240824090949","DOIUrl":"https://doi.org/10.2174/0122117385314533240824090949","url":null,"abstract":"Introduction: Carbon dots (CDs), by virtue of their electrical and optical properties, emit intense light and fluorescence. They have attributes like photostability, high quantum yield (QY), high emission, and scalability. In the recent past, theranostic-CDs have been widely used in sensing, imaging, and medication administration. Furthermore, CDs may provide significant promise to detect and ability to cross blood-brain barrier (BBB) along with a drug to treat numerous neurodegenerative disorders (ND), such as Parkinson's disease (PD), Alzheimer's disease (AD), and multiple sclerosis.Method: This review aims at exploring the immense utility of CDs in the arena of theranostics. The immense utility of CDs was investigated through a systematic exploration of previously published data in the relevant field. The application of CDs is well extended to treat life-threatening disorders, like diabetes and cancer. In order to keep harmful substances out of the brain, the blood- -brain barrier (BBB) forms a defensive barrier.Results: Water and gases being simple molecules can traverse the BBB without getting filtered out, but several large molecules suffer to reach the site of action owing to their poor solubility. CDs have recently been employed for delivering drugs to the brain and to assess the central nervous system. An in-depth study of relevant literature indicates that CDs are the next-generation carrier with an innate potential to subside the drawbacks of conventional nanoparticles.Conclusion: This review illustrates several biomedical applications of CDs, primarily focusing on neurological illnesses, diabetes, and cancers. It also confers the usefulness of CDs in diagnostic imaging.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Overview of the Anticancer Potential of Silver Nanostructures against Cervical Cancer. 银纳米结构对宫颈癌的抗癌潜力概述

Pharmaceutical nanotechnology Pub Date : 2024-09-27 DOI: 10.2174/0122117385335239240924061439

Adarsh Kumar, Dhruv Varshney, Shivam Kumar, Sarmistha Saha

{"title":"An Overview of the Anticancer Potential of Silver Nanostructures against Cervical Cancer.","authors":"Adarsh Kumar, Dhruv Varshney, Shivam Kumar, Sarmistha Saha","doi":"10.2174/0122117385335239240924061439","DOIUrl":"https://doi.org/10.2174/0122117385335239240924061439","url":null,"abstract":"Women are impacted by the extremely common cancer known as cervical cancer worldwide. Although preventive vaccines for cervical cancer are successful, treatment of cervical cancer is far less satisfactory because of multidrug resistance and side effects. There is an increasing need for alternative treatment modalities due to the rather aggressive and non-specific nature of conventional chemotherapeutics. With the advent of new technologies, scientists are working harder to create novel drug delivery strategies for chemotherapy of cervical cancer. Metal nanoparticles, and particularly silver nanoparticles, are a relatively new class with a lot of promise in the field of cancer biology. Nanoparticle therapeutics are attractive platforms for clinically relevant drug development because of their powerful anti-cancer properties, correspondingly attenuated side effects, and cancer-specific targeting. In this review, we provide an overview of the most recent uses of nanotechnology, particularly silver nanostructures, in the diagnosis and treatment of cervical cancer. The salient features of silver nanoparticle-based therapeutic concepts that are novel, viable, and attainable are emphasized in this review, along with those that pose a significant obstacle to their progress toward clinical application.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparations, Applications, Patents, and Marketed Formulations of Nanoemulsions - A Comprehensive Review. 纳米乳剂的制备、应用、专利和上市配方 - 全面回顾。

Pharmaceutical nanotechnology Pub Date : 2024-09-27 DOI: 10.2174/0122117385325186240912110731

