Pharmaceutical nanotechnology最新文献

{"title":"Nano Milling Application of Mutamba (West Indian Elm) Leaves Extract to Enhance its In vitro Bioactivity.","authors":"Yuda Prasetya Nugraha, Juniar Kalpika Resmi, Muhammad Luthfi Shidik, Rachmat Mauludin, Muhamad Insanu, Sophi Damayanti, Benny Permana, Siti Farah Rahmawati, Neng Fisheri Kurniati, Nizar Happyana, Ade Danova, Heni Rachmawati","doi":"10.2174/0122117385338502250417020845","DOIUrl":"https://doi.org/10.2174/0122117385338502250417020845","url":null,"abstract":"<p><strong>Background: </strong>Guazuma ulmifolia or mutamba has been traditionally used for many years as a slimming agent. Various studies reported the antihyperlipidemic activity of mutamba leaves extract due to its flavonoid content.</p><p><strong>Objective: </strong>This research was conducted to improve the bioactivity of mutamba leaves extract by applying ball-milling technology.</p><p><strong>Methods: </strong>Unground dried mutamba leaves were extracted in ethanol 40%. The resulting extract (ME) was nano-milled and characterized for its physicochemical parameters. The ball milling process was optimized by performing in various durations, ball and powder ratios, and rotation speed.</p><p><strong>Results: </strong>The optimized process of ball milling produced nano-extract (NanoME) with a particle size of 492,57±55,96 nm, confirmed with particle size and SEM. Compared with ME, the crystallinity and thermal behavior of NanoME did not change by particle size reduction. The reduction of particle size also did not improve the HMG-CoA reductase inhibitor activity. ME and NanoME showed comparable activity compared to Pravastatin. However, the bioactivities of NanoME, including DPPH antioxidant activities, improved 8-fold compared to ME.</p><p><strong>Conclusion: </strong>The improvement of these activities was attributed to the increase in their flavonoid content. This study emphasizes the role of particle size reduction or nano-extract preparation in increasing the biological activity of plant extracts.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144006871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response Surface Optimization, Fabrication and In-vitro Investigation of Elastic Nanovesicles Loaded with Flunarizine.","authors":"Mahmood A Haiss, Shaimaa N Abd Alhammid","doi":"10.2174/0122117385392040250404114249","DOIUrl":"https://doi.org/10.2174/0122117385392040250404114249","url":null,"abstract":"<p><strong>Background: </strong>Different variables have been used for the preparation of elastic nanovesicles. In this work, the ethanol injection method has been used to prepare flunarizine spanlastic nanovesicles and study the potential of these variables on vesicle size, encapsulation efficiency, and vesicle elasticity.</p><p><strong>Objective: </strong>The objective of this study was to encapsulate flunarizine dihydrochloride (FHC), a medication with low solubility in water, within nano-elastic vesicles made from Span 60. These vesicles, known as nano-spanlastics, were developed to provide non-invasive trans-nasal delivery and offer a potential therapeutic option for migraines. The ideal formula for flunarizine spanlastic nanovesicles should have the lowest possible particle size and PdI, highest possible zeta potential, vesicle elasticity, drug entrapment, and dissolving efficiency.</p><p><strong>Methods: </strong>An experimental design was followed during the preparation of flunarizine-loaded nanospanlastics utilizing the ethanol injection method and a number of edge activators (EAs). To investigate how the independent parameters affected the features of elastic vesicles and choose the best formula, Design-Expert®, software was used. The screening of 18 formulation and process aspects affecting vesicle size, polydispersity index, deformability index, zeta potential, drug entrapment, and in-vitro release was made easier by the experimental design.</p><p><strong>Results: </strong>The selected Flunarizine spanlastic nanovesicles exhibited a vesicle size of 135 ± 2.81 nm, PdI 0.2462 ± 0.01, ZP -28 ± 0.92 mV, relative deformability of 13.96 ± 0.76 g, EE% of 78.37 ± 1.42, and dissolution efficiency of about 90%.</p><p><strong>Conclusion: </strong>The successful preparation of Flunarizine-loaded spanlastic nanovesicles using ethanol injection method significantly improved the drug's solubility. Flunarizine spanlastic formulations made up of Span 60 and EAs (Tween 40 and SDC) were prepared using various weight ratios of Span 60: EA. The study presented a viable and successful method for nasal delivery of the medication for migraine treatment.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144027810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Preparation Techniques for Polymeric Nanoparticles and their Application in Drug Delivery.","authors":"Harish Bhardwaj, Soniya Sarthi, Rajendra Kumar Jangde","doi":"10.2174/0122117385366838250314110525","DOIUrl":"https://doi.org/10.2174/0122117385366838250314110525","url":null,"abstract":"<p><p>Nanotechnology has advanced significantly in recent decades, with the production and design of nanomaterials becoming a focal point of research. Nanomedicine, a key component of this field, involves the development of nanoscale materials for applications in imaging and drug delivery. Current research predominantly focuses on the synthesis of precisely characterized nanomaterials, particularly in terms of their size and morphology, as these parameters play a critical role in determining the behavior of nanomaterials in vivo. This paper reviews various methods for the preparation of polymeric nanoparticles, including solvent evaporation, nanoprecipitation, emulsification/ solvent diffusion, salting out, dialysis, supercritical fluid technology (SCF), and monomer polymerization techniques. Additionally, it discusses approaches such as emulsion, mini-emulsion, microemulsion, interfacial polymerization, controlled/living radical polymerization, and ionic gelation/ coacervation. Each preparation method is described in terms of its characteristics, advantages, limitations, and potential applications. The paper also explores pharmaceutical considerations and challenges associated with novel drug delivery systems. Recent literature examples are presented to highlight the impact of preparation techniques on the physicochemical properties of nanoparticles.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aptamer-Decorated Nanocarrier for Selectively Targeting Cancer Cells.","authors":"Thangavel Lakshmipriya, Subash C B Gopinath","doi":"10.2174/0122117385372567250304072634","DOIUrl":"https://doi.org/10.2174/0122117385372567250304072634","url":null,"abstract":"","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143616724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancements in Nanoparticle-Based Targeted Drug Delivery Systems for Breast Cancer.","authors":"Roshni Kunte, Prafulla Sabale, Suchita Waghmare, Manasi Nikam Jiwankar, Vidya Sabale","doi":"10.2174/0122117385339882241206095441","DOIUrl":"https://doi.org/10.2174/0122117385339882241206095441","url":null,"abstract":"<p><p>Cancer is a leading cause of death and life-threatening disease globally. It is connected to persistent tissue damage and unregulated cellular proliferation. In females, breast cancer plays a crucial role in death rates. Chemotherapy, alongside surgery, radiation, and hormone therapy, is a first-line treatment, but its non-specific action harms both cancerous and healthy cells, causing severe side effects. The treatment options for breast cancer are based on the disease stage, which spans from stages 0 to IV. To mitigate this issue, novel strategies focusing on specific targets have been introduced in recent times. Advanced nanocarriers are focused on tumor-specific drug delivery using active targeting based on ligand-receptor identification, this approach has the potential to demonstrate enhanced efficacy compared to passive targeting strategies in the context of therapy for human breast cancer. Surface alteration can assist overcome this issue. This overview focuses on modified nano-sized carriers, including liposomes, micelles, polymeric nanocarriers, carbon dots, and gold nanoparticles. It has been studied to improve therapeutics efficacy, bioavailability, and pharmacokinetics features via mechanisms. The primary aim is no longer confined to merely enveloping cancer medications in novel formulations for diverse delivery pathways; instead, the emphasis lies on precise cancer targeting. This review focuses on the stages of breast cancer, obstacles, types of breast cancer therapies, techniques, and various nanocarriers using ligand-mediated drug delivery systems and their mechanisms.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano Drug Delivery Carriers (Nanocarriers): A Promising Targeted Strategy in Tuberculosis and Pain Treatment.","authors":"Rahul Pal, Prachi Pandey, Himmat Singh Chawra, Zuber Khan","doi":"10.2174/0122117385367493250224103839","DOIUrl":"https://doi.org/10.2174/0122117385367493250224103839","url":null,"abstract":"<p><strong>Background: </strong>Tuberculosis (TB) and chronic pain are global health concerns that affect millions of people, often requiring long-term, effective treatment strategies. The conventional therapies used to manage these conditions come with significant limitations. In TB, long treatment durations, poor compliance, drug resistance, and toxicity of first-line drugs are key challenges. Similarly, pain management faces issues, such as inadequate targeting, systemic side effects, and tolerance to analgesics, limiting traditional therapy efficacy.</p><p><strong>Objective: </strong>The objective of this review is to explore the potential of nanocarriers as a targeted drug delivery strategy for improving treatment outcomes in TB and pain management. It aims to explore how these advanced systems improve drug bioavailability (BA), control release, reduce side effects, and enhance therapeutic outcomes.