Mansi Chauhan, Rupa Mazumder, Anjana Rani, Rashmi Mishra, Rashmi Saxena Pal

{"title":"Preparations, Applications, Patents, and Marketed Formulations of Nanoemulsions - A Comprehensive Review.","authors":"Mansi Chauhan, Rupa Mazumder, Anjana Rani, Rashmi Mishra, Rashmi Saxena Pal","doi":"10.2174/0122117385325186240912110731","DOIUrl":"https://doi.org/10.2174/0122117385325186240912110731","url":null,"abstract":"Nanoemulsions have emerged as versatile colloidal dispersions with promising applications in various fields, including pharmaceuticals, food, and cosmetics. These nano-sized emulsions, stabilized by surfactants, offer unique advantages such as enhanced ingredient penetration efficacy and versatile dosage forms. This article provides an extensive overview of nanoemulsions, covering their composition, methods of preparation, and applications in drug delivery, the food industry, and cosmetics. Various high-energy and low-energy methods for nanoemulsion preparation are discussed, along with their advantages and limitations. Additionally, the article highlights the potential of nanoemulsions in improving drug bioavailability, stability, and therapeutic efficacy, especially in oral, topical, parenteral, intranasal, ocular, and pulmonary drug delivery. Furthermore, nanoemulsions are explored as carriers for encapsulating flavoring agents, nutraceuticals, and natural preservatives in the food industry, as well as their use in cosmetic formulations. Current clinical trials involving nanoemulsions and recent patents in the field are also summarized, providing insights into ongoing research and development efforts. Lastly, a selection of marketed nanoemulsion formulations is presented, showcasing their practical applications and commercial availability. Overall, nanoemulsions hold great promise as effective delivery systems with broad applications across various industries.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Second Hyper-Zagreb Index and Coindex of Chemical Nanostructures in Drugs. 第二次超萨格勒布指数和药物中化学纳米结构的共同指数。

Pharmaceutical nanotechnology Pub Date : 2024-09-27 DOI: 10.2174/0122117385307798240830072353

Mohammed Alsharafi, Yusuf Zeren, Haifa Ahmed, Abdu Alameri

{"title":"The Second Hyper-Zagreb Index and Coindex of Chemical Nanostructures in Drugs.","authors":"Mohammed Alsharafi, Yusuf Zeren, Haifa Ahmed, Abdu Alameri","doi":"10.2174/0122117385307798240830072353","DOIUrl":"https://doi.org/10.2174/0122117385307798240830072353","url":null,"abstract":"Introduction: Various dendrimer nanoparticles have properties like multivalency, controlled size, and surface functionality that make them promising nanocarriers for targeted drug delivery and other applications in pharmaceutical sciences. The precise tunability of dendrimers is an advantage over other nanoparticles. The topological descriptors can be used to predict the physicochemical properties of dendrimers and optimize their branching pattern for specific applications. The second hyper-Zagreb index and co-index are computed for various chemical structures, including dendrimers, to facilitate the correlation between their structure and biological activity.Method: In this study, the second Hyper-Zagreb index and second Hyper-Zagreb polynomials were calculated for various chemical structures, such as the molecular graph of poly(propyl) ether imine dendrimer PETIM, nanostar dendrimer (D3[p]), polypropylenimine octaamine dendrimer (NS1[p]) and (NS2[p]), polymer dendrimer (NS3[p]) and NS5[p]), fullerene dendrimer (NS4[p]), and other classes of dendrimers.Result: By computing formulae and analyzing data and figures, we obtained new insights into the features of structure-property connections for these types of compounds of nanostar dendrimers.Conclusion: The results can be used to optimize the properties of dendrimers for specific applications.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Significant Prospective on Nanorobotics in Precision Medicine and Therapeutic Interventions. 纳米机器人在精准医疗和治疗干预中的重要前景。

Pharmaceutical nanotechnology Pub Date : 2024-09-26 DOI: 10.2174/0122117385310095240913102242

Sakshi Soni, Arpana Purohit, Priyanshu Nema, Rashmi Rawal, Ajay Kumar, Vandana Soni, Sushil K Kashaw

引用次数: 0

A Review on Ocular Nanoformulation Based Formulations with Highlights on Pediatric Ocular Pharmacokinetics. 眼部纳米制剂综述，重点介绍小儿眼部药代动力学。

Pharmaceutical nanotechnology Pub Date : 2024-09-26 DOI: 10.2174/0122117385307184240826041920

Ravinder Verma, Manisha Bhatia, Mithun Mojumder, Suraj Patel, Vivek Kumar Mishra, Pooja Mathur, Shailendra Bhatt, Jai Bharti Sharma

{"title":"A Review on Ocular Nanoformulation Based Formulations with Highlights on Pediatric Ocular Pharmacokinetics.","authors":"Ravinder Verma, Manisha Bhatia, Mithun Mojumder, Suraj Patel, Vivek Kumar Mishra, Pooja Mathur, Shailendra Bhatt, Jai Bharti Sharma","doi":"10.2174/0122117385307184240826041920","DOIUrl":"https://doi.org/10.2174/0122117385307184240826041920","url":null,"abstract":"The potential use of nanoparticle-based formulations is being explored rapidly for drug delivery in ocular treatment. Despite having several advancements in the area of ocular therapy, the pharmacokinetics-based formulation development for pediatric ocular treatment is still not in proper focus. There are an inadequate number of degenerative ocular ailments with childhood onset. The purpose of this review is to focus on the pharmacokinetics studies of nanoparticle- based formulations for treating ocular diseases and problems associated with the ocular treatment of the pediatric population. Recent studies on pharmaceutical modeling of ocular formulations have also been discussed. Nanoparticle-based formulations were collected by conducting a literature survey on PubMed, Science Direct, and other portals. In this review, we have explored in detail the explanation behind the inequality among available ocular treatment regimens for youngsters as well as adults by specifically focusing on those diseases that can be distressing for children. Latest innovative developments and advancements in drug delivery systems and challenges in their usage particularly for young infant patients were also discussed. It can be concluded that the bioavailability of ocular formulations and their effect on ocular cells can be further enhanced manifolds by the development of nanoparticles-based formulations.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advancements in Nanopharmaceuticals for Novel Drug Delivery Systems. 用于新型给药系统的纳米药物的最新进展。