</p><p><strong>Methods: </strong>This systematic review used databases like PubMed, Elsevier, Scopus, Google Scholar, Google Patents, and ResearchGate, etc., to collect original review articles from the past 15 years (September 1, 2007 to September 1, 2024).</p><p><strong>Results: </strong>The review also revealed that these advanced systems offer promising solutions for overcoming the limitations of conventional therapies, such as poor patient compliance and drug toxicity. Nanocarriers represent a transformative approach in both TB and pain management, with the potential to revolutionize treatment paradigms and improve patient outcomes.</p><p><strong>Conclusion: </strong>In conclusion, nanocarriers represent a highly promising approach for advancing treatment strategies in both TB and pain management. The review underscores that nanocarrier systems, such as nanoemulsion, nanosuspension, nanocrystal, liposomes, niosomes, dendrimer, and polymeric nanoparticles, offer substantial improvements in drug delivery by enhancing BA, ensuring targeted release, and reducing systemic side effects.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143586464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanotechnology Platform for the Delivery of Docetaxel and Tyrosine Kinase Inhibitors for HER2-Positive Breast Cancer Therapy.","authors":"Bharathi Mandala, Yvonne Berko, Gantamur Battogtok, Funmilola Fisusi, Haijun Gao, Emmanuel O Akala","doi":"10.2174/0122117385373466250219070753","DOIUrl":"https://doi.org/10.2174/0122117385373466250219070753","url":null,"abstract":"<p><strong>Background: </strong>HER2-positive breast cancer is an aggressive subtype characterized by the overexpression of the HER2 receptor, a transmembrane glycoprotein critical for tumor progression. Current therapies often face challenges like drug resistance and systemic toxicity, necessitating the development of advanced drug delivery systems.</p><p><strong>Objective: </strong>This study aimed to fabricate and determine the cytotoxicity of pH-sensitive PLA nanoparticles dual-loaded with docetaxel and each of the small molecule tyrosine kinase inhibitors (STKIs) (tucatinib, neratinib, lapatinib) in HER2-positive breast cancer cells.</p><p><strong>Method: </strong>Nanoparticles were synthesized by a dispersion polymerization method using an acidlabile crosslinking agent, and PEG and lactide macromonomers. They were characterized for structure (TEM), surface morphology (SEM), particle size, polydispersity index, zeta potential, and drug loading capacity. Cytotoxicity was assessed in vitro on SKBR3 and MCF7 breast cancer cell lines, with IC50 values compared across formulations.</p><p><strong>Results: </strong>The nanoparticles were spherical with nanoscale sizes and negative zeta potential values. In vitro studies demonstrated enhanced antiproliferative effects of the drug-loaded nanoparticles, with synergistic activity observed between docetaxel and the STKIs. The drug concentrations were halved in combination formulations and resulted in better cytotoxicity compared to single-drug treatments, particularly against SKBR3 cells. The IC50 values were lower in SKBR3 cells than in MCF7 cells, highlighting the role of HER2 expression in the activity of TKIs.</p><p><strong>Conclusion: </strong>The pH-sensitive PLA nanoparticles effectively co-delivered docetaxel and STKIs and demonstrated enhanced efficacy and reduced drug dosages in HER2-positive breast cancer models. This study provides a foundation for further exploration of nanoparticle-based combination therapies with potential applications in treating other aggressive cancer types.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143493205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emulgel-Based Formulations of Clobetasol Propionate: Formulation Development, Characterization, and Pharmacological Evaluation.","authors":"Kuldeep Singh, Jeetendra Kumar Gupta, Divya Jain, Mukesh Chandra Sharma, Shivendra Kumar, Ramkumar Chaudhary, Sakshi Mishra","doi":"10.2174/0122117385327270241224080729","DOIUrl":"https://doi.org/10.2174/0122117385327270241224080729","url":null,"abstract":"<p><p>Topical formulations of corticosteroids, particularly clobetasol propionate (CP), are commonly used to treat a range of dermatological conditions. CP is a potent corticosteroid known for its efficacy in managing inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses. Emulgel-based formulations of CP have emerged as an innovative approach, offering advantages like improved drug solubility, enhanced skin penetration, and extended drug release. This review aims to provide an updated overview of the latest advancements in the development and evaluation of CP emulgel formulations. Key aspects discussed include the selection and optimization of emulgel components, formulation characterization, in vitro drug release, and pharmacological activities such as anti-inflammatory and anti-pruritic effects. Emphasis is placed on recent studies and innovations that underscore the potential of CP emulgels in dermatological therapy, highlighting their promising applications in enhancing therapeutic efficacy and patient outcomes.