Pharmaceutical nanotechnology Pub Date : 2024-09-25 DOI: 10.2174/0122117385324246240826042254

Kai Bin Liew, Ee Va Koh, Xue Er Kong, Nurdina Aleyah Ismail, Rabiatul Adawiyah Abu Bakar, Phei Er Kee, Syed Haroon Khalid, Hiu Ching Haroon Phang

{"title":"Recent Advancements in Nanopharmaceuticals for Novel Drug Delivery Systems.","authors":"Kai Bin Liew, Ee Va Koh, Xue Er Kong, Nurdina Aleyah Ismail, Rabiatul Adawiyah Abu Bakar, Phei Er Kee, Syed Haroon Khalid, Hiu Ching Haroon Phang","doi":"10.2174/0122117385324246240826042254","DOIUrl":"https://doi.org/10.2174/0122117385324246240826042254","url":null,"abstract":"Nanoparticles have found applications across diverse sectors, including agriculture, food, cosmetics, chemicals, mechanical engineering, automotive, and oil and gas industries. In the medical field, nanoparticles have garnered considerable attention due to their great surface area, high solubility, rapid dissolution, and enhanced bioavailability. Nanopharmaceuticals are specifically designed to precisely deliver drug substances to targeted tissues and cells, aiming to optimize therapeutic efficacy while minimizing potential adverse effects. Furthermore, nanopharmaceuticals offer advantages, such as expedited therapeutic onset, reduced dosages, minimized variability between fed and fasted states, and enhanced patient compliance. The increasing interest in nanopharmaceuticals research among scientists and industry stakeholders highlights their potential for various medical applications from disease management to cancer treatment. This review examines the distinctive characteristics of ideal nanoparticles for efficient drug delivery, explores the current types of nanoparticles utilized in medicine, and delves into the applications of nanopharmaceuticals, including drug and gene delivery, as well as transdermal drug administration. This review provides insights into the nanopharmaceuticals field, contributing to the development of novel drug delivery systems and enhancing the potential of nanotechnology in healthcare.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142351504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in the Preparation, Properties, and Applications of Solid Lipid Nanoparticles in Drug Delivery. 固体脂质纳米颗粒的制备、特性和药物输送应用的最新进展》（Recent Advances in the Preparation, Properties, and Applications of Solid Lipid Nanoparticles in Drug Delivery）。

Pharmaceutical nanotechnology Pub Date : 2024-09-19 DOI: 10.2174/0122117385333634240911075833

Ujjwal Kumar Biswas, Anindya Bose, Ankita Parmanik

{"title":"Recent Advances in the Preparation, Properties, and Applications of Solid Lipid Nanoparticles in Drug Delivery.","authors":"Ujjwal Kumar Biswas, Anindya Bose, Ankita Parmanik","doi":"10.2174/0122117385333634240911075833","DOIUrl":"https://doi.org/10.2174/0122117385333634240911075833","url":null,"abstract":"Solid lipid nanoparticles (SLNs) are one of the extensively utilized nanocarriers in the pharmaceutical field due to their biocompatibility and biodegradability. These features of the carrier system have fuelled its use as the drug delivery system since the last three decades. This review presents different SLN preparation techniques, such as high shear homogenization, hot homogenization, cold homogenization, microemulsion-based technique, etc. The physicochemical nature of SLNs, comprising drug loading, drug release, particle size, zeta potential, stability, cytotoxicity, and cellular uptake, has been concisely discussed. The article also explains why SLNs are preferred to develop drug delivery systems in several pharmaceutical preparations. The key ingredients like lipid, surfactant/ stabilizer accompanied by co-surfactant, cryoprotectant, or charge modifiers used to fabricate SLNs are also briefly conferred. Here is an elaborate discussion of drugs that are used through various routes by the SLN carrier system and their outcome for utilization of this system. Regulatory aspects, patent aspects, and future prospects of SLN are also discussed here.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanocurcumin-containing Spongy Membrane for Improving the Quality of Hard and Soft Tissues in the Extracted Tooth Area: A Double-Blind Split- Mouth Clinical Trial Study. 用于改善拔牙区软硬组织质量的含纳米姜黄素海绵膜：双盲分口临床试验研究》。

Pharmaceutical nanotechnology Pub Date : 2024-08-30 DOI: 10.2174/0122117385311052240820114853

Sina Hessari, Farzin Ahmadpour, Javad Yazdani, Yasmin Golparvar Atashi, Solmaz Maleki Dizaj, Simin Sharifi

{"title":"Nanocurcumin-containing Spongy Membrane for Improving the Quality of Hard and Soft Tissues in the Extracted Tooth Area: A Double-Blind Split- Mouth Clinical Trial Study.","authors":"Sina Hessari, Farzin Ahmadpour, Javad Yazdani, Yasmin Golparvar Atashi, Solmaz Maleki Dizaj, Simin Sharifi","doi":"10.2174/0122117385311052240820114853","DOIUrl":"https://doi.org/10.2174/0122117385311052240820114853","url":null,"abstract":"Background: The assessment of the hard and soft tissue conditions is part of the overall dental treatments.Aim: In this study, we investigated nano curcumin-containing membranes to improve the quality of the hard and soft tissues in the extracted tooth area as a clinical trial study.Methods: After the patient was selected following the inclusion and exclusion criteria, the patients who had teeth extracted from both sides of the mouth (split mouth) on the side of the intervention received a membrane containing nanocurcumin, and on the control side, no material was placed in the socket. For data analysis, SPSS software version 24 was used. A significance threshold was deemed to be less than 0.05 in terms of probability.Results: Two months after tooth extraction, during implant placement, the average gingival thickness on the \"intervention side,\" was 3.1±0.34 mm, while the average gingival thickness on the \"control side\" was 2.6±0.42 mm. Then, the membrane could improve the quality of soft tissue (P< 0.0001). As another outcome, the application of this membrane did not significantly affect bone repair in these patients compared to the control group (P = 0.72). However, the histology data revealed that the newly generated bone of the intervention group was seen close to the membrane, demonstrating the osteoconductive ability of the membrane.Conclusion: Based on the obtained results, the newly developed membrane can be used to improve the quality of hard and soft tissues in the extracted tooth area. Nonetheless, more efforts in nanocurcumin dosage adjustment are needed for hard tissue regeneration in future studies.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid Crystalline Lipid Nanoparticles: Emerging Trends and Applications in Skin Cancer. 液晶脂质纳米颗粒：皮肤癌的新趋势和应用。

Pharmaceutical nanotechnology Pub Date : 2024-08-30 DOI: 10.2174/0122117385312450240816055942

Kamya Varshney, Rupa Mazumder, Anjna Rani, Pratibha Pandey, Malakapogu Ravindra Babu

{"title":"Liquid Crystalline Lipid Nanoparticles: Emerging Trends and Applications in Skin Cancer.","authors":"Kamya Varshney, Rupa Mazumder, Anjna Rani, Pratibha Pandey, Malakapogu Ravindra Babu","doi":"10.2174/0122117385312450240816055942","DOIUrl":"https://doi.org/10.2174/0122117385312450240816055942","url":null,"abstract":"Liquid crystalline lipid nanoparticles (LCNPs) represent a type of membrane-based nano-carriers formed through the self-assembly of lyotropic lipids. These lipids, such as unsaturated monoglycerides, phospholipids, and co-lipids, create liquid crystals or vesicles with an aqueous core enclosed by a natural or synthetic phospholipid bilayer upon exposure to an aqueous medium. Liquid crystalline lipid nanoparticles (LCNPs), akin to liposomes, have garnered significant attention as nanocarriers suitable for a diverse range of hydrophobic and hydrophilic molecules. Their notable structural advantage lies in a mono-channel network organization and the presence of multiple compartments, resulting in heightened encapsulation efficiency for various substances. Cubosomes, spongosomes, hexosomes, and multicompartment nanoparticles are examples of lipid nanocarriers with interior liquid crystalline structures that have recently gained a lot of interest as effective drug delivery systems. Additionally, LCNPs facilitate the sustained release of encapsulated compounds, including therapeutic macromolecules. This review delves into the structure of liquid crystalline lipid nanoparticles, explores preparation techniques, and outlines their applications in the context of skin cancer.","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142110622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0