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revealing the Antidiabetic Potential of Herbal Nanoparticles.","authors":"Kunal Datta, Soubhik Bhattacharyya, Christina Narzary, Reshmi Mukherjee, Angana Naskar, Shazma Imam, Subarno Chakraborty, Dhrubajyoti Sarkar","doi":"10.2174/0122117385357690250214072827","DOIUrl":"https://doi.org/10.2174/0122117385357690250214072827","url":null,"abstract":"<p><p>Diabetes is a chronic metabolic disorder that is characterized by high postprandial blood sugar levels and increased fasting, which disrupts physiological balance and causes organ damage. Owing to the global health risk of type 2 diabetes, natural remedies have shown promise as viable alternatives because of their outstanding antidiabetic properties. Nevertheless, the therapeutic use of these compounds is rather restricted due to their inadequate solubility, instability in the gastrointestinal tract, low absorption, and other related factors. Currently, the development of nanoscale systems is a notable approach to enhancing the delivery of phytochemicals. This study aims to investigate the advancements in drug delivery techniques using nanoparticles, with a particular focus on enhancing the effectiveness of herbal remedies in the treatment of diabetes. This study aims to enrich our understanding of nanotechnology's potential in enlightening drug delivery systems by employing database repositories like PubMed, Scopus, Google Scholar, and Web of Science. Based on their categorization and structure, nano-systems are classified into liposomes, nanostructured lipid carriers, phytosomes, niosomes, solid lipid nanoparticles, self-nano emulsifying drug delivery systems, and inorganic nano-carriers. This study intricately describes the formulation process, selection criteria, and mechanism of herb-loaded nanoparticles using an example of the pharmacokinetic and pharmacodynamic properties of antidiabetic herbal drugs. Researchers have proven that nanoformulations of herb-loaded antidiabetic drugs improve compliance and therapeutic efficacy by resolving pharmacokinetic and biopharmaceutical issues. We could expect the creation of nanoformulations to be a viable method for optimizing the therapeutic effectiveness of plant-produced antidiabetic compounds.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143468760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorating Paraquat-Induced Nephrotoxicity in Rats: Protective Effects of Nanocurcumin on Renal Histology and Molecular Pathways.","authors":"Davood Ahmadi Moghaddam, Mehdi Rahimi, Nejat Kheiripour, Zohre Sadeghian, Sara Soleymani Asl, Zahra Azizi, Akram Ranjbar","doi":"10.2174/0122117385361582250112083125","DOIUrl":"https://doi.org/10.2174/0122117385361582250112083125","url":null,"abstract":"<p><strong>Background: </strong>Paraquat (PQ) is a common herbicide, and its mortality results from injury to several organs, including the kidneys. Nanocurcumin and curcumin have anti-inflammatory and anti-oxidative activities, but their involvement in PQ-induced kidney damage is unclear. Therefore, the goal of our study was to compare nanocurcumin and curcumin in male rats whose kidneys were damaged by PQ.</p><p><strong>Method: </strong>42 eight-week male albino Wistar rats were put into six groups at random as control, control + curcumin, control + nanocurcumin, PQ, PQ + curcumin, PQ + nanocurcumin for 7 days. The kidney tissues and serum were collected at the end of this period. Total antioxidant capacity (TAC), lipid peroxidation (LPO), total thiol Molecule (TTM), urea, creatinine, and blood urea nitrogen (BUN) levels were assessed. The histopathological evaluation of kidney damage was performed at the end of our study. Moreover, the gene expression was assessed by biochemical and Reverse transcription polymerase chain reaction (RT-PCR) analysis.</p><p><strong>Result: </strong>Curcumin and nanocurcumin administration alleviated PQ-induced renal injury, as evidenced by reduced serum creatinine and BUN levels. The levels of antioxidant markers, like TAC and TTM, increased and decreased the levels of oxidative stress indexes like LPO. Furthermore, our result shows up-regulating the expression of nuclear factor-like 2 (Nrf2), NAD (P) H: quinine oxidoreductase 1 (NQO1), Heme oxygenase 1 (HO-1), and down-regulating the expression of Kelchlike ECH-associated protein 1 (Keap-1) in renal tissue.</p><p><strong>Conclusion: </strong>Niosomal curcumin was more advantageous than ordinary curcumin in lowering oxidative stress and renal tissue damage induced by paraquat intoxication.</p>","PeriodicalId":19774,"journal":{"name":"Pharmaceutical nanotechnology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143414